Creation of PROTAC-based nanomedicine against glioblastoma

Research Project

Project/Area Number	24K18566
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 50020:Tumor diagnostics and therapeutics-related
Research Institution	Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Principal Investigator	ドアンテイキンユン公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (70838870)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	PROTAC / glioma / micelle
Outline of Research at the Start	We aim to develop nanomedicine for treating malignant glioblastoma utilizing PROteolysis TAgeting Chimeras (PROTAC), as a therapeutic agent using polymeric micelles composed of polyethylene glycol (PEG) block aromatic aldehyde polymers.