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Role of IP3 Receptor in the Regulation of Synaptic Plasticity, Neuronal Function and Neuronal Development

Research Project

Project/Area Number 25221002
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Mikoshiba Katsuhiko  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30051840)

Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥215,800,000 (Direct Cost: ¥166,000,000、Indirect Cost: ¥49,800,000)
Fiscal Year 2017: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2013: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
KeywordsIP3受容体 / カルシウムイオン(Ca2+) / スパイン / シナプス可塑性 / 長期増強 / アストロサイト / IP3 / 神経回路 / X線結晶構造解析 / アロステリック構造変化 / チャネル開口機構 / 神経伝達物質・受容体 / シグナル伝達 / 脳・神経 / 神経伝達・受容体 / Ca2+振動 / トランスグルタミナーゼ / 神経疾患 / スパイン形成 / 小脳性運動失調 / カルシウム振動 / アポトーシス / IRBIT / クルーズ・トリパノソーマ
Outline of Final Research Achievements

IP3 receptor (IP3R)-deficient mice exhibit cerebellar ataxia, epileptic seizure-like symptom and retardation of neuronal development. However, it was a longstanding controversy if IP3R/Ca2+ signaling is involved in neuronal plasticity. We generated knock-out mice of all IP3R isoforms (IP3R1-3), and knock-out mice with region- or neuron-specific deletion of IP3R1. Mice lacking IP3R1 in Purkinje neurons demonstrated regulation of CaMKII/actin cytoskeleton/spine formation by IP3R1 (PNAS). LTP regulation by transport machines of IP3R1-coding mRNA (Nature Neurosci), modulatory roles of glial IP3R2 on gliotransmitter release to regulate neuronal functions (Nature Commun, J Clinical Invest), protein quality control by IP3R-associating ERp44 (Mol Cell) were also discovered. Much evidence, including GABA receptor regulation (Cell Rep) and apoptosis regulation by IP3R-bound IRBIT (eLIFE, PNAS), strongly indicates that IP3R controls synaptic plasticity.

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (179 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (6 results) Journal Article (74 results) (of which Int'l Joint Research: 28 results,  Peer Reviewed: 74 results,  Open Access: 26 results,  Acknowledgement Compliant: 19 results) Presentation (92 results) (of which Int'l Joint Research: 26 results,  Invited: 58 results) Book (1 results) Remarks (6 results)

  • [Int'l Joint Research] National Institute Health/Penn State College of Medicine/University of Cincinnati, Cincinnati(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Liverpool/University of Oxford/Cardiff University(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] KU Leuven/Vrije Universiteit Brussel/University of Leuven(ベルギー)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Universite Bordeaux Segalen/Elole Normale Superieur/INSERM U1215, Neurocentre Magendie(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute/Technical University of Dortmund/University of Konstanz(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Blocking IP3 signal transduction pathways inhibits melatonin-induced Ca2+ signals and impairs P. falciparum development and proliferation in erythrocytes2018

    • Author(s)
      Pecenin Mateus Fila、Borges-Pereira Lucas、Levano-Garcia Julio、Budu Alexandre、Alves Eduardo、Mikoshiba Katsuhiko、Thomas Andrew、Garcia Celia R.S.
    • Journal Title

      Cell Calcium

      Volume: 72 Pages: 81-90

    • DOI

      10.1016/j.ceca.2018.02.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model2018

    • Author(s)
      Saito Kozo、Shigetomi Eiji、Yasuda Rei、Sato Ryuichi、Nakano Masakazu、Tashiro Kei、Tanaka Kenji F.、Ikenaka Kazuhiro、Mikoshiba Katsuhiko、Mizuta Ikuko、Yoshida Tomokatsu、Nakagawa Masanori、Mizuno Toshiki、Koizumi Schuichi
    • Journal Title

      Glia

      Volume: 66 Issue: 5 Pages: 1053-1067

    • DOI

      10.1002/glia.23300

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Remodeling of Ca2+ signaling in cancer: Regulation of inositol 1,4,5-trisphosphate receptors through oncogenes and tumor suppressors.2017

    • Author(s)
      Ando H, Kawaai K, Bonneau B, Mikoshiba K.
    • Journal Title

      Adv Biol Regul.

      Volume: pii: S2212-4926(17) Pages: 30188-4

    • DOI

      10.1016/j.jbior.2017.12.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RNG105/Caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation2017

    • Author(s)
      Kei Nakayama, Rie Ohashi, Yo Shinoda, Maya Yamazaki, Manabu Abe, Akihiro Fujikawa, Shuji Shigenobu, Akira Futatsugi, Masaharu Noda, Katsuhiko Mikoshiba, Teiichi Furuichi, Kenji Sakimura, and Nobuyuki Shiina
    • Journal Title

      eLife

      Volume: 6 Pages: 1-32

    • DOI

      10.7554/elife.29677

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-lapse imaging of microRNA activity reveals the kinetics of microRNA activation in single living cells2017

    • Author(s)
      Ando Hideaki、Hirose Matsumi、Kurosawa Gen、Impey Soren、Mikoshiba Katsuhiko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-16

    • DOI

      10.1038/s41598-017-12879-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ2017

    • Author(s)
      Chamero Pablo、Weiss Jan、Alonso Maria Teresa、Rodriguez-Prados Macarena、Hisatsune Chihiro、Mikoshiba Katsuhiko、Leinders-Zufall Trese、Zufall Frank
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41598-017-09638-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rearing-environment-dependent hippocampal local field potential differences in wild-type and inositol trisphosphate receptor type 2 knockout mice2017

    • Author(s)
      Tanaka Mika、Wang Xiaowen、Mikoshiba Katsuhiko、Hirase Hajime、Shinohara Yoshiaki
    • Journal Title

      The Journal of Physiology

      Volume: 595 Issue: 20 Pages: 6557-6568

    • DOI

      10.1113/jp274573

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns2017

    • Author(s)
      Casey Jillian P.、Hirouchi Taisei、Hisatsune Chihiro、Lynch Bryan、Murphy Raymond、Dunne Aimee M.、Miyamoto Akitoshi、Ennis Sean、van der Spek Nick、O’Hici Bronagh、Mikoshiba Katsuhiko、Lynch Sally Ann
    • Journal Title

