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Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex

Research Project

Project/Area Number 25221204
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Animal production science
Research InstitutionThe University of Tokyo

Principal Investigator

Takahashi Shin-Ichiro  東京大学, 大学院農学生命科学研究科(農学部), 教授 (00197146)

Co-Investigator(Kenkyū-buntansha) 伯野 史彦  東京大学, 大学院農学生命科学研究科(農学部), 助教 (30282700)
伊藤 昭博  国立研究開発法人理化学研究所, 環境資源科学研究センター, 客員主管研究員 (40391859)
梅原 崇史  国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー (20415095)
西原 真杉  東京大学, 大学院農学生命科学研究科(農学部), 教授 (90145673)
佐伯 泰  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員 (80462779)
Research Collaborator Chida Kazuhiro  
Kataoka Naoyuki  
Yamanaka Daisuke  
Fukushima Toshiaki  
Asano Tomoichiro  
Takenaka Asako  
Higashi Yusuke  University of Missouri
Girnita Leonard  Karolinska Institute
Torres-Aleman Ignacio  Cajal Institute
Duan Cunming  University of Michigan
Weghuber Julian  University of Applied Sciences Upper Austria
Belfiore Antonino  University Magna Graecia of Catanzaro
O'Connor Rosemary  University of Cork
Forbes Briony  Flinders University
Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥215,800,000 (Direct Cost: ¥166,000,000、Indirect Cost: ¥49,800,000)
Fiscal Year 2017: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2016: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2015: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2014: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2013: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Keywords代謝・内分泌制御 / インスリン / インスリン様成長因子 / インスリン受容体基質 / 細胞内シグナル伝達 / 糖尿病 / がん / インスリン様活性 / 細胞内シグナル / 増殖 / 翻訳 / スプライシング / 糖取り込み / インスリン抵抗性 / 成長異常
Outline of Final Research Achievements

Insulin-like growth factors (IGFs) and insulin induce a variety of bioactivities, including growth, differentiation, survival, increased anabolism, and decreased catabolism in many cell types and in vivo. Insulin receptor substrates (IRSs) are known to be major substrates of their receptor kinases, mediating IGF/insulin signals to direct bioactivities. In this study, we discovered that IRSs form high-molecular-mass complexes (IRSomes) even without IGF/insulin stimulation. These complexes contain proteins (IRSAPs), which modulate tyrosine phosphorylation of IRSs by receptor kinases, control IRS stability, determine intracellular localization of IRSs, and regulate RNA metabolism, as well as RNAs themselves. In addition, we demonstrated that low molecular weight compounds which modulate interaction between IRS and the specific IRSAPs can improve symptoms of various age-related diseases including cancer and diabetes, disorder of modulation of insulin-like activities.

Academic Significance and Societal Importance of the Research Achievements

IRSは、インスリン/IGFの作用発現を仲介するシグナル分子と考えられてきたが、本研究により、ホルモンの刺激とは独立して、他のタンパク質やRNAなどと相互作用し、インスリン様活性を修飾する「足場タンパク質」としても機能していることを示した。研究過程で、IRSomeにはRNAが含まれ、これが複合体の形成と同時に、RNA代謝を調節している、また、アミノ酸欠乏のシグナル自身がインスリン様活性を誘導するという全く新しい代謝調節機構の存在も明らかにし、これらの学術的意義は高い。本研究の成果は、成長異常、糖尿病、老化、がんなどに対して、全く新しい機序で作用する薬剤や治療法の開発への利用が期待できる。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(10 results)
  • 2019 Research Progress Assessment (Verification Result) ( PDF )
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (202 results)

All 2019 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (20 results) Journal Article (33 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 32 results,  Open Access: 17 results,  Acknowledgement Compliant: 8 results) Presentation (133 results) (of which Int'l Joint Research: 66 results,  Invited: 26 results) Book (2 results) Remarks (12 results) Funded Workshop (2 results)

