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Molecular mechanism of ABC proteins involved in cholesterol homeostasis

Research Project

Project/Area Number 25221203
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Applied biochemistry
Research InstitutionKyoto University

Principal Investigator

Ueda Kazumitsu  京都大学, 農学研究科, 教授 (10151789)

Co-Investigator(Kenkyū-buntansha) 赤津 裕康  名古屋市立大学, 大学院医学研究科, 教授 (00399734)
戸田 好信  天理医療大学, 医療学部, 教授 (10444465)
長尾 耕治郎  京都大学, 大学院工学研究科, 助教 (40587325)
田中 亜路  安田女子大学, 薬学部, 講師 (60509040)
Co-Investigator(Renkei-kenkyūsha) KATO HIROAKI  京都大学, 大学院・薬学研究科, 教授 (90204487)
UESUGI MOTONARI  京都大学, 化学研究所, 教授 (10402926)
KUSUMI AKIHIRO  京都大学, 沖縄科学技術大学院大学, 教授 (50169992)
Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥207,480,000 (Direct Cost: ¥159,600,000、Indirect Cost: ¥47,880,000)
Fiscal Year 2017: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2016: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2013: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
KeywordsABC蛋白質 / トランスポーター / コレステロール / 動脈硬化 / アルツハイマー病 / 増殖シグナル / 結晶構造解析 / iPS細胞 / 神経細胞 / 1分子生物学 / 構造生物学 / 膜環境 / 多能性幹細胞 / 阻害剤 / 中枢神経細胞 / 3次元構造解析
Outline of Final Research Achievements

ATP Binding Cassette (ABC) proteins play important physiological roles through transporting hydrophobic substances, and defects in their functions are related to various diseases. In this project, we tried to reveal the functional mechanisms and physiological roles of ABC proteins involved in cholesterol homeostasis. By integrating biochemical/cell biological studies, single molecule tracking and crystal structure analyses, we proposed the novel mechanism of HDL (so-called good cholesterol) generation, in which ABCA1 directly loads excess cholesterol onto apolipoprotein A-I. Furthermore, we revealed that ABCA1 is involved in the uneven distribution of cholesterol in the plasma membrane and the modulation of cell growth signaling. We also succeeded in establishing the platform of ABC protein research by revealing the functional mechanism of multidrug exporter ABCB1 based on detailed structure analyses.

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A+: Progress in the research exceeds the initial goal. More than expected research results are expected.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (112 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 18 results,  Open Access: 9 results,  Acknowledgement Compliant: 9 results) Presentation (85 results) (of which Int'l Joint Research: 18 results,  Invited: 17 results) Remarks (4 results)

  • [Int'l Joint Research] University of Illinois at Chicago(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Illinois at Chicago/National Institutes of Health(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation.2018

    • Author(s)
      Masato Ishigami, Fumihiko Ogasawara, Kohjiro Nagao, Hidehiko Hashimoto, Yasuhisa Kimura, Noriyuki Kioka and Kazumitsu Ueda
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 6170-6170

    • DOI

      10.1038/s41598-018-24428-6

    • NAID

      120006502578

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 過剰なコレステロールは、なぜ健康にとってよくないのか?2018

    • Author(s)
      植田和光
    • Journal Title

      化学と生物

      Volume: 56 Pages: 165-170

    • NAID

      130007601950

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation2017

    • Author(s)
      Ichikawa, T., Kita, M., Matsui, T.S., Ichikawa-Nagasato, A., Araki, T., Chiang, S.H., Sezaki, T., Kimura, Y., Ueda, K., Deguchi, S., Saltiel, A.R., Kioka, N.
    • Journal Title

      Journal of Cell Science

      Volume: 130 Issue: 20 Pages: 3517-3531

    • DOI

      10.1242/jcs.200691

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lysophosphatidylcholine export by human ABCA72017

    • Author(s)
      Maiko Tomioka, Yoshinobu Toda, Noralyn B. Manucat, Hiroyasu Akatsu, Manabu Fukumoto, Nozomu Kono, Hiroyuki Arai, Noriyuki Kioka, and Kazumitsu Ueda
    • Journal Title

