The role of ST6GAL2 and GM3 synthase dysregulation in the pathogenesis of Medulloblastoma. An in-vitro study.

• Project/Area Number: 24K19553
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Fukushima Medical University
• Principal Investigator: ムダシル バキット 福島県立医科大学, 医学部, 助教 (70943306)
• Project Period (FY): 2024-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2026: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2025: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: Medulloblastoma / Sialic acid / Brain / Neurosurgery

Outline of Research at the Start

The research explores how a sugar called sialic acid, normally found in cell membranes, affects a child's brain tumor called medulloblastoma and affects their behavior and response to treatment.

この研究では、通常細胞膜に存在するシアル酸と呼ばれる糖が、髄芽腫と呼ばれる子どもの脳腫瘍にどのような影響を与え、子どもの行動や治療への反応に影響を与えるかを探っている。