Elucidation and therapeutic application of immunoinhibitory mechanisms in osteosarcoma through tumor infiltrating lymphocyte analysis

• Project/Area Number: 24KJ0999
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Multi-year Fund
• Section: 国内
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: 有賀 茜 東京医科歯科大学, 大学院医歯学総合研究科, 特別研究員(DC1)
• Project Period (FY): 2024-04-23 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥2,300,000 (Direct Cost: ¥2,300,000); Fiscal Year 2026: ¥300,000 (Direct Cost: ¥300,000); Fiscal Year 2025: ¥300,000 (Direct Cost: ¥300,000); Fiscal Year 2024: ¥1,700,000 (Direct Cost: ¥1,700,000)

Outline of Research at the Start

骨肉腫の腫瘍浸潤リンパ球(Tumor infiltrating lymphocytes: TILs) 解析およびRNA-seq を用いた免疫プロファイリング解析によって, TIL療法の妨げとなる免疫抑制機序を解明する. TIL 療法およびTIL療法と免疫チェックポイント阻害薬の複合治療を含めた, 骨肉腫の新しいがん免疫療法の開発の基盤となる研究を行う.