      Journal of Neurology

      Volume: 264 Issue: 7 Pages: 1444-1453

    • DOI

      10.1007/s00415-017-8545-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ2017

    • Author(s)
      Sugawara Takeyuki、Hisatsune Chihiro、Miyamoto Hiroyuki、Ogawa Naoko、Mikoshiba Katsuhiko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 114 Issue: 26

    • DOI

      10.1073/pnas.1617270114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle2017

    • Author(s)
      Wang Qian、Yue Wendy Wing Sze、Jiang Zheng、Xue Tian、Kang Shin H.、Bergles Dwight E.、Mikoshiba Katsuhiko、Offermanns Stefan、Yau King-Wai
    • Journal Title

      Current Biology

      Volume: 27 Issue: 12 Pages: 1791-1800.e5

    • DOI

      10.1016/j.cub.2017.05.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis2017

    • Author(s)
      Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F (15番目/51名)他
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 114 Issue: 22

    • DOI

      10.1073/pnas.1700111114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency2017

    • Author(s)
      Butler Michael R.、Ma Hongwei、Yang Fan、Belcher Joshua、Le Yun-Zheng、Mikoshiba Katsuhiko、Biel Martin、Michalakis Stylianos、Iuso Anthony、Kri?aj David、Ding Xi-Qin
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 27 Pages: 11189-11205

    • DOI

      10.1074/jbc.m117.782326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography2017

    • Author(s)
      Hamada K, Miyatake H, Terauchi A, Mikoshiba K
    • Journal Title

      PNAS (Proceedings of the National Academy of Sciences of the United States of America)

      Volume: 114(18) Issue: 18 Pages: 4661-4666

    • DOI

      10.1073/pnas.1701420114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins.2017

    • Author(s)
      Kawaai K, Ando H, Satoh N, Yamada H, Ogawa N, Hirose M, Mizutani A, Bonneau B, Seki G, Mikoshiba K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114(15) Issue: 15 Pages: 3921-3926

    • DOI

      10.1073/pnas.1618514114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+ channels2017

    • Author(s)
      Sakuragi S, Niwa F, Oda Y, Mikoshiba K, Bannai H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 486 Issue: 4 Pages: 879-885

    • DOI

      10.1016/j.bbrc.2017.03.096

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Basal ryanodine receptor activity suppresses autophagic flux2017

    • Author(s)
      Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G
    • Journal Title

      Biochem Pharmacol.

      Volume: 132 Pages: 133-142

    • DOI

      10.1016/j.bcp.2017.03.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Parkin promotes proteasomal degradation of synaptotagmin IV by accelerating polyubiquitination.2017

    • Author(s)
      Kabayama, H., Tokushige, N., Takeuchi, M., Kabayama, M., Fukuda M. and Mikoshiba, K.
    • Journal Title

      Mol. Cell. Neurosci.

      Volume: 80 Pages: 89-99

    • DOI

      10.1016/j.mcn.2017.02.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IP(3) receptor mutations and brain diseases in human and rodents2017

    • Author(s)
      Hisatsune C, Mikoshiba K.
    • Journal Title

      J Neurochem.

      Volume: 印刷中 Issue: 6 Pages: 790-807

    • DOI

      10.1111/jnc.13991

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] InsP3 Signaling in Apicomplexan Parasites2017

    • Author(s)
      Garcia Celia R.S.、Alves Eduardo、Pereira Pedro H. S.、Bartlett Paula J.、Thomas Andrew P.、Mikoshiba Katsuhiko、Plattner Helmut、Sibley L. David
    • Journal Title

      Current Topics in Medicinal Chemistry

      Volume: 17 Issue: 19 Pages: 2158-2165

    • DOI

      10.2174/1568026617666170130121042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Astrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP.2017

    • Author(s)
      Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K.
    • Journal Title

      Glia

      Volume: 65 Issue: 1 Pages: 502-513

    • DOI

      10.1016/j.bbrc.2016.09.034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Astrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP2017

    • Author(s)
      Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K
    • Journal Title

      Glia

      Volume: 65 Issue: 3 Pages: 502-513

    • DOI

      10.1002/glia.23107

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Probes for manipulating and monitoring IP32016

    • Author(s)
      Miyamoto A, Mikoshiba K.
    • Journal Title

      Cell Calcium

      Volume: S0143-4160(16) Pages: 30188-9

    • DOI

      10.1016/j.ceca.2016.11.003

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of postsynaptic inositol 1, 4, 5-trisphosphate receptors in depotentiation in guinea pig hippocampal CA1 neurons.2016

    • Author(s)
      Sugita M, Yamazaki Y, Goto JI, Fujiwara H, Aihara T, Mikoshiba K, Fujii S.
    • Journal Title

      Brain Research

      Volume: 1642 Pages: 154-162

    • DOI

      10.1016/j.brainres.2016.03.033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain2016

    • Author(s)
      H Monai, M Ohkura, M Tanaka, Y Oe, A Konno, H Hirai, K Mikoshiba, S Itohara, J Nakai, Y Iwai & H Hirase
    • Journal Title

      Nature communications

      Volume: 7 Issue: 1 Pages: 11100-11100

    • DOI

      10.1038/ncomms11100

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.2016

    • Author(s)
      Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J.
    • Journal Title

      J Clin Invest

      Volume: 126(5) Issue: 5 Pages: 1983-1997

    • DOI

      10.1172/jci82859

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons2016

    • Author(s)
      Fujii S, Yamazaki Y, Goto J, Fujiwara H, Mikoshiba K.
    • Journal Title

      Learn & Memory

      Volume: 23(5) Issue: 5 Pages: 208-20

    • DOI

      10.1101/lm.041053.115

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.2016

    • Author(s)
      Staats KA, Humblet-Baron S, Bento-Abreu A, Scheveneels W, Nikolaou A, Deckers K, Lemmens R, Goris A, Van Ginderachter JA, Van Damme P, Hisatsune C, Mikoshiba K, Liston A, Robberecht W, Van Den Bosch L.
    • Journal Title

      Hum Mol Genet.

