| Project/Area Number |
24KF0195
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 43020:Structural biochemistry-related
|
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| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
西増 弘志 東京大学, 先端科学技術研究センター, 教授 (00467044)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
ACHARYA SUNDARAM 東京大学, 先端科学技術研究センター, 外国人特別研究員
|
|---|
| Project Period (FY) |
2024-11-15 – 2027-03-31
|
| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2026: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2025: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2024: ¥300,000 (Direct Cost: ¥300,000)
|
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| Outline of Research at the Start |
In this study, we aim to solve the cryo-EM structure of the DinG-HNH-Cascade-target dsDNA complex to understand its unique DNA cleavage mechanism. Furthermore, we will engineer the CRISPR complex to develop new genome engineering tools.
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