| Budget Amount *help |
¥173,160,000 (Direct Cost: ¥133,200,000、Indirect Cost: ¥39,960,000)
Fiscal Year 2017: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2016: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2015: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
Fiscal Year 2014: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2013: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Outline of Final Research Achievements |
The proteasome is an intracellular proteolytic enzyme complex that regulates the turnover of proteins and plays an essential role in advancing various biological reactions. This study aimed to elucidate the mechanism that governs proteasome and the mechanism leading to the pathological condition by a failure of proteasome function in molecular and in vivo levels. As a result, we identified molecules necessary for proteasome production, elucidated the role of the tissue-specific proteasome, and discovered various compensatory mechanisms for proteasome dysfunction.
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