      Volume: 5(16) Issue: 16 Pages: 3491-3499

    • DOI

      10.1093/hmg/ddw190

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development2016

    • Author(s)
      Uchida K, Nakazawa M, Yamagishi C, Mikoshiba K, Yamagishi H.
    • Journal Title

      Developmental Biology

      Volume: 418(1) Issue: 1 Pages: 89-97

    • DOI

      10.1016/j.ydbio.2016.08.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj52016

    • Author(s)
      R. Ushioda, A. Miyamotod, M. Inoue, S. Watanabe, M. Okumurae, K. Maegawa, K. Uegaki, S. Fujii, Y. Fukuda, M. Umitsu, J. Takagi, K. Inaba, K. Mikoshibad, and K. Nagata
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113(41) Issue: 41 Pages: 6055-6063

    • DOI

      10.1073/pnas.1605818113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope2016

    • Author(s)
      Miyamoto A, Sugiura K, Mikoshiba K.
    • Journal Title

      Cell Calcium.

      Volume: 61 Pages: 1-9

    • DOI

      10.1016/j.ceca.2016.09.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chronic multiscale imaging of neuronal activity in the awake common marmoset2016

    • Author(s)
      Yamada Y, Matsumoto Y, Okahara N, and Mikoshiba K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 35722-35722

    • DOI

      10.1038/srep35722

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact2016

    • Author(s)
      Bonneau B, Ando H, Kawaai K, Hirose M, Takahashi-Iwanaga H, Mikoshiba K.
    • Journal Title

      Elife

      Volume: e19896 Pages: 1-27

    • DOI

      10.7554/elife.19896

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle2016

    • Author(s)
      Hashimoto M, Doi M, Kurebayashi N, Furukawa K, Hirawake-Mogi H, Ohmiya Y, Sakurai T, Mita T, Mikoshiba K, Nara T.
    • Journal Title

      FEBS Open Bio.

      Volume: 6(12) Issue: 12 Pages: 1178-1185

    • DOI

      10.1002/2211-5463.12126

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] cAMP-Dependent Calcium Oscillations of Astrocytes: An Implication for Pathology2016

    • Author(s)
      Ujita S, Sasaki T, Asada A, Funayama K, Gao M, Mikoshiba K, Matsuki N, Ikegaya Y.
    • Journal Title

      Cereb Cortex.

      Volume: in press Pages: bhv310-bhv310

    • DOI

      10.1093/cercor/bhv310

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ashraf M. Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells.2016

    • Author(s)
      Matsu-Ura T, Sasaki H, Okada M, Mikoshiba K, Ashraf M.
    • Journal Title

      Stem Cell Res Therapy

      Volume: 7(1) Issue: 1 Pages: 7-7

    • DOI

      10.1186/s13287-016-0286-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morpholino antisense oligo inhibits trans-splicing of pre-inositol 1,4,5-trisphosphate receptor mRNA of Trypanosoma cruzi and suppresses parasite growth and infectivity.2016

    • Author(s)
      Hashimoto M, Nara T, Mita T, Mikoshiba K.
    • Journal Title

      Parasitol Int.

      Volume: 65 Issue: 3 Pages: 175-179

    • DOI

      10.1016/j.parint.2015.12.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Application of Genetically Encoded Indicators to Mammalian Central Nervous System2015

    • Author(s)
      Yamada Y, Mikoshiba K.
    • Journal Title

      Front Mol Neurosci.

      Volume: 8(76) Pages: 175-9

    • DOI

      10.3389/fnmol.2015.00076

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium2015

    • Author(s)
      Hiroko Bannai, Fumihiro Niwa, Mark W. Sherwood, Amulya Nidhi Shrivastava, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Levi, Antoine Triller, Katsuhiko Mikoshiba
    • Journal Title

      Cell Reports

      Volume: 13 Issue: 12 Pages: 2768-2780

    • DOI

      10.1016/j.celrep.2015.12.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues. PLoS One. 10 e0141569 (2015).2015

    • Author(s)
      Ando H, Hirose M, Gainche L, Kawaai K, Bonneau B, Ijuin T, Itoh T, Takenawa T, Mikoshiba K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: 1-20

    • DOI

      10.1371/journal.pone.0141569

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons.2015

    • Author(s)
      Yamazaki Y, Fujii S, Goto JI, Fujiwara H, Mikoshiba K
    • Journal Title

      Neuroscience

      Volume: 311 Pages: 195-206

    • DOI

      10.1016/j.neuroscience.2015.10.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites2015

    • Author(s)
      Mossaad E, Furuyama W, Enomoto M, Kawai S, Mikoshiba K, Kawazu S
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 59 Issue: 5 Pages: 2890-2892

    • DOI

      10.1128/aac.04805-14

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.2015

    • Author(s)
      Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, Shinoda T, Hikita T, Muraoka S, Iizuka M, Nimura A, Mizoguchi A, Shiina N, Sokabe M, Okano H, Mikoshiba K, Kaibuchi K
    • Journal Title

      Nature Neuroscience

      Volume: in press Issue: 5 Pages: 698-707

    • DOI

      10.1038/nn.3984

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IRBIT is novel determinant of catecholamine homeostasis through the TH phosphorylation by CaMKIIα2015

    • Author(s)
      Katsuhiro Kawaai, Akihiro Mizutani, Hirotaka Shoji, Naoko Ogawa, Etsuko Ebisui, Yukiko Kuroda, Shigeharu Wakana, Tsuyoshi Miyakawa, Chihiro Hisatsune, Katsuhiko Mikoshiba
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 未定 Issue: 17 Pages: 5515-5520

    • DOI

      10.1073/pnas.1503310112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ERp44 exerts redox-dependent control of blood pressure at the ER2015

    • Author(s)
      Chihiro Hisatsune, Etsuko Ebisui, Masaya Usui, Naoko Ogawa, Akio Suzuki, Nobuko Mataga, Hiromi Takahashi-Iwanaga, and Katsuhiko Mikoshiba
    • Journal Title

      Molecular Cell

      Volume: 未定 Issue: 6 Pages: 1015-27

    • DOI

      10.1016/j.molcel.2015.04.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Apoptosis induction-related cytosolic calcium responses revealed by the dual FRET imaging of calcium signals and caspase-3 activation in a single cell2015

