Navigate homogenesis nephrogenesis in kidney organoid by microfabrication of 3D extracellular matrix.

Research Project

Project/Area Number	24K21098
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	Han Aifang 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 (30938832)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2024: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	nephrogenesis / extracellular matrix / kidney organoid / microfabrication
Outline of Research at the Start	The applicant will identify how ECM can regulate nephrogenesis patterning in kidney organoid by varying multi-aspects of ECM properties (geometry, mechanical stiffness, and chemical composition), and develop proper nephron tissues in kidney organoids using the underlying mechanisms.