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Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur species

Research Project

Project/Area Number 25220103
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation and chemicals
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kumagai Yoshito  筑波大学, 医学医療系, 教授 (00250100)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
蕨 栄治  筑波大学, 医学医療系, 講師 (70396612)
石井 功  昭和薬科大学, 薬学部, 教授 (90292953)
西田 基宏  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90342641)
新開 泰弘  筑波大学, 医学医療系, 助教 (10454240)
Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥215,670,000 (Direct Cost: ¥165,900,000、Indirect Cost: ¥49,770,000)
Fiscal Year 2017: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2016: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2015: ¥35,750,000 (Direct Cost: ¥27,500,000、Indirect Cost: ¥8,250,000)
Fiscal Year 2014: ¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2013: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000)
Keywords親電子物質 / シグナル伝達 / 環境応答 / 化学修飾 / 活性イオウ分子 / 環境中親電子物質
Outline of Final Research Achievements

Environmental electrophiles covalently bind to thiol groups in proteins to form protein adducts. In the present study, we found that exposure of cultured cells to environmental electrophiles such as naphthoquinones, methylmercury, cadmium and crotonaldehyde at lower concentrations activated redox signaling pathways through covalent modification of sensor proteins. However, exposure to these electrophiles at higher concentrations disrupted the redox signaling pathways and caused substantial cytotoxicity through non-selective covalent modification of cellular proteins. It was also found that while reaction of environmental electrophiles with reactive sulfur species (RSS) resulted in formation of their sulfur adducts, knockdown of cystathionine γ-lase, an enzyme to produce RSS, enhanced the modulation of redox signaling and toxicity in vitro and in vivo, whereas treatment with Na2S4 diminished these phenomena during exposure to environmental electrophiles.

Assessment Rating
Verification Result (Rating)

A+

Result (Rating)

A+: Progress in the research exceeds the initial goal. More than expected research results are expected.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report

Research Products

(635 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research Journal Article Presentation Book Remarks

  • [Int'l Joint Research] Sonoma State University(アメリカ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Sonoma State University(アメリカ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Sonoma State University(アメリカ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species2018

    • Author(s)
      西田基宏、外山喬士、熊谷嘉人、富田拓郎.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Issue: 12 Pages: 1239-1243

    • DOI
      10.1248/yakushi.14-00209-1
    • NAID
      130004712987
    • Year and Date
      2018-08-31
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive Oxygen Species Signaling and Redox Homeostasis Regulated by 8-Nitro-cGMP2018

    • Author(s)
      Akaike T.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Issue: 4 Pages: 515-519

    • DOI
      10.1248/yakushi.13-00251-3
    • NAID
      130003391199
    • Year and Date
      2018-08-31
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.2018

    • Author(s)
      Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K,Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 495 Pages: 2165-2170

    • DOI
      10.1016/j.bbrc.2017.12.088
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL2018

    • Author(s)
      Kaneko K.、Miyamoto Y.、Tsukuura R.、Sasa K.、Akaike T.、Fujii S.、Yoshimura K.、Nagayama K.、Hoshino M.、Inoue S.、Maki K.、Baba K.、Chikazu D.、Kamijo R.
    • Journal Title

      Nitric Oxide

      Volume: 72 Pages: 46-51

    • DOI
      10.1016/j.niox.2017.11.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Important Role of endothelial caveolin-1 in the protective role of endothelium-dependent hyperpolarization against nitric oxide-mediated nitrative stress in microcirculation in mice2018

    • Author(s)
      Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 71 Pages: 113-126

    • DOI
      10.1097/fjc.0000000000000552
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-252018

    • Author(s)
      Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
    • Journal Title

      ACS chemical neuroscience

      Volume: 9 Pages: 217-223

    • DOI
      10.1021/acschemneuro.7b00363
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?2018

    • Author(s)
      Heppner David E.、Hristova Milena、Ida Tomoaki、Mijuskovic Ana、Dustin Christopher M.、Bogdandi Virag、Fukuto Jon M.、Dick Tobias P.、Nagy Peter、Li Jianing、Akaike Takaaki、van der Vliet Albert
    • Journal Title

      Redox Biol

      Volume: 14 Pages: 379-385

    • DOI
      10.1016/j.redox.2017.10.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 活性イオウによる生体防御応答、エネルギー代謝と寿命制御2018

    • Author(s)
      澤 智裕、赤池孝章
    • Journal Title

      実験医学増刊「レドックス疾患学」

      Volume: 36 Pages: 649-655

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 概論 レドックス疾患学:レドックス制御の破綻による病態と新たな疾患概念2018

    • Author(s)
      本橋ほづみ、赤池孝章、内田浩二、末松 誠
    • Journal Title

      実験医学増刊「レドックス疾患学」

      Volume: 36 Pages: 642-648

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 硫黄呼吸の発見:ペルスルフィド産生酵素による新しいエネルギー代謝2018

    • Author(s)
      西村 明、赤池孝章
    • Journal Title

      現代化学

      Volume: 565 Pages: 55-59

    • NAID
      40021493631
    • Related Report
      2017 Annual Research Report
  • [Journal Article] 活性イオウによるミトコンドリア機能制御2018

    • Author(s)
      西田基宏、西村明幸、下田 翔
    • Journal Title

      実験医学 増刊

      Volume: 36 Pages: 663-668

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cystathionine γ-lyase-produced NO H2S controls endothelial NO bioavailability and systemic blood pressure2018

    • Author(s)
      Szijarto I, Marko L, Filipovic MR, Tabeling C, Tsvetkov D, Wang N, Rabelo L, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M
    • Journal Title

      Hypertension

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural and functional insights into S-thiolation of human serum albumins2018

    • Author(s)
      Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Gimenez-Bastida JA, Schneider C, Uchida K
    • Journal Title

      Scientific Reports

      Volume: 8(1) Pages: 932-932

    • DOI
      10.1038/s41598-018-19610-9
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation.2018

    • Author(s)
      Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, Martinon F, Busso N
    • Journal Title

      J Biol Chem

      Volume: 293 Pages: 2546-2557

    • DOI
      10.1074/jbc.m117.806869
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 食品成分の変質2018

    • Author(s)
      石井功
    • Journal Title

      第6版衛生薬学 健康と環境

      Volume: - Pages: 225-236

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 食品とアレルギー2018

    • Author(s)
      石井功
    • Journal Title

      第6版衛生薬学 健康と環境

      Volume: - Pages: 237-238

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor.2018

    • Author(s)
      Ishii Tetsuro、Warabi Eiji、Mann Giovanni E.
    • Journal Title

      Free Radic Biol Med.

      Volume: -

    • DOI
      10.1016/j.freeradbiomed.2018.01.026
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deletion of both <i>p62</i> and <i>Nrf2</i> spontaneously results in the development of nonalcoholic steatohepatitis2018

    • Author(s)
      Akiyama K, Warabi E, Okada K, Shoda J
    • Journal Title

      Exp. Anim.

      Volume: - Issue: 2 Pages: 201-218

    • DOI
      10.1538/expanim.17-0112
    • NAID
      120006478277
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.2018

    • Author(s)
      Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.
    • Journal Title

      J Physiol Sci

      Volume: 印刷中 Pages: 1-12

    • DOI
      10.1007/s12576-016-0519-3
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017

    • Author(s)
      Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
    • Journal Title

      Chemical Research in Toxicology

      Volume: 30 Pages: 2209-2217

    • DOI
      10.1021/acs.chemrestox.7b00278
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity2017

    • Author(s)
      Yoshida Eiko、Kurita Masaru、Eto Komyo、Kumagai Yoshito、Kaji Toshiyuki
    • Journal Title

      Toxicology

      Volume: 392 Pages: 40-46

    • DOI
      10.1016/j.tox.2017.09.013
    • NAID
      120006399226
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 1177-1177

    • DOI
      10.1038/s41467-017-01311-y
    • NAID
      120006365562
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of Unfolded Protein Response by Methylmercury2017

    • Author(s)
      Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 40 Issue: 9 Pages: 1595-1598

    • DOI
      10.1248/bpb.b17-00359
    • NAID
      130006038778
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells2017

    • Author(s)
      Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
    • Journal Title

      Chemical Research Toxicology

      Volume: 30 Pages: 1673-1684

    • DOI
      10.1021/acs.chemrestox.7b00120
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017

    • Author(s)
      Abiko Yumi、Shinkai Yasuhiro、Unoki Takamitsu、Hirose Reiko、Uehara Takashi、Kumagai Yoshito
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 4814-4814

    • DOI
      10.1038/s41598-017-04590-z
    • NAID
      120006329286
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017

    • Author(s)
      Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 104 Pages: 118-128

    • DOI
      10.1016/j.freeradbiomed.2016.12.047
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides2017

    • Author(s)
      Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y.
    • Journal Title

      Toxicol Sci

      Volume: 156 Pages: 412-421

    • DOI
      10.1093/toxsci/kfw268
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of redox signaling by nitrated nucleotide and reactive cysteine persulfides. Nitric Oxide: Biology and Pathobiology.2017

    • Author(s)
      Sawa T, Kumagai Y, Akaike T.
    • Journal Title

      Nitric Oxide: Biology and Pathobiology

      Volume: 3 Pages: 231-235

    • DOI
      10.1016/b978-0-12-804273-1.00017-x
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 環境中親電子物質のレドックスシグナル伝達変動および毒性発現とそれらを制御する活性イオウ分子2017

    • Author(s)
      熊谷嘉人、安孫子ユミ
    • Journal Title

      硫酸と工業

      Volume: 70 Pages: 9-16

    • NAID
      40021306408
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 環境中親電子物質に対する生体応答と捕獲・不活性化因子2017

    • Author(s)
      熊谷嘉人
    • Journal Title

      最新医学「エピジェネティックスと環境科学」

      Volume: 72 Pages: 77-81

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of l -cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome2017

    • Author(s)
      Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.
    • Journal Title

      Free Radic Biol Med.

      Volume: 106 Pages: 69-79

    • DOI
      10.1016/j.freeradbiomed.2017.02.023
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.2017

    • Author(s)
      keda, M. Ishima, Y. Shibata, A. Chuang, V. T. G. Sawa, T. Ihara, H. Watanabe, H. Xian, M. Ouchi, Y. Shimizu, T. Ando, H. Ukawa, M. Ishida, T. Akaike, T. Otagiri, M. Maruyama, T.
    • Journal Title

      Anal Chim Acta

      Volume: 969 Pages: 18-25

    • DOI
      10.1016/j.aca.2017.03.027
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactive sulfur species inactivate Ca 2+ /calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue2017

    • Author(s)
      Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.
    • Journal Title

      Biochem J

      Volume: 474 Pages: 2547-2562

    • DOI
      10.1042/bcj20170092
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free radical biology & medicine

      Volume: 印刷中 Pages: 132-140

    • DOI
      10.1016/j.freeradbiomed.2017.01.024
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.2017

    • Author(s)
      Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 8304-8304

    • DOI
      10.1038/s41598-017-08588-5
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage2017

    • Author(s)
      Hoshino Marie、Kaneko Kotaro、Miyamoto Yoichi、Yoshimura Kentaro、Suzuki Dai、Akaike Takaaki、Sawa Tomohiro、Ida Tomoaki、Fujii Shigemoto、Ihara Hideshi、Tanaka Junichi、Tsukuura Risa、Chikazu Daichi、Mishima Kenji、Baba Kazuyoshi、Kamijo Ryutaro
    • Journal Title

      Free Radio Bios Med

      Volume: 110 Pages: 63-71

    • DOI
      10.1016/j.freeradbiomed.2017.05.022
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling2017

    • Author(s)
      Alvarez L, Bianco CL, Toscano JP, Lin J. Akaike T, Fukuto JM.
    • Journal Title

      Antioxid Redox Signal

      Volume: 27 Pages: 622-633

    • DOI
      10.1089/ars.2017.7081
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diversity and microevolution of CRISPR loci in Helicobacter cinaedi2017

    • Author(s)
      Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI
      10.1371/journal.pone.0186241
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of reactive persulfide species in chronic obstructive pulmonary disease.2017

    • Author(s)
      Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M
    • Journal Title

      Thorax.

      Volume: 72 Pages: 1074-1083

    • DOI
      10.1136/thoraxjnl-2016-209359
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ニトロ化環状ヌクレオチドと活性イオウ分子によるレドックスシグナル制御と生理機能2017

    • Author(s)
      藤井重元、赤池孝章
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 2194-2195

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 活性イオウ分子:システインパースルフィドの新規生合成経路の発見とその生理機能2017

    • Author(s)
      西村 明、赤池孝章
    • Journal Title

      硫酸と工業

      Volume: 70 Pages: 1-9

    • NAID
      40021404464
    • Related Report
      2017 Annual Research Report
  • [Journal Article] TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.2017

    • Author(s)
      Shimauchi Tsukasa、Numaga-Tomita Takuro、Ito Tomoya、Nishimura Akiyuki、Matsukane Ryosuke、Oda Sayaka、Hoka Sumio、Ide Tomomi、Koitabashi Norimichi、Uchida Koji、Sumimoto Hideki、Mori Yasuo、Nishida Motohiro
    • Journal Title

      JCI Insight.

