| Project/Area Number |
24K23243
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
劉 品吾 京都大学, 医学研究科, 研究員 (60886563)
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| Project Period (FY) |
2024-07-31 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | CaMKII / AMPAR / NMDAR / GluSnFR / super-resolution imaging |
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| Outline of Research at the Start |
Synaptic plasticity, crucial for memory and other brain functions, involves synaptic proteins with unclear regulation. We propose that synaptic protein condensates formed via liquid-liquid phase separation (LLPS) are key to synaptic plasticity.
This study aims to explore memory mechanisms through LLPS in vivo. By using photoactivatable proteins, we will manipulate LLPS in living cultures and observe neuron network changes with light stimulation.
The findings could uncover mechanisms of memory formation and extinction, potentially leading to therapies for disorders like dementia and PTSD.
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