Study into the effect of candidalysin exotoxin secretion and fungal ROS generation on C. albicans infection on human hepatocytes

Research Project

Project/Area Number	24K18435
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Tokyo Institute of Technology
Principal Investigator	Chen Xinyue 東京工業大学, 生命理工学院, 助教 (50817369)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	candidalysin exotoxin / fungal ROS generation / Candida albicans / morphological transition / human hepatocytes
Outline of Research at the Start	This proposed study aims to explore the pathogenic mechanism of Candida albicans on human hepatocytes by clarifying the link between candidalysin exotoxin secretion and fungal ROS generation during morphological transition.