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Design of Novel Biomaterials which Scavenge Reactive Oxygen Species and Their Applications

Research Project

Project/Area Number 25220203
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionUniversity of Tsukuba

Principal Investigator

NAGASAKI Yukio  筑波大学, 数理物質系, 教授 (90198309)

Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥202,670,000 (Direct Cost: ¥155,900,000、Indirect Cost: ¥46,770,000)
Fiscal Year 2017: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2016: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2015: ¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2014: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
Fiscal Year 2013: ¥53,950,000 (Direct Cost: ¥41,500,000、Indirect Cost: ¥12,450,000)
Keywordsナノメディシン / ゲル / 抗酸化剤 / 再生医療 / アルツハイマー病 / 放射線保護 / バイオマテリアル / DDS / 抗酸化ナノメディシン / 癒着防止剤 / 放射線保護剤 / 認知症 / 心筋梗塞 / 脳梗塞 / 活性酸素種 / ナノ粒子 / 歯周病 / 抗がん剤 / がん免疫療法 / 酸化ストレス / 安定ラジカル / 表面コーティング / ポリエチレングリコール / 細胞分化抑制 / 血液活性化抑制 / 血液透析 / 活性酸素 / PICフラワーミセル / インジェクタブルゲル / 局所炎症モデル / シリカ含有ナノ粒子 / ポリマードラッグ
Outline of Final Research Achievements

We designed "redox polymers" which selectively erase "bad" reactive oxygen species out of reactive oxygen species (ROS) which are double-edged sword, and developed innovative medical technology as new biomaterials. It was confirmed that by using redox polymer as a surface modification agent, contact activation of blood and tissues was suppressed, and nonspecific differentiation of stem cells was suppressed. At the same time, we attained the development of Alzheimer's and radiation protection materials by redox nanoparticles and the enhancement of the effect on anti-cancer and suppression of their side effects. We developed anti-oxidant injectable gel and developed it for periodontal disease, diabetes treatment, tissue adhesion prevention agent after surgical operation, etc. Such a polymerized antioxidant was able to demonstrate the usefulness that it can be deployed extremely widely.

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (121 results)

All 2018 2017 2015 2014 2013

All Journal Article (38 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 38 results,  Open Access: 16 results,  Acknowledgement Compliant: 8 results) Presentation (75 results) (of which Int'l Joint Research: 25 results,  Invited: 27 results) Book (8 results)

  • [Journal Article] Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts.2017

    • Author(s)
      Asanuma H, Sanada S, Yoshitomi T, Sasaki H, Takahama H, Ihara M, Takahama H, Shinozaki Y, Mori H, Asakura M, Nakano A, Sugimachi M, Asano Y, Minamino T, Takashima S, Nagasaki Y, Kitakaze M.
    • Journal Title

      Cardiovasc Drugs Ther.

      Volume: 31 Issue: 5-6 Pages: 501-510

    • DOI

      10.1007/s10557-017-6758-6

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral nanotherapeutics: Redox nanoparticles attenuate ultraviolet B radiation-induced skin inflammatory disorders in Kud:Hr- hairless mice2017

    • Author(s)
      Feliciano Chitho P.、Nagasaki Yukio
    • Journal Title

      Biomaterials

      Volume: 142 Pages: 162-170

    • DOI

      10.1016/j.biomaterials.2017.07.015

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Newly Designed Silica-Containing Redox Nanoparticles for Oral Delivery of Novel TOP2 Catalytic Inhibitor for Treating Colon Cancer2017

    • Author(s)
      Vong Long Binh、Kimura Shinya、Nagasaki Yukio
    • Journal Title

      Advanced Healthcare Materials

      Volume: 6 Issue: 20

    • DOI

      10.1002/adhm.201700428

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice2017

    • Author(s)
      Hosoo H, Marushima A, Nagasaki Y, Hirayama A, Ito H, Puentes S, Mujagic A, Tsurushima H, Tsuruta W, Suzuki K, Matsui H, Matsumaru Y, Yamamoto T, Matsumura
    • Journal Title

      Stroke

      Volume: 48 Issue: 8 Pages: 2238-2247

    • DOI

      10.1161/strokeaha.116.016356

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease2017

    • Author(s)
      Boonruamkaew Phetcharat、Chonpathompikunlert Pennapa、Vong Long Binh、Sakaue Sho、Tomidokoro Yasushi、Ishii Kazuhiro、Tamaoka Akira、Nagasaki Yukio
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 3785-3785