    • Author(s)
      Miyamoto A, Miyauchi H, Kogure T, Miyawaki A, Michikawa T, Mikoshiba K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 460(1) Issue: 1 Pages: 82-7

    • DOI

      10.1016/j.bbrc.2015.02.045

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release2015

    • Author(s)
      Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.
    • Journal Title

      Cell Calcium

      Volume: 460(1) Issue: 3 Pages: 82-7

    • DOI

      10.1016/j.ceca.2015.05.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis2015

    • Author(s)
      Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.
    • Journal Title

      J Clin Investigation

      Volume: 125(8) Issue: 8 Pages: 3269-79

    • DOI

      10.1172/jci76765

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A dominant negative form of inositol 1,4,5-trisphosphate receptor induces metacyclogenesis and increases mitochondrial density in Trypanosoma cruzi.2015

    • Author(s)
      Hashimoto M, Nara T, Enomoto M, Kurebayashi N, Yoshida M, Sakurai T, Mita T, Mikoshiba K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 466 Issue: 3 Pages: 475-480

    • DOI

      10.1016/j.bbrc.2015.09.053

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells2015

    • Author(s)
      Voronina S, Collier D, Chvanov M, Middlehurst B, Beckett AJ, Prior IA, Criddle DN, Begg M, Mikoshiba K, Sutton R, Tepikin AV.
    • Journal Title

      Biochem J.

      Volume: 465 Issue: 3 Pages: 405-412

    • DOI

      10.1042/bj20140398

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of IP3 receptor signaling in cell functions and diseases2015

    • Author(s)
      Katsuhiko Mikoshiba
    • Journal Title

      Adv Biol Regul.

      Volume: 57 Pages: 217-27

    • DOI

      10.1016/j.jbior.2014.10.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IRBIT: A regulator of ion channels and ion transporters2014

    • Author(s)
      Ando H, Kawaai K, Mikoshiba K
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 印刷中 Issue: 10 Pages: 2195-204

    • DOI

      10.1016/j.bbamcr.2014.01.031

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdk5/p35 is required for motor coordination and cerebellar plasticity.2014

    • Author(s)
      He X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M, Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
    • Journal Title

      J Neurochem.

      Volume: 131(1) Issue: 1 Pages: 53-64

    • DOI

      10.1111/jnc.12756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An interplay between 2 signaling pathways: melatonin-cAMP and IP3-Ca2+ signaling pathways control intraerythrocytic development of the malaria parasite Plasmodium falciparum.2014

    • Author(s)
      Furuyama, W., Enomoto, M., Mossaad, E., Kawai, S., Mikoshiba, K and Kawazu, S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 446(1) Issue: 1 Pages: 125-131

    • DOI

      10.1016/j.bbrc.2014.02.070

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.2014

    • Author(s)
      Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Ebisui E, Ogawa N, Matsui M, Takeuchi T, Mikoshiba K, Tsubota K.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 6 Pages: e99205-e99205

    • DOI

      10.1371/journal.pone.0099205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.2014

    • Author(s)
      Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 38 Pages: 3966-3975

    • DOI

      10.1073/pnas.1409730111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.2014

    • Author(s)
      Klar J, Hisatsune C, Baig SM, Tariq M, Johansson AC, Rasool M, Malik NA, Ameur A, Sugiura K, Feuk L, Mikoshiba K, Dahl N.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 11 Pages: 4773-80

    • DOI

      10.1172/jci70720

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs2014

    • Author(s)
      Hendron E, Wang X,Zhou Y, Cai X, Goto JI, Mikoshiba K, Baba Y, Kurosaki T, Wang Y, Gill DL.
    • Journal Title

      Cell Calcium

      Volume: 56(6) Issue: 6 Pages: 482-492

    • DOI

      10.1016/j.ceca.2014.10.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-β1 and β4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells2014

    • Author(s)
      Ishida S, Matsu-Ura T, Fukami K, Michikawa T, Mikoshiba K.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 1 Pages: e86410-e86410

    • DOI

      10.1371/journal.pone.0086410

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity2014

    • Author(s)
      Wu YW, Tang X, Arizono M, Bannai H, Shih PY, Dembitskaya Y, Kazantsev V, Tanaka M, Itohara S, Mikoshiba K, Semyanov A.
    • Journal Title

      Cell Calcium

      Volume: 55(2) Issue: 2 Pages: 119-129

    • DOI

      10.1016/j.ceca.2013.12.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mGluR5 Dynamics in Astrocytes Using Quantum Dots2014

    • Author(s)
      Arizono M, Bannai H, Mikoshiba K.
    • Journal Title

      Curr Protoc Neurosci.

      Volume: 66:2.21.1-2.21.18. Issue: 1

    • DOI

      10.1002/0471142301.ns0221s66

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inositol 1,4,5-Trisphosphate receptor regulates replication, differentiation, infectivity, and virulence of the parasitic protist Trypanosoma cruzi2013

    • Author(s)
      Hashimoto M
    • Journal Title

      Mol Microbiology

      Volume: 87(6) Issue: 6 Pages: 1133-50

    • DOI

      10.1111/mmi.12155

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal microscopic systems for long-term imaging of intracellular calcium using a ratiometric genetically-encoded calcium indicator.2013

    • Author(s)
      Miyamoto A, Bannai H, Michikawa T, Mikoshiba K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 434 Issue: 2 Pages: 252-257

    • DOI

      10.1016/j.bbrc.2013.02.112

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irbit Mediates Synergy Between Ca2+ and cAMP Signaling Pathways During Epithelial Transport in Mice.2013

    • Author(s)
      Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S
    • Journal Title

      Gastroenterology

      Volume: S0016-5085(13) Issue: 1 Pages: 232-241

    • DOI

      10.1053/j.gastro.2013.03.047

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice.2013

    • Author(s)
      Hisatsune C, Ogawa N, Mikoshiba K.
    • Journal Title

      Transgenic Res.

      Volume: 22 Issue: 6 Pages: 1241-7

    • DOI

      10.1007/s11248-013-9711-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.2013

    • Author(s)
      Akl H, Monaco G, La Rovere R, Welkenhuyzen K, Kiviluoto S, Vervliet T, Molgo J, Distelhorst CW, Missiaen L, Mikoshiba K, Parys JB, De Smedt H, Bultynck G.
    • Journal Title

      Cell Death Dis.

