Targeted Delivery of Biodistribution-Guided Recombinant Adeno-associated Viral Vector (AAV) to Specific Hepatocytes

• Project/Area Number: 24K18551
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Jichi Medical University
• Principal Investigator: Nemekhbayar Baatartsogt 自治医科大学, 医学部, 助教 (40972716)
• Project Period (FY): 2024-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2024: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: AAV / Gene Therapy / Liver target

Outline of Research at the Start

Gene therapy and CRISPR-based gene editing are promising for treating genetic disorders. Achieving precise cell targeting is crucial to lower dosages and minimize adverse effects, advancing these therapies to clinical application.