      Volume: 2 Pages: 93358-93358

    • DOI
      10.1172/jci.insight.93358
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway.2017

    • Author(s)
      Phosri Sarawuth、Arieyawong Ajaree、Bunrukchai Kwanchai、Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Front Pharmacol

      Volume: 8 Pages: 428-428

    • DOI
      10.3389/fphar.2017.00428
    • Related Report
      2017 Annual Research Report
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  • [Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.2017

    • Author(s)
      Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 7511-7511

    • DOI
      10.1038/s41598-017-07903-4
    • NAID
      120006343876
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy.2017

    • Author(s)
      Guan Yu、Nakano Daisuke、Zhang Yifan、Li Lei、Liu Wenhua、Nishida Motohiro、Kuwabara Takashige、Morishita Asahiro、Hitomi Hirofumi、Mori Kiyoshi、Mukoyama Masashi、Masaki Tsutomu、Hirano Katsuya、Nishiyama Akira
    • Journal Title

      Pharmacol Sci

      Volume: 135 Pages: 81-88

    • DOI
      10.1016/j.jphs.2017.09.002
    • Related Report
      2017 Annual Research Report
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  • [Journal Article] Purinergic P2Y 6 receptors: A new therapeutic target of age-dependent hypertension2017

    • Author(s)
      Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M, and Nishida M. M
    • Journal Title

      Pharmacol Res

      Volume: 120 Pages: 51-59

    • DOI
      10.1016/j.phrs.2017.03.013
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases2017

    • Author(s)
      Nishimura Akiyuki、Sunggip Caroline、Oda Sayaka、Numaga-Tomita Takuro、Tsuda Makoto、Nishida Motohiro
    • Journal Title

      Pharmacol Ther

      Volume: 180 Pages: 113-128

    • DOI
      10.1016/j.pharmthera.2017.06.010
    • Related Report
      2017 Annual Research Report
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  • [Journal Article] Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology2017

    • Author(s)
      Yamaguchi Yohei、Iribe Gentaro、Nishida Motohiro、Naruse Keiji
    • Journal Title

      Progress in Biophysics and Molecular Biology

      Volume: 130 Pages: 264-272

    • DOI
      10.1016/j.pbiomolbio.2017.06.010
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC3 Channels in Cardiac Fibrosis2017

    • Author(s)
      Numaga-Tomita Takuro、Oda Sayaka、Shimauchi Tsukasa、Nishimura Akiyuki、Mangmool Supachoke、Nishida Motohiro
    • Journal Title

      Front Cardiovasc Med

      Volume: 4 Pages: 56-56

    • DOI
      10.3389/fcvm.2017.00056
    • Related Report
      2017 Annual Research Report
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  • [Journal Article] 心臓リモデリングにおけるTRPCチャネルの役割とその治療応用2017

    • Author(s)
      西田基宏、西山和宏、田中智弘
    • Journal Title

      心臓

      Volume: 49 Pages: 1213-1218

    • NAID
      130007580256
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid 2D DIGE Proteomic Analysis of Mouse Liver2017

    • Author(s)
      Kamata Shotaro、Ishii Isao
    • Journal Title

      Methods Mol Biol

      Volume: 1664 Pages: 153-166

    • DOI
      10.1007/978-1-4939-7268-5_13
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis2017

    • Author(s)
      Han Sang Jun、Noh Mi Ra、Jung Jung-Min、Ishii Isao、Yoo Jeongsoo、Kim Jee In、Park Kwon Moo
    • Journal Title

      Free Radic Biol Med

      Volume: 112 Pages: 423-432

    • DOI
      10.1016/j.freeradbiomed.2017.08.017
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion2017

    • Author(s)
      Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 435-445

    • DOI
      10.1093/nar/gkw745
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles.2017

    • Author(s)
      Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 12902-12902

    • DOI
      10.1038/s41598-017-12926-y
    • NAID
      120006355828
    • Related Report
      2017 Annual Research Report
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  • [Journal Article] Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis2017

    • Author(s)
      Komine S, Akiyama K, Warabi E, Oh S, Kuga K, Ishige K, Togashi S, Yanagawa T, Shoda J
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 11977-11977

    • DOI
      10.1038/s41598-017-12358-8
    • NAID
      120006353920
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Environmental Electrophiles: Protein Adducts, Modulation of Redox Signaling, and Interaction with Persulfides/Polysulfides2017

    • Author(s)
      Kumagai Y, Abiko Y.
    • Journal Title

      Chemical Research in Toxicology.

      Volume: 30 Pages: 203-219

    • DOI
      10.1021/acs.chemrestox.6b00326
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced interleukin-11 production2017

    • Author(s)
      Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Pages: 205-216

    • DOI
      10.1074/jbc.m116.744755
    • NAID
      120006023247
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MiR30‐GALNT1/2 Axis‐Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Journal Title

      J. Am. Heart Assoc.

      Volume: 6

    • DOI
      10.1161/jaha.116.003601
    • NAID
      120006360780
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] プリン作動性シグナルの心血管系における役割2017

    • Author(s)
      西村明幸、西田基宏.
    • Journal Title

      日本薬理学雑誌

      Volume: 149 Pages: 84-90

    • NAID
      130005306336
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プリン作動性P2Y6受容体はアンジオテンシンAT1受容体とヘテロ二量体化を形成してアンジオテンシンII誘発性高血圧を促進する2017

    • Author(s)
      西村明幸、西田基宏.
    • Journal Title

      Science Signaling Japanese Scientists in Science Signaling 2016

      Volume: - Pages: 14-14

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors2017

    • Author(s)
      Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 41984-41984

    • DOI
      10.1038/srep41984
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic Monophosphorothioate Rp-Isomer as a Potent Inhibitor of Protein Kinase G1α2017

    • Author(s)
      Ahmed KA, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 40 Issue: 3 Pages: 365-374

    • DOI
      10.1248/bpb.b16-00880
    • NAID
      130005398514
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.2017

    • Author(s)
      Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T.
    • Journal Title

      Biochem. J.

      Volume: 474 Pages: 1149-1162

    • DOI
      10.1042/bcj20160999
    • Related Report
      2016 Annual Research Report
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  • [Journal Article] レドックスシグナルの活性イオウ分子制御.2017

    • Author(s)
      笠松真吾、守田匡伸、赤池孝章.
    • Journal Title

      ファルマシア

      Volume: 53 Pages: 210-214

    • NAID
      130005398269
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension.2017

    • Author(s)
      A. Nishimura, C. Sunggip, H. Tozaki-Saitoh, T. Shimauchi, T. Numaga-Tomita, K. Hirano, T. Ide, J-M. Boeynaems, H. Kurose, M. Tsuda, B. Robaye, K. Inoue and M. Nishida
    • Journal Title

      Sci Signal.

      Volume: Jan 19;9(411)

    • DOI
      10.1126/scisignal.aac9187
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chemical toxicology of reactive species in the atmosphere: two decades of progress in an electron acceptor and an electrophile2016

    • Author(s)
      Kumagai Y, Abiko Y, Luong CN.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 41 Issue: Special Pages: SP37-SP47

    • DOI
      10.2131/jts.41.SP37
    • NAID
      130005251461
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator2016

    • Author(s)
      Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 41 Issue: 6 Pages: 775-781

    • DOI
      10.2131/jts.41.775
    • NAID
      130005281972
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.2016

    • Author(s)
      Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 1-10

    • DOI
      10.1038/srep28944
    • NAID
      120005822867
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.2016

    • Author(s)
      Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    • Journal Title

      Free Radic Biol Med.

      Volume: 97 Pages: 136-147

    • DOI
      10.1016/j.freeradbiomed.2016.05.013
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis.2016

    • Author(s)
      Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI
      10.1371/journal.pone.0160521
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immobilization of the gas signaling molecule H2S by radioisotopes: detection, quantification, and in vivo imaging.2016

    • Author(s)
      Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J.
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 55 Pages: 9365-9370

    • DOI
      10.1002/anie.201603813
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury.2016

    • Author(s)
      Marko L, Szijarto IA, Filipovic MR, Kassmann M, Balogh A, Park JK, Przybyl L, N'Diaye G, Kramer S, Anders J, Ishii I, Muller DN, Gollasch M.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 27517-27517

    • DOI
      10.1038/srep27517
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice.2016

    • Author(s)
      Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.
    • Journal Title

      Endocrinology

      Volume: 印刷中 Pages: 1839-1851

    • DOI
      10.1210/en.2015-1768
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.2016

    • Author(s)
      Wedmann R, Onderka C, Wei S, Szijarto IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR.
    • Journal Title

      Chem Sci

      Volume: 7 Pages: 3414-3426

    • DOI
      10.1039/c5sc04818d
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition),2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagycineol.

      Volume: 12(1) Pages: 1-122

    • DOI
      10.1080/15548627.2015.1100356
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes.2016

    • Author(s)
      Watanabe Y, Honda S, Konishi A, Satoko Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.
    • Journal Title

      Nat Commun13508

      Volume: 7 Pages: 1-12

    • DOI
      10.1038/ncomms13508
    • NAID
      120005895485
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.2016

    • Author(s)
      Ohbuchi K, Mori Y, Ogawa K, Warabi E, Yamamoto M, Hirokawa T.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI
      10.1371/journal.pone.0162543
    • NAID
      120005853320
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ignavine: orthosteric enhancer of the &micro; opioid receptor.2016

    • Author(s)
      Ohbuchi K, Miyagi C, Suzuki Y, Mizuhara Y, Mizuno K, Omiya Y, Yamamoto M, Warabi E, Sudo Y, Yokoyama A, Miyano K, Hirokawa T, Uezono Y.
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 31748-31748

    • DOI
      10.1038/srep31748
    • NAID
      120005851329
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.2016

    • Author(s)
      Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F
    • Journal Title

      Hum Mol Genet.

      Volume: 25 Pages: 3321-3340

    • DOI
      10.1093/hmg/ddw180
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis2016

    • Author(s)
      Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
    • Journal Title

      J Dermatol Sci.

      Volume: 83 Pages: 9-17

    • DOI
      10.1016/j.jdermsci.2016.05.005
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The role of peroxiredoxin I in cisplatin-induced ototoxicity.2016

    • Author(s)
      Le Q, Tabuchi K, Warabi E, Hara A.
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Pages: 205-212

    • DOI
      10.1016/j.anl.2016.06.001
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis2016

    • Author(s)
      Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 39383-39383

    • DOI
      10.1038/srep39383
    • NAID
      120005997825
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling2016

    • Author(s)
      Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 37001-37001

    • DOI
      10.1038/srep37001
    • NAID
      120006323744
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor.2016

    • Author(s)
      M. Hagimori, T. Murakami, K. Shimizu, M. Nishida, T. Ohshima, T. Mukai
    • Journal Title

      Medicinal Chemical Communications

      Volume: 7 Pages: 1003-1006

    • DOI
      10.1039/c6md00023a
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys

      Volume: 595 Pages: 140-146

    • DOI
      10.1016/j.abb.2015.11.008
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines.2016

    • Author(s)
      Kawamura Y, Tomida J, Miyoshi-Akiyama T, Okamoto T, Narita M, Hashimoto K, Cnockaert M, Vandamme P, Morita Y, Sawa T, Akaike T.
    • Journal Title

      Systematic and Applied Microbiology

      Volume: 39 Pages: 307-312

    • DOI
      10.1016/j.syapm.2016.06.004
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mice deficient in Angiopoietin-like protein 2 (Angptl2) gene show increased susceptibility to bacterial infection due to attenuated macrophage activity.2016

    • Author(s)
      Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291 Pages: 18843-18852

    • DOI
      10.1074/jbc.m116.720870
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endogenous occurrence of protein S-guanylation in Echerichia coli: Target identification and genetic regulation.2016

    • Author(s)
      Tsutsuki H, Jung M, Zhang T, Ono K, Ida T, Kunieda K, Ihara H, Akaike T, Sawa T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 478 Pages: 7-11

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modification of Tau by 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation2016

    • Author(s)
      Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Pages: 22714-22720

    • DOI
      10.1074/jbc.m116.734350
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.2016

    • Author(s)
      Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 480 Pages: 180-186

    • DOI
      10.1016/j.bbrc.2016.10.022
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation.2016

    • Author(s)
      Kasamatsu S, Nishimura A, Morita M, Matsunaga T, Abdul Hamid H, Akaike T.
    • Journal Title

      Molecules

      Volume: 21 Pages: 1721-1730

    • DOI
      10.3390/molecules21121721
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Re-emerging reactive sulfur-containing compounds and their unique biological functions2016

    • Author(s)
      井田智章、松永哲郎、藤井重元、澤 智裕、赤池孝章.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 147 Issue: 5 Pages: 278-284

    • DOI
      10.1254/fpj.147.278
    • NAID
      130005150958
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive sulfur species-modified protein thiols: new methods for polysulfurated protein analysis2016

    • Author(s)
      笠松真吾、藤井重元、赤池孝章.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 147 Issue: 5 Pages: 299-302

    • DOI
      10.1254/fpj.147.299
    • NAID
      130005150953
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 巻頭言 セレンディピティと抗菌薬の新しい分指標的.2016

    • Author(s)
      赤池孝章.
    • Journal Title

      化学療法の領域.

      Volume: 32 Pages: 1621-1621

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 酸化ストレス病態とバイオマーカー.2016

    • Author(s)
      藤井重元、赤池孝章.
    • Journal Title

      生体の科学

      Volume: 67 Pages: 418-419

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 58 Issue: 2 Pages: 1-8

    • DOI
      10.3164/jcbn.15-111
    • NAID
      130005132519
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells2016

    • Author(s)
      Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T.
    • Journal Title

      Toxicology and Applied Pharmacology.

      Volume: 295 Pages: 37-46

    • DOI
      10.1016/j.taap.2016.01.020
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation2016

    • Author(s)
      Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    • Journal Title

      Biochemistry.

      Volume: 55 Pages: 751-61

    • DOI
      10.1021/acs.biochem.5b00774
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nrf2 as an Endothelial Mechanosensitive Transcription Factor: Going With the Flow.2016

    • Author(s)
      McSweeney SR, Warabi E, Siow RC.
    • Journal Title

      Hypertension,

      Volume: 67 Pages: 20-29

    • DOI
      10.1161/hypertensionaha.115.06146
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.2016

    • Author(s)
      T. Numaga-Tomita, M. Nishida, J.W. Jr. Putney and Y. Mori
    • Journal Title

      Biochem J.

      Volume: 473(2) Pages: 201-210

    • DOI
      10.1042/bj20150596
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sustained bAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner2016

    • Author(s)
      S. Mangmool, T. Denkaew, S. Phosri, D. Pinthong, W. Parichatikanond, T. Shimauchi and M. Nishida
    • Journal Title

      Molecular Endocrinology

      Volume: 30(1) Pages: 118-132

    • DOI
      10.1210/me.2015-1201
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.2016

    • Author(s)
      S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
    • Journal Title

      Mol Pharmacol.

      Volume: 89(3) Pages: 348-363

    • DOI
      10.1124/mol.115.102863
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells2016

    • Author(s)
      Fujiwara Y, Yamamoto C, Yoshida A, Kumagai Y, Kaji T.
    • Journal Title

      Archives of Toxicology

      Volume: 印刷中 Pages: 259-267

    • DOI
      10.1007/s00204-014-1420-6
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015

    • Author(s)
      Saund SS, Sosa V, Henriquez, Nguyen QNN, Soeda S, Bianco CL, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.
    • Journal Title

      Archives Biochemistry and Biophysics.