      Biochimica Biophysica Acta

      Volume: 1862 Issue: 7 Pages: 658

    • DOI

      10.1016/j.bbalip.2017.03.012

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Vinculin Association with Actin Cytoskeleton is Necessary for Stiffness-dependent Regulation of Vinculin Behavior.2017

    • Author(s)
      Tomohiro Omachi, Takafumi Ichikawa, Yasuhisa Kimura, Kazumitsu Ueda, and Noriyuki Kioka.
    • Journal Title

      PLos One

      Volume: 12 Issue: 4 Pages: e0175324-e0175324

    • DOI

      10.1371/journal.pone.0175324

    • NAID

      120006309292

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix2017

    • Author(s)
      Ayaka Ichikawa Nagasato, Hiroshi Yamashita, Michinori Matsuo, Kazumitsu Ueda and Noriyuki Kioka
    • Journal Title

      Bioscience Biotechnology Biochemistry

      Volume: 印刷中 Issue: 6 Pages: 1136-1147

    • DOI

      10.1080/09168451.2017.1289074

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol2017

    • Author(s)
      Shu-Lin Liu, Ren Sheng, Jae Hun Jung, Li Wang, Ewa Stec, Matthew J O’Connor, Seohyoen Song, Rama Kamesh Bikkavilli, Robert A Winn, Daesung Lee, Kwanghee Baek, Kazumitsu Ueda, Irena Levitan, Kwang-Pyo Kim and Wonhwa Cho
    • Journal Title

      Nature Chemical Biology

      Volume: 13 Issue: 3 Pages: 268-274

    • DOI

      10.1038/nchembio.2268

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes2017

    • Author(s)
      Mito Kuroda, Hiroki Wada, Yasuhisa Kimura, Kazumitsu Ueda and Noriyuki Kioka
    • Journal Title

      Journal of Cell Science

      Volume: 130 Issue: 5 Pages: 989-1002

    • DOI

      10.1242/jcs.194779

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production2016

    • Author(s)
      Osamu Sano, Maki Tsujita, Yuuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, and Michinori Matsuo
    • Journal Title

      PLoS One

      Volume: 11 Issue: 5 Pages: e0155400-e0155400

    • DOI

      10.1371/journal.pone.0155400

    • NAID

      120005997762

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells2015

    • Author(s)
      Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 10 Pages: 1880

    • DOI

      10.1194/jlr.m058164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum2015

    • Author(s)
      Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 39 Pages: 23464-23477

    • DOI

      10.1074/jbc.m115.662668

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA12015

    • Author(s)
      Shimpei Ito, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 79 Issue: 5 Pages: 775-781

    • DOI

      10.1080/09168451.2014.993358

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCB4 exports phosphatidylcholine in a sphingomyel-independent manner2015

    • Author(s)
      Zhao, Y., Ishigami, M., Nagao, K., Hanada, K., Kono, N., Arai, H., Matsuo, M., Kioka, N., and Ueda, K.
    • Journal Title

      J. Lipid Res.

      Volume: 56 Issue: 3 Pages: 644

    • DOI

      10.1194/jlr.m056622

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane2014

    • Author(s)
      Sano, O., Ito, S., Kato, R., Shimizu, Y., Kobayashi, A., Kimura, Y., Kioka, N., Hanada, K., Ueda K., and Matsuo, M.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 10 Pages: e109886-e109886

    • DOI

      10.1371/journal.pone.0109886

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I.2014

    • Author(s)
      Risa Omura, Kohjiro Nagao, Norihiro Kobayashi, Kazumitsu Ueda, and Hiroyuki Saito
    • Journal Title

      J Lipid Res.

