| Project/Area Number |
24KF0145
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 37010:Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
菅 裕明 東京大学, 大学院理学系研究科(理学部), 教授 (00361668)
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| Co-Investigator(Kenkyū-buntansha) |
KO TONGIL 東京大学, 大学院理学系研究科(理学部), 外国人特別研究員
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| Project Period (FY) |
2024-10-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2026: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2025: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2024: ¥500,000 (Direct Cost: ¥500,000)
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| Outline of Research at the Start |
The aim of this project is to utlize RaPID technology to facilitate the discovery of novel photoswitchable ligands. 1) The first objective will be to synthesize a variety of photoswitchable amino acids. 2) These monomers would then need to be incorporated into tRNAs through the use of flexizymes developed by the Suga lab. 3) Finally, these non-standard photoswitchable amino acids will be used to make random libraries of cyclic peptides through FIT. The libraries will be screened against b-tubulin through in vitro selection to find photoswitchable binders.
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