Exploration of T- and B-cell receptors to eliminate the foreign body reaction from synthetic polymeric scaffolds

Research Project

Project/Area Number	24K19917
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 57040:Regenerative dentistry and dental engineering-related
Research Institution	Osaka University
Principal Investigator	LARANJEIRA・ABE GABRIELA 大阪大学, 大学院歯学研究科, 特任助教(常勤) (30964952)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2025: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2024: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Scaffolds / Foreign Body Reaction / T-cells / B-cells
Outline of Research at the Start	Foreign body response (FBR) is a physiological response to implanted biomaterials, and can result in fibrosis or tissue regeneration. However, the role of T- and B-cells in the FBR is not well understood. Therefore, tissue regeneration models will be used to study T- and B- cells in the FBR of biomaterials.