Exploring the inflammatory mediators degraded by MMP-2 in MMP-2-deficient mice with knee arthritis through a novel TMT-TAILS quantitative proteomics

Research Project

Project/Area Number	24K19850
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 57020:Oral pathobiological science-related
Research Institution	Tohoku University
Principal Investigator	Yang MuChen 東北大学, 歯学研究科, 助教 (50886447)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	MMP-2-deficient mice / Arthritis / Knee joint
Outline of Research at the Start	MMP-2 deficiency causes knee arthritis by failing to degrade specific inflammatory mediators. This study will use TMT-TAILS proteomics to identify these mediators in MMP-2-knockout mice, aiming to clarify the inflammatory mechanism and propose knee joint protection strategies.