| Budget Amount *help |
¥215,800,000 (Direct Cost: ¥166,000,000、Indirect Cost: ¥49,800,000)
Fiscal Year 2017: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2013: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
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| Outline of Final Research Achievements |
We have investigated the roles of CAMASP3, a microtubule minus-end binding protein, in cell structure and functions, and found: 1) CAMSAP3 anchors microtubules to the apical cortex in intestinal epithelial cells and the microtubule arrays thus organized play a pivotal role for proper assembly of organelles including the nucleus and Golgi complex; 2) CAMSAP3-anchored microtubules transport the ubiquitin-specific kinase USP47 to cell junctions via KIFC3, and stabilize them by suppressing cadherin degradation; 3) CAMSAP3 accumulates in the axon of a neuron, and determines axon number through regulation of microtubule dynamics; and 4) the CAMSAP3-dependent regulation of microtubule dynamics functions to suppress EMT in lung carcinoma cells. We have also uncovered other important functions of CAMSAP3 in epithelial and neuroepithelial morphogenesis.
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