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Unveiling the Clonal Dynamics of Extrachromosomal DNA in Refractory Pediatric Brain Tumors

Research Project

Project/Area Number 24KF0252
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeMulti-year Fund
Section外国
Review Section Basic Section 50010:Tumor biology-related
Research InstitutionNagoya City University

Principal Investigator

川内 大輔  名古屋市立大学, 医薬学総合研究院(医学), 教授 (10400996)

Co-Investigator(Kenkyū-buntansha) CHAPMAN OWEN  名古屋市立大学, 医薬学総合研究院(医学), 外国人特別研究員
Project Period (FY) 2024-11-15 – 2027-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2026: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2025: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2024: ¥400,000 (Direct Cost: ¥400,000)
Outline of Research at the Start

To investigate the role of ecDNA in the evolution of therapeutic resistance in pediatric tumors, we will first, develop hypotheses by sequencing patient tumors before and after therapeutic intervention; and second, validate ecDNA evolution by sequencing tumor models under therapeutic pressure.

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Published: 2024-11-22   Modified: 2025-03-21  

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