  • [Int'l Joint Research] University of Missouri/University of Michigan/University of North Carolina(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Flinders University/University of Sydney(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Univ of Applied Sciences Upper Austria(オーストリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(スウェーデン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Cajal Institute(スペイン)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Michigan/University of Missouri(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Cajal Institute(Spain)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(Sweden)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Flinders University(Australia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of College Cork(Ireland)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Michigan/University of Missouri(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Cajal Institute(Spain)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Applied Sciences(Austria)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of College Cork(Ireland)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Michigan/Tulane University(米国)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] Cajal Institute(Spain)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(Sweden)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation2019

    • Author(s)
      Ueda Koji、Nakatsu Yusuke、Yamamotoya Takeshi、Ono Hiraku、Inoue Yuki、Inoue Masa-Ki、Mizuno Yu、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Takahashi Shin-Ichiro、Matsubara Akio、Asano Tomoichiro
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 17 Pages: 1637-1648

    • DOI

      10.18632/oncotarget.26691

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.2019

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
    • Journal Title

      Cell Rep.

      Volume: 26 Issue: 12 Pages: 3221-3230

    • DOI

      10.1016/j.celrep.2019.02.066

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] インスリン様シグナルと代謝制御性アミノ酸シグナル:次世代栄養学『AI Nutrition』の提唱2019

    • Author(s)
      高橋伸一郎、伯野史彦、山中大介、中林靖、豊島由香、竹中麻子
    • Journal Title

      実験医学

      Volume: 37 Pages: 514-520

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling2018

    • Author(s)
      Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
    • Journal Title

      Elife

      Volume: 7

    • DOI

      10.7554/elife.32893

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serine phosphorylation by mTORC1 promotes IRS-1 degradation through SCF-b-TRCP E3 ubiquitin ligase2018

    • Author(s)
      Yoneyama Y, Inamitsu T, Chida K, Iemura SI, NatsumeT, Maeda T, Hakuno F, Takahashi S-I
    • Journal Title

      iScience

      Volume: 5 Pages: 1-18

    • DOI

      10.1016/j.isci.2018.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.2018

    • Author(s)
      Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
    • Journal Title

      Oncotarget

      Volume: 9(74) Issue: 74 Pages: 33871-33883

    • DOI

      10.18632/oncotarget.26049

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SM22α (Smooth Muscle Protein 22-α) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis.2018

    • Author(s)
      Sukhanov S, Higashi Y, Shai SY, Snarski P, Danchuk S, D'Ambra V, Tabony M, Woods TC, Hou X, Li Z, Ozoe A, Chandrasekar B, Takahashi S-I, Delafontaine P.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 38 Issue: 10 Pages: 2306-2317

    • DOI

      10.1161/atvbaha.118.311134

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IGF-I receptor signaling pathways2018

    • Author(s)
      Hakuno F, Takahashi SI.
    • Journal Title

      J. Mol. Endocrinol.

      Volume: - Issue: 1 Pages: T69-T86

    • DOI

      10.1530/jme-17-0311

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 解説 アミノ酸の新機能:血中プロファイルに応じた脂質代謝の変動2018

    • Author(s)
      西宏起、伯野史彦、高橋伸一郎
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 76 Pages: 467-471

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 成長ホルモンは,実は「異化ホルモン」である2018

    • Author(s)
      高橋伸一郎、伯野史彦
    • Journal Title

      成長代謝

      Volume: 9 Pages: 1-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylinositol 3-Kinase-associated Protein (PI3KAP)/XB130 Crosslinks actin Filaments through its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 cells2016

    • Author(s)
      Daisuke Yamanaka, Takeshi Akama, Kazuhiro Chida, Shiro Minami, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Journal Title

      frontiers in Endocrinology

      Volume: 7 Pages: 89-89

    • DOI

      10.3389/fendo.2016.00089

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.2016

    • Author(s)
      Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S, Yamanouchi K, Nishihara M
    • Journal Title

      Experimental Cell Research

      Volume: 347 Issue: 2 Pages: 367-377

    • DOI

      10.1016/j.yexcr.2016.08.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes2016

    • Author(s)
      Liu TY, Yu BC, Kakino M, Fujimoto H, Ando Y, Hakuno F, Takahashi S-I
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 35438-35438

