M-MDSC as osteoclast precursors in inflammatory bowel disease associated apical periodontitis

Research Project

Project/Area Number	24K23537
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Multi-year Fund
Review Section	0907:Oral science and related fields
Research Institution	Tohoku University
Principal Investigator	MOESANDARKYAW 東北大学, 歯学研究科, 助教 (80996405)
Project Period (FY)	2024-07-31 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	M-MDSC / Osteoclast precursors / IBD / Apical periodontitis / Bone resorption
Outline of Research at the Start	Inflammatory bowel diseases cause chronic inflammation and complications like therapy-resistant apical periodontitis. The underlying cause may be Monocytic Myeloid-derived Suppressor Cells, which expand under inflammatory conditions and can act as osteoclast precursors, promoting bone resorption.