      Volume: 588 Pages: 15-24

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i>S</i>-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells2015

    • Author(s)
      Toyama T, Abiko Y, Katayama Y, Kaji T, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 887-893

    • DOI
      10.2131/jts.40.887
    • NAID
      120006551789
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells2015

    • Author(s)
      Abiko Y, Puga A, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 873-886

    • DOI
      10.2131/jts.40.873
    • NAID
      130005108871
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice2015

    • Author(s)
      Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 837-841

    • DOI
      10.2131/jts.40.837
    • NAID
      130005108870
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.2015

    • Author(s)
      Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1796-1802

    • DOI
      10.1021/acs.chemrestox.5b00245
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RSSによる環境中親電子物質の解毒代謝.2015

    • Author(s)
      熊谷嘉人、内田浩二.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 358-363

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation2015

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1301-1306

    • DOI
      10.1021/acs.chemrestox.5b00101
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Biotin-PEAC<sub>5</sub>-maleimide labeling assay to detect electrophiles2015

    • Author(s)
      Abiko Y, Luong NC, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 3 Pages: 405-411

    • DOI
      10.2131/jts.40.405
    • NAID
      130005068421
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.2015

    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology

      Volume: 印刷中 Pages: 838-847

    • DOI
      10.1021/tx500416y
    • NAID
      130005483607
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions2015

    • Author(s)
      Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    • Journal Title

      Journal of Molecular Medicine.

      Volume: 印刷中 Pages: 879-889

    • DOI
      10.1007/s00109-015-1271-5
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The development of fluorescent probes for visualizing intracellular hydrogen polysulfides2015

    • Author(s)
      Wei Chen, Ethan W. Rosser, Tetsuro Matsunaga, Armando Pacheco, Takaaki Akaike, and Ming Xian
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 54 Pages: 13961-13965

    • DOI
      10.1002/anie.201506887
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia.2015

    • Author(s)
      Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F
    • Journal Title

      J Am Heart Assoc.

      Volume: 4

    • DOI
      10.1161/jaha.115.002125
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25.2015

    • Author(s)
      K. Kunieda, H. Tsutsuki, T. Ida, Y. Kishimoto, S. Kasamatsu, T. Sawa, N. Goshima, M. Itakura, M. Takahashi, T. Akaike, H. Ihara
    • Journal Title

      ACS Chem. Neurosci.

      Volume: 6 Pages: 1715-1725

    • DOI
      10.1021/acschemneuro.5b00196
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 8-Mercapto-cyclic GMP mediates hydrogen sulfide-induced stomatal closure in Arabidopsis2015

    • Author(s)
      Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S.
    • Journal Title

      Plant Cell Physiol

      Volume: 56 Pages: 1481-1489

    • DOI
      10.1093/pcp/pcv069
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nitric Oxide (NO).2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      生体の科学

      Volume: 66 Pages: 396-397

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 細菌感染における酸化ストレスシグナル制御と感染防御論.2015

    • Author(s)
      赤池孝章.
    • Journal Title

      日本細菌学雑誌

      Volume: 70 Pages: 339-349

    • NAID
      130005094695
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 活性イオウ分子種による酸化ストレス制御.2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 502-506

    • NAID
      40020484751
    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性イオウ分子による酸化・ニトロ化ストレス制御.2015

    • Author(s)
      笠松真吾、井田智章、藤井重元、赤池孝章.
    • Journal Title

      Respiratory Medical Research

      Volume: 3 Pages: 70-75

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 9. 感染性微生物:H. cinaedi.2015

    • Author(s)
      松永哲郎, 藤井重元, 赤池孝章.
    • Journal Title

      動脈硬化予防

      Volume: 14 Pages: 66-71

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性システインパースルフィド.2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      医学のあゆみ「レドックスUPDATE 」

      Volume: 別冊 Pages: 41-44

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube.2015

    • Author(s)
      Horie M, Warabi E, Komine S, Oh S, Shoda J.
    • Journal Title

      PLOS ONE

      Volume: 10 Pages: 12-12

    • DOI
      10.1371/journal.pone.0144835
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases.2015

    • Author(s)
      LR Gentry, A. Nishimura, A.D. Cox, T.D. Martin, D. Tsygankov, M. Nishida, T.C. Elston and C.J. Der
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290(37) Pages: 22851-22861

    • DOI
      10.1074/jbc.m115.656710
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRP Channels: Their Function and Potentiality as Drug Targets.2015

    • Author(s)
      Nishida M, Kuwahara K, Kozai D, Sakaguchi R, Mori Y.
    • Journal Title

      Innovative Medicine

      Volume: - Pages: 195-218

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RSSによるGタンパク質/TRP2015

    • Author(s)
      西田基宏,森泰生,
    • Journal Title

      細胞工学

      Volume: 34 Pages: 366-371

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心臓レジリエンスを制御する酸素シグナリング2015

    • Author(s)
      西田基宏,西村明幸.
    • Journal Title

      実験医学(増刊)

      Volume: 33 Pages: 1562-1567

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ガス様シグナルの破綻と疾患2015

    • Author(s)
      西田基宏,島内司,
    • Journal Title

      医学のあゆみ

      Volume: 254 Pages: 334-338

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization.2015

    • Author(s)
      Madurga A, Golec A, Pozarska A, Ishii I, Mizikova I, Nardiello C, Vadasz I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 309

    • DOI
      10.1152/ajplung.00134.2015
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice2015

    • Author(s)
      Kamata S, Akahoshi N, Ishii I.
    • Journal Title

      FEBS Open Bio.

      Volume: 5 Pages: 535-541

    • DOI
      10.1016/j.fob.2015.06.008
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis2015

    • Author(s)
      Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I.
    • Journal Title

      FEBS Open Bio

      Volume: 5 Pages: 357-368

    • DOI
      10.1016/j.fob.2015.04.012
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia/reperfusion injury.2015

    • Author(s)
      Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 印刷中

    • DOI
      10.1152/ajpheart.00333.2014
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RSSの生合成系とタンパク質機能制御.2015

    • Author(s)
      渡邊泰男、石井功、蕨栄治.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 372-376

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.2015

    • Author(s)
      Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 282 Pages: 195-206

    • DOI
      10.1016/j.taap.2014.11.015
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-Mercuration and neurotoxicity induced by methyl mercury2015

    • Author(s)
      Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
    • Journal Title

      Neurotoxicity Research

      Volume: 27 Pages: 99-105

    • DOI
      10.1007/s12640-014-9494-8
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1.2015

    • Author(s)
      Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
    • Journal Title

      Mol Ther.

      Volume: 23 Pages: 549-560

    • DOI
      10.1038/mt.2014.217
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] H2Sの生体内生成とシグナル機能の正体:システインパースルフィドの再発見と新機能.2015

    • Author(s)
      赤池孝章
    • Journal Title

      細胞工学

      Volume: 34 Pages: 346-348

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RSSによる抗酸化・レドックスシグナル制御.2015

    • Author(s)
      井田智章, 藤井重元, 赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 354-357

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カルシウムシグナルの基本機構とその可能性2015

    • Author(s)
      森泰生、森誠之、西田基宏
    • Journal Title

      Clinical Calcium

      Volume: 1 Pages: 47-58

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62 deficiency enhances α-synuclein pathology in mice2015

    • Author(s)
      Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, Mori F, Warabi E, Yanagawa T, Ueno S, Itoh K, Wakabayashi K.
    • Journal Title

      Brain Pathol

      Volume: 印刷中 Pages: 552-564

    • DOI
      10.1111/bpa.12214
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice2015

    • Author(s)
      4)Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.
    • Journal Title

      Human Molecular Genetics

      Volume: 24 Pages: 1092-105

    • DOI
      10.1093/hmg/ddu522
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. Journal of agricultural and food chemistry.2014

    • Author(s)
      Abiko Y, Mizokawa M, Kumagai Y.
    • Journal Title

      J Agric Food Chem.

      Volume: 62 Pages: 10936-10944

    • DOI
      10.1021/jf5030592
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility2014

    • Author(s)
      Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
    • Journal Title

      Free Radic Biol Med

      Volume: 77 Pages: 82-94

    • DOI
      10.1016/j.freeradbiomed.2014.09.007
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glutathione adduct of methylmercury activates the Keap1-Nrf2 pathway in SH-SY5Y cells.2014

    • Author(s)
      Yoshida E, Abiko Y, Kumagai Y.
    • Journal Title

      Chem Res Toxicol.

      Volume: 27 Pages: 1780-1786

    • DOI
      10.1021/tx5002332
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] <i>S</i>-Mercuration of cellular proteins by methylmercury and its toxicological implications2014

    • Author(s)
      Kanda H, Shinkai Y, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 39 Issue: 5 Pages: 687-700

    • DOI
      10.2131/jts.39.687
    • NAID
      130004690955
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.2014

    • Author(s)
      Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.
    • Journal Title

      Journal of Neurochemistry

      Volume: 130 Pages: 826-838

    • DOI
      10.1111/jnc.12762
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] たくさん繋がるS.2014

    • Author(s)
      澤智裕、熊谷嘉人、赤池孝章.
    • Journal Title

      実験医学増刊「驚愕の代謝システム」

      Volume: 32 Pages: 46-50

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter cinaedi meningitis: a case report and review of previous cases2014

    • Author(s)
      Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, Akaike T.
    • Journal Title

      J Neurol Sci

      Volume: 347 Pages: 396-397

    • DOI
      10.1016/j.jns.2014.10.011
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical and bacteriological characteristics of Helicobacter cinaedi infection.2014

    • Author(s)
      Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T.
    • Journal Title

      J Infect Chemother.

      Volume: 20 Pages: 517-526

    • DOI
      10.1016/j.jiac.2014.06.007
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Scientific Reports

      Volume: (印刷中) Pages: 4680-4680

    • DOI
      10.1038/srep04680
    • NAID
      120005649608
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by tegulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell metab

      Volume: 9 Pages: 712-21

    • DOI
      10.1016/j.cmet.2014.03.006
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem J2014

    • Author(s)
      Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
    • Journal Title

      Biochem J

      Volume: 459 Pages: 251-263

    • DOI
      10.1042/bj20131262
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 第3章炎症の慢性化と収束を制御するメディエーター フリーラジカル制御系:硫化水素・活性イオウ分子と炎症.2014

    • Author(s)
      藤井重元, 井田智章, 澤 智裕, 赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 131-137

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling2014

    • Author(s)
      Nishida M, Toyama T and Akaike T
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: (In press) Pages: 10-17

    • DOI
      10.1016/j.yjmcc.2014.02.003
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] システインパースルフィドの生体内生成と生理機能再発現:活性イオウ分子による抗酸化・レドックスシグナル制御.2014

    • Author(s)
      赤池孝章.
    • Journal Title

      実験医学

      Volume: 36 Pages: 2123-2126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素と炎症2014

    • Author(s)
      井田智章, 赤池孝章, 澤 智裕, 藤井重元.
    • Journal Title

      感染・炎症・免疫

      Volume: 44 Pages: 16-21

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure2014

    • Author(s)
      Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
    • Journal Title

      Cardiovascular Research

      Volume: 104 Pages: 183-193

    • DOI
      10.1093/cvr/cvu185
    • NAID
      120005619790
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model of homocystinuria.2014

    • Author(s)
      Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 306(12)

    • DOI
      10.1152/ajprenal.00623.2013
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice.2014

    • Author(s)
      Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I.
    • Journal Title

      Mol Nutr Food Res

      Volume: 58 Pages: 1309-1321

    • DOI
      10.1002/mnfr.201300758
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Functional Polymorphisms in Interferon Regulatory Factor 2 (IRF2) with Susceptibility to Systemic Lupus Erythematosus: A Case-Control Association Study.2014

    • Author(s)
      Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N.
    • Journal Title

      PLoS One

      Volume: 9

    • DOI
      10.1371/journal.pone.0109764
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.2014

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K
    • Journal Title

      Int J Hepatol.

      Volume: 未定 Pages: 1155-1155

    • DOI
      10.1155/2014/584650
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress.2014

    • Author(s)
      Ito T, Kimura S, Seto K, Warabi E, Kawachi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
    • Journal Title

      J Dermatol Sci.

      Volume: 74 Pages: 9-17

    • DOI
      10.1016/j.jdermsci.2013.12.002
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity.2014

    • Author(s)
      Ohtsuka S, Ishii Y, Matsuyama M, Ano S, Morishima Y, Yanagawa T, Warabi E, Hizawa N.
    • Journal Title

      Eur J Immunol.

      Volume: 44 Pages: 1084-1092

    • DOI
      10.1002/eji.201344091
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62/Sequestosome1の生理機能.2014

    • Author(s)
      7.蕨 栄治
    • Journal Title

      生化学(日本生化学会誌)

      Volume: 86 Pages: 783-787

    • NAID
      40020314244
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RSSの生合成系とタンパク質機能制御.2014

    • Author(s)
      8.渡邊泰男,石井 功,蕨 栄治.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 372-376

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: (印刷中) Pages: 7606-7611

    • DOI
      10.1073/pnas.1321232111
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification and quantification of in vivo metabolites of 9,10-phenanthrenequinone in human urine associated with producing reactive oxygen species.2014

    • Author(s)
      Asahi M, Kawai M, Toyama T, Kumagai Y, Chuesaard T, Tang N, Kameda T. Havakawa K and Toriba A
    • Journal Title

      Chem Res Toxicol.

      Volume: 27(1) Pages: 41-48

    • DOI
      10.1021/tx400338t
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ambient vapor samples activate the Nrf2-ARE pathway in human bronchial epithelial BEAS-2B cells.2014

    • Author(s)
      Yasuhiro Shinkai, Syun Nakajima, Arantza Eiguren-Fernandez, Emma Di Stefano, Debra A. Schmitz, John R. Froines, Arthur K. Cho, Yoshito Kumagai
    • Journal Title

      Environ Toxicol.