    • DOI

      10.1038/srep35438

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of effects of blood amino acidand hormone level for controlling triglyceride accumulation in the liver of rats using Self-Organizing Map2016

    • Author(s)
      Masato Masuda, Yasushi Nakabayashi, Ryuji Shioya, Hiroki Nishi, Shin-Ichiro Takahashi, Fumihiko Hakuno
    • Journal Title

      International Journal of Intelligent Information Systems

      Volume: 5 Issue: 6 Pages: 88-93

    • DOI

      10.11648/j.ijiis.20160506.12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アミノ酸シグナルを利用した高品質食資源の開発技術の確立2016

    • Author(s)
      高橋伸一郎、潮秀樹、加藤久典、伯野史彦、柴田重信、竹中麻子、豊島由香、勝俣昌也、中島一喜
    • Journal Title

      JATAFFジャーナル

      Volume: 4 Pages: 4-4

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Journal Article] When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016

    • Author(s)
      L Girnita, S-I Takahashi, C Crudden, T Fukushima, C Worrall, H Furuta, H Yoshihara, F Hakuno, A Girnita
    • Journal Title

      Progress in Molecular Biology and Translational Science

      Volume: 141 Pages: 277-311

    • DOI

      10.1016/bs.pmbts.2016.04.001

    • ISBN
      9780128093863
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構2016

    • Author(s)
      高橋伸一郎、福嶋俊明、安藤康年、伯野史彦
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 74 Pages: 21-25

    • NAID

      40020705836

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tumor Necrosis Factor (TNF)-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-I Causes Insulin Resistance in 3T3-L1 Adipocytes2015

    • Author(s)
      Ando Y, Shinozawa Y, Iijima Y, Yu B-C, Sone M, Ooi Y, Watanaka Y, Chida K, Hakuno F, Takahashi S-I
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 9 Pages: 5881-5892

    • DOI

      10.1074/jbc.m114.624759

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of insulin receptor substrates signaling dynamics on microstructured surfaces.2015

    • Author(s)
      Lanzerstorfer P, Yoneyama Y, Hakuno F, Muller U, Hoglinger O, Takahashi SI, Weghuber J
    • Journal Title

      FEBS J.

      Volume: 282 Issue: 6 Pages: 987-1005

    • DOI

      10.1111/febs.13213

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins.2015

    • Author(s)
      Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S.
    • Journal Title

      Front Endocrinol (Lausanne).

      Volume: 6 Pages: 73-73

    • DOI

      10.3389/fendo.2015.00073

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015

    • Author(s)
      Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
    • Journal Title

      Mediators Inflamm.

      Volume: 2015 Issue: 1 Pages: 125380-125380

    • DOI

      10.1155/2015/125380

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid increase in fibroblast growth factor 2 in protein malnutrition and its impact on growth and lipid metabolism.2015

    • Author(s)
      Yori Ozaki, Kenji Saito, Kyoko Nakazawa, Morichika Konishi, Nobuyuki Itoh, Fumihiko Hakuno, Shin-Ichiro Takahashi, Hisanori Kato and Asako Takenaka
    • Journal Title

      British Journal of Nutrition

      Volume: 114 Issue: 9 Pages: 1410-1418

    • DOI

      10.1017/s0007114515002846

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo loss of function study reveals the short stature homeobox-containing (shox) gene plays indispensable roles in early embryonic growth and bone formation in zebrafish.2015

    • Author(s)
      Sawada R., Kamei H., Hakuno F., Takahashi S., Shimizu T.
    • Journal Title

      Dev. Dyn.

      Volume: 244 Issue: 2 Pages: 146-156

    • DOI

      10.1002/dvdy.24239

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015

    • Author(s)
      Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
    • Journal Title

      Nature communications

      Volume: 6 Issue: 1 Pages: 6780-6780

    • DOI

      10.1038/ncomms7780

    • NAID

      120006348510

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.2014

    • Author(s)
      Liu C, Luan J, Bai Y, Li Y, Lu L, Liu Y, Hakuno F, Takahashi S, Duan C, Zhou J.
    • Journal Title

      Gen Comp Endocrinol

      Volume: 197 Pages: 82-91

    • DOI

      10.1016/j.ygcen.2013.12.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats2014

