Circuit coordination of neuropeptide and neurotransmitter signals in hippocampus

• Project/Area Number: 24K18613
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Zhou Yijun 国立研究開発法人理化学研究所, 脳神経科学研究センター, 基礎科学特別研究員 (70983956)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2025: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: hippocampus / Pro-opiomelanocortin / melanocortin 4 receptor

Outline of Research at the Start

POMC neuron secreted neuropeptides are co-released, acting slowly on MC4R expressed in the CA1 region. This local neuropeptidyl pathway is not yet well-understood.In this study, we aim to independently manipulating of neurotransmitters and neuropeptides within CA3 and CA1 regions simultaneously.