      Volume: 29 Pages: 1292-1300

    • DOI
      10.1002/tox.21860
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress.2014

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H and Oike Y
    • Journal Title

      Molecular Cancer Research

      Volume: 12 Pages: 239-249

    • DOI
      10.1158/1541-7786.mcr-13-0336
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] S-guanylation proteomics for redox-based mitochondrial signaling.2014

    • Author(s)
      Rahaman MM, Sawa T, Ahtesh am AK, Khan S, Inoue H, Irie A. Fujii S, and Akaike T.
    • Journal Title

      Antioxid Redox Signal.

      Volume: 20 Pages: 295-307

    • DOI
      10.1089/ars.2012.4606
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 心臓におけるTRPチャネルの多様な役割.2014

    • Author(s)
      北島直幸、西田基宏.
    • Journal Title

      実験医学

      Volume: 32 Pages: 527-533

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor a-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells2014

    • Author(s)
      Kaori Seto
    • Journal Title

      Int J Hepatol 2014

      Volume: xx Pages: 2147-2153

    • DOI
      10.3892/or.2013.2387
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>Garcinia vilersiana</i> bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells2013

    • Author(s)
      Yasuhiro Shinkai, Ichiro Yamanaka, Ho Huynh Thuy Duong, Nguyen Thi Quynh, Yasunori Kanaho, Yoshito Kumagai
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 875-878

    • DOI
      10.2131/jts.38.875
    • NAID
      130004447090
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells2013

    • Author(s)
      Chang B, Iwamoto N, Inaba T, Shinkai Y, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 5 Pages: 793-797

    • DOI
      10.2131/jts.38.793
    • NAID
      10031191738
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the Keap1/Nrf2 pathway in the cellular response to methylmercury.2013

    • Author(s)
      Kumagai Y, Kanda H, Shinkai Y and Toyama T
    • Journal Title

      Oxid Med Cell Longev.

      Volume: (Online) Pages: 848279-848279

    • DOI
      10.1155/2013/848279
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of Keap1 Modified by 2-tert-Butyl-1,4- benzoquinone with GSH: Evidence for S-Transarylation.2013

    • Author(s)
      Yumi Abiko, Yoshito Kumagai
    • Journal Title

      Chem Res Toxicol.

      Volume: 26 Pages: 1080-1087

    • DOI
      10.1021/tx400085h
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation.2013

    • Author(s)
      Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 436 Pages: 212-216

    • DOI
      10.1016/j.bbrc.2013.05.075
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A convenient method to assess chemical modification of protein thiols by electrophilic metals2013

    • Author(s)
      Toyama T, Shinkai Y, Kaji T and Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38(3) Issue: 3 Pages: 477-484

    • DOI
      10.2131/jts.38.477
    • NAID
      10031158913
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling2013

    • Author(s)
      Koizumi R, Taguchi K, Hisamori M, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 3 Pages: 317-324

    • DOI
      10.2131/jts.38.317
    • NAID
      10031158897
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレスと親電子シグナル制御.2013

    • Author(s)
      熊谷嘉人
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 787-793

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous NItrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria2013

    • Author(s)
      Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
    • Journal Title

      Mol Cell.

      Volume: 52 Pages: 794-804

    • DOI
      10.1016/j.molcel.2013.10.024
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nitrated cGMP: a new player in guard cell signaling2013

    • Author(s)
      Joudoi T, Hatakeyama T, Maeda T, Akaike T, Sawa T and Iwai S.
    • Journal Title

      Plant Cell.

      Volume: 25 Pages: 558-571

    • DOI
      10.1105/tpc.112.105049
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescent probes for live cell imaging of endogenous guanine nitration.2013

    • Author(s)
      Saito Y, Ito C, Fujii S, Sawa T, Akaike T and Arimoto H.
    • Journal Title

      Chembiochem

      Volume: 14 Pages: 1068-1071

    • DOI
      10.1002/cbic.201300129
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP^+ cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
    • Journal Title

      Neuroscience.

      Volume: 231 Pages: 206-215

    • DOI
      10.1016/j.neuroscience.2012.11.044
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Nitrosylated a-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis.2013

    • Author(s)
      Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
    • Journal Title

      FASEB J.

      Volume: 27 Pages: 391-398

    • DOI
      10.1096/fj.12-217794
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)2013

    • Author(s)
      Karim Md F, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, A kaike T and Yamagata K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 157-163

    • DOI
      10.1016/j.bbrc.2013.10.020
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide- and reactive oxygen species-derived electrophilic messenger.2013

    • Author(s)
      Fujii S and Akaike T.
    • Journal Title

      Antioxid Redox Signal.

      Volume: 19 Pages: 1236-1246

    • DOI
      10.1089/ars.2012.5067
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulation of redox signalling by an electrophilic cyclic nucleotide.2013

    • Author(s)
      Akaike T, Nishida M and Fujii S.
    • Journal Title

      J Biochem.

      Volume: 153 Pages: 131-138

    • DOI
      10.1093/jb/mvs145
    • NAID
      40019566342
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide2013

    • Author(s)
      Sawa T, Ihara H, Ida T, Fujii S, Nishida M and Akaike T.
    • Journal Title

      Nitric Oxide.

      Volume: 34 Pages: 10-18

    • DOI
      10.1016/j.niox.2013.04.004
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] レドックスシグナル制御と酸化ストレスバイオマーカー.2013

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      精神科救急

      Volume: 16 Pages: 69-72

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素シグナルの調節機構ROS毒性説から脱却した新たな概念.2013

    • Author(s)
      居原秀、井田智章、赤池孝章.
    • Journal Title

      Fragrance Journal

      Volume: 41 Pages: 75-80

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NOシグナリング研究の最前線.2013

    • Author(s)
      澤 智裕、赤池孝章.
    • Journal Title

      Heart View

      Volume: 17 Pages: 88-92

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] はじめに -活性酸素と分子状酸素のバイオセンサーと生体応答-2013

    • Author(s)
      赤池孝章、末松誠.
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 727-727

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素とガス状分子のシグナルネットワーク.2013

    • Author(s)
      澤 智裕、赤池孝章.
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 776-780

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction2013

    • Author(s)
      Watari K, Nakaya M, Nishida M, Kim KM, Kurose H
    • Journal Title

      PLoS One

      Volume: 8

    • DOI
      10.1371/journal.pone.0068351
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GRK6-deficient mice exhibit reduced recycling of senescent red blood cells and impaired apoptotic cell clearance causing autoimmunity2013

    • Author(s)
      Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H
    • Journal Title

      Nature Communications.

      Volume: 4 Pages: 1-11

    • DOI
      10.1038/ncomms2540
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice2013

    • Author(s)
      Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 434 Pages: 201-216

    • DOI
      10.1016/j.bbrc.2013.03.040
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.2013

    • Author(s)
      Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, Hofmann F, Schlossmann J, Dietrich A, Gudermann T, Nishida M, Del Galdo S, Wieland T, Kuhn M.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 33 Pages: 2121-2129

    • DOI
      10.1161/atvbaha.113.001974
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox control of cardiovascular homeostasis by Angiotensin II.2013

    • Author(s)
      Sunggip C, Kitajima N & Nishida M*.
    • Journal Title

      Curr Pharm Des.

      Volume: 19 Pages: 3022-3032

    • DOI
      10.2174/1381612811319170008
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレスによるレドックス恒常性異常と心筋リモデリング.2013

    • Author(s)
      西田基宏.
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 875-878

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPチャネルの生理機能と病態生理.2013

    • Author(s)
      西田基宏、角田将明、北島直幸.
    • Journal Title

      Clinical Calcium

      Volume: 23 Pages: 561-568

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硫化水素のケミカルバイオロジー.2013

    • Author(s)
      北島直幸、西田基宏.
    • Journal Title

      日薬理誌

      Volume: 141 Pages: 350-351

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硫化水素アニオンによるレドックス恒常性制御とその臨床応用.2013

    • Author(s)
      西田基宏、澤智裕.
    • Journal Title

      生化学

      Volume: 85 Pages: 996-999

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.2013

    • Author(s)
      Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, Tohya K, Ishizaki T, Niki I, Kimura T
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 442 Pages: 227-233

    • DOI
      10.1016/j.bbrc.2013.11.023
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse.2013

    • Author(s)
      Ang AD, Rivers-Auty J, Hegde A, Ishii I, Bhatia M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 305

    • DOI
      10.1152/ajpgi.00044.2013
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホモシステイン血症再考.2013

    • Author(s)
      石井功
    • Journal Title

      生化学

      Volume: 85 Pages: 1067-1071

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative expression of N-acetylglucosamyl- transfererase V in oral squamous cell carcinoma correlates with poor prognosis2013

    • Author(s)
      Seto K, Uchida F, Baba O, Miyoshi E,et.al.
    • Journal Title

      SpringerPlus.

      Volume: 2 Pages: 657-657

    • DOI
      10.1186/2193-1801-2-657
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.2013

    • Author(s)
      Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, and Sakurai T.
    • Journal Title

      J Neurosci.

      Volume: 33 Pages: 14767-14777

    • DOI
      10.1523/jneurosci.2954-12.2013
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequestosome1/p62: A regulator of redox sensitive voltage-activated potassium channels, arterial remodeling, inflammation and neurite outgrowth.2013

    • Author(s)
      Ishii T, Warabi E, Siow RC, Mann GE.
    • Journal Title

      Free Radic Biol Med.

      Volume: 65 Pages: 102-116

    • DOI
      10.1016/j.freeradbiomed.2013.06.019
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise Reduces Inflammation and Oxidative Stress in Obesity-Related Liver Diseases2013

    • Author(s)
      Oh S, Tanaka K, Warabi E, Shoda J.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: 45 Pages: 2214-2222

    • DOI
      10.1249/mss.0b013e31829afc33
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model.2013

    • Author(s)
      Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, IidaM,Tohnai G, Qiang Q, Tanaka F, Yanagawa T, WarabiE,Ishii T, Sobue G
    • Journal Title

      J Neurosci.

      Volume: 33 Pages: 7710-7727

    • DOI
      10.1523/jneurosci.3021-12.2013
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of a Sulfur Adduct of 1,4-Naphthoquinone during Reaction with a Polysulfide2018

    • Author(s)
      R Hirose, Y Shinkai, Y Abiko, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 1,4-NQ-Mediated Activation of PTEN/Akt/CREB Signaling in Primary Mouse Hepatocytes2018

    • Author(s)
      Y Abiko, Y Shinkai, T Unoki, R Hirose, T Uehara, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cystathionine Gamma-Lyase Is a Key Protein Repressing Methylmercury Poisoning Symptoms in Mice2018

    • Author(s)
      M Akiyama, Y Shinkai, I Ishii, T Akaike, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cadmium-Mediated Activation of the HSP90/ HSF1 Pathway Regulated by Reactive Persulfides and Polysulfides2018

    • Author(s)
      Y Shinkai, A Masuda, M Akiyama, M Xian, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter cinaediの骨髄内持続感染と動脈硬化病因論2018

    • Author(s)
      西村 明、松永哲郎、津々木博康、小野勝彦、守田匡伸、藤井重元、井田智章、澤 智裕、河村好章、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子種定量解析システムの開発と新しいシステインパースルフィド合成酵素の発見2018

    • Author(s)
      井田智章、守田匡伸、魏 范研、松永哲郎、西村 明、居原 秀、澤 智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5によるホルムアルデヒド代謝機構とタンパク質ポリスルフィド化による制御2018

    • Author(s)
      藤井重元、笠松慎吾、Md. Morshedul Alam、井田智章、守田匡伸、居原 秀、西村 明、松永哲郎、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア/イオウ呼吸選択的sulfide-quinone reductase(SQR;硫化水素キノン還元酵素)欠損マウスの開発2018

    • Author(s)
      守田匡伸、南嶋洋司、井田智章、松永哲郎、西村 明、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子種定量解析システムの開発と新しいシステインパースルフィド合成酵素の発見2018

    • Author(s)
      井田智章、赤池孝章
    • Organizer
      異分野融合を見据えた次世代レドックス生理科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子種によるミトコンドリア機能制御の解明2018

    • Author(s)
      西村 明、赤池孝章
    • Organizer
      異分野融合を見据えた次世代レドックス生理科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア/イオウ呼吸選択的sulfide-quinone reductase(SQR)欠損マウスの開発2018

    • Author(s)
      守田匡伸、赤池孝章
    • Organizer
      異分野融合を見据えた次世代レドックス生理科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホルムアルデヒド代謝酵素アルコールデヒドロゲナーゼ5のタンパク質ポリスルフィド化による活性制御機構.2018

    • Author(s)
      藤井重元、赤池孝章
    • Organizer
      異分野融合を見据えた次世代レドックス生理科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細菌と真菌におけるシステインパースルフィド産生機構とその生理的意義2018

    • Author(s)
      西村 明、高木博史、松永哲郎、井田智章、守田匡伸、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新興感染症菌Helicobacter cinaediの骨髄内における潜伏感染と細胞内寄生性の解析2018

    • Author(s)
      松永哲郎、西村 明、守田匡伸、藤井重元、井田智章、澤 智裕、河村好章、赤池孝章
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細菌の活性イオウ産生によるオートファジー制御と宿主内増殖への影響2018

    • Author(s)
      藤井重元、松永哲郎、井田智章、西村 明、小野勝彦、澤 智裕、赤池孝章
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sulfur respiration in mammals and its implication for tumor biology2018

    • Author(s)
      Takaaki Akaike, Tomoaki Ida, Md. Morshedul Alam, Akira Nishimura, Masanobu Morita, Tetsuro Matsunaga, Hozumi Motohashi
    • Organizer
      The Cold Spring Harbor Asia Conference on Cancer & Metabolism
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiovascular Aging Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor2018

    • Author(s)
      Nishida M
    • Organizer
      Angiotensin Gordon Research Conference 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cystathionine gamma-lyase欠損母マウスにおける授乳行動異常2018

    • Author(s)
      赤星軌征、半田博紀、横山輝、石井功
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二系統の高ホモシステイン血症マウスにおける脳脊髄液アミノ酸組成異常2018

    • Author(s)
      横山輝、赤星軌征、石井功
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 親電子ストレスを制御するレドックスシグナル伝達と活性イオウ分子2017

    • Author(s)
      熊谷嘉人
    • Organizer
      第39回日本薬学会九州支部コロキウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Environmental electrophile exposure and health2017

