Characterization of dominant negative ACTA2 variants : a zebrafish model for non-syndromic aortic aneurysms

• Project/Area Number: 24K18891
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Oita University
• Principal Investigator: Sebastian WulanApridita 大分大学, 医学部, 特任助教 (60979540)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2024: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: acta2 / zebrafish / aortic disease

Outline of Research at the Start

ACTA2 gene is a causal gene of non-syndromic hereditary aortic disease which is not easy to diagnose due to the limited symptoms. Investigation of pathogenecity of ACTA2 gene variants in zebrafish will lead to the development of an early diagnostic methods for non-syndromic hereditary aortic disease