| Project/Area Number |
24KF0187
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
杉原 加織 東京大学, 生産技術研究所, 准教授 (60740800)
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| Co-Investigator(Kenkyū-buntansha) |
ZHENG JIANLU 東京大学, 生産技術研究所, 外国人特別研究員
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| Project Period (FY) |
2024-11-15 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2026: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2025: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Outline of Research at the Start |
Non-pathogenic antibody (RTO) binds to monomeric PF4, whereas KKO, a pathogenic antibody, binds to the PF4/heparin complex, activating platelets and causing HIT. A major challenge lies in the fact that RTO targets an epitope on the surface of the PF4 monomer that partially overlaps with the KKO epitope in the tetramer. To address this, we employ mechanochromic polydiacetylene as a colorimetric transducer, enabling the distinction between pathogenic and non-pathogenic antibodies, something other detection methods cannot achieve.
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