    • Author(s)
      Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Narumi Akiyama-Akanishi, Asako Takenaka, Hisanori Kato, Kazuhiro Chida, Fumihiko Hakuno, Shiro Minami, Shin-Ichiro Takahashi
    • Journal Title

      Endocrine Journal

      Volume: 61 Issue: 5 Pages: 499-512

    • DOI

      10.1507/endocrj.EJ13-0514

    • NAID

      130004443967

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver2014

    • Author(s)
      Yokota S-I, Nakamura K, Ando M, Kamei H, Hakuno F, Takahashi S-I, Shibata S. 2014 Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 905-914

    • DOI

      10.1016/j.fob.2014.10.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters.2014

    • Author(s)
      Kaneko M, Hakuno F, Kamei H, Yamanaka D, Chida K, Minami S, Coe RI, Takahashi S-I.
    • Journal Title

      Bicohem Biophysic Res Commun.

      Volume: 443 Issue: 2 Pages: 505-510

    • DOI

      10.1016/j.bbrc.2013.11.132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014

    • Author(s)
      Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S-I.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 5 Pages: 24-24

    • DOI

      10.3389/fendo.2014.00024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.2014

    • Author(s)
      Yori Ozaki, Tomoya Takeda, Narumi Akanishi, Fumihiko Hakuno, Yuka Toyoshima, Shin-Ichiro Takahashi & Asako Takenaka
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: - Issue: 1 Pages: 130-138

    • DOI

      10.1080/09168451.2014.877825

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Something old, something new and something borrowed; emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation2013

    • Author(s)
      Girnita L, Worrall C, Takahashi S-I, Seregard S, Girnita A
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: なし Issue: 13 Pages: 2403-2427

    • DOI

      10.1007/s00018-013-1514-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 解説:インスリン様活性と高齢化社会で克服すべき疾病2013

    • Author(s)
      高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
    • Journal Title

      化学と生物

      Volume: 51 Pages: 389-399

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割2013

    • Author(s)
      高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 934-941

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 進化から学ぶ動物の一生に果たすインスリン様ペプチドの役割2019

    • Author(s)
      高橋伸一郎
    • Organizer
      日本抗加齢医学会 専門医・指導士認定委員会講習会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Roles of IRS-1-Induced Cell Competition in Myogenic Differentiation.2019

    • Author(s)
      Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rbfox2 protein mediates exon 11 inclusion in insulin receptor alternative splicing in hepatoma cells2019

    • Author(s)
      Naoyuki Kataoka, Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary arginine deficiency increases lipid content in the liver through a decrease in adenine nucleotide metabolites2019

    • Author(s)
      Yamanaka Daisuke, Hiroki Nishi, Yuki Goda, Mikako Kumano, Haruka Nagata, Sakiko Taniguchi, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Function of pyrroline-5-carboxylate reductase 2 (PYCR2) which associates with insulin receptor substrate (IRS) 2 in cell survival in neuroblastoma cells.2019

    • Author(s)
      Eisuke Kaba, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi.
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes2019

    • Author(s)
      Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019

    • Author(s)
      Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The mechanism of cell competition induced by differential IRS-1 expression in myoblasts.2019

    • Author(s)
      Ryosuke OKINO, Ami USUI, Fumihiko HAKUNO, Shin-Ichiro TAKAHASHI
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Somatomedins and I.2018

    • Author(s)
      Shin-Ichrio Takahashi
    • Organizer
      Amgen Scholars Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Two Years in IGF Research 2016-20182018

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      The 9th GRS-IGF International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of Amino Acids on Hepatic Gene Expression of Insulin-like Growth Factor-I2018

    • Author(s)
      Haruka Nagata, Daisuke Yamanaka, Hiroki Nishi, Yuuki Gouda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      The 9th GRS-IGF International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The difference of IRS-1 protein expression level caused cell competition2018

    • Author(s)
      Fumihiko Hakuno, Ami Usui, Hiroyasu Kamei, Ryosuke Okino, Yosuke Yoneyama, Shin-Ichiro Takahashi
    • Organizer
      The 9th GRS-IGF International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct pathways of GH and TNF-a for suppression of insulin-dependent glucose uptake2018

