| Budget Amount *help |
¥218,140,000 (Direct Cost: ¥167,800,000、Indirect Cost: ¥50,340,000)
Fiscal Year 2017: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2016: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥55,250,000 (Direct Cost: ¥42,500,000、Indirect Cost: ¥12,750,000)
Fiscal Year 2013: ¥57,460,000 (Direct Cost: ¥44,200,000、Indirect Cost: ¥13,260,000)
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| Outline of Final Research Achievements |
The PIWI-piRNA pathway is a conserved cellular pathway that represses transposable elements (TEs) and plays an important role in germline development. We have recently generated PIWI KO hamster (Syrian hamster; Mesocricetus auratus) in which three of its four distinct PIWIs are expressed in the ovary and found that PIWI KO female are sterile.We have also found novel chromatin domains termed DADs (Differentially Accessible Domains) which span more than mega bases, get transiently accessible in embryonic male germ cells right after the reprogramming event, and turn back to closed state during gonocyte. Interestingly, TEs located in DAD become activated during mid-gonocyte stages.
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