Human HSC interactions with T cells to enhance engraftment in humanized bone organ model

• Project/Area Number: 24K23297
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0802:Biomedical structure and function and related fields
• Research Institution: Kumamoto University
• Principal Investigator: HO Pui・Yu 熊本大学, 国際先端医学研究機構, 特定事業研究員 (40888385)
• Project Period (FY): 2024-07-31 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 造血幹細胞移植

Outline of Research at the Start

By the use of huMSC-derived humanized bone organ model, we investigate the behavior of huHSCs shortly after transplantation. We will study how the transplanted huHSCs actively "talk" with the CD4 T cells in BM niche to reshape the microenvironment to support the their own expansion.