    • Author(s)
      Lisa Nakata, Meri Yonezawa-Sone, Tomomi Ogata, Kouhei Kasahara, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      The 9th GRS-IGF International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アミノ酸シグナルとインスリン様シグナルによる物質代謝の調節2018

    • Author(s)
      高橋伸一郎
    • Organizer
      第39回日本基礎老化学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] アルギニン不足は肝臓におけるアデニンヌクレオチド代謝経路化合物の減少を介して肝臓脂肪量を増加させる2018

    • Author(s)
      山中大介, 西宏起, 合田祐貴, 熊野未佳子, 長田悠加, 谷口紗貴子, 伊藤公一, 伯野史彦, 高橋伸一郎
    • Organizer
      第12回アミノ酸学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Insulin receptor substrate (IRS)1を過剰発現した筋芽細胞で観察される細胞競合の発生メカニズム2018

    • Author(s)
      沖野良輔、臼井杏美、伯野史彦、高橋伸一郎
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Introduction: Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals2017

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017

    • Author(s)
      Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular functions and physiological significance of a novel PI 3-kinase-binding protein that potentiates IGF activities2017

    • Author(s)
      Daisuke Yamanaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin receptor substrates-associated proteins that are involved in the insulin resistance2017

    • Author(s)
      Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of Insulin-like activities through alternative splicing of Insulin Receptor pre-mRNA2017

    • Author(s)
      Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Temporal regulation of insulin-like growth factor signaling by IRS-1-dependent feedback loops2017

    • Author(s)
      ousuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF/insulin signaling through a novel mechanism2017

    • Author(s)
      Toshiaki Fukushima, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapid increase in fibroblast growth factor 21 under protein malnutrition and its impact on growth, insulin secretion and lipid metabolism2017

    • Author(s)
      Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Insulin/Insulin-like growth factor signaling in hypoxia/reoxygenation induced catch-up growth in zebrafish embryo2017

    • Author(s)
      Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short stature with IGF-I receptor gene anomaly.2017

    • Author(s)
      Yuki Kawashima, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early embryonic insulin receptor substrate-1 signaling underpins neural crest cell survival contributing to catch-up growth induced by changing environmental oxygen tension in developing zebrafish.2017

    • Author(s)
      Hiroyasu Kamei, Yosuke Yoneyama, Fumihiko Hakuno, Rie Sawada, Toshiaki Shimizu, Cunming Duan, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hepatic steatosis induced by amino acid deficiency or by manipulation of the dietary amino acid composition2017

    • Author(s)
      Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Ryuji Shioya, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of tissue-specific alternative splicing of insulin receptor pre-mRNA2017

    • Author(s)
      Takahito Nakura, Atsufumi Ozoe, Yuka Narita, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of IRS-1-induced cell competition in myogenic differentiation2017

    • Author(s)
      Ami Usui, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amino acid-deficiency signal induces insulin-like effects on regulation of gluconeogenic gene regulation independently of insulin signaling in hepatocytes2017

    • Author(s)
      Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lysine deficiency signal selectively induces lipid accumulation in muscle and adipose tissues of rats2017

    • Author(s)
      Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Hiroyasu Kamei, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Kazuhiro Chida, Masugi Nishihara, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The SCFβ-TRCP E3 ligase complex induces IRS-1 degradation mediated by mTORC1 pathway2017

    • Author(s)
      Tomomi Inamitsu, Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary amino acids control lipid accumulation in the liver, skeletal muscle or adipose tissue in an amino acid-specific manner2017

    • Author(s)
      Daisuke Yamanaka, Hiroki Nishi, Yuki Goda, 1Mikako Kumano, Koichi Ito, Masaya Katsumata, Hisanori Kato, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prolonged IGF signaling by IRS-1-mediated control of delayed IGF-IR internalization2017

    • Author(s)
      Yosuke Yoneyama, Fumihiko, Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serine phosphorylation of GLUT4 positively controls glucose transport activity of GLUT4 causing insulin resistance by growth hormone2017

