Identification a novel bone-generating macrophage subset and their molecular mechanisms.

• Project/Area Number: 24K19848
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Matsumoto Dental University
• Principal Investigator: 何 治鋒 松本歯科大学, 総合歯科医学研究所, 助教 (10980047)
• Project Period (FY): 2024-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2024: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: Macrophage

Outline of Research at the Start

This study provides an idea that combines skeletal stem cells, the Wnt signaling network, and macrophages in bone healing. We execute this idea using two Mφ ablation methods and mouse genetic approaches to explore the fate of skeletal stem cells and the activation of Wnt signaling within them.