In vivo function-persistent polymersome nanoreactor with tumor-specific activation and safe clearance/metabolism for synergistic oxidation-chemo-immunotherapy

Research Project

Project/Area Number	24K21109
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 90120:Biomaterials-related
Research Institution	Kyushu University
Principal Investigator	WEN PANYUE 九州大学, 先導物質化学研究所, 学術研究員 (00976623)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2025: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2024: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	polymersome nanoreactor
Outline of Research at the Start	the applicant presents a function-persistent polymersome nanoreactor with tumor-specific activation and safe clearance/metabolism for synergistic oxidation-chemo-immunotherapy. Polymersome nanoreactor is fabricated by self-assembly of block copolymer consisting of PEG segment, ROS-responsive polymeric prodrug segment, tumor pH-responsive segment, and photo-crosslinker segment, with lactate oxidase (LOD).