    • Author(s)
      Fumihiko Hakuno, Chihiro Watanabe, Lisa Nakata,Mamiko Kubo, Meri-Yonezawa-Sone, Kohei, Kasahara, Shin‐Ichiro Takahashi
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of novel anti-diabetic drugs by interrupting the association between DGKζ and IRS-12017

    • Author(s)
      Bu-Chin Yu, Akihiro Ito, Minoru Yoshida, Yasutoshi Ando, Tin-Yu Liu, Fumihiko Hukuno, Kazuhiro Chida , Shin-Ichiro Takahashi.
    • Organizer
      Gordon Research Conference on IGF & insulin physiology & Diseases
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インスリン受容体基質がcap非依存的翻訳促進に果たす新規機能2016

    • Author(s)
      中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] アミノ酸シグナルを利用した臓器特異的な脂肪蓄積技術の確立とその利用2016

    • Author(s)
      高橋伸一郎、潮秀樹、加藤久典、柴田重信、竹中麻子、鈴木由香、勝俣昌也、中島一喜、塩谷隆二
    • Organizer
      知の集積と活用の場産学官連携協議会ポスターセッション
    • Place of Presentation
      東京海洋大学越中島キャンパス八十五周年記念会館(東京都、江東区)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 栄養情報と成長を繋ぐホルモン、インスリン様ペプチド2016

    • Author(s)
      高橋伸一郎
    • Organizer
      第30回東北成長障害・成長因子研究会
    • Place of Presentation
      仙台国際ホテル(宮城県、仙台市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] インスリン受容体基質に相互作用するタンパク質2016

    • Author(s)
      高橋伸一郎
    • Organizer
      東北大学医学部セミナー
    • Place of Presentation
      東北大学医学部(宮城県、仙台市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アミノ酸シグナルとインスリン様シグナル: 低タンパク質栄養状態に応答した代謝調節の分子機構と高品質畜産物開発技術への利用2016

    • Author(s)
      高橋伸一郎
    • Organizer
      動物・飼料に関する月例研究会
    • Place of Presentation
      馬事畜産会館(東京都、中央区)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The Novel Role of Glucose Transporter 4 Serine Phosphorylation in Insulin Resistance Induced by Growth Hormone2016

    • Author(s)
      Chihiro Watanabe, Mamiko Kubo, Meri Yonezawa-Sone, Kohei Kasahara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      ENDO2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AMPシグナルとインスリン様シグナルのクロストークから明らかとなったインスリン様活性の新しい調節機構2016

    • Author(s)
      高橋伸一郎
    • Organizer
      第13回GPCR研究会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 栄養と代謝を繋ぐホルモン:アミノ酸シグナルとインスリン様シグナル2016

    • Author(s)
      高橋伸一郎
    • Organizer
      赤ちゃん歯科ネットワーク講演会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2016

    • Author(s)
      Takashito Nakura, Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi.
    • Organizer
      RNA2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin receptor substrates (IRSs), interacting with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulate cap-independent translation2016

    • Author(s)
      Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi
    • Organizer
      RNA2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アミノ酸シグナルによるインスリン様活性の調節:栄養に応答した物質代謝調節のダイナミクス2016

    • Author(s)
      高橋伸一郎
    • Organizer
      平成28年度日本農芸化学会東北支部シンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of a new method for evaluating cell mechano-response to multidirectional and anisotropic mechanical strain by using photodegradable hydrogel2016

    • Author(s)
      KAWAMURA Ryuzo; KWOKHOI, Ng; TANAKA Taisei; KOJIMAMasaru; ARAI Tatsuo; YONEYAMA, Yosuke; HAKUNO, Fumihiko; TAKAHASHI, Shin-ichiro; TAKAGI, Toshiyuki; KANAMORI, Toshiyuki; NAKABAYASHI Seiichiro; SUGIURA Shinji
    • Organizer
      コロイドおよび界面化学討論会
    • Related Report
      2016 Annual Research Report
  • [Presentation] OR複合体1経路がインスリン受容体基質の分解とインスリン様成長因子(IGF)I受容体のエンドサイトーシスに果たす役割2016