      Volume: 4 Issue: 5 Pages: e632-e632

    • DOI

      10.1038/cddis.2013.140

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct roles of M1 and M3 muscarinic acetylcholine receptors controlling oscillatory and non-oscillatory [Ca2+]i increase.2013

    • Author(s)
      Nakamura K, Hamada K, Terauchi A, Matsui M, Nakamura T, Okada T, Mikoshiba K.
    • Journal Title

      Cell Calcium

      Volume: 54(2) Issue: 2 Pages: 111-119

    • DOI

      10.1016/j.ceca.2013.05.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral blood flow modulation by basal forebrain or whisker stimulation can occur independent of large cytosolic Ca2+ signaling in astrocytes2013

    • Author(s)
      Norio Takata, Terumi Nagai, Katsuya Ozawa, Yuki Oe, Katsuhiko Mikoshiba, Hajime Hirase
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 6 Pages: e66525-e66525

    • DOI

      10.1371/journal.pone.0066525

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved detection of electrical activity with a voltage probe based on a voltage-sensing phosphatase2013

    • Author(s)
      Tsutsui H, Jinno Y, Tomita A, Niino Y, Yamada Y, Mikoshiba K, Miyawaki A & Okamura Y
    • Journal Title

      J. Physiol. , Epub 2013 Jul 8

      Volume: 591(Pt 18) Issue: 18 Pages: 4427-37

    • DOI

      10.1113/jphysiol.2013.257048

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice.2013

    • Author(s)
      Sugawara T, Hisatsune C, Le TD, Hashikawa T, Hirono M, Hattori M, Nagao S, Mikoshiba K.
    • Journal Title

      J Neurosci.

      Volume: 33 Issue: 30 Pages: 12186-96

    • DOI

      10.1523/jneurosci.0545-13.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p35 Deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model.2013

    • Author(s)
      Jang A, Liew H, Kim YM, Choi H, Kim S, Lee SH, Ohshima T, Mikoshiba K, Suh YH.
    • Journal Title

      Curr Alzheimer Res.

      Volume: 10(8) Pages: 829-843

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid-β25–35 induces impairment of cognitive function andlong-term potentiation through phosphorylation of collapsinresponse mediator protein 2.2013

    • Author(s)
      Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y
    • Journal Title

      Neurosci Res

      Volume: 77 Issue: 3 Pages: 180-185

    • DOI

      10.1016/j.neures.2013.08.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.2013

    • Author(s)
      Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba K.
    • Journal Title

      Front Neural Circuits.

      Volume: 7 Pages: 156-156

    • DOI

      10.3389/fncir.2013.00156

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation.2013

    • Author(s)
      Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba K, Suh YH, Cho S, Park SK.
    • Journal Title

      J Biol Chem.

      Volume: 288(52) Issue: 52 Pages: 36878-36889

    • DOI

      10.1074/jbc.m113.494856

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アストロサイトの活動を仕切る拡散障壁2013

    • Author(s)
      有薗美沙 , 坂内博子 , 丹羽史尋 , 御子柴克彦
    • Journal Title

      生物物理

      Volume: 43(2) Pages: 105-106

    • NAID

      10031151793

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] IP3 receptor/Ca2+ channel as a regulator in cell death and life2018

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      BBRC Symposium 2018 at Beijing, China, June 1 2018 organized by BBRC and Peking University and Tsinghua University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3 receptor: IP3-gated Ca2+ channel2018

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      Gordon Research Conference, Ligand Recognition and Molecular Gating, March 4-9, 2018, Ventura, CA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳を探る、脳を育む、生と死を制御するカルシウム2018

    • Author(s)
      御子柴克彦
    • Organizer
      100回記念藤森サロン講演会, 2018年 4月22日, 吉祥寺東急REIホテル
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 平成29年度「橋渡し研究戦略的推進フォーラム」成果活用支援2018

    • Author(s)
      御子柴克彦
    • Organizer
      疾病克服戦略会議 ―感染症―、2月5日、東京都八重洲カンファレンスセンター
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] [特別講演] 細胞内カルシウム動態と高次脳機能 ー神経変性疾患の病態解明へ向けて2018

    • Author(s)
      御子柴克彦
    • Organizer
      第11回 相模原・北里神経科学フォーラム 「高次脳機能を支えるシグナル伝達経路」, 2018年6月11日, 北里大学医学部臨床教育研究等(IPE棟)IPEホール
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] IP3-Mediated Gating Mechanism of IP3 Receptor2018

    • Author(s)
      Kozo Hamada, Hideyuki Miyatake, Akiko Terauchi, Katsuhiko Mikoshiba
    • Organizer
      Gordon Research Conference, Ligand Recognition and Molecular Gating, March 4-9, 2018, Ventura, CA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiology and pathology of the brain revealed by single molecule dynamics2018

    • Author(s)
      坂内博子、御子柴克彦
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] IP3 receptor/Ca2+ channel as a regulator in cell death and life2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      9th Weinman Symposium International Conference on Gene, Metabolism, and Cancer、Hawai, Nov 30th-Dec 1st
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathophysiological mechanism of brain aging and brain degeneration caused by abnormal calcium signaling2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      Mini-Nobel Forum Symposium “Brain Aging” Aug. 16 2017 at Nobel Forum, Solna, Karolinska Institutet, Stockholm, Sweden
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular and Ca2+ signaling network that regulates cell function2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      Janelia Research Campus November 5-8, 2017, Emerging Tools for Acquisition and Interpretation of Whole-Brain Functional Data
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [Plenary Lecture] Mechanism of IP3 receptor channel gating and its role in cell function and disease2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      28th Ion Channel meeting 6th SFICT Workshop, 2017 Sept 10-13, France Sete
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [Keynote Lecture] IP3 receptor/Calcium signaling: Its role in physiology and pathophysiology2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      38th Congress of the International Union of Physiological Sciences - IUPS 「RHYTHMS OF LIFE」at the Riocentro Convention Center, Rio de Janeiro, Brazil, August, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Brain degeneration caused by abnormal calcium signaling2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      The 4th RIKEN-Karolinska Institutet-SciLifeLab Joint Symposium:Life Science Frontiers in Health, Disease and Aging, Kobe, Japan, Nobember 16-17, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of IRBIT, a nexus in cell signaling linked to IP3R, in apoptosis2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      The 3rd Special International Symposium on "Current Trends in Cancer and Signaling", Nov 23-Nov 25, Ulsan, Korea.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      Gordon Research Conference, Calcium Signalling, June 18-23, 2017, Lucca, Italy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ2017