      Volume: 55 Issue: 11 Pages: 2423-2431

    • DOI

      10.1194/jlr.d049445

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Selective elimination of human pluripotent stem cells by a marine natural product derivative.2014

    • Author(s)
      Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, and Motonari Uesugi
    • Journal Title

      J Am Chem Soc

      Volume: 136 Issue: 28 Pages: 9798-9801

    • DOI

      10.1021/ja501795c

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 善玉コレステロール産生の初期段階の可視化2014

    • Author(s)
      石神正登、植田和光
    • Journal Title

      Bio Industry

      Volume: 31 Pages: 41-46

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 膜脂質輸送にかかわるABC蛋白質2014

    • Author(s)
      植田和光、冨岡麻衣子
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 1151-1165

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog2014

    • Author(s)
      Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, Hiroaki Kato
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 111 Issue: 11 Pages: 4049-4054

    • DOI

      10.1073/pnas.1321562111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A chemical probe that labels human pluripotent stem cells2014

    • Author(s)
      Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M
    • Journal Title

      Cell reports

      Volume: 6 Issue: 6 Pages: 1165-74

    • DOI

      10.1016/j.celrep.2014.02.006

    • NAID

      120005466668

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1.2013

    • Author(s)
      Matsuda, A., Nagao, K, Matsuo, M., Kioka N. and Ueda, K.
    • Journal Title

      J. Neurochem.

      Volume: (in press) Issue: 1 Pages: 93-101

    • DOI

      10.1111/jnc.12275

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Live cell analysis of the conformational changes in human multidrug transporter MDR12018

    • Author(s)
      Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
    • Organizer
      7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of transmembrane helix 4 of human ABCB42018

    • Author(s)
      Shun Ogawa, Kento Suenaga, Noriyuki Kioka, Yasuhisa Kimura, Kazumitsu Ueda
    • Organizer
      7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses of chimera proteins of ABCA1 suggest the importance of the C-terminal domain of ABCA2 and ABCA13, linked to the Alzheimer’s disease and schizophrenia2018

    • Author(s)
      Yusuke Okamoto, Koh Nagata, Rinshi Kasai, Yasuhisa Kimura, Noriyuki Kioka and Kazumitsu Ueda
    • Organizer
      7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Substrate entry mechanism of human MDR12018

    • Author(s)
      Yasuhisa Kimura, Shuichi Inoue, Noriyuki Kioka, Kazumitsu Ueda
    • Organizer
      7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト多剤排出ポンプMDR1 (ABCB1)の構造変化において ATPが果たす役割の検討2018

    • Author(s)
      二股良太,小笠原史彦, 市川尚文,木村泰久, 木岡紀幸,植田和光
    • Organizer
      日本農芸化学会 2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ABCA1は細胞内でコレステロールを動かすことによって細胞遊走を制御する2018

    • Author(s)
      伊藤志帆、木岡紀幸、植田和光
    • Organizer
      日本農芸化学会 2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リン脂質輸送体ABCB4の 基質取り込みゲートの解析2018

    • Author(s)
      小川峻、末永健人、木岡紀幸、木村泰久、植田和光
    • Organizer
      日本農芸化学会 2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光反応性ホスファチジルコリンを用いた脂質抱合型apoA-Iの標識手法の確立2018

    • Author(s)
      藤本和希、木村泰久、安部真人、三芳秀人、植田和光
    • Organizer
      日本農芸化学会 2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キメラタンパク質を用いたABCAサブファミリータンパク質のC末端領域の機能解析2018

    • Author(s)
      岡本雄介、永田紅、笠井倫志、木村泰久, 木岡紀幸, 植田和光
    • Organizer
      日本農芸化学会 2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コレステロール認識配列CRACは、ヒトABCG4のコレステロール輸送において重要である2017

    • Author(s)
      見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
    • Organizer
      2017年(平成29年度)日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトABCB6によるポルフィリン認識機構の解析2017

    • Author(s)
      西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
    • Organizer
      2017年(平成29年度)日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ビネキシンのホスファチジン酸結合領域の解析2017

    • Author(s)
      伊藤 有亮. 、市川 尚文、折田 雄一郎、安部 真人、木村 泰久、植田 和光、三芳 秀人、木岡 紀幸
    • Organizer
      2017年(平成29年度)日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子内FRETを用いたヒト多剤排出ポンプ(ABCB1,MDR1)の構造変化解析手法の確立2017

    • Author(s)
      二股良太、小笠原史彦、市川尚文、木村泰久、木岡紀幸、植田和光
    • Organizer
      2017年(平成29年度)日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ABCA1とapoA-Iによるコレステロール排出メカニズム解明への新しい定量的アプローチ2017