    • Author(s)
      米山鷹介、稲光智美、伯野史彦、高橋伸一郎
    • Organizer
      第6回TOR研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノ酸シグナルに応答した肝臓への脂質蓄積機構の解明2016

    • Author(s)
      西宏起、亀井宏泰、山中大介、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第6回TOR研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Actin cytoskeleton remodeling dynmics of adherent cells under to the photo-induced mechanical strain of gelatin substrate2016

    • Author(s)
      Kwokhoi Ng, Kentaro Iketaki, Ryuzo Kawamura, Seiichiro Nakabayashi, Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi, Fumiki Yanagawa, Toshiyuki Takagi, Shinji Sugiura, Toshiyuki Kanamori, Hiroshi Yoshikawa
    • Organizer
      日本生物物理学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel Roles of the Akt Substrate, AS47 in GH-Induced Inhibition of Insulin-Stimulated Glucose Uptake in Adipocytes without Affecting GLUT4 Translocation to Plasma Membranes2016

    • Author(s)
      Meri Yonezawa-Sone, Kouhei Kasahara, Lisa Nakata, Chihiro Watanabe, Keitaro Yamanouchi, Masugi Nishihara, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      8th International Congress of GRS-IGF society,
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ソマトメジンと私2016

    • Author(s)
      高橋伸一郎
    • Organizer
      第41回東京成長ホルモン成長因子セミナー
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] RNAを含むインスリン受容体基質複合体の新機2016

    • Author(s)
      高橋伸一郎
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] SCFユビキチンリガーゼ複合体によるリン酸化依存的なインスリン受容体基質の分解制御2016

    • Author(s)
      稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 全アミノ酸あるいはリジンを不足させた食餌を給餌した成長期のラットでは脂肪組織が増加する2016

    • Author(s)
      合田祐貴、西宏起、山中大介、亀井宏泰、勝俣昌也、加藤久典、豊島由香、竹中麻子、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 巨大なシグナル分子複合体IRSomeがインスリン活性の調節に果たす新しい役割2015

    • Author(s)
      高橋伸一郎、伯野史彦、安藤康年
    • Organizer
      BMB2015 (第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] セリン/スレオニンホスファターゼPP1/PP2Aがインスリン受容体基質のリン酸化と分解の調節に果たす役割2015

    • Author(s)
      稲光智美、米山鷹介、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      BMB2015 (第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] クラスリンアダプタータンパク質AP-2との相互作用を介したIRS-1によるIGF-I受容体エンドサイトーシスの新規フィードバック制御機構2015

    • Author(s)
      米山鷹介、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      BMB2015 (第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 筋分化過程でIRS-1の発現量の違いが細胞競合を引き起こす2015

    • Author(s)
      臼井杏美、米山鷹介、千田和広、高橋伸一郎、伯野史彦
    • Organizer
      BMB2015(第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Metabolic diseases, metabolic syndrome, metabolomics, and aging2015

    • Author(s)
      BuChin Yu, TingYu Liu, Yasutoshi Ando, Akihiro Ito, Minoru Yoshida, Fumihiko Hakuno, Kazuhiro Chida and Shin-Ichiro Takahashi
    • Organizer
      BMB2015(第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] GLUT4のセリンリン酸化が糖膜透過能に果たす役割2015

    • Author(s)
      渡部千尋, 久保真実子, 米澤(曽根)芽里, 伯野史彦, 高橋伸一郎
    • Organizer
      BMB2015(第38回日本分子生物学会年会/第88回日本生化学大会合同大会)
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Insulin Receptor Substrate-Associated Proteins: The keys to regulate insulin-like actions2015

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      Invited lecture hosted by Dr. Rosemary O’Connor at University College Cork
    • Place of Presentation
      University College Cork (Cork, Ireland)
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Insulin receptor substrates- associated proteins which are related with insulin resistance2015

    • Author(s)
      Bu-Chin Yu, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
    • Place of Presentation
      Cajal Institute (Madrid, Spain)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatty liver caused by acute amino acid deficiency2015

    • Author(s)
      Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
    • Place of Presentation
      Cajal Institute (Madrid, Spain)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of alternative splicing of insulin receptor RNA by insulin receptor substrate2015