    • Author(s)
      Katsuhiko Mikoshiba
    • Organizer
      20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease (CaBP20)、淡路島、10月22-26日
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳の発生分化における分子薬理学的解析2017

    • Author(s)
      御子柴克彦
    • Organizer
      慶應義塾大学医学部薬理学講義、慶應義塾大学医学部講義講堂、6月14日、東京都
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] カルシウムによる多彩な機能とその破綻による疾病: 今後の展望2017

    • Author(s)
      御子柴克彦
    • Organizer
      慶應義塾大学医学部開設100年記念シンポジウム [山中伸弥(ノーベル賞受賞者)、Fred Gage(神経幹細胞の発見者)と伴に招待講演]、5月13日ホテルニューオータニ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 特別講義「生命先端科学」2017

    • Author(s)
      御子柴克彦
    • Organizer
      目白大学講義
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Gating mechanism of the brain-enriched IP3 receptor isoform revealed by mutagenesis and X-ray crystallography2017

    • Author(s)
      御子柴克彦
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] [Late-Breaking Topics] Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography2017

    • Author(s)
      Kozo Hamada, Hideyuki Miyatake, Akiko Terauchi, Katsuhiko Mikoshiba
    • Organizer
      Gordon Research Conference, Calcium Signalling, June 18-23, 2017, Lucca, Italy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular mechanism supporting brain functions revealed by single molecule dynamics and subcellular Ca2+ signaling2017

    • Author(s)
      BANNAI Hiroko, Fumihiro Niwa, Shigeo Sakuragi, Katsuhiko Mikoshiba
    • Organizer
      11th International Symposium on Nanomedicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3受容体の結晶構造からひもとくアロステリック機構と疾病メカニズム2017

    • Author(s)
      濱田耕造、宮武秀行、寺内明子、御子柴克彦
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A new approach to decoding of Ca2+ signals in a single cell2017

    • Author(s)
      Hiroko Bannai, Fumihiro Niwa, Shigeo Sakuragi, Katsuhiko Mikoshiba
    • Organizer
      第54回 日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新規microRNAイメージング技術を用いたmicroRNA活性化のkinetics解析2017

    • Author(s)
      安東英明、廣瀬松美、黒澤元、Soren Impey、御子柴克彦
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography2017

    • Author(s)
      濱田耕造、宮武秀行、寺内明子、御子柴克彦
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family2017

    • Author(s)
      Kawaai K, Ando H, Satoh N, Yamada H, Ogawa N, Hirose M, Mizutani A, Bonneau B, Seki G, Mikoshiba K
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] パーキン依存的なポリユビキチン化によるシナプトタグミン4のプロテアソームによる分解2017

    • Author(s)
      樺山博之、徳重直子、竹内誠、 樺山実幸、福田光則 、御子柴克彦
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IP3 receptor/ER Ca2+ channel, a nexus in cell dynamics2016

    • Author(s)
      御子柴克彦
    • Organizer
      SFB 894 MEETING 2016
    • Place of Presentation
      Saarland University, ハンブルグ, ドイツ
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diseases mediated by the dysgeneration of IP3 receptors2016

    • Author(s)
      御子柴克彦
    • Organizer
      FASEB会議 Science Research Conference on Calcium and Cell Function
    • Place of Presentation
      リスボン、ポルトガル
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of IP3 receptor in cell functions and diseases2016

    • Author(s)
      御子柴克彦
    • Organizer
      Calcium Signaling: From Stores To Channels
    • Place of Presentation
      ノースカロライナ、アメリカ
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IRBIT, a newly discovered pseudo-ligand of IP3 receptor, a nexus in cell signaling2016

    • Author(s)
      御子柴克彦
    • Organizer
      ブラジル実験生物学会
    • Place of Presentation
      イグアス、ブラジル
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3 receptor /Ca2+ signaling in development, cell function and diseases2016

    • Author(s)
      御子柴克彦
    • Organizer
      丸中良典研究室開設25周年・京都府立医科大学生理学開講135年記念講演会 「イオンチャネル・輸送・シグナル伝達に関する国際シンポジウム」
    • Place of Presentation
      京都市、京都府
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3受容体の構造解析とその発生・分化・可塑性における役割 ~その生理機能と病態像の解明~2016

    • Author(s)
      御子柴克彦
    • Organizer
      横浜市立大学医学部特別講義
    • Place of Presentation
      横浜市立大学、横浜市、神奈川県
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳の発生分化における分子薬理学的解析2016

    • Author(s)
      御子柴克彦
    • Organizer
      慶應大学医学部薬理学講義
    • Place of Presentation
      慶應大学医学部、東京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 保健、神経科学、高齢化2016

    • Author(s)
      御子柴克彦
    • Organizer
      AVRIST討論会「イノベーションの国、日本」
    • Place of Presentation
      パリ、フランス
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オリジナルな研究で世界をリードするには!2015

    • Author(s)
      御子柴克彦
    • Organizer
      慶應大学11月度GESLセミナー開催
    • Place of Presentation
      慶應義塾大学理工学部、日吉、神奈川県
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of IP3 receptor signaling in cell function: health and disease2015

    • Author(s)
      御子柴克彦
    • Organizer
      上海交通大学Bio-X研究所特別講演
    • Place of Presentation
      上海、中国
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3 receptor as a signaling hub in health and disease2015

    • Author(s)
      御子柴克彦
    • Organizer
      SIAIS BIOFORUM 2015
    • Place of Presentation
      上海、中国
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How to create exciting trends in Neurochemistry!2015

    • Author(s)
      御子柴克彦
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティー、大宮、埼玉
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IP3 receptor / calcium signaling: from discovery to its physiological function and diseases2015