    • Author(s)
      三好里奈、小笠原史彦、石神正登、永田紅、木村泰久、木岡紀幸、植田和光
    • Organizer
      2017年(平成29年度)日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Vinculin Promotes Nuclear Localization of TAZ to Inhibit ECM Stiffness-Dependent Differentiation into Adipocytes2017

    • Author(s)
      Mito Kuroda, Hiroki Wada, Yasuhisa Kimura, Kazumitsu Ueda, and Noriyuki Kioka
    • Organizer
      Gorden Research Conference on Fibronectin, Integrin & Related Molecules
    • Place of Presentation
      Ventura, CA
    • Year and Date
      2017-01-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞遊走とコレステロール合成に与えるABCA1の影響2017

    • Author(s)
      伊藤志帆、木岡紀幸、植田和光
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分子内FRETを用いたヒト多剤排出ポンプMDR1(ABCB1)変異体の構造変化解析2017

    • Author(s)
      二股良太,小笠原史彦, 市川尚文,木村泰久, 木岡紀幸,植田和光
    • Organizer
      日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトABCB4の基質取り込み経路の検討2017

    • Author(s)
      小川峻、末永健人、木岡紀幸、木村泰久、植田和光
    • Organizer
      日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分子内FRETを用いたヒト多剤 排出ポンプMDR1(ABCB1)の 構造変化解析手法の確立2017

    • Author(s)
      二股良太,小笠原史彦, 市川尚文,木村泰久, 木岡紀幸,植田和光
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 定量的アプローチによるABCA1とapoA-Iによる脂質排出メカニズムの解明2017

    • Author(s)
      三好里奈、小笠原史彦、石神正登、永田紅、木村泰久、木岡紀幸、植田和光
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポルフィリンのカルボキシル基はヒトABCB6によるポルフィリン認識に重要である2017

    • Author(s)
      西澤奈美、木村泰久、大貫元、木岡紀幸、植田和光
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ABCA1は細胞内でコレステロールを動かすことによって細胞遊走を制御する2017

    • Author(s)
      伊藤志帆、木岡紀幸、植田和光
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトABCB4の第4膜貫通ヘリックスの機能解析2017

    • Author(s)
      小川峻、末永健人、木岡紀幸、木村泰久、植田和光
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ABCA1によるHDL産生機構と膜脂質動態の制御2016

    • Author(s)
      植田和光
    • Organizer
      第89回日本生化学会大会シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Mechanism of Multidrug Export by MDR12016

    • Author(s)
      Kazumitsu Ueda
    • Organizer
      Celebrating 30 Years of Research on Multidrug Resistance and ABC transporters
    • Place of Presentation
      Bethesda, USA
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of nascent HDL formation by ABCA1 and apoA-I2016

    • Author(s)
      Kazumitsu Ueda
    • Organizer
      57th International Conference on the Bioscience of Lipids
    • Place of Presentation
      France, Chamonix
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of action of ABCA1 and ABCB12016

    • Author(s)
      Kazumitsu Ueda
    • Organizer
      9th Annual SFB35 Symposium "Transmembrane Transporters in Health and Disease"
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-08-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Focal Adhesion Protein Vinculin Regulates ECM-Stiffness Dependent Differentiation to Adipocytes through Promoting Nuclear Localization of YAP/TAZ2016

    • Author(s)
      Mito Kuroda, Hiroki Wada, Kazumitsu Ueda, and Noriyuki Kioka
    • Organizer
      12th International Congress on Cell Biology (ICCB2016)
    • Place of Presentation
      Prague, Chech Republic
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 健康をたもつしくみ2016

    • Author(s)
      植田和光
    • Organizer
      梅ナビライブ
    • Place of Presentation
      インテックス大阪
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 健康を守るABC蛋白質の作用メカニズム2016

    • Author(s)
      植田和光
    • Organizer
      第80回 日本生化学会中部支部シンポジウム
    • Place of Presentation
      三重大学
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ABCA1によるHDL産生機構~1分子イメージングによる解析2016

    • Author(s)
      永田紅、石神正登、笠井倫志、中田千枝子、吉村安寿弥、John Heuser、楠見明弘、植田和光
    • Organizer
      日本膜学会第38年会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2016-05-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] HDL産生を担うABCA1の1分子解析2016

