Elucidating the involvement of transient receptor potential vanilloid-type 4 in mechanical stimuli-induced swallowing reflex

Research Project

Project/Area Number	24K19847
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 57010:Oral biological science-related
Research Institution	Matsumoto Dental University
Principal Investigator	Roy RitaRani 松本歯科大学, 歯学部, 助教 (70963487)
Project Period (FY)	2024-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	Swallowing reflex / TRPV4
Outline of Research at the Start	The mechanical threshold to trigger swallowing increases among older people with dysphagia. Understanding the molecular mechanisms of mechanical stimuli-induced swallowing may help to develop therapeutics for dysphagia. The present study will explore the critical roles of TRPV4 in mechanical stimuli-induced swallowing reflexes.