    • Author(s)
      Kumagai Y
    • Organizer
      National Conference of Toxicology2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The phase-zero reaction: capture and inactivation of electrophiles by persulfides2017

    • Author(s)
      Kumagai Y
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Is environmental electrophile an essential item for exposome?2017

    • Author(s)
      Kumagai Y
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The chemical biology of environmental electrophiles2017

    • Author(s)
      Kumagai Y
    • Organizer
      Special seminar at University of Bordeaux school of Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 水銀が操る生体応答とトキシコロジー2017

    • Author(s)
      熊谷嘉人
    • Organizer
      第17回日本抗加齢医学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The chemical biolgy of environmental electrophiles2017

    • Author(s)
      Kumagai Y
    • Organizer
      Special seminar at National Taiwan University of School of Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 親電子性金属に対する新たな防御応答システムの提案2017

    • Author(s)
      熊谷嘉人
    • Organizer
      メタルバイオサイエンス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子はカドミウムの不活性化を介して生体応答および肝毒性の惹起を負に制御する2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Environmental electrophiles activate redox signaling transduction pathways through covalent modification of sensor proteins2017

    • Author(s)
      Abiko Y, Kumagai Y
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー 日韓次世代シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリスルフィドNa2S4はイオウ付加体形成を通じて1,4-NQによる PTEN/ Akt/CREB シグナルの活性化と細胞毒性を抑制する2017

    • Author(s)
      鵜木隆光、安孫子ユミ、新開泰弘、広瀬玲子、上原孝、熊谷嘉人
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] CSE 欠損による親電子ストレスに対する感受性増強と CSE 高発現による還元 ストレスに対する生体応答2017

    • Author(s)
      秋山雅博、蕨栄治、鵜木隆光、新開泰弘、赤池孝章、熊谷嘉人
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性および生体応答の制御2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリサルファイドモデル化合物Na2S4は1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化を抑制する2017

    • Author(s)
      安孫子ユミ、新開泰弘、鵜木隆光、広瀬玲子、上原孝、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子およびその産生酵素は1,4-NQ曝露によるHSP90/HSF1シグナルの活性化を抑制する2017

    • Author(s)
      広瀬玲子、安孫子ユミ、新開泰弘、鵜木隆光、土屋幸弘、渡邊泰男、 赤池孝章、熊谷 嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化と活性イオウ分子によるその制御2017

    • Author(s)
      鵜木隆光、新開泰弘、増田章、秋山雅博、Ming XIAN、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウスにおけるアクリルアミドの神経毒性に対するCSEの役割2017

    • Author(s)
      秋山雅博、安孫子 ユミ、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ビスメチル水銀スルフィドの生成を介したニンニクのヘキサン抽出成分によるメチル水銀の毒性軽減2017

    • Author(s)
      Yunjie DING、安孫子ユミ、秋山雅博、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メチル水銀を低毒性化する食用植物中生理活性物質としてのper/polysulfides2017

    • Author(s)
      片山優助、安孫子ユミ、秋山雅博、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子を介したカドミウムの肝毒性の防御機構2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化はポリサルファイドモデル化合物Na2S4により抑制される2017

    • Author(s)
      安孫子ユミ、新開泰弘、鵜木隆光、広瀬怜子、上原孝、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドミウムによるHSP90の化学修飾を介する転写因子HSF1の活性化と活性イオウ分子によるその制御2017

    • Author(s)
      鵜木隆光、新開泰弘、増田章、秋山雅博、Xian Ming、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウスにおけるアクリルアミドの神経毒性に対する活性イオウ分子の役割2017

    • Author(s)
      秋山雅博、安孫子ユミ、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] システインパースルフィド産生酵素(Cysteine Persulfide Synthase, CPERSE)の発見2017

    • Author(s)
      赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5の酵素活性制御におけるタンパク質ポリスルフィド化機能2017

    • Author(s)
      井田智章、笠松真吾、Md. Morshedul Alam、守田匡伸、居原 秀、西村 明、松永哲郎、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] システインtRNA合成酵素によるミトコンドリア形態および機能の制御.2017

    • Author(s)
      松永哲郎、井田智章、魏 范研、西村明幸、守田匡伸、藤井重元、西田基宏、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPによるオートファジー誘導を介した感染防御機構と硫化水素による制御2017

    • Author(s)
      藤井重元、カーン シャザダ、松永哲郎、井田智章、小野勝彦、澤 智裕、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 硫化水素代謝酵素Sqrdlの生体における機能解析2017

    • Author(s)
      守田匡伸、南嶋洋司、井田智章、松永哲郎、笠松真吾、西村 明、藤井重元、市瀬 史、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酵母におけるシステインパースルフィド合成経路と生理的役割の解明2017

    • Author(s)
      西村 明、那須野 亮、松永哲郎、井田智章、笠松真吾、守田匡伸、藤井重元、高木博史、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イオウ呼吸とイオウストレス:ほ乳類における新しいエネルギー代謝とレドックス病態2017

    • Author(s)
      赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、本橋ほづみ
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新しいシステインパースルフィド産生酵素の同定と機能解析2017

    • Author(s)
      井田智章、守田匡伸、魏 范研、松永哲郎、西村 明、Jung Minkyung、赤司壮一郎、居原 秀、澤 智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 種横断的システインパースルフィド産生酵素:Cysteinyl-tRNA synthetase2017

    • Author(s)
      西村 明、井田智章、赤司壮一郎、守田匡伸、松永哲郎、笠松真吾、藤井重元、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPとタンパク質poly-S-グアニル化を介した親電子シグナル制御2017

    • Author(s)
      赤司壮一郎、笠松真吾、ジョン ミンギョン、松永哲郎、井田智章、藤井重元、澤 智裕、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sulfide Quinone reductase (SQR) 欠損マウスの作製とイオウ代謝解析2017

    • Author(s)
      守田匡伸、松永哲郎、井田智章、西村 明、笠松真吾、藤井重元、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規システインパースルフィド合成酵素の同定と機能解析2017

    • Author(s)
      井田智章、守田匡伸、魏 范研、松永哲郎、西村 明、Jung Minkyung、赤司壮一郎、居原 秀、澤 智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] システイニルtRNA合成酵素によるミトコンドリア機能制御の解明2017

    • Author(s)
      松永哲郎、井田智章、魏 范研、澤 智裕、守田匡伸、西村 明、笠松真吾、田沼延公、藤井重元、島 礼、居原 秀、西田基宏、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イオウ呼吸とイオウストレス:新しいエネルギー代謝とレドックス病態の提案2017

    • Author(s)
      赤池孝章、西村 明、井田智章、松永哲郎、守田匡伸、藤井重元、本橋ほづみ
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酵母におけるシステインパースルフィド合成経路とその生理的役割の解明2017

    • Author(s)
      西村 明、那須野 亮、松永哲郎、井田智章、笠松真吾、守田匡伸、藤井重元、高木博史、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5タンパク質ポリスルフィド化の酵素活性制御機能2017

    • Author(s)
      Jung Minkyung、西村 明、笠松真吾、Md. Morchedul Alam、井田智章、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 硫化水素代謝酵素sulfide quinone reductaseの生体における機能解析2017

    • Author(s)
      守田匡伸、松永哲郎、井田智章、西村 明、笠松真吾、藤井重元、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 8-ニトロ-cGMPとS-グアニル化を介する細菌感染防御機構と硫化水素による制御2017

    • Author(s)
      藤井重元、松永哲郎、井田智章、小野勝彦、澤 智裕、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cysteine polysulfidation governed by cysteinyl-tRNA synthetase (CARSs)2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      Se2017 - 200 Years of Selenium Research (The 11th International Symposium on Selenium in Biology and Medicine and The 5th International Conference on Selenium in the Environment and Human Health)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mediates mitochondrial functions and bioenegetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      S-Bio 2017 Plant and Human Sulfur Biology Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of a novel persulfide synthase that mediates mitochondrial sulfur respiration2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      2nd Karolinska-Tohoku Joint Symposium on Medical Sciences
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase governs endogenous hydropersulfide production and mediates mitochondrial functions and bioenergetics2017

    • Author(s)
      Takaaki Akaike
    • Organizer
      AARS2017: IUBMB Focused Meeting on Aminoacyl-tRNA Synthetase
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of cysteinyl-tRNA synthetase for production of cysteine hydropersulfide2017

    • Author(s)
      Akira Nishimura, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Minkyung Jung, Shigemoto Fujii, Hozumi Motohashi, Takaaki Akaike
    • Organizer
      AARS2017: IUBMB Focused Meeting on Aminoacyl-tRNA Synthetase
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Moonlighting functions of cysteinyl-tRNA synthetase: Cysteine hydropersulfide production and regulation of mitochondrial biogenesis and bioenergetics2017

    • Author(s)
      Takaaki Akaike, Akira Nishimura, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi
    • Organizer
      SfRBM 2017 - 24th Annual Meeting of the Society for Redox Biology and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteine hydropersulfide production catalyzed by cysteinyl-tRNA synthetases2017

    • Author(s)
      Tomoaki Ida, Akira Nishimura, Masanobu Morita, Hozumi Motohashi, Takaaki Akaike
    • Organizer
      SfRBM 2017 - 24th Annual Meeting of the Society for Redox Biology and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteinyl-tRNA synthetase (CARS) は活性パースルフィド産生とミトコンドリア機能をコントロールしている2017

    • Author(s)
      赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ・パースルフィド解析システムの開発と応用2017

    • Author(s)
      井田智章、赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲノム編集マウスを用いた硫化水素代謝酵素sulfide-quinone reductaseの機能解析2017

    • Author(s)
      守田匡伸、井田智章、松永哲郎、西村 明、藤井重元、赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酵母における活性イオウ分子種:システインパースルフィドの生理的役割の解明2017

    • Author(s)
      西村 明、吉川雄樹、那須野 亮、松永哲郎、井田智章、守田匡伸、藤井重元、高木博史、赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子によるオートファジー制御:8-ニトロ-cGMPを介するメカニズム2017

    • Author(s)
      藤井重元、松永哲郎、井田智章、小野勝彦、澤 智裕、赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ニトロソグルタチオン還元酵素(GSNOR)選択的欠損マウスの開発2017

    • Author(s)
      松永哲郎、西村 明、笠松真吾、Md. Morshedul Alam、井田智章、守田匡伸、居原 秀、藤井重元、下田 翔、西田基宏、本橋ほづみ、赤池孝章
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reactive persulfide-dependent redox signaling in neuronal cells and its impairment by exposure to electrophiles2017

    • Author(s)
      Shigemoto Fujii, Hideshi Ihara, Shingo Kasamatsu, Akira Nishimura, Tomoaki Ida, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteine persulfide formation via cysteinyl-tRNA synthetase and its involvement in mitochondrial bioenergetics2017

    • Author(s)
      Takaaki Akaike, Tomoaki Ida, Masanobu Morita, Shigemoto Fujii, Akira Nishimura, Tetsuro Matsunaga, Minkyung Jung, Hozumi Motohashi
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New strategies for drug development of heart failure2017

    • Author(s)
      Nishida M
    • Organizer
      Graduate School of Medical Sciences, Inje University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of cardiac plasticity by TRPC3 channels2017

    • Author(s)
      Nishida M
    • Organizer
      YU/KU-NIPS Symposium2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New strategies for drug development of heart failure2017

    • Author(s)
      Nishida M
    • Organizer
      Graduate School of Pharmaceutical Sciences, Mahidol University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic detoxification of environmental electrophile by reactive cysteine persulfides2017

    • Author(s)
      Nishida M
    • Organizer
      Korea/Russia joint symposium 2017 (Marine Effective compounds Open Wellness)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリアダイナミクスのレドックス制御2017

    • Author(s)
      西田基宏
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPC3-Nox2複合体形成による心筋可塑性制御2017

    • Author(s)
      西田基宏
    • Organizer
      Research PlaNet 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウによるミトコンドリア品質管理と心疾患リスク制御2017

    • Author(s)
      西田基宏
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPチャネル複合体を標的とした心不全治療戦略2017

    • Author(s)
      西田基宏
    • Organizer
      第4回iHFフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] GTP結合タンパク質Drp1のシステイン修飾を介した心筋早期老化の分子制御機構と創薬への適用2017

    • Author(s)
      西田基宏
    • Organizer
      生体機能と創薬シンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心不全リスクを制御するレドックスシグナル2017

    • Author(s)
      西田基宏
    • Organizer
      Molecular Cardiovascular Metabolic Conference (MCMC) 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心血管病の新たな標的としてのTRPC3-Nox2複合体2017

    • Author(s)
      西田基宏
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シルニジピンによるミトコンドリア品質維持と適応拡大2017

    • Author(s)
      西田基宏
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア品質管理に着目した新しい疾患治療戦略2017

    • Author(s)
      西田基宏
    • Organizer
      第27回日本循環薬理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cardiac mitochondrial quality control by reactive sulfide species2017

    • Author(s)
      Motohiro Nishida
    • Organizer
      ConBio2017国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPC3-Nox2機能連関によるROS産生と心臓リモデリング2017

    • Author(s)
      冨田拓郎、北島直幸、西村明幸、西田基宏
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 環境ストレスに対する心臓リモデリングにおけるTRPC3/6チャネルの役割2017

    • Author(s)
      冨田 拓郎、島内 司、小田紗矢香、西村 明幸、西田 基宏
    • Organizer
      TRP研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPCタンパク質のチャネル活性非依存的な役割とその病態生理学的意義2017

    • Author(s)
      冨田拓郎、島内司、小田紗矢香、西田基宏
    • Organizer
      心血管膜輸送研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Drp1-細胞骨格の相互作用による心筋ミトコンドリアの品質管理2017

    • Author(s)
      西村明幸、島内司、冨田拓郎、西田基宏
    • Organizer
      オルガネラ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢に伴うAT1R-P2Y6R複合体によるアンジオテンシンII誘発性高血圧の制御2017

    • Author(s)
      西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メチル水銀による心筋ミトコンドリア品質管理の分子機構2017

    • Author(s)
      西村明幸、冨田拓郎、西田基宏
    • Organizer
      メチル水銀研究ミーティング
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice2017

    • Author(s)
      Sayaka Oda, Motohiro Nishida
    • Organizer
      2017 Yonsei -Korea -NIPS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017

