A novel mechanism of menopause-induced endometrial cancer that develops through functional loss of the helicase family

• Project/Area Number: 24K19688
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Kanazawa University
• Principal Investigator: HASAN MAHADI 金沢大学, 疾患モデル総合研究センター, 助教 (90953068)
• Project Period (FY): 2024-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2024: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: Endometrial Cancer

Outline of Research at the Start

This study will clarify how female hormone changes induces the onset of Endometrial cancer (EC) focusing on the endocrine-regulated BLM functions that are involved in the mutation of the target genes and the onset of EC. Applying this new mechanism is expected to predict the population at risk of EC after menopause and prevent the development of EC.