| Project/Area Number |
24K23047
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
LI RUICHEN 東京大学, ニューロインテリジェンス国際研究機構, 特任研究員 (71001070)
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| Project Period (FY) |
2024-07-31 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Multi-system Model / Autonomic Nervous System / Heart Rate / Blood Pressure / Neurodiversity / Interoception / Multi-system modeling / Autonomic nervous system / Emotional states |
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| Outline of Research at the Start |
This project will provide a computational modeling method by integrating cardiovascular, respiratory, and autonomic nervous systems. The multi-system model will be established to reproduce and predict the interoceptive signals representing mental performances, such as blood pressure and heart rate variability, and further investigate the interaction mechanisms between them and emotional fluctuations.
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| Outline of Annual Research Achievements |
I developed a computational model that integrates the cardiovascular, respiratory, and autonomic nervous systems to simulate how heart rate and blood pressure are regulated. This model was used to compare individuals with typical development and those with different conditions of neurodiversity, such as autism spectrum disorder.
By fitting the model to existing physiological data, I identified differences in how the autonomic nervous system functions in these groups under specific tests, such as posture change and breathing tasks. The results suggest that individuals with autism may show increased sensitivity to nervous system signals and may benefit from breathing-based support.
In the next stage, I will apply this model to analyze more detailed individual differences.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
In line with the original plan, I developed a multi-system computational model to simulate how the autonomic nervous system (ANS) regulates heart rate and blood pressure under both typical developmental (TD) and neurodivergent conditions, such as autism spectrum disorder (ASD).
The model construction was completed more smoothly than expected, and promising results were obtained in investigating autonomic control modes on interoceptive responses and simulating these responses based on sympathetic-parasympathetic balance during various autonomic function tests.
I have presented the findings at three international conferences. A journal paper and another conference presentation are currently in preparation.
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| Strategy for Future Research Activity |
In the next stage, I will apply the model to analyze individual differences more precisely, focusing on how different autonomic control patterns affect heart rate (HR) and blood pressure (BP) responses. Published HR and BP data will be used for model fitting and validation. Specifically, I will map reported data onto simulation surfaces defined by sympathetic and parasympathetic activity under various autonomic tests in both autism and control groups. I will also incorporate respiratory inputs with varying rates and amplitudes to explore their effects on restoring HR and BP responses under dysfunctional ANS regulation. A journal paper and a new conference presentation are currently in preparation.
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