The impact of free fatty acids receptor GPR120 on osteocytes regulates bone metabolism under diet-induced obesity

Research Project

Project/Area Number	24K23573
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Multi-year Fund
Review Section	0907:Oral science and related fields
Research Institution	Tohoku University
Principal Investigator	MA JINGHAN 東北大学, 歯学研究科, 助教 (51000880)
Project Period (FY)	2024-07-31 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	GPR120 / osteocyte / DHA / tooth movement / obesity
Outline of Research at the Start	After comparing bone metabolism in WT and GPR120 KO mice under obesity conditions, we can understand GPR120's role in obesity-induced bone loss. Analyzing these results will help identify GPR120 and other genes as potential therapeutic targets for future treatments.