Impacts of the migratory dendritic cells on tumor-specific T cell fate in the thymus

• Project/Area Number: 24K18461
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Chiba University
• Principal Investigator: ワン ヤンソン 千葉大学, 大学院医学研究院, 特任助教 (60982296)
• Project Period (FY): 2024-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2024: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: Thymus / Dendritic cells / central tolerance / Anti-tumor immunity

Outline of Research at the Start

Tumor cells adapt different strategies to establish immune tolerance. It is well known that tumor progression establishes periphery tolerance to dampen anti-tumor T cell responses, whereas the role of central tolerance in tumor progression is still a question remaining unanswered.