    • Author(s)
      御子柴克彦
    • Organizer
      University of Sao Paulo Special seminar
    • Place of Presentation
      Sao Paulo, Brazil
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 次代(あす)を荷う子を育てるために ~脳科学からの視点~2015

    • Author(s)
      御子柴克彦
    • Organizer
      世田谷聖母幼稚園特別講演会
    • Place of Presentation
      世田谷聖母幼稚園、世田谷区、東京
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Molecular properties of IP3 receptor as a signaling hub in health and disease2015

    • Author(s)
      御子柴克彦
    • Organizer
      Vanderbilt University Special Seminar
    • Place of Presentation
      Vanderbilt University, Nashville, USA
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural and Biochemical Properties of IP3 Receptor Signaling Complex in Health & Disease2015

    • Author(s)
      御子柴克彦
    • Organizer
      BBRC Symposium: Trends in Biochemistry and Biophysics
    • Place of Presentation
      Bangalore, India
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞移動におけるLong-IRBITの機能解析2015

    • Author(s)
      伊藤 諒 他
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳型NBCe1特異的なグリア細胞内pH調節機構について2015

    • Author(s)
      長谷川尚美 等
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス悪性黒色腫細胞におけるLong-IRBITの機能解析2015

    • Author(s)
      白石葵 他
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪細胞分化におけるIRBITの役割2015

    • Author(s)
      杉山友梨 他
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] IRBITによるautophagyの抑制的な調節機構について2015

    • Author(s)
      菅井かれん 他
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] IP3 receptor/Ca2+ signaling in neuronal function and neurodegeneration2014

    • Author(s)
      御子柴克彦
    • Organizer
      Seminar at Ecole Normal Superieur
    • Place of Presentation
      Ecole Normal Superieur, Paris, France
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Essential role of IP3 receptor signaling in cell survival of Plasmodium Falciparum (Malaria) and Trypanosoma Cruzi (Chagas Disease)2014

    • Author(s)
      御子柴克彦
    • Organizer
      Seminaire conjoint Separtements Neuroscience departement des Parasites et Insectes Vecteurs
    • Place of Presentation
      Pateur, Paris, France
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生命先端科学2014

    • Author(s)
      御子柴克彦
    • Organizer
      目白大学特別講義
    • Place of Presentation
      目白大学、和光
    • Year and Date
      2014-12-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] RNA granule構成因子RNG105は記憶の成立に関与する2014

    • Author(s)
      中山 啓 他
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳科学 最近の進歩2014

    • Author(s)
      御子柴克彦
    • Organizer
      三鷹ネットワーク大学
    • Place of Presentation
      三鷹、東京
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] How to conduct original research that leads the world2014

    • Author(s)
      御子柴克彦
    • Organizer
      野依スクール
    • Place of Presentation
      葉山 IPC生産性国際交流センター
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「膜分子のふるまい」を見て「細胞内シグナル」を知る2014

    • Author(s)
      坂内博子 他
    • Organizer
      第52回日本生物物理学会年会 ラマン顕微分光および先端光計測が拓く生物物理の視界
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] カルシウムシグナルによるシナプス構造の競合的制御2014

    • Author(s)
      Fumihiro Niwa 他
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] IP3 receptors and calcium in health and disease-from crystal structure to in vivo analysis2014

    • Author(s)
      御子柴克彦
    • Organizer
      ISN special conference
    • Place of Presentation
      Tokyo Univ. Tokyo
    • Year and Date
      2014-09-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of IP3 receptor signaling in cell functions and diseases2014

    • Author(s)
      御子柴克彦
    • Organizer
      Bologna Special Seminar
    • Place of Presentation
      Research Institute IOR Bologna, Italy
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of IP3 receptor signaling in cell functions and diseases2014

    • Author(s)
      御子柴克彦
    • Organizer
      Fifty-Fifth International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
    • Place of Presentation
      U. Bologna, Italy
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 量子ドット 1 分子イメージングで迫る細胞膜の自己組織化戦略2014

    • Author(s)
      坂内 博子 他
    • Organizer
      第37回 日本神経科学大会  Neuroscience 2014
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成熟小脳において 1 型 IP3 受容体はプルキンエ細胞の樹状突起スパインの形態制御に関わる2014

    • Author(s)
      菅原 健之 他
    • Organizer
      第37回 日本神経科学大会  Neuroscience 2014
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内カルシウムによる GABA シナプスの恒常的制御2014

    • Author(s)
      丹羽 史尋 他
    • Organizer
      第37回 日本神経科学大会  Neuroscience 2014
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 御子柴克彦2014

    • Author(s)
      御子柴克彦
    • Organizer
      特別講義
    • Place of Presentation
      山形大学
    • Year and Date
      2014-09-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「脳を探る、脳を育む」2014

    • Author(s)
      御子柴克彦
    • Organizer
      経営文化フォーラム
    • Place of Presentation
      学士会館, 東京
    • Year and Date
      2014-07-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IP3受容体の構造解析とその発生・分化・可塑性における役割~その生理機能・病態像の解明~2014

    • Author(s)
      御子柴克彦
    • Organizer
      特別講義
    • Place of Presentation
      横浜市立大学
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IP3 receptor: structural analysis and its role in setting the trajectory of cell signaling2014

    • Author(s)
      御子柴克彦
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      目白大学特別講義
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation2014

    • Author(s)
      Misa Arizono 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Blockage of Spontaneous Ca2+ Oscillation Causes Cell Death in Intraerythrocitic Plasmodium falciparum2014

    • Author(s)
      Masahiro Enomoto 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye2014

    • Author(s)
      Takaaki Inaba 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of IP3 receptor of the parasitic protist, Trypanosoma cruzi and antisense oligonucleotides targeting the receptor inhibits the parasite host cell invasion2014

    • Author(s)
      Muneaki Hashimoto 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] An interplay between 2 signaling pathways: a melatonin-cAMP and IP3-Ca2+ signaling pathways, controls intraerythrocytic development of malaria parasite Plasmodium falciparum2014

    • Author(s)
      Wakako Furuyama 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Macropinocytosis mediates Sema3A-induced growth cone collapse2014

    • Author(s)
      Kabayama Hiroyuki 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Competing calcium signals control GABA synaptic structure2014