    • Author(s)
      永田紅、石神正登、笠井倫志、吉村安寿弥、永岩耕太、John HEUSER、楠見明弘、植田和光
    • Organizer
      2016年(平成28年度)日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトABCA1の細胞外ドメインに対するモノクローナル抗体の作製とエピトープ探索2016

    • Author(s)
      三好里奈, 冨岡麻衣子, 小笠原史彦, 木村泰久, 木岡紀幸, 植田和光
    • Organizer
      2016年(平成28年度)日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Reconstitution of human ABCA1 in nanodisc for the functional analysis2016

    • Author(s)
      川野邊峻哲、木村泰久、木岡紀幸、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The C-terminal domain of ABCA1 is important for lipid efflux and immobilization on the plasma membrane.2016

    • Author(s)
      岡本雄介、永田紅、笠井倫志、楠見明弘、木村泰久、木岡紀幸、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of ABCA1 in the modulation of cell migration.2016

    • Author(s)
      伊藤志帆、松尾道憲、木岡紀幸、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of the CRAC domain in TM6 of human ABCG4.2016

    • Author(s)
      見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The extracellular domain of ABCA1 plays important roles in HDL generation2016

    • Author(s)
      小笠原史彦, 石神正登, 木村泰久, 木岡紀幸, 植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleotide induces conformational change in the channel subunit of KATP channel2016

    • Author(s)
      木村泰久、菅野亮、松尾道憲、加藤博章、光岡薫、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crystallographic study of the ABC transporter, CmABCB1 covalently bound to substrate derivatives.2016

    • Author(s)
      松岡敬太, 廣兼諒, 小段篤史, 山口知宏, 中津亨, 植田和光, 加藤博章
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serial Femtosecond Crystallography of an ABC Transporter.2016

    • Author(s)
      大山諒, 潘東青, 中津亨, 佐藤友美, 山口知宏, 小段篤史, 植田和光, 岩田想, 加藤博章
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of functional role of TMD0 of human ABCB62016

    • Author(s)
      西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      オーストリア、インスブルック
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ABCA1による細胞膜脂質ドメインの変化を介した細胞遊走の制御2015

    • Author(s)
      伊藤志帆、松尾道憲、木岡紀幸、植田和光
    • Organizer
      第38回 日本分子生物学会年会・第88回 日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] HDL産生におけるABCA1細胞外ドメインの脂質蓄積機能2015

    • Author(s)
      小笠原史彦, 石神正登, 木村泰久, 木岡紀幸, 植田和光
    • Organizer
      第38回 日本分子生物学会年会・第88回 日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] コレステロールの細胞膜二層間動態と低分子量GTPaseCdc42によるフィードバック制御機構2015

    • Author(s)
      岸本拓磨、永松信哉、植田 和光、小林俊秀
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船橋(東京)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] HDL産生過程でABCA1が二量体化することの生理的意味の解明2015

    • Author(s)
      石神正登、永田 紅、永岩耕太、笠井倫志、楠見明弘、長尾耕治郎、 斎藤博幸、木村泰久、木岡紀幸、植田和光
    • Organizer
      第57回日本脂質生化学会
    • Place of Presentation
      一橋大学(東京)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトMDR1の内向き構造安定化機構の検討2015

    • Author(s)
      津山智美、木村泰久、木岡紀幸、加藤博章、植田和光
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] NPC1L1依存的なコレステロール取込みを阻害するクロサルノコシカケ由来新規天然物fomiroid Aの同定2015

    • Author(s)
      千場 智尋, 櫻田 剛史, 渡邊 理恵, 山口 宏二, 木村 泰久, 木岡 紀幸, 河岸 洋和, 松尾 道憲, 植田 和光
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒトMDR1の基質取り込みゲート機構の解析2015

    • Author(s)
      末永健人、井上修一、木村泰久、木岡紀幸、加藤博章、植田和光
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ATP加水分解活性測定系を用いたヒトABCA1とABCA7の輸送基質の解析2015

    • Author(s)
      橋本秀彦、石神正登、木村泰久、植田和光
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] アミノ酸置換導入によるABCA1のコレステロール認識機構の解析2015

