Elucidating the role of Cnot3 in regulating social behavior in Autism Spectrum Disorder

Research Project

Project/Area Number	24K18632
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 51030:Pathophysiologic neuroscience-related
Research Institution	Okinawa Institute of Science and Technology Graduate University
Principal Investigator	ハイサムモハメドアリモハメド沖縄科学技術大学院大学, 細胞シグナルユニット, ポストドクトラルスカラー (10940249)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2025: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	Autism / Social Interaction / mRNA deadenylation
Outline of Research at the Start	The research aims to understand the role of CNOT3 in ASD pathogenesis by investigating its function in social behavior deficits using a mutant Cnot3 mouse model. Through behavioral testing, brain activity mapping, and molecular analysis, we seek to understand Cnot3's impact on social impairments.