    • Author(s)
      Hirofumi Niwa 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] IP3R1 regulates cerebellar circuits by maintaining spine morphology of Purkinje cells in adult mice2014

    • Author(s)
      Takeyuki Sugawara 他
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生命科学における真理の探究 オリジナルな研究で世界をリードするには2014

    • Author(s)
      御子柴克彦
    • Organizer
      第1回10年先を見据えた世界的トップリーダーから学ぶ生命理工学フォーラム
    • Place of Presentation
      東京工業大学
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Macropinocytosis mediates Sema3A-induced growth cone collapse2013

    • Author(s)
      Kabayama Hiroyuki, Takeuchi Makoto, Taniguchi Masahiko, Tokushige Naoko, Kozaki Shunji, Mizutani Akihiro, Nakamura Takeshi, and Mikoshiba Katsuhiko
    • Organizer
      18th International Conference on Calcium Binding Proteins and Calcium Function in Health and Disease
    • Place of Presentation
      Kiruna, Sweden
    • Related Report
      2013 Annual Research Report
  • [Presentation] IP3R1 regulates cerebellar circuits by maintaining spine morphology of Purkinje cells in adult mice2013

    • Author(s)
      Takeyuki Sugawara, Le Dinh Tung, Moritoshi Hirono, Soichi Nagao, Chihiro Hisatsune and Katsuhiko Mikoshiba
    • Organizer
      18th International Conference on Calcium Binding Proteins and Calcium Function in Health and Disease
    • Place of Presentation
      Kiruna, Sweden
    • Related Report
      2013 Annual Research Report
  • [Presentation] Receptor-selective diffusion barrier confers enhanced IP3/Ca2+ signaling induced by metabotropic receptor stimulation on astrocytic processes2013

    • Author(s)
      Misa Arizono, Hiroko Bannai,Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W Sherwood,Takeshi Nakamura,Katsuhiko Mikoshiba
    • Organizer
      18th International Conference on Calcium Binding Proteins and Calcium Function in Health and Disease
    • Place of Presentation
      Kiruna, Sweden
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of synaptic GABA-A receptor lateral mobility and clustering by IP3/Ca2+ signaling2013

    • Author(s)
      Fumihiro Niwa, Hiroko Bannai, Mark W Sherwood, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Levi, Antoine Triller and Katsuhiko Mikoshiba
    • Organizer
      18th International Conference on Calcium Binding Proteins and Calcium Function in Health and Disease
    • Place of Presentation
      Kiruna, Sweden
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前脳基底部刺激および感覚刺激はアストロサイトCa2+シグナルとは独立に脳血流変化を起こす2013

    • Author(s)
      高田 則雄, 永井 てるみ, 小澤 克也, 御子柴 克彦,平瀬 肇
    • Organizer
      Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会ならびに第23回日本神経回路学会大会)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] IP3 receptor/channel and axonal guidance2013

    • Author(s)
      Carmen Chan, Hiroki Akiyama, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi
    • Organizer
      Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会ならびに第23回日本神経回路学会大会)
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抑制性シナプス制御におけるカルシウムの驚くべき作用 -1分子イメージングで明らかになったこと-2013

    • Author(s)
      坂内博子、丹羽史尋、Antoine Triller、御子柴克彦
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural analysis of IP3 receptors and their role in various cell functions and diseases

    • Author(s)
      御子柴克彦
    • Organizer
      18th International Conference on Calcium Binding Proteins and Calcium Function in Health and Disease
    • Place of Presentation
      Kiruna, Sweden
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of IP3 receptor in cell function and diseases

    • Author(s)
      御子柴克彦
    • Organizer
      International Society of antioxidants in nutrition & Health Award Ceremony
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The role of IP3 receptor in cell function and diseases

    • Author(s)
      御子柴克彦
    • Organizer
      Seminar at Cardiff School of Biosciences
    • Place of Presentation
      Cardiff, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IP3 receptor: its discovery and establishing a new signaling concept

    • Author(s)
      御子柴克彦
    • Organizer
      3rd RIKEN-Liverpool Symposium
    • Place of Presentation
      Liverpool, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Novel technology changes the traditional concept

    • Author(s)
      御子柴克彦
    • Organizer
      Seminar at University of Bordeaux Segalen
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IP3 receptor/Ca2+ signaling: its role in development, cell function and diseases

    • Author(s)
      御子柴克彦
    • Organizer
      4th ECS Workshop “Ca2+ and cell death
    • Place of Presentation
      Leuven, Belgium
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 超高齢社会における基礎科学の役割

    • Author(s)
      御子柴克彦
    • Organizer
      Asian Aging Summit 2013
    • Place of Presentation
      イイノホール、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳疾患の分子病態解明と発症機構の解明

    • Author(s)
      御子柴克彦
    • Organizer
      脳神経系の分子病態・治療研究の最前線
    • Place of Presentation
      長崎大学、長崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次代(あす)を荷う子を育てるために ~脳科学からの視点~

    • Author(s)
      御子柴克彦
    • Organizer
      世田谷聖母幼稚園特別講演会
    • Place of Presentation
      世田谷、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 実験医学 2018年3月号2018

    • Author(s)
      濱田耕造、御子柴克彦
    • Total Pages
      145
    • Publisher
      羊土社
    • Related Report
      2017 Annual Research Report
  • [Remarks] 小脳回路を正しく維持する仕組みを解明

    • URL

      http://www.riken.jp/pr/press/2017/20170613_1/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 脳の働きに重要なIP3受容体の動作原理を解明

    • URL

      http://www.riken.jp/pr/press/2017/20170418_2/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室のホームページ

    • URL

      http://www.riken.jp/research/labs/cbs/dev_neurobiol/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 御子柴 克彦, M.D., Ph.D. 発生神経生物研究チーム

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2016 Annual Research Report
  • [Remarks] 理研BSI 発生神経生物研究チーム 御子柴 克彦 M.D., Ph.D.

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2015 Annual Research Report
  • [Remarks] Brain Science Institute 発生神経生物研究チーム

    • URL

      http://www.brain.riken.jp/jp/faculty/details/29

    • Related Report
      2013 Annual Research Report

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Published: 2013-06-20   Modified: 2022-03-29  

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