Establishing a novel culture system for lymphoid-biased HSC expansion

Research Project

Project/Area Number	24K19206
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 54010:Hematology and medical oncology-related
Research Institution	Kumamoto University
Principal Investigator	王雨馨熊本大学, 国際先端医学研究機構, 特定研究員(国際先端医学研究拠点施設) (20988597)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2025: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	造血幹細胞 / リンパ球分化 / 代謝
Outline of Research at the Start	We aim to establish a novel ex vivo culture system to enrich/expand lymphoid-biased HSCs by modulation of the amino acid concentration in the culture medium, and to elucidate the molecular mechanisms behind it. This study is expected to overcome the limitation of HSCs transplantation.