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
    • Place of Presentation
      Cajal Institute (Madrid, Spain)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Negative feedback regulation of IGF-I receptor internalization by insulin receptor substrates2015

    • Author(s)
      Fumihiko Hakuno, Yousuke Yoneyama, Shin-Ichiro Takahashi
    • Organizer
      International Seminar: Current boundaries of the expanding landscape of insulin-like activities and beyond
    • Place of Presentation
      Cajal Institute (Madrid, Spain)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IGF-I研究の最前線2015

    • Author(s)
      高橋伸一郎
    • Organizer
      GH/IGF-I & longevity
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都、港区)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アミノ酸シグナルを利用した白肝の生産技術の開発-なぜ、動物のタンパク質栄養状態の悪化は成長遅滞と肝脂肪蓄積を引き起こすか2015

    • Author(s)
      高橋伸一郎
    • Organizer
      第55回澱粉研究懇談会
    • Place of Presentation
      ホテルラヴィエ川良(神奈川県、伊東市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] インスリン様活性から見たクワシオルコル2015

    • Author(s)
      高橋伸一郎
    • Organizer
      第15回新生児栄養フォーラム
    • Place of Presentation
      飯田橋レインボービル(東京都、新宿区)
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Effect of branched-chain amino acids on insulin secretion during feeding2015

    • Author(s)
      Mami Horiuchi, Tomoya Takeda, Yori Ozaki, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin-induced acetyl-CoA carboxylase alpha is responsible for triglyceride accumulation in primary hepatocytes of low protein diet-fed rats.2015

    • Author(s)
      Yusuke Taguchi, Yuka Toyoshima, Reiko Tokita, Hisanori Kato, Shin-Ichiro Takahashi, Shiro Minami.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein malnutrition increases the amount and phosphorylation of 4E-binding protein 1 (4E-BP1) to accumulate lipid in rat liver2015

    • Author(s)
      Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Fumiaki Yoshizawa, Shin-Ichiro Takahashi, Hisanori Kato, and Shiro Minami
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝臓におけるアミノ酸欠乏に応答したインスリン受容体基質(IRS)-2量の増加とトリグリセリドの蓄積の新規分子機構2015

    • Author(s)
      西宏起、亀井宏泰、山中大介、赤西成美、森友美、合田佑貴、豊島由香、竹中麻子、潮秀樹、加藤久典、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      日本農芸化学会2015年大会
    • Place of Presentation
      岡山大学津島キャンパス、岡山
    • Year and Date
      2015-03-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] IRS1を恒常的に発現したL6筋芽細胞は細胞競合を引き起こし、筋分化が抑制される2015

    • Author(s)
      伯野史彦、米山鷹介、臼井杏美、高橋伸一郎
    • Organizer
      第4回細胞競合コロキウム
    • Place of Presentation
      北海道大学 遺伝子病制御研究所、北海道
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] IRS-1の細胞膜への恒常的発現が骨格筋分化に及ぼす影響の解析2015

    • Author(s)
      臼井杏美、伯野史彦、米山鷹介、高橋伸一郎
    • Organizer
      第4回細胞競合コロキウム
    • Place of Presentation
      北海道大学 遺伝子病制御研究所、北海道
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] IRS-1 is a negative feedback regulator of IGF-I receptor internalization via interaction with AP-2 clathrin adaptor complex2015

    • Author(s)
      Yosuke Yoneyama, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PI 3-kinase-binding protein PI3KAP plays an important role in cell migration and is required for embryogenesis in zebrafish2015

    • Author(s)
      Hiroki Kawauchi, Daisuke Yamanaka, Hiroyasu Kamei, Fumihiko Hakuno, Shiro Minami, Kazuhiro Chida, and Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells2015

    • Author(s)
      Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diacylglycerol kinase zeta and PIP5K1 cooperatively enhanced insulin-induced glucose uptake in 3T3-L1 adipocytes2015

    • Author(s)
      Fumihiko Hakuno, Ting-Yu Liu T, M Kakino, Hitoshi Fujimoto, Yasutoshi Ando, Kