| Project/Area Number |
24KF0022
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 37010:Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
菅 裕明 東京大学, 大学院理学系研究科(理学部), 教授 (00361668)
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| Co-Investigator(Kenkyū-buntansha) |
LEE KANG JU 東京大学, 大学院理学系研究科(理学部), 外国人特別研究員
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| Project Period (FY) |
2024-04-23 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2025: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Outline of Research at the Start |
Macrocyclic peptides have received considerable interest in drug discovery as a promising drug modality, but their low cell permeability has restricted their use to extracellular targets. Given that many drug targets reside inside cells, a generally applicable strategy for the discovery of cell-permeable and bioactive peptides is a strong demand. This research aims to address this challenging task by developing a novel mRNA display-based system, employing a pseudo-natural product library that possesses strategically positioned backbone N-methyl groups.
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