xosomes, regulated by SPRED2, reshape tumor microenvironment via activating IL6/ STAT3 signaling

Research Project

Project/Area Number	24K23356
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Multi-year Fund
Review Section	0901:Oncology and related fields
Research Institution	Okayama University
Principal Investigator	高桐岡山大学, 医歯薬学域, 助教 (10998644)
Project Period (FY)	2024-07-31 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	exosome / tumor microenvironment / SPRED2 / macrophage
Outline of Research at the Start	がん由来エクソソームは、腫瘍微小環境に働きかけ、がんの増殖・進展・転移を促す。本研究では、エクソソーム分泌に関わるERKシグナル伝達経路の全容を解明し、その内因性抑制因子SPRED2によるエクソソーム放出と腫瘍免疫調整機構の解明に挑戦する。