    • Author(s)
      小笠原、木村泰久、植田和光
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single molecule imaging of the membrane lipid transporterABCA12015

    • Author(s)
      植田和光
    • Organizer
      The 15th International Membrane Research Forum
    • Place of Presentation
      京都
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] HDL産生時にABCA1は輸送したコレステロールを一時的に細胞外ドメイン内に蓄積する2015

    • Author(s)
      石神正登、長尾耕治郎、木村泰久、木岡紀幸、植田和光
    • Organizer
      日本農芸化学会関西支部例会第488回講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-01-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ABCA1の作用メカニズムー1分子イメージングによる解明の試み2015

    • Author(s)
      植田和光
    • Organizer
      第26回ビタミンE研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ナノディスクを用いたヒトABCA1の機能解析系の構築2014

    • Author(s)
      川野邊峻哲、木村泰久、木岡紀幸、植田和光
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanism of outward transport of membrane lipids by ABC proteins2014

    • Author(s)
      植田和光
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒトABCA1とABCA7の輸送基質の解析2014

    • Author(s)
      冨岡 麻衣子、ノラリン・マニュカット、植田 和光
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 精製タンパク質を用いたヒトABCG4の機能解析2014

    • Author(s)
      木村泰久、平山裕士、木岡紀幸、松尾道憲、植田和光
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ABCA1のダイマー化のメカニズムの解析2014

    • Author(s)
      石神正登、永田紅、笠井倫志、永岩耕太、提坂友梨奈、楠見明宏、植田和光
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 健康を守るトランスポーターABC蛋白質2014

    • Author(s)
      植田和光
    • Organizer
      2014年度日本農芸化学会関西支部大会 日本農芸化学会創立90周年・関西支部創立80周年記念大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Monomer-dimer conversion of ABCA1 during HDL formation2014

    • Author(s)
      植田和光
    • Organizer
      Bordeaux-Kyoto Symposium
    • Place of Presentation
      Bordeaux, France
    • Year and Date
      2014-05-05 – 2014-05-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] コレステロール恒常性維持の鍵をにぎるヒトABCA1の分子メカニズム2014

    • Author(s)
      植田和光、永田 紅、冨岡麻衣子、石神正登、川野邊峻哲、伊藤晋平、提坂友梨奈、橋本秀彦
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オメガ3脂肪酸によるリポタンパク質の質的制御を介した生理作用2014

    • Author(s)
      松尾 道憲、斉藤 貴将、中塔 充宏、木岡 紀幸、小川 順、植田 和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 精製タンパク質を用いたヒトABCタンパク質の機能解析2014

    • Author(s)
      木村泰久、平山裕士、井上修一、津山智美、木岡紀幸、松尾道憲、加藤博章、植田和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] HDL産生におけるABCA1のダイマー化の生理的意義の解析2014

    • Author(s)
      石神正登、永田紅、笠井倫志、永岩耕太、提坂友梨奈、楠見明弘、植田和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABCG1とABCG4による脂質ラフトを介した細胞機能の制御2014

    • Author(s)
      伊藤志帆、佐野修、松尾道憲、植田和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABCB4によるホスファチジルコリン排出はスフィンゴミエリンに依存する2014

    • Author(s)
      趙 禹、石神正登、長尾耕治郎、花田健太郎、松尾道憲、木岡紀幸、植田和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] アミノ酸置換導入によるABCA1の基質認識部位の解析2014

    • Author(s)
      伊藤晋平、長尾耕治郎、木村泰久、植田和光
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28 – 2014-03-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] Monomer-dimer conversion of ABCA1 during HDL formation2014

    • Author(s)
      植田和光
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulation of HMG-CoA reductase activity by ABCG12014

    • Author(s)
      Michinori Matsuo, Taro Watanabe, Ayako Hirai, and Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanism and physiological significance of ABCA1 dimerization during HDL generation2014

    • Author(s)
      Masato Ishigami, Koh Nagata, Rinshi Kasai, Kota Nagaiwa, Yurina Sagesaka, Akihiro Kusumi, Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] Substrate recognition of human ABCG1 and ABCG42014