    • Author(s)
      小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内 司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
    • Organizer
      TRP研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017

    • Author(s)
      小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内 司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
    • Organizer
      第131回日本薬理学会近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高血糖誘発性心不全におけるTRPC6チャネルの役割2017

    • Author(s)
      小田紗矢香、冨田拓郎、西村明幸、西田基宏
    • Organizer
      第16回 次世代を担う若手ファーマ・バイオフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高血糖誘発性心不全におけるTRPC6チャネルの役割2017

    • Author(s)
      小田紗矢香、冨田拓郎、西村明幸、西田基宏
    • Organizer
      心血管膜輸送研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プリン作動性受容体P2Y6Rの機能多様性とその病態生理学的意義2017

    • Author(s)
      下田翔、西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      オルガネラ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プリン作動性受容体P2Y6Rの機能多様性とその病態生理学的意義2017

    • Author(s)
      下田翔、西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      第7回 名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel targets of homocysteine, a risk factor for cardiovascular disease2017

    • Author(s)
      Ishii I
    • Organizer
      2017 Fall International Convention of the Pharmaceutical Society of Korea
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cystathionine gamma-lyase欠損マウスにおける妊娠高血圧症候群と育児放棄2017

    • Author(s)
      赤星軌征、半田博紀、石井功
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cystathionine γ-lyase欠損マウスにおける乳清アミノ酸成分の異常2017

    • Author(s)
      半田博紀、横山輝、赤星軌征、石井功
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] BDNF-p75NTR signaling axis regulates circadian activation of Nrf2 in astrocytes2017

    • Author(s)
      Ishii T, Warabi E, Mann GE
    • Organizer
      24th Annual Meeting of the Society for Redox Biology and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NASH自然発症マウスにおける腸内細菌叢と腸管上皮バリア機能の異常2017

    • Author(s)
      秋山健太郎、蕨 栄治、 正田純一
    • Organizer
      JDDW2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] p62:Nrf2遺伝子二重欠損(DKO)♀マウスは♂と比較して非アルコール性脂肪性肝炎(NASH)の肝病変は軽度である2017

    • Author(s)
      長岡亜実、秋山健太郎、蕨 栄治、正田純一
    • Organizer
      JDDW2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 継続的運動はDHEA産生増加を介してKupffer細胞(KC)貪食能の向上によるLPSに対する生体クリアランス増大と炎症応答の低下を誘導する2017

    • Author(s)
      小峰昇一、 秋山健太郎、蕨 栄治、正田純一
    • Organizer
      JDDW2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] スルフォラファンによる転写因子Nrf2の賦活化が運動耐容能に与える影響2017

    • Author(s)
      小峰昇一、呉世昶、蕨 栄治、正田純一
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 継続的な運動負荷がエンドトキシンのクリアランスと炎症応答に与える影響2017

    • Author(s)
      小峰昇一、秋山健太郎、蕨 栄治、正田純一
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] p62: Nrf2遺伝子二重欠損(DKO)マウスのNASH病態の性差と女性ホルモンの関わり2017

    • Author(s)
      長岡亜実、秋山健太郎、蕨 栄治、正田純一
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] p62: Nrf2遺伝子二重欠損マウスの非アルコール性脂肪性肝炎発症における腸管由来のエンドトキシンの関与2017

    • Author(s)
      秋山健太郎、蕨 栄治、正田純一
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Environmental electrophiles: Modulation of redox signaling and interaction with persulfides/polysulfides.2017

    • Author(s)
      熊谷嘉人.
    • Organizer
      第90回日本細菌学会総会 国際シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メチル水銀のケミカルバイオロジー2017

    • Author(s)
      熊谷嘉人.
    • Organizer
      基盤(S)公開シンポジウム メチル水銀研究の現状と展望
    • Place of Presentation
      一の坊(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アセトアミノフェン投与マウスにおけるアセトアミノフェンーイオウ付加体:新しい解毒機構.2017

    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本市国際交流会館(熊本県、熊本市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動模倣薬の新たなストラテジー2017

    • Author(s)
      西田基宏.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動による心血管疾患改善の分子メカニズム.2017

    • Author(s)
      小田紗矢香、島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mechanism underlying redox regulation of cardiac mitochondria dynamics.2017

    • Author(s)
      Motohiro Nishida.
    • Organizer
      第94回日本生理学会・日韓合同シンポジウム
    • Place of Presentation
      アクトシティ浜松(静岡県、浜松市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional and Physical coupling between TRPC3 and Nox2 underlies maladaptive cardiac fibrosis.2017

    • Author(s)
      Takuro Numaga-Tomita, Naoyuki Kitajima, Akiyuki Nishimura, Motohiro Nishida.
    • Organizer
      第94回日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県、浜松市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of environmental electrophile-mediated cardiac vulnerability by reactive persulfides.2017

    • Author(s)
      Motohiro Nishida.
    • Organizer
      日本細菌学会・国際サテライトシンポジウム
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPCチャネル阻害による末梢循環改善作用の解明.2017

    • Author(s)
      冨田拓郎、島内司、西村明幸、西田基宏.
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県、長崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジヒドロピリジン系Ca2+拮抗薬シルニジピンのエコファーマ研究2017

    • Author(s)
      西田基宏.
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県、長崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] TRPC3-Nox2複合体形成による心臓リモデリング制御.2017

    • Author(s)
      西田基宏.
    • Organizer
      心脈管作動物質学会
    • Place of Presentation
      琉球大学(沖縄県、西原町)
    • Related Report
      2016 Annual Research Report
  • [Presentation] New strategies for drug development of heart failure2017

    • Author(s)
      Nishida M.
    • Organizer
      Medical Research Seminar in Malaysia Sabah University
    • Place of Presentation
      Kota Kinabalu Sabah(Malaysia)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性イオウ分子種:システインポリスルフィドの生体機能と代謝制御.2017

    • Author(s)
      赤池孝章.
    • Organizer
      第19回日本質量分析学会北海道談話会講演会
    • Place of Presentation
      旭川医科大学教育推進センター(北海道、旭川市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Persulfide regulation of mitochondrial number and function.2017

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2017 NO Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott (Venture, CA, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of cardiac oxygen remodeling via electrophilic modification of Drp12016

    • Author(s)
      Nishida M.
    • Organizer
      The 89th Annual Meeting of the Japanese Biochemical Society (international symposium)
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The phase-zero reaction: capture of electrophiles mediated by reactive sulfur species.2016

    • Author(s)
      Kumagai Y.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Stoweflake Conference Center (Stowe, USA)
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPC channels in cardiovascular stress resilience2016

    • Author(s)
      Nishida M.
    • Organizer
      International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research”
    • Place of Presentation
      東京医科歯科大学(東京都、文京区)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Redox regulation of G proteins in cardiac remodeling2016

    • Author(s)
      Nishida M.
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The chemical biology of electrophiles and reactive sulfur species.2016

    • Author(s)
      Kumagai Y.
    • Organizer
      The special seminar for visiting professor of China Medical University
    • Place of Presentation
      China Medical University(Shenyang, China)
    • Year and Date
      2016-04-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 親電子シグナルを制御する活性イオウ分子.2016

    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会第136年会(横浜)2016年3/28
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of Reactive Sulfur Species in Detoxification of Methylmercury: Phase Zero Reaction for Electrophile Trapping and Detoxification.2016

    • Author(s)
      Kumagai Y
    • Organizer
      Society of Toxicology 55th Annual Meeting Society of Toxicology and Japanese Society of Toxicology Mini-Symposium
    • Place of Presentation
      New Orleans(アメリカ)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1,4-naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its modulation by reactive sulfur species in human A431 cells.2016

    • Author(s)
      Unoki T, Shinkai Y, Sha L, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans(アメリカ)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protective effect of sodium tetrasulfide on covalent modification of cellular proteins and cellular toxicity mediated by 1,4-naphthoquinone, an atmospheric electrophile.2016

    • Author(s)
      Hirose R, Unoki T, Shinkai Y, Abiko Y, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans(アメリカ)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of cystathionine gamma-lyase in the health risks of methylmercury.2016

    • Author(s)
      Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans(アメリカ)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of Nrf2 through S-transmerculation of methylmercury glutathione adduct to Keap1 in SH-SY5Y cells.2016

    • Author(s)
      Abiko Y, Yoshida E, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans(アメリカ)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境中親電子物質による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの撹乱.2016

    • Author(s)
      熊谷嘉人
    • Organizer
      第89回日本薬理学会年会 日本薬理学会・日本毒性学会共催シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Polysulfides and Redox Signaling.2016

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference.
    • Place of Presentation
      Ventura(アメリカ)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メチル水銀による活性イオウ分子の捕獲.2016

    • Author(s)
      安孫子ユミ 、吉田映子、熊谷嘉人.
    • Organizer
      第15回分子予防環境医学研究会大会
    • Place of Presentation
      自治医科大学(栃木県・下野市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性イオウ分子によるカドミウムの毒性防御.2016

    • Author(s)
      鵜木隆光、新開泰弘、秋山雅博、熊谷嘉人.
    • Organizer
      第32回臨床フリーラジカル会議
    • Place of Presentation
      京都・烟河(京都府・亀岡市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 親電子・活性イオウ分子付加体の化学と解析法.2016

    • Author(s)
      安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      新学術領域研究 「酸素生物学」 第3回技術支援セミナー
    • Place of Presentation
      名古屋大学シンポジオン(愛知県・名古屋市)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] メチル水銀と活性イオウ分子との反応により生じるビスメチル水銀サルファイド.2016

    • Author(s)
      安孫子ユミ
    • Organizer
      メチル水銀研究ミーティング
    • Place of Presentation
      LMJ東京研修センター(東京都・文京区)
    • Year and Date
      2016-01-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] メチル水銀に対する新奇リスク軽減因子としての活性イオウ分子.2016

    • Author(s)
      秋山雅博
    • Organizer
      メチル水銀研究ミーティング
    • Place of Presentation
      LMJ東京研修センター(東京都・文京区)
    • Year and Date
      2016-01-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] フェーズゼロ反応:活性イオウ分子による親電子物質の捕獲.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] カドミウムによるレドックスシグナル伝達経路の活性化とその制御系.2016

    • Author(s)
      新開泰弘、熊谷嘉人.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子によるカドミウムの毒性防御の分子機構.2016

    • Author(s)
      新開泰弘、熊谷嘉人.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 環境中親電子物質によるレドックスシグナル伝達の活性化と破綻.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 親電子物質/電子受容体で活性イオウ分子の役割を探る.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      第12回レドックスイノベーションシンポジウム
    • Place of Presentation
      熊本大学(熊本県、熊本市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 環境中に存在する親電子物質および電子受容体で活性イオウ分子の役割を探る.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの破綻.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 反応性環境物質によるタンパク質の化学修飾とそれに対する生体防御系.2016

    • Author(s)
      熊谷嘉人.
    • Organizer
      第89回産業衛生学会教育講演
    • Place of Presentation
      福島県文化センター(福島県、福島市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The phase-zero reaction: caputure of electrophiles by reactive sulfur species.2016

    • Author(s)
      Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. Satellite Symposium on Chemical Biology of Reactive Persulfide
    • Place of Presentation
      東北大学医学部(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Reactive sulfur species as a regulator molecule for the phase-zero reaction to attenuate reactivity of electrophiles.2016

    • Author(s)
      Kumagai Y
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Coriandrum sativum L.葉抽出液中の脂肪族親電子物質によるNrf2活性化 および無機三価ヒ素の細胞毒性軽減.2016

    • Author(s)
      安孫子ユミ、溝河真衣、里見綾香、熊谷嘉人.
    • Organizer
      第22回ヒ素シンポジウム
    • Place of Presentation
      産総研臨界副都心センター(東京都、港区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 親電子プローブを用いたMRM-MS による生体試料中の活性イオウ分子の定量法の構築.2016

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、井田智章、赤池孝章、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都、品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アセトアミノフェンの新規イオウ付加体の同定.2016

    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都、品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cystathionine gamma-lyase はメチル水銀中毒症状を抑制する鍵分子である.2016

    • Author(s)
      秋山雅博、安孫子ユミ、新開泰弘、鵜木隆光、Ding Yunjie、外山喬士、吉田映子、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都、品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 親電子物質による生体影響の二面性:SH-SY5Y 細胞におけるメチル水銀曝露により生じるAkt/CREB/Bcl-2 経路の活性化と破綻.2016

    • Author(s)
      鵜木隆光、安孫子ユミ、外山喬士、上原孝、坪井康次、西田基宏、鍜冶利幸、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都、品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] カドミウムの肝毒性に対する活性イオウ分子の防御的役割.2016

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人.
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化とその防御的役割.2016

    • Author(s)
      新開泰弘、増田章、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アセトアミノフェンの新規代謝経路:イオウ付加体の同定.2016

    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 1,4-ナフトキノンによるHSF90/HSF1経路の活性化と活性イオウ分子によるその制御.2016

    • Author(s)
      鵜木隆光、新開泰弘、沙亮、広瀬玲子、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] メチル水銀曝露による健康リスクを制御する活性イオウ分子の役割.2016

    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Capture of methylmercury by persulfides to form bismethylmercury sulfide.2016

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Organizer
      IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
    • Place of Presentation
      Convention Center in Merida (Merida, Mexico)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 1,4-Naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its negative regulation by reactive sulfur species in human A431 cells.2016

    • Author(s)
      Unoki T, Shinkai Y, Sha L, Hirose R, Kumagai Y.
    • Organizer
      IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
    • Place of Presentation
      Convention Center in Merida (Merida, Mexico)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Methylmercury activates and disrupts the Akt/CREB/Bcl-2 signal transduction pathway in SH-SYSY cells.2016

    • Author(s)
      Kumagai Y, Unoki T, Abiko Y, Toyama T.
    • Organizer
      The 52nd European Congress of the European Societies of Toxicology
    • Place of Presentation
      FEBES, Conference and Exhibition Centre (Seville, Spain)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An atmospheric electrophile activates heat shock factor 1 through S-arylation of heat shock protein 90.2016

    • Author(s)
      Hirose R, Unoki T, Abiko Y, Shinkai Y, Sha R, Kumagai Y.
    • Organizer
      The 52nd European Congress of the European Societies of Toxicology
    • Place of Presentation
      FEBES, Conference and Exhibition Centre (Seville, Spain)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Capture of reactive sulfur species by methylmercury to form bismethylmercury sulfide: Implication of the disruptionof redox homeostasis.2016

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of reactive sulfur species as a key molecule to diminish toxicity of the environmental electrophile in mice.2016

    • Author(s)
      Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sodium tetrasulfide, a reactive sulfur species, protects cells from 1,4-naphthoquinone induced cytotoxicity through sulfur adduct formation.2016

    • Author(s)
      Unoki T, Shinkai Y, Abiko Y, Hirose R, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Translation-coupled protein polysulfuration, a unique biosynthesis pathway of cysteine persulfide.2016

    • Author(s)
      Ida T, Ihara H, Wei F, Tomozawa K, Kasamatsu S, Morita M, Matsunaga T, Kumagai Y, Sawa T, Motohashi H, Fujii S, Akaike T.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein poly-S-guanylation: Reversible post-translational modification regulated by protein polysulfur and 8-nitrocGMP.2016

    • Author(s)
      Akashi S, Kasamatsu S, Jung M, Matsunaga T, Ida T, Fujii S, Sawa T, Kumagai Y, Motohashi H, Akaike T.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of cystathionine γ-lyase overexpressing Tg mouse.2016

    • Author(s)
      Warabi E, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] p62:Nrf2遺伝子二重欠損マウスの肝蔵、内臓脂肪、腸内環境の解析よりみた NASH発症機序の解明.2016

    • Author(s)
      秋山健太郎、蕨栄治、正田純一.
    • Organizer
      第41回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 継続的な運動はKupffer細胞の異物貪食能の増大により、菌体内毒素(LPS)のクリアランスを増大させ、LPS刺激による炎症応答を低下させる.2016

    • Author(s)
      小峰昇一、秋山健太郎、蕨栄治、正田純一.
    • Organizer
      第41回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 継続的な運動負荷は菌体内毒素(LPS)クリアランスを増大させ、LPS刺激による炎症応答を低下させる.2016

    • Author(s)
      小峰昇一、秋山健太郎、蕨栄治、正田純一.
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター(岩手県、盛岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症マウスにおける Kupffer 細胞の表現形質の変化と発症機序との関連性.2016

    • Author(s)
      秋山健太郎、蕨栄治、正田純一.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 親電子物質からの生体防御におけるトランススルフレーション酵素(CBS・CTH)の役割.2016

    • Author(s)
      石井功
    • Organizer
      フォーラム2016衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京、品川区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Possible roles of H2S/RSS and homocysteine in the redox signaling via electrophiles.2016

    • Author(s)
      Ishii I
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic applications of NO
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dietary deprivation of each proteinogenic amino acid induces altered systemic adaptive responses in mice.2016

    • Author(s)
      Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Karube K, Kasahara T, Ishii I.
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic applications of NO
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice.2016

    • Author(s)
      Kamata S, Yamamoto J, Karube K, Ohkubo R, Kasahara T, Ishii I.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myocardial early senescence mediated by mitochondria-cytoskeleton interaction2016

    • Author(s)
      Nishida M.
    • Organizer
      The 39th Annual Meeting of the Molecular Biology Society of Japan (international symposium)
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 末梢循環障害におけるTRPC6チャネルの役割.2016

    • Author(s)
      冨田拓郎、島内司、西村明幸、西田基宏.
    • Organizer
      第26回日本循環薬理学会
    • Place of Presentation
      信州大学(長野県、松本市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動による虚血後の末梢循環回復効果におけるTRPC6の役割2016

    • Author(s)
      冨田拓郎、島内司、西村明幸、西田基宏.
    • Organizer
      心血管膜輸送研究会
    • Place of Presentation
      九州大学(福岡県、福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞膜TRPC3-NOX2相互作用による心臓の硬さ制御2016

    • Author(s)
      冨田拓郎、北島直幸、西村明幸、西田基宏.
    • Organizer
      オルガネラ研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] TRPC3 underlies ROS-mediated cardiac remodeling2016

    • Author(s)
      Takuro Numaga-Tomita, Naoyuki Kitajima, Akiyuki Nishimura, Motohiro Nishida.
    • Organizer
      International and Interdiciplinary Symposium 2016
    • Place of Presentation
      東京医科歯科大学(東京都、文京区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPCチャネルによる心筋細胞の低酸素適応2016

    • Author(s)
      冨田拓郎、松金良祐、北島直幸、西村明幸、西田基宏.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ROS-generating TRPC channels in cardiac remodeling.2016

    • Author(s)
      Takuro Numaga-Tomita, Naoyuki Kitajima, Akiyuki Nishimura, Motohiro Nishida.
    • Organizer
      Molecular Cardiovascular Conference II
    • Place of Presentation
      東京ドームホテル(東京都、文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] シグナル複合体プラットフォームとしてのTRPC3の役割.2016

    • Author(s)
      冨田拓郎、北島直幸、西村明幸、森泰生、西田基宏.
    • Organizer
      TRPチャネル研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ROS-generating TRPC channels in cardiac remodeling.2016

    • Author(s)
      Takuro Numaga-Tomita, Naoyuki Kitajima, Akiyuki Nishimura, Motohiro Nishida.
    • Organizer
      第9回国際NO学会, 第16回日本NO学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Redox-dependent Regulation of H-Ras palmitoylation.2016

    • Author(s)
      Akiyuki Nishimura, Tomoya Ito, Takuro Numaga-Tomita, Motohiro Nishida.
    • Organizer
      第9回国際NO学会 第16回日本NO学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developmentally upregulated P2Y6 receptor promotes angiotensin II-induced hypertensive signaling.2016

    • Author(s)
      Akiyuki Nishimura, Caloline Sunggip, Takuro Numaga-Tomita, Motohiro Nishida.
    • Organizer
      International and Interdisciplinary Symposium 2016
    • Place of Presentation
      東京医科歯科大学(東京都、文京区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性イオウによるH-Rasパルミトイル化の調節機構2016

    • Author(s)
      西村明幸、冨田拓郎、西田基宏.
    • Organizer
      オルガネラ研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Developmentally upregulated P2Y6 receptor promotes angiotensin II-induced hypertensive signaling.2016

    • Author(s)
      Akiyuki Nishimura, Caloline Sunggip, Takuro Numaga-Tomita, Motohiro Nishida.
    • Organizer
      Molecular Cardiovascular Conference II
    • Place of Presentation
      東京ドームホテル(東京都、文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 活性イオウによる心筋ミトコンドリア品質管理の分子機構2016

    • Author(s)
      西村明幸、島内司、冨田拓郎、西田基宏.
    • Organizer
      心血管膜輸送研究会
    • Place of Presentation
      九州大学(福岡県、福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 加齢に伴うAT1R-P2Y6R複合体形成によるアンジオテンシンII誘発性高血圧の制御2016

    • Author(s)
      西村明幸、Caroline Sunggip、冨田拓郎、西田基宏.
    • Organizer
      第63回中部日本生理学会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Drp1-細胞骨格の相互作用による心筋ミトコンドリアの品質管理2016

    • Author(s)
      西村明幸、島内司、石川達也、冨田拓郎、西田基宏.
    • Organizer
      第26回日本循環薬理学会
    • Place of Presentation
      信州大学(長野県、松本市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Suppression of adriamycin-induced cardiotoxicity by isothiocyanate.2016

    • Author(s)
      Tomoya Ito, Akiyuki Nishimura, Takuro Tomita and Motohiro Nishida.
    • Organizer
      第9回国際NO学会 第16回日本NO学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of TRPC6 enhances endothelium function and improves peripheral arterial disease.2016

    • Author(s)
      Tsukasa Shimauchi, Takuro Numaga-Tomita, Akiyuki Nishimura, Motohiro Nishida.
    • Organizer
      第9回国際NO学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 末梢循環障害におけるTRPC6チャネルの役割.2016

    • Author(s)
      島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      第11回TRP研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of lipid-activated TRPC channels in peripheral arterial disease2016

    • Author(s)
      Tsukasa Shimauchi, Takuro Numaga-Tomita, Motohiro Nishida.
    • Organizer
      The 9th KOREA-JAPAN conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Yonsei University(Seoul )
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drp1-細胞骨格の相互作用による心筋ミトコンドリア品質管理.2016

    • Author(s)
      島内司、西村明幸、冨田拓郎、西田基宏.
    • Organizer
      オルガネラ研究会
    • Place of Presentation
      岡崎カンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 下肢虚血後の末梢循環障害におけるTRPC6チャネルの役割.2016

    • Author(s)
      島内司、冨田拓郎、伊藤智哉、西村明幸、西田基宏.
    • Organizer
      第69回酸化ストレス学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドキソルビシン心筋症におけるTRPC3/Nox2の役割.2016

    • Author(s)
      島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      心血管膜輸送研究会
    • Place of Presentation
      九州大学(福岡県、福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドキソルビシン心筋症におけるTRPC3/Nox2複合体の役割.2016

    • Author(s)
      島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      第130回薬理学会近畿部会
    • Place of Presentation
      京都大学 (京都府、京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] S-nitrosylation of NF-κB underlies down-regulation of angiotensin type 1 receptors induced by ATP in cardiac fibroblasts2016

    • Author(s)
      Sayaka Oda, Akiyuki Nishimura, Takuro Numaga-Tomita, Motohiro Nishida.
    • Organizer
      第9回国際NO学会
    • Place of Presentation
      仙台国際センター (宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動による末梢循環機能回復におけるTRPC6の役割.2016

    • Author(s)
      小田紗矢香、島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      第6回生理学研究所・名古屋大学医学系研究科 合同シンポジウム
    • Place of Presentation
      名古屋大学(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 末梢血流障害における運動を介したTRPC6チャネルリン酸化機構の解明.2016

    • Author(s)
      小田紗矢香、島内司、冨田拓郎、西村明幸、西田基宏.
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都大学(京都府、京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] TRPC3-dependent ROS negatively regulates hypoxic stress-induced adaptive hypertrophy of rat cardiomyocytes.2016

    • Author(s)
      Kakeru Shimoda, Ryosuke Matsukane, Tomoya Ito, Akiyuki Nishimura, Takuro Numaga-Tomita, Motohiro Nishida
    • Organizer
      第9回国際NO学会 第16回日本NO学会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 加齢に伴うAT1R-P2Y6R複合体形成によるアンジオテンシンII誘発性高血圧の制御.2016

    • Author(s)
      下田翔、西村明幸、Caroline Sunggip、冨田拓郎、西田基宏.
    • Organizer
      第6回名古屋大学・生理学研究所合同シンポジウム
    • Place of Presentation
      名古屋大学(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] プリン作動性受容体P2Y6Rの機能多様性とその病態生理学的意義.2016

    • Author(s)
      下田翔、西村明幸、Caroline Sunggip、冨田拓郎、西田基宏.
    • Organizer
      心血管膜輸送研究会
    • Place of Presentation
      九州大学(福岡県、福岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] メチル水銀による心不全リスク増加の分子機構.2016

    • Author(s)
      西田基宏.
    • Organizer
      環境省メチル水銀研究会
    • Place of Presentation
      LMJ東京研修センター(東京都、文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Myocardial early senescence mediated by mitochondria-cytoskeleton interaction.2016

    • Author(s)
      Motohiro Nishida.
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心不全治療の温故創新 ~運動を模倣する創薬~.2016

    • Author(s)
      西田基宏.
    • Organizer
      天然薬物研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] メチル水銀による心疾患リスク増加の分子機構とその予防治療.2016

    • Author(s)
      西田基宏.
    • Organizer
      日本薬学会・フォーラム2016衛生部会
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都、品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 活性イオウによる心筋のストレス適応・不適応の分子制御.2016

    • Author(s)
      西田基宏.
    • Organizer
      日本獣医学会比較薬理毒性分科会
    • Place of Presentation
      日本大学(神奈川県、藤沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 気道炎症と呼気NO.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      京都国際会館(京都府、京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体防御応答のレドックス制御機構.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第27回日本生体防御学会学術総会
    • Place of Presentation
      九州大学病院キャンパス(福岡県、福岡市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのミトコンドリア機能制御.2016

    • Author(s)
      赤池孝章.
    • Organizer
      生理学研究所研究会「オルガネラネットワークの制御機構とその生理的意義」
    • Place of Presentation
      生理学研究所(愛知県、岡崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新しいCysteine Persulfide Synthaseの発見とそのユニークなレドックス制御メカニズム.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第12回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      熊本大学(熊本県、熊本市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドによるレドックス制御の分子基盤.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種によるミトコンドリア機能制御.2016

    • Author(s)
      赤池孝章、井田智章.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体内タンパク質ポリスルフィドの検出とその生成機構.2016

    • Author(s)
      赤池孝章、笠松真吾.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細菌感染におけるレドックスシグナル制御機構.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第28回微生物学シンポジウム
    • Place of Presentation
      愛知学院大学(愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ生成酵素の発見:ミトコンドリア形態形成とエネルギー代謝の新しいメカニズム.2016

    • Author(s)
      赤池孝章.
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル(岐阜県、岐阜市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Host defense and oxidative stress signaling in microbial infections.2016

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 13th Korea-Japan International Symposium on Microbiology
    • Place of Presentation
      The-K Hotel Gyeongju (Gyeongbuk, Korea)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteine transfer RNA synthetases moonlighting as novel cysteine persulfide synthases (CPERSs).2016

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase controls protein polysulfidation and mitochondrial functions.2016

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2016 Thiol-Based Redox Regulation & Signaling Gordon Research Conference
    • Place of Presentation
      Stoweflake Conference Center (Stowe, VT, USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cysteinyl-tRNA synthetase is a major source of reactive persulfide and controls mitochondrial biology.2016

    • Author(s)
      Takaaki Akaike.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Glutathione adduct of methylmercury activates Nrf2 through covalent modification of Keap1in SH-SY5Y Cells.2015

    • Author(s)
      Kumagai Y, Abiko Y, Yoshida E.
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies.
    • Place of Presentation
      Honolulu(アメリカ)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリア品質管理を主眼とするエコファーマ研究2015

    • Author(s)
      西田基宏
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 心虚血再灌流障害におけるホモシステインの新規作用機序.2015

    • Author(s)
      石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明.2015

    • Author(s)
      井田智章、居原秀、魏范研、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機水銀の神経毒性発現における8-ニトロ-cGMPの役割と活性イオウ分子による制御.2015

    • Author(s)
      藤井重元、笠松真吾、居原秀、津々木博康、石崎健勝、井田智章、澤智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質poly-S-グアニル化を介した親電子シグナルの可逆的制御.2015

    • Author(s)
      赤司壮一郎、笠松真吾、ジョンミンギョン、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Antioxidant Electrophilic Signaling Regulated by Reactive Sulfur Species and Its Translational Biosynthesis.2015

    • Author(s)
      赤池孝章
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] メスp62/Sqstm1遺伝子欠損マウスを用いたEstradiolとNAFLDとの関係の解析.2015

    • Author(s)
      池内美穂,蕨 栄治,長岡亜実,秋山健太郎,正田 純一.
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] p62: Nrf2遺伝子二重欠損マウスは血清中エンドトキシンが増加し,脂肪性肝炎を発症する.2015

    • Author(s)
      秋山健太郎,蕨 栄治,岡田浩介,正田 純一.
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 絶食によるマウス臓器タンパク質リモデリングの網羅的プロテオーム解析2015

    • Author(s)
      2.鎌田祥太郎、山本隼也、海沼亮、大谷遥香、戸坂優花、笠原忠、石井功.
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] The spatial distribution of glutathione persulfide in the mouse lens revealed by atmospheric-pressure MALDI MS imaging.2015

    • Author(s)
      Yoshioka T, Goto S, Okuda Y, Kubo A, Ishii I, Hishiki T, Yamamoto T, Takano N, Hoshino T, Nakamura T, Suematsu M, Kajimura M.
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心筋の低酸素ストレス適応におけるTRPC3チャネルの役割2015

    • Author(s)
      松金良祐、冨田拓郎、濱瀬健司、井手友美、西田基宏
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      海峡メッセ下関(山口県・下関市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] P2Y6受容体のリガンド非依存的活性化の分子機構2015

    • Author(s)
      重松智博、西村明幸、濱瀬健司、井手友美、西田基宏
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      海峡メッセ下関(山口県・下関市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心筋梗塞後の心筋老化誘導におけるミトコンドリアGTP結合タンパク質Drp1の役割2015

    • Author(s)
      島内司、西村明幸、冨田拓郎、西田基宏
    • Organizer
      第128回日本薬理学会近畿部会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府・豊中市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] アンジオテンシンII誘発性高血圧に対するP2Y6受容体の役割2015

    • Author(s)
      西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      第128回日本薬理学会近畿部会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府・豊中市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein-Bound Reactive Sulfur Species and Its Translational Biosynthesis: Potential Implication for Oxidative Stress and Tumor Biology.2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 46th International Symposium of The Princess Takamatsu Cancer Research Fund.
    • Place of Presentation
      パレスホテル東京(東京都・千代田区)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TRPCチャネルを制御する新規膜貫通タンパク質OGU1の機能解析2015

    • Author(s)
      伊藤智哉、高橋重成、加藤賢太、西田基宏、森泰生、相澤康則
    • Organizer
      第62回中部日本生理学会大会
    • Place of Presentation
      富山大学(富山県・富山市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 梢循環障害におけるTRPC6チャネルの役割2015

    • Author(s)
      冨田拓郎、島内司、西村明幸、西田基宏
    • Organizer
      第62回中部日本生理学会大会
    • Place of Presentation
      富山大学(富山県・富山市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chemical Biology of Electrophiles.2015

    • Author(s)
      Kumagai Y
    • Organizer
      CEPID-Redoxoma seminar in University of Sao Paulo
    • Place of Presentation
      Sao Paulo(ブラジル)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Contribution of the Keap1-Nrf2 pathway and CBS/CSE to produce reactive sulfur species to protection against methylmercury.2015

    • Author(s)
      Kumagai Y
    • Organizer
      The 9th Congress of Toxicology in Developing Countries
    • Place of Presentation
      Natal(ブラジル)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Imitation of kinesitherapy by inhibition of TRPC6 channel activities.2015

    • Author(s)
      Nishida M, Numaga-Tomita T, Shimauchi T, Matsukane R, Nishimura A.
    • Organizer
      International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015).
    • Place of Presentation
      熊本大学(熊本県・熊本市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 親電子物質のケミカルバイオロジー:化学修飾を介したレドックスシグナル伝達および毒性発現とそれらを制御する活性イオウ分子.2015

    • Author(s)
      熊谷嘉人
    • Organizer
      持田製薬株式会社 創薬研究所セミナー
    • Place of Presentation
      持田製薬創薬研究所(静岡県・御殿場市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 雌性p62遺伝子欠損マウスの表現型の解析-女性ホルモンの過食肥満と肝脂肪化に及ぼす影響の検討.2015

    • Author(s)
      池内美穂, 蕨 栄治, 正田純一.
    • Organizer
      日本消化器関連学会週間(JDDW)
    • Place of Presentation
      グランドプリンスホテル新高輪 国際館パミール(東京都・港区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] NASH自然発症モデルマウスの腸内環境よりみた疾病病態の解析と発症機序の解明.2015

    • Author(s)
      秋山健太郎, 池内美穂, 蕨 栄治, 正田純一.
    • Organizer
      日本消化器関連学会週間(JDDW)
    • Place of Presentation
      グランドプリンスホテル新高輪 国際館パミール(東京都・港区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cytathionine β synthase is required to maintain glutathione hydropersulfide, a novel antioxidant molecule, in the murine lens.2015

    • Author(s)
      Yoshioka T, Goto S, Okuda Y, Kubo A, Ishii I, Hishiki T, Yamamoto T, Takano N, Hoshino T, Nakamura T, Nagaoka T, Yoshida A, Suematsu M, Kajimura M.
    • Organizer
      10th World Congress for Microcirculation
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 親電子性キノン化合物によるタンパク質修飾のBiotin-(PEAC)5-maleimide-ELISA を用いた検出.2015

    • Author(s)
      安孫子ユミ、Luong Cong Nho、熊谷嘉人.
    • Organizer
      フォーラム2015:衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] メチル水銀曝露による健康リスクに対する活性イオウ分子の役割.2015

    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      フォーラム2015:衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] カドミウムの防御応答に関わるHSP/HSF1経路の活性化と活性イオウ分子によるその制御.2015

    • Author(s)
      増田章、新開泰弘、熊谷嘉人.
    • Organizer
      フォーラム2015:衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食餌誘導性高ホモシステイン血症感受性マウスの解析.2015

    • Author(s)
      戸坂優花、大谷遥香、三浦あす美、長田知子、鎌田祥太郎、石井功.
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      日本大学薬学部(千葉県・船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 短期絶食によるマウス全身性応答1(臓器別遺伝子発現変化).2015

    • Author(s)
      鎌田祥太郎、山本隼也、三浦あす美、長田知子、海沼亮、石井功.
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      日本大学薬学部(千葉県・船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 短期絶食によるマウス全身性応答2(臓器別タンパク質発現変化).2015

    • Author(s)
      大谷遥香、山本隼也、戸坂優花、鎌田祥太郎、石井功.
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      日本大学薬学部(千葉県・船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] TRPCチャネルによる心循環恒常性の制御機構2015

    • Author(s)
      西田基宏
    • Organizer
      日本生理学会北海道地方会(生理系分科会)
    • Place of Presentation
      旭川医科大学(北海道・旭川市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Reactive persulfide species: Its antioxidant redox signaling and translational biosynthesis.2015

    • Author(s)
      Takaaki Akaike
    • Organizer
      文部科学省 私立大学戦略的研究基盤形成支援事業 生体分子コバレント修飾の革新的解析拠点形成 第2回国際シンポジウム New Aspects of Covalent modifications from Small to Large Molecules.
    • Place of Presentation
      昭和薬科大学(東京都・町田市)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Negative regulation of cardiac remodeling by S-polythiolation of G proteins.2015

    • Author(s)
      Nishida M.
    • Organizer
      2nd Symposium of SPU Innovative Project for Pharmaceutical Analyses of Covalent Modification in Biomolecule.
    • Place of Presentation
      昭和薬科大学(東京都・町田市)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴う生体内レドックスホメオスタシスの変動.2015

    • Author(s)
      安孫子ユミ、吉田映子、熊谷嘉人.
    • Organizer
      第10回メタルバイオサイエンス研究会
    • Place of Presentation
      名古屋国際センター ホール(愛知県・名古屋市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子による修飾.2015

    • Author(s)
      新開泰弘、鵜木隆光、鍜冶利幸、熊谷嘉人.
    • Organizer
      第10回メタルバイオサイエンス研究会
    • Place of Presentation
      名古屋国際センター ホール(愛知県・名古屋市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト型NASH(非アルコール性脂肪性肝炎)を自然発症する新しい動物モデル.2015

    • Author(s)
      蕨 栄治.
    • Organizer
      新技術説明会(日本学術振興会主催)
    • Place of Presentation
      JST東京本部別館(東京都・千代田区)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん代謝産物Rasの親電子シグナル制御2015

    • Author(s)
      西田基宏
    • Organizer
      第3回がんと代謝研究会
    • Place of Presentation
      石川県立音楽堂交流ホール(石川県・金沢市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾を介したシグナル伝達活性化.2015

    • Author(s)
      熊谷嘉人
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 親電子物質の不活性化に関与する活性イオウ分子:フェーズゼロ反応の提案.2015

    • Author(s)
      熊谷嘉人:
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] システイン・活性イオウ分子産生酵素CSEのアセトアミノフェン肝障害における保護的役割.2015

    • Author(s)
      石井功、安孫子ユミ、鎌田祥太郎、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体内でのメチル水銀解毒代謝におけるCSEの役割.2015

    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性イオウ分子と酸化ストレスが介在する1,2-ナフトキノンによる可逆的なKeap1-Nrf2経路の活性化.2015

    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biotin-(PEAC)5-maleimide-ELISAを用いた親電子性キノン化合物によるタンパク質修飾の簡便アッセイの提案.2015

    • Author(s)
      安孫子ユミ、Nho Cong Luong、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性イオウ分子Na2S4はイオウ付加体形成を通じて1,4-NQによる細胞毒性を軽減する.2015

    • Author(s)
      鵜木隆光、新開泰弘、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性イオウ分子システインパースルフィドのタンパク質翻訳機構:タンパク質ポリチオール化.2015

    • Author(s)
      赤池孝章
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他(石川県・金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Dynamin-related protein 1の酸化修飾による病的心臓リモデリング制御2015

    • Author(s)
      西田基宏、西村明幸、永井直杜、外山喬士、冨田(沼賀)拓郎、熊谷嘉人、赤池孝章
    • Organizer
      第15回日本NO学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府・豊中市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] システインパースルフィドの新しいタンパク質翻訳機構:タンパク質ポリチオール化.2015

    • Author(s)
      赤池孝章
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県・徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Reactive sulfur species and reactive oxygen species-mediated reversible activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone.2015

    • Author(s)
      Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju(韓国)
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Methylmercury glutathione adduct activates Nrf2 through S-transmercuration to Keap1 in SH-SY5Y cells.2015

    • Author(s)
      Abiko Y, Yoshida E, Kumagai Y.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju(韓国)
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.2015

    • Author(s)
      Kumagai Y
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju(韓国)
    • Year and Date
      2015-06-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion.2015

    • Author(s)
      石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠.
    • Organizer
      第16回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      日本薬学会 長井記念ホール(東京都・渋谷区)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高ホモシステイン血症マウスにおける血中α-fetoprotein蓄積.2015

    • Author(s)
      鎌田祥太郎、赤星軌征、石井功.
    • Organizer
      第16回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      日本薬学会 長井記念ホール(東京都・渋谷区)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質S-ポリチオール化による親電子シグナル制御.2015

    • Author(s)
      赤司壮一郎、笠松真吾、Jung Minkyung、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤 智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス.2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性酸素シグナル伝達機構の解明2015

    • Author(s)
      赤池孝章
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 雌性p62遺伝子欠損マウスの表現型の解析と中高齢女性におけるメタボリック症候群の発症機序の解明.2015

    • Author(s)
      池内美穂,蕨 栄治,正田純一.
    • Organizer
      第51回日本肝臓学会
    • Place of Presentation
      ホテル日航熊本他(熊本県・熊本市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎自然発症モデルマウスにおける腸内環境の変化とNASH発症機序の解明.2015

    • Author(s)
      秋山健太郎,池内美穂,青山希,蕨 栄治,正田純一.
    • Organizer
      第51回日本肝臓学会
    • Place of Presentation
      ホテル日航熊本他(熊本県・熊本市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Environmental electrophiles-mediated modulation of redox signal transduction pathways and toxicity regulated by reactive sulfur species.2015

    • Author(s)
      Kumagai Y
    • Organizer
      2015 International Conference on Industrial Hygiene and Occupational Medicine
    • Place of Presentation
      高雄(台湾)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] p62/Sqstm1の生理的機能.2015

    • Author(s)
      蕨 栄治.
    • Organizer
      鳥取大学医学部セミナー
    • Place of Presentation
      鳥取大学(鳥取県・米子市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論2015

    • Author(s)
      赤池孝章
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜県・岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Suppression of arsenite-induced cytotoxicity and activation of Nrf2 by aliphatic electrophiles from Coriandrum sativum L. leaf extract in HepG2 cells.2015

    • Author(s)
      Abiko Y, Mizokawa M, Kumagai Y.
    • Organizer
      Society of Toxicology 54th Annual Meeting
    • Place of Presentation
      San Diego, United States
    • Year and Date
      2015-03-21 – 2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015

    • Author(s)
      Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
    • Organizer
      Society of Toxicology 54th Annual Meeting
    • Place of Presentation
      San Diego, United States
    • Year and Date
      2015-03-21 – 2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 親電子物質のレドックスシグナル伝達変動とそれを制御する活性イオウ分子2015

    • Author(s)
      熊谷嘉人
    • Organizer
      生理学研究所生体情報研究系心循環シグナル研究部門公開セミナー
    • Place of Presentation
      自然科学研究機構岡崎統合バイオサイエンスセンター(愛知県・岡崎市)
    • Year and Date
      2015-03-16
    • Related Report
      2014 Annual Research Report
    • Invited
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