| Project/Area Number |
24KF0198
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
|
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| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Cabral Horacio 東京大学, 大学院工学系研究科(工学部), 准教授 (10533911)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CHEN PENGWEN 東京大学, 大学院工学系研究科(工学部), 外国人特別研究員
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|---|
| Project Period (FY) |
2024-11-15 – 2027-03-31
|
| Project Status |
Granted (Fiscal Year 2024)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2026: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2025: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2024: ¥500,000 (Direct Cost: ¥500,000)
|
|---|
| Outline of Research at the Start |
Year 1: Develop Cas9/sgRNA-loaded nanocarriers (pH- and enzyme-sensitive). Characterize morphology and stimuli-responsiveness. Test gene-editing efficiency in vitro.
Year 2: Conduct in vivo studies on tumor-specific editing and off-target effects.
Year 3: Validate in vivo efficacy against KRAS, and prepare patent and publications.
|
