| Project/Area Number |
24K21927
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ロンゴ リアム 東京工業大学, 地球生命研究所, 特任准教授 (40955027)
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| Co-Investigator(Kenkyū-buntansha) |
松浦 友亮 東京工業大学, 地球生命研究所, 教授 (50362653)
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| Project Period (FY) |
2024-06-28 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2025: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2024: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | protein evolution / evolvability / sequence reconstruction / functional promiscuity |
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| Outline of Research at the Start |
Ancestral sequences are thought to be multifunctional, allowing them to operate on diverse substrates. In other words, ancestral enzymes with multifunctionality are thought to have evolved into extant enzymes with high specificity. Multidrug efflux transporters, on the other hand, exist in all three domains of life and can transport drugs with diverse chemical structures. Existing multidrug efflux transporters retain the multifunctionality that enzymes often lose during evolution. What kind of evolutionary process did multifunctional proteins go through to arrive at their modern properties?
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