Engineering a 3D construct with perfusable and functional capillary networks using scaffold-free method

Research Project

Project/Area Number	24K21088
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	Saga University
Principal Investigator	YU JUNJIE 佐賀大学, 医学部, 助教 (80969345)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2024: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	scaffold-free method / human-derived cells / spheroid / Kenzan / capillary networks
Outline of Research at the Start	Once the graft is constructed without capillary networks, it couldn't receive the nutrients and oxygen from the blood supply after implantation, which may compromise the cell survival. This research aims to engineer a scaffold-free 3D construct with the perfusable and functional capillary networks.