Development of a novel cancer immunotherapy model targeting human macrophages

• Project/Area Number: 24K18516
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kobe University
• Principal Investigator: Afroj Tania 神戸大学, 医学研究科, 学術研究員 (50913034)
• Project Period (FY): 2024-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2024: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: macrophages / cancer immunotherapy / Humanized mice

Outline of Research at the Start

To elucidate the role of human macrophages in the tumor microenvironment, I propose to develop a humanized mouse model to investigate of the function of human macrophages treated with novel anti-human SIRPα antibodies.