    • Author(s)
      Yasuhisa Kimura, Hiroshi Hirayama, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] High-resolution crystal Structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote.2014

    • Author(s)
      A. Kodan., T. Yamaguchi, T. Nakatsu, K. Sakiyama, C.J. Hipolito, A. Fujioka, R. Hirokane, Y. Kimura, H. Suga, K. Ueda, and H. Kato
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] Different substrate specificity of ABCA1 and ABCA72014

    • Author(s)
      Maiko Tomioka, Noralyn Mañucat, Masato Ishigami, Nozomu Kono, Hiroyuki Arai, Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABCB4 functions in different membrane domain with ABCA1 as SM is necessary for its activity2014

    • Author(s)
      Yu Zhao, Masato Ishigami, Kohjiro Nagao, Kentaro Hanada, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2014-03-09 – 2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABCA1によるHDL(善玉コレステロール)産生メカニズム2014

    • Author(s)
      植田和光
    • Organizer
      第7回 レドックス・ライフイノベーション シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-03-06 – 2014-03-07
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ABCG1とABCG4は脂質を輸送することによって細胞膜の脂質ラフト領域を壊す2013

    • Author(s)
      伊藤志帆、松尾道憲、植田和光
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-01 – 2013-12-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児脂質代謝異常とトランスポーター異常ーABC蛋白質を中心として2013

    • Author(s)
      植田和光
    • Organizer
      第27回小児脂質研究会
    • Place of Presentation
      福井
    • Year and Date
      2013-11-09 – 2013-11-10
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] プロテインキナーゼCによるABCG1のリン酸化解析2013

    • Author(s)
      松尾道憲、渡邊太郎、植田和光
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] アストログリア細胞からのアポリポタンパクE含有リポタンパク質分泌への脂肪酸の影響2013

    • Author(s)
      中塔充宏、朴時範、岸野重信、小川順、松尾道憲、植田和光
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] ATPase activity of human ABCG1 is stimulated by cholesterol and choline phospholipids2013

    • Author(s)
      Yasuhisa Kimura, Hiroshi Hirayama, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda
    • Organizer
      Benzon Symposium No. 59 - Membrane proteins: Structure, Function and Dynamics
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2013-08-19 – 2013-08-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABC48-ヒトABCトランスポーター発現系ライブラリーの構築と細胞内局在の解析―2013

    • Author(s)
      松尾道憲、福田麻菜、植田和光
    • Organizer
      第8回トランスポーター研究会年会
    • Place of Presentation
      熊本
    • Year and Date
      2013-06-15 – 2013-06-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] ABCG1の発現による脂質ラフト構造破壊に伴うシグナル伝達系の変化2013

    • Author(s)
      伊藤志帆、渡邊太郎、植田和光、松尾道憲
    • Organizer
      第8回トランスポーター研究会年会
    • Place of Presentation
      熊本
    • Year and Date
      2013-06-15 – 2013-06-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] アストログリア細胞におけるABCトランスポーターを介したコレステロール排出への脂肪酸の影響2013

    • Author(s)
      中塔充宏、朴時範、岸野重信、小川順、植田和光、松尾道憲
    • Organizer
      第8回トランスポーター研究会年会
    • Place of Presentation
      熊本
    • Year and Date
      2013-06-15 – 2013-06-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] 好熱性真核生物の ABC 多剤排出トランスポーターの X 線結晶構造解析2013

    • Author(s)
      廣兼 諒、小段 篤史、中津 亨、 山口 知宏、植田 和光、加藤 博章
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Year and Date
      2013-06-12 – 2013-06-14
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学大学院農学研究科応用生命科学専攻細胞生化学研究室

    • URL

      http://www.biochemistry.kais.kyoto-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 京都大学大学院農学研究科細胞生化学研究室

    • URL

      http://www.biochemistry.kais.kyoto-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学物質―細胞統合システム拠点

    • URL

      http://www.icems.kyoto-u.ac.jp/ja/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学大学院農学研究科細胞生化学研究室

    • URL

      http://www.biochemistry.kais.kyoto-u.ac.jp

    • Related Report
      2015 Annual Research Report

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Published: 2013-06-20   Modified: 2022-02-28  

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