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Uncovering the history of multifunctional transporters

Research Project

Project/Area Number 24K21927
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Research InstitutionTokyo Institute of Technology

Principal Investigator

ロンゴ リアム  東京工業大学, 地球生命研究所, 特任准教授 (40955027)

Co-Investigator(Kenkyū-buntansha) 松浦 友亮  東京工業大学, 地球生命研究所, 教授 (50362653)
Project Period (FY) 2024-06-28 – 2026-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2025: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2024: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsprotein evolution / evolvability / sequence reconstruction / functional promiscuity
Outline of Research at the Start

Ancestral sequences are thought to be multifunctional, allowing them to operate on diverse substrates. In other words, ancestral enzymes with multifunctionality are thought to have evolved into extant enzymes with high specificity. Multidrug efflux transporters, on the other hand, exist in all three domains of life and can transport drugs with diverse chemical structures. Existing multidrug efflux transporters retain the multifunctionality that enzymes often lose during evolution. What kind of evolutionary process did multifunctional proteins go through to arrive at their modern properties?

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Published: 2024-07-03   Modified: 2024-08-28  

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