Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly

Research Project

Project/Area Number	24K21101
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	National Cardiovascular Center Research Institute
Principal Investigator	Soni Raghav 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー (10967863)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2025: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2024: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	Cerebral atherosclerosis / Ablation / MR imaging / photothermal treatment / self-assembly
Outline of Research at the Start	we propose developing a supramolecular self-assemble polymer based targeted MR probe equipped with heat generating particles, which can cauterize cerebral atherosclerosis in a spatially specific manner using MR imaging and photothermal treatment