    • DOI

      10.1038/s41598-017-03411-7

    • NAID

      120007128892

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management2017

    • Author(s)
      Nagasaki Yukio、Mizukoshi Yutaro、Gao Zhenyu、Feliciano Chitho P.、Chang Kyungho、Sekiyama Hiroshi、Kimura Hiroyuki
    • Journal Title

      Acta Biomaterialia

      Volume: 57 Pages: 127

    • DOI

      10.1016/j.actbio.2017.04.031

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Application of surface enhanced Raman spectroscopy as a diagnostic system for hypersialylated metastatic cancers2017

    • Author(s)
      Shashni Babita、Horiguchi Yukichi、Kurosu Kosuke、Furusho Hitoshi、Nagasaki Yukio
    • Journal Title

      Biomaterials

      Volume: 134 Pages: 143-153

    • DOI

      10.1016/j.biomaterials.2017.04.038

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of UV-Induced Melanin Production by Accumulation of Redox Nanoparticles in the Epidermal Layer <i>via</i> Iontophoresis2017

    • Author(s)
      Shiota K, Hama S, Yoshitomi T, Nagasaki Y, Kogure K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 6 Pages: 941-944

    • DOI

      10.1248/bpb.b17-00155

    • NAID

      130005688066

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice2017

    • Author(s)
      Feliciano Chitho P.、Tsuboi Koji、Suzuki Kenshi、Kimura Hiroyuki、Nagasaki Yukio
    • Journal Title

      Biomaterials

      Volume: 129 Pages: 68-82

    • DOI

      10.1016/j.biomaterials.2017.03.011

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitroxide radical-containing nanoparticles as potential candidates for overcoming drug resistance in epidermoid cancers2017

    • Author(s)
      Shashni Babita、Alshwimi Abdulaziz、Minami Kentaro、Furukawa Tatsuhiko、Nagasaki Yukio
    • Journal Title

      Polymer

      Volume: 116 Pages: 429-438

    • DOI

      10.1016/j.polymer.2017.02.052

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Gd3N@C80 encapsulated redox nanoparticles for high-performance magnetic resonance imaging2017

    • Author(s)
      Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura and Yukio Nagasaki
    • Journal Title

      J. Biomater. Sci. Polym. Ed.

      Volume: 印刷中 Issue: 10-12 Pages: 1036-1050

    • DOI

      10.1080/09205063.2017.1288774

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific accumulation of orally administered redox nanotherapeutics in the inflamed colon reducing inflammation with dose-response efficacy2015

    • Author(s)
      Long Binh Vong, John Mo, Bertil Abrahamsson and Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: 210 Pages: 19-25

    • DOI

      10.1016/j.jconrel.2015.05.275

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis,2015

    • Author(s)
      Akiko Eguchi, Toru Yoshitomi, Milos Lazic, Casey D. Johnson, Long Binh Vong, Alexander Wree, Davide Povero, Bettina G. Papouchado, Yukio Nagasaki, Ariel E. Feldstein,
    • Journal Title

      Nanomedicine

      Volume: 10 Issue: 17 Pages: 2697-2708

    • DOI

      10.2217/nnm.15.87

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox nanoparticles inhibit curcumin oxidative degradation and enhance its therapeuc effect on prostate cancer2015

    • Author(s)
      Sindhu Thangavel, Toru Yoshitomi, Meena Kishore Sakharkar and Yukio Nagasaki
    • Journal Title

      Journal of Controlled Release

      Volume: 209 Pages: 110-119

    • DOI

      10.1016/j.jconrel.2015.04.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design of high-performance anti-adhesion agent using injectable gel with an anti-oxidative stress function.2015

    • Author(s)
      Nakagawa H, Matsumoto Y, Matsumoto Y, Miwa Y, Nagasaki Y
    • Journal Title

      Biomaterials

      Volume: 69 Pages: 165-173

    • DOI

      10.1016/j.biomaterials.2015.08.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer2015

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 55 Pages: 54-63

    • DOI

      10.1016/j.biomaterials.2015.03.037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ROS-scavenging Nanomedicine for Treatment of Oxidative Stress Injuries2014

    • Author(s)
      Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Advanced Healthcare Materials

      Volume: 3 Issue: 8 Pages: 1149-1161

    • DOI

      10.1002/adhm.201300576

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impacts of PEGylation on the gene-delivery system2014

    • Author(s)
      Yutaka Ikeda, Yukio Nagasaki
    • Journal Title

      Journal of Applied Polymer Science

      Volume: 131 Issue: 9 Pages: 40293-40293

    • DOI

      10.1002/app.40293

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The behavior of ROS-scavenging nanoparticles in blood2014

    • Author(s)
      Madoka Shimizu, Toru Yoshitomi, Yukio Nagasaki
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 3 Pages: 166-173

    • DOI

      10.3164/jcbn.13-85

    • NAID

      130004466752

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silica-installed redox nanoparticles for novel oral nanotherapeutics- Improvement in intestinal delivery with anti-inflammatory effects2014

    • Author(s)
      Md. Amran Hossain, Mayo Yamashita, Long Binh Vong, Yutaka Ikeda and Yukio Nagasaki
    • Journal Title

      Journal of Drug Targeting

      Volume: 22 Issue: 7 Pages: 638-647

    • DOI

      10.3109/1061186x.2014.928716

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of nitroxide radicals-containing polymer for scavenging ROS from cigarette smoke2014

    • Author(s)
      Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki
    • Journal Title

      Science and Technology for Advanced Materials

      Volume: 15 Issue: 3 Pages: 035002-035002

    • DOI

      10.1088/1468-6996/15/3/035002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral nanotherapeutics: Effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Kazuya Morikawa, Shinji Saito, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 6 Pages: 806-813

    • DOI

      10.1039/c3bm60212e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model2014

    • Author(s)
      Chiaki Abe, Yoshihiro Uto, Ayaka Kawasaki, Chiho Noguchi, Ryo Tanaka, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori
    • Journal Title

      Journal of Controlled Release

      Volume: 182 Pages: 67-72

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and use of silica-containing redox nanoparticles, siRNP for high-performance peritoneal dialysis2014

    • Author(s)
      Yukio Nagasaki, Tatsuya Yaguchi, Takuma Matsumura, Toru Yoshitomi, Yutaka Ikeda, Atsushi Ueda, and Aki Hirayama
    • Journal Title

      Biomaterials Science

      Volume: 2 Issue: 4 Pages: 522-529

    • DOI

      10.1039/c3bm60236b

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indomethacin-loaded redox nanoparticles improve oral bioavailability of indomethacin and suppress its small intestinal inflammation2014

    • Author(s)
      Toru Yoshitomi, Sha Sha, Long Binh Vong, Pennapa Chonp athompikunlert, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Therapeutic Delivery

      Volume: 5 Issue: 1 Pages: 29-38

    • DOI

      10.4155/tde.13.133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated atherogenic index following oral administration of quaternized polyamine nanogels2014

    • Author(s)
      Yukio Nagasaki, Tsuyoshi Yamazaki, Akihiko Kikuchi, Mariko Harada-Shiba
    • Journal Title

      Colloid and Surface: B

      Volume: 113 Pages: 237-242

    • DOI

      10.1016/j.colsurfb.2013.09.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation.2013

    • Author(s)
      Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y
    • Journal Title

      J Control Release

      Volume: 172 Issue: 3 Pages: 914-920

    • DOI

      10.1016/j.jconrel.2013.10.009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel protein PEGylation chemistry via glutalaldehydefunctionalized PEG, Bioconjugate Chemistry, Vol. 24, No.11, pp.1824-1827(2013) (doi: 10.1021/bc400169s)2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Bioconjugate Chemistry

      Volume: 11 Issue: 11 Pages: 1824-1827

    • DOI

      10.1021/bc400169s

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coffee component Hydroxyl Hydro Quinone (HHQ) as a novel ligand for PPAR gamma and implications for breast cancer2013

    • Author(s)
      Babita Shashni, Karun Sharma, Rumani Singh, Kishore R Sakharkar, Sarinder K. Dhillon, Yukio Nagasaki, and Meena K. Sakharkar
    • Journal Title

      BMC (BioMedCentral) Genomics

      Volume: 14(Suppl 5):S6 Issue: S5

    • DOI

      10.1186/1471-2164-14-s5-s6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox Nanoparticle Therapeutics to Cancer -Increase in therapeutic effect of doxorubicin, suppressing its adverse effect-2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of Controlled Release

      Volume: 172 Issue: 1 Pages: 137-143

    • DOI

      10.1016/j.jconrel.2013.08.011

    • NAID

      120007130564

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of sugar-oligonucleotide conjugates installed gold nanoparticle for effective delivery to hepatic parenchymal cells2013

    • Author(s)
      Yutaka Ikeda, Daisuke Kubota, Yukio Nagasaki
    • Journal Title

      Colloid and Polymer Science

      Volume: Vol. 291 Issue: 12 Pages: 2959-2964

    • DOI

      10.1007/s00396-013-3029-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NSAID-induced Small Intestinal Inflammation by Orally Administered Redox Nanoparticles2013

    • Author(s)
      Sha Sha, Long Binh Vong, Pennapa Chonpathompikunlert, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 33 Pages: 8393-8400

    • DOI

      10.1016/j.biomaterials.2013.06.032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-performance waveguide-mode biosensor for detection of Factor IX uses PEG-based blocking agents to suppress non-specific binding and improve sensitivity2013

    • Author(s)
      Thangavel Lakshmipriya, Makoto Fujimaki, Subash C.B. Gopinath, Koichi Awazu, Yukichi Horiguchi and Yukio Nagasaki
    • Journal Title

      Analyst

      Volume: Vol.138 Issue: 10 Pages: 2863-2870

    • DOI

      10.1039/c3an00298e

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Performance Surface Acoustic Wave Immunosensing System on PEG/Aptamer Hybridized Surface,2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Langmuir

      Volume: 29 Issue: 24 Pages: 7369-7376

    • DOI

      10.1021/la304548m

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Biomaterials Science

      Volume: 1 Issue: 4 Pages: 361-367

    • DOI

      10.1039/c2bm00156j

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 1 Issue: 4 Pages: 529-535

    • DOI

      10.1039/c2tb00031h

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR gamma in breast cancer pathophysiology2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Journal of Drug Targeting

      Volume: 21 Issue: 2 Pages: 161-174

    • DOI

      10.3109/1061186x.2012.736998

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Biocompatible Nanoreactor for Silica/Gold Hybrid Nanoparticles Preparation2013

    • Author(s)
      長崎幸夫
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 102 Pages: 778-782

    • DOI

      10.1016/j.colsurfb.2012.09.034

    • NAID

      120007137069

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 機能性PEGの設計と展開2018

    • Author(s)
      長崎幸夫
    • Organizer
      高分子学会医用高分子研究会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] 抗酸化能を有するナノメディシンの開発2018

    • Author(s)
      長崎幸夫
    • Organizer
      第34回日本毒性病理学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] 抗酸化ナノメディシンの開発と機能2018

    • Author(s)
      長崎幸夫
    • Organizer
      国立感染症研究所学友会シンポジウム
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice2018

    • Author(s)
      Yukio Nagasaki, Koji Tsuboi, Kenshi Suzuki, Hiroyuki Kimura, Chitho P. Feliciano
    • Organizer
      8th Annual Meeting of the International Society of Radiation Neurobiology (ISRN2018)
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neurovascular Unit Protection Using Nitroxide Radicals-containing Nanoparticles (TEMPO-RNP) for Cerebral Ischemia-reperfusion Injury in Mice2018

    • Author(s)
      Hisayuki Hosoo, Aiki Marushima, Yukio Nagasaki, Aki Hirayama, Hiromu Ito, Sandra Puentes, Arnela Mujagic, Hideo Tsurushima, Wataro Tsuruta, Kensuke Suzuki, Hirofumi Matsui, Yuji Matsumaru, Tetsuya Yamamoto, Akira Matsumura
    • Organizer
      International Stroke Conference 2018
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラットインプラント周囲炎モデルに対するレドックスインジェクタブルゲルの抗酸化作用2018

    • Author(s)
      小澤僚太郎、斉田牧子、坂上 奨、丸尾勝一郎、川股亮太、櫻井 孝、長崎幸夫、木本克彦
    • Organizer
      日本補綴歯科学会西関東支部学術大会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Novel Antioxidative Nanotherapeitics by Nitroxide-radical Containing Polymer Nanoparticles2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of Antioxidative Biointerface2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The 8th International Symposium on Surface Science (ISSS)
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of silica-containing redox nanoparticles for high-performance nanotherapeutics2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The 5th International Symposium on Smart Biomaterials---the 5th Hoffman Family Symposium
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design of redox nanomedicine2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      1st Minisymposium on Material Biology
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] レドックスインジェクタブルゲルの設計と評価2017

    • Author(s)
      長崎幸夫
    • Organizer
      ゲルワークショップ イン 松山
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] Construction of Nitroxyl Radical Containing Polymer and its Application for Drug Development and Medical Device2017

    • Author(s)
      Yutaka Ikeda, Yukio Nagasaki
    • Organizer
      8-th Spin Conference on Nitroxides (SPIN2017)
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] Antioxidative nanomedicine for colitis and cancer2017

    • Author(s)
      Long Binh Vong, and Yukio Nagasaki
    • Organizer
      The 10thツ?ietnam 窶?Japan Scientific Exchange Meeting (VJSE2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Antioxidative Nanotherapeutics2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Biomaterials International 2017
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel biointerface that suppresses blood coagulation and cell morphological changes by scavenging excess reactive oxygen species2017

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The 15th International Conference on Advanced Materials (IUMRS-ICAM2017),
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗酸化ナノメディシンの設計と評価2017

    • Author(s)
      長崎幸夫
    • Organizer
      高分子学会関東支部湘南地区講演会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] "Redox polymer nanotherapeutics: A safe and effective therapy in gastrointestinal disorder and cancer",2017

    • Author(s)
      Long Binh Vong, Yukio Nagasaki
    • Organizer
      The International Symposium on Pure & Applied Chemistry (ISPAC) 2017
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノメディシンを目指したレドックスポリマーの設計と応用2017

    • Author(s)
      長崎幸夫
    • Organizer
      第66回高分子学会春季年会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] Newly Designed Antioxidative Nanomedicine2017

    • Author(s)
      Yukio Nagsaki
    • Organizer
      Tilateral Japan-Israel-Czech Republic International Symposium of Polymer Therapeutics Focusing on the Targeted Nanomedicines
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Nanomedicine for Protection against the Late-Effects of Ionizing Radiation2017

    • Author(s)
      Chitho Parayno Feliciano, Yukio Nagasaki
    • Organizer
      the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic improvement in bacterial infection by antioxidative nanoparticle2017

    • Author(s)
      Yutaka Ikeda, Kazuniro Shoji, Chitho Feliciano, Shinji Saito, Yukio Nagasaki
    • Organizer
      the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of redox equilibrium in colitis and colon cancer by specific accumulation of orally administered redox nanoparticles2017

    • Author(s)
      Long Binh Vong, Yukio Nagasaki
    • Organizer
      the 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大気圧プラズマを用いた抗酸化機能を有する界面の構築2017

    • Author(s)
      池田 豊、北野 勝久、 長崎幸夫
    • Organizer
      第27回日本MRS年次大会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 性酸素種除去能を有する培養表面による間葉系幹細 胞の幹細胞性の維持2017

    • Author(s)
      犬塚直希、池田 豊、後藤光昭、赤池敏弘、 長崎幸夫
    • Organizer
      第27回日本MRS年次大会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] ovel Cardiovascular Therapeutics by Redox Injectable Hydrogel effective Maintenance of Local Nitric Oxide Generation to Induce Angiogenesis2017

    • Author(s)
      Long Binh Vong, Quoc Thang Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu,Yukio Nagasaki
    • Organizer
      The 3rd International Inovation in Cancer Research and Regenerative Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral redox nanotherapeutics for treatment of ulcerative colitis and colon cancer2017

    • Author(s)
      Long Bih Vong, Yukio Nagasaki
    • Organizer
      254th American Chemical Society National Meeting
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Cardiovascular Therapeutics by Redox Injectable Hydrogel - Effective Maintenance of Local Nitric Oxide Generation to Induce Angiogenesis2017

    • Author(s)
      Long Bih Vong, Thang Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu,Yukio Nagasaki
    • Organizer
      254th American Chemical Society National Meeting
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セラグノーシスを目指した多機能性イオンデリバリー システムの開発2017

    • Author(s)
      金 雅覧、 長崎幸夫
    • Organizer
      第27回日本MRS年次大会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] pH and Temperature Dependent Structure of MeO-PEG-b-PMNT/PAAc polyion complexes2017

    • Author(s)
      Masato Takahashi, Yukio Nagasaki
    • Organizer
      The 15th International Conference on Advanced Materials
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Gd3N@C80 encapsulated redox nano-contrast agent for magnetic resonance imaging: high contrast and suppression of adverse effect2017

    • Author(s)
      Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura, and Yukio Nagasakia
    • Organizer
      2017 Conference of the Federation of Asian Society for Molecular Imaging (FASMI 2017)
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗酸化ナノメディシンを用いた重度感染治療法の開発2017

    • Author(s)
      池田 豊, 庄司和弘,ChithoP.Feliciano, 斎藤慎二,長崎幸夫
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] ナノ粒子ホウ素薬剤の設計と評価2017

    • Author(s)
      長崎幸夫
    • Organizer
      第14回日本中性子捕捉療法学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Application of Surface-Enhanced Raman Spectroscopy for Detection of Hypersialylated Metastatic Cancers2017

    • Author(s)
      Babita Shashni, Yukichi Horiguchi, Kosuke Kurosu, Hitoshi Furusho, Yukio Nagasaki
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Unexpectedly suppressed adverse effect of chemotherapeutics by intestinally accumulated antioxidative nanoparticle2017

    • Author(s)
      Long B. Vong, Shinya Kimura, Yukio Nagasaki
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] TEMPO含有高分子とPEGからなる二元および三元 ブロック共重合体のミセル構造2017

    • Author(s)
      高橋 倫太郎、三輪 祥多郎、藤井 翔太、Vong B. Long、長崎 幸夫、櫻井和朗
    • Organizer
      第66回高分子学会討論会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 柔らかな生体高分子の特徴を活用した新規超分子 光不斉反応系の開発と反応機構の解明2017

    • Author(s)
      豊岡 壮太、奥木 暢、藤城 祐也、西嶋 政樹、荒木 保幸、坂本 清志、池田 豊、高井 まどか、長崎 幸夫、井上 佳久、和田 健彦
    • Organizer
      第66回高分子学会討論会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Regulation of nitric oxide release by poly(arginine)-assisted redox injectable hydrogel in cardiovascular therapeutics2017

    • Author(s)
      Binh Long Vong, Quoc Thang Bui, Tsutomu Tomita, Hiroki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
    • Organizer
      第66回高分子学会討論会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] サンゴ共生体の保護を目指した取り組み ―抗活性酸素剤による高温ストレス下でのサンゴ幼生の生存率の向上―2017

    • Author(s)
      元根 啓佑、高木 俊幸、油屋 駿介、新里 宙也、長崎 幸夫、竹山 春子、青木 航、植田 充美
    • Organizer
      環境微生物系学会合同大会2017
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 細胞の品質管理を可能にする培養機材表面の構築-大気圧プラズマを用いた検討-2017

    • Author(s)
      池田 豊、北野勝久、長崎幸夫
    • Organizer
      第46回高分子学会医用高分子研究会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] エキセナチドをコントロールドリリース可能な抗酸化インジェクタブルゲルによる2型糖尿 病治療2017

    • Author(s)
      坂上 奨 、石井 志郎 、長崎 幸夫
    • Organizer
      日本DDS学会第33回学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 抗酸化作用を持つナノメディシンの重度感染症治療への応用2017

    • Author(s)
      池田 豊、庄司 和弘 、Chitho Feliciano 、斎藤 慎二 、長崎 幸夫
    • Organizer
      日本DDS学会第33回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Silica-containing redox nanoparticles for oral cancer therapeutics of novel topoisomerase II inhibitor2017

    • Author(s)
      Binh Long Vong 、Shinya Kimura 、Yukio Nagasaki
    • Organizer
      日本DDS学会第33回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗酸化ナノ粒子による肝臓疾患治療への道2017

    • Author(s)
      長崎幸夫
    • Organizer
      第24回肝細胞研究会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] In vitro三次元培養を可能にする機能ハイドロゲル創製における酸化ストレス 除去の必要性2017

    • Author(s)
      中路 正、池田 豊、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 抗酸化ナノメディシンの感染症治療への展2017

    • Author(s)
      池田 豊、庄司 和弘、Chitho Feliciano、斎藤 慎二、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] ROS-scavenging nanoparticle for oral delivery of novel TOP2 inhibitor in treating colon cancer2017

    • Author(s)
      Long Binh Vong、Shinya Kimura, Yukio Nagasaki
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease2017

    • Author(s)
      Boonruamkaew Phetcharat、Chonpathompikunlert Pennapa、Vong Binh Long、坂上 奨、 冨所 康志、石井 一弘、玉岡 晃、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホウ素含有レドックスナノ粒子:活性酸素種除去することにより高質なホウ素 捕捉療法を目指す2017

    • Author(s)
      高 振宇、堀口 諭吉、中井 啓、松村 明、鈴木 実、小野 公二、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Novel Gd3N@C80 encapsulated redox contrast agent for magnetic resonance imaging with high contrast and low adverse effect2017

    • Author(s)
      高 振宇、中西 勇介、野田 祥子、大町 遥、篠原 久典、木村 寛之、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] エキセナチドを徐放する抗酸化インジェクタブルゲルによる新しい2型糖尿病治療2017

    • Author(s)
      坂上 奨、石井 志郎、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Diagnosis of Hypersialylated Metastatic Cancers by Phenylboronic Acid-installed PEGylated Gold Nanoparticle2017

    • Author(s)
      Shashni Babita、Horiguchi Yukichi、Kurosu Kosuke、Furusho Hitoshi、Nagasaki Yukio
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疼痛治療を目指した局所麻酔薬担持レドックスインジェクタブルゲルの開発2017

    • Author(s)
      水越 雄太郎、高 振宇、Chitho Feliciano、張 京浩、関山 裕詩、木村 寛之、長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] 新規活性酸素消去剤RNPによる脳虚血再灌流障害に対するneuro-endthelial protection効果の検証2017

    • Author(s)
      細尾 久幸、丸島 愛樹、長崎 幸夫、平山 暁、伊藤 紘、Sandra Puentes、Arnela Mujagic、 鶴嶋 英夫、松井 裕史、鶴田 和太郎、鈴木 謙介、山本 哲哉、松丸 祐司、松村 明
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Dvelopment of silica-containing redox nanoparticles for oral drug delivery to treat colon cancer2017

    • Author(s)
      Long Binh Vong,Shinya Kimura,Yukio Nagasaki
    • Organizer
      第66回高分子学会春季年会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Design of GLP-1 Analog Loaded Redox-Active Injectable Gel as A Novel Anti-Diabetic Drug2017

    • Author(s)
      Sho Sakaue, Shiro Ishii,Yukio Nagasaki
    • Organizer
      第66回高分子学会春季年会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Surface construction of anti-oxidative cell culture dish preventing cell dysfunction -Application for various substrates by using atmospheric plasma2017

    • Author(s)
      Yutaka Ikeda, Katsuhisa Kitanon, Yukio Nagasaki
    • Organizer
      第66回高分子学会春季年会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Controllable NO releasing redox injectable hydrogel for myocardial infarction model in mice2017

    • Author(s)
      Long Binh Vong, Quoc Thang Bui, Tomita Tsutomu, Hiroaki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Presentation] Antioxidative nanomedicine for colitis and cancer2017

    • Author(s)
      Long Binh Vong, and Yukio Nagasaki
    • Organizer
      The 10thツ?ietnam-Japan Scientific Exchange Meeting (VJSE2017)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ovel Cardiovascular Therapeutics by Redox Injectable Hydrogel effective Maintenance of Local Nitric Oxide Generation to Induce Angiogenesis2017

    • Author(s)
      Long Binh Vong, Quoc Thang Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
    • Organizer
      The 3rd International Inovation in Cancer Research and Regenerative Medicine
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗酸化作用を持つナノメディシンの重度感染症治療への応用2017

    • Author(s)
      池田 豊, 庄司和弘,ChithoP.Feliciano, 斎藤慎二,長崎幸夫
    • Organizer
      日本DDS学会第33回学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Silica-containing redox nanoparticles for oral cancer therapeutics of novel topoisomerase II inhibitor2017

    • Author(s)
      Binh Long Vong ,Shinya Kimura ,Yukio Nagasaki
    • Organizer
      日本DDS学会第33回学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ROS-scavenging nanoparticle for oral delivery of novel TOP2 inhibitor in treating colon cancer2017

    • Author(s)
      Long Binh Vong,Shinya Kimura, Yukio Nagasaki
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease2017

    • Author(s)
      Boonruamkaew Phetcharat,Chonpathompikunlert Pennapa,Vong Binh Long,坂上奨, 冨所 康志,石井 一弘,玉岡 晃,長崎幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] エキセナチドを徐放する抗酸化インジェクタブルゲルによる新しい2型糖尿病治療2017

    • Author(s)
      坂上 奨 、石井 志郎 、長崎 幸夫
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diagnosis of Hypersialylated Metastatic Cancers by Phenylboronic Acid-installed PEGylated Gold Nanoparticle2017

    • Author(s)
      Shashni Babita,Horiguchi Yukichi,Kurosu Kosuke,Furusho Hitoshi,Nagasaki Yukio
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nitric oxide -A key player for novel target of immunotherapeutics-2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      PachfiCem2015,
    • Place of Presentation
      Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redox Injectable Gels for Local Inflammation Treatments2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      PachfiCem2015,
    • Place of Presentation
      Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redox Nanotherapeutics for Antioxidative Treatments2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The first International Conference on Microstructure and Property of Materials,
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Anti-oxidative Nanotherapeutics2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      5th Asian Biomaterials Congress(ABMC5)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redox Nanotherapeutics for Antioxidative Treatments,2015

    • Author(s)
      Yukio Nagasaki
    • Organizer
      The 9th International Symposium on Intelligent Drug Delivery System
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redox Polymer Therapeutics for Anti-oxidative Stress Diseases2014

    • Author(s)
      Yukio Nagasaki
    • Organizer
      International Conference on Polymeric Biomaterilas, Bioengineering and Biodiagnostics (Biomaterials2014)
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Redox Polymers as Biomaterials2014

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Bio-based Polymers and Composits 2014 (BiPoCo2014)
    • Place of Presentation
      Visegradmm, Hungary
    • Year and Date
      2014-08-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Redox polymer nanoparticles for novel therapeutics against oxidative stress2014

    • Author(s)
      Yukio Nagasaki
    • Organizer
      Frontiers of Polymer Colloids, -From Synthesis to Macro-scale Applications-
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2014-07-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス障害に対するレドックスポリマーナノ治療2014

    • Author(s)
      長崎幸夫
    • Organizer
      文科省新学術教育研究超高速バイオアッセンブラ第7回公開シンポジウム
    • Place of Presentation
      東京大学駒場キャンパス、東京
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Novel Nanoparticle Design for External Beam Treatments2014

    • Author(s)
      Yukio Nagasaki
    • Organizer
      4th Summer Symposium on Nanomaterials and their application to Biology and Medicine
    • Place of Presentation
      Adam Mickiewicz University in Poznan
    • Year and Date
      2014-06-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] ACS Symposium Series 12532017

    • Author(s)
      .Long Binh Vong, Yukio Nagasaki
    • Publisher
      American Chemical Society
    • Related Report
      2017 Annual Research Report
  • [Book] CSJカレントレビュー、日本化学会編2017

    • Author(s)
      1.長崎幸夫
    • Publisher
      化学同人
    • Related Report
      2017 Annual Research Report
  • [Book] ACS Symposium Series 12532017

    • Author(s)
      Long Binh Vong, Yukio Nagasaki
    • Publisher
      American Chemical Society
    • Related Report
      2016 Annual Research Report
  • [Book] CSJカレントレビュー、日本化学会編2017

    • Author(s)
      長崎幸夫
    • Publisher
      化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] 医学のあゆみ2015

    • Author(s)
      長崎幸夫、
    • Total Pages
      200
    • Publisher
      医薬歯出版
    • Related Report
      2015 Annual Research Report
  • [Book] Environmentally-Responsive Nanogels for siRNA Delivery, Advanced Delivery and Therapeutic Applications of RNAi2013

    • Author(s)
      長崎幸夫
    • Total Pages
      150
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] PEGylated Ceramic Nanophosphors for Near-infrared Fluorescence Bioimaging2013

    • Author(s)
      長崎幸夫
    • Total Pages
      61
    • Publisher
      Future Science, London
    • Related Report
      2013 Annual Research Report
  • [Book] 大腸粘膜に対する経口型レドックスナノ粒子の集積と潰瘍性大腸炎治療効果の増強2013

    • Author(s)
      長崎幸夫
    • Total Pages
      257
    • Publisher
      シーエム-シー出版
    • Related Report
      2013 Annual Research Report

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Published: 2013-06-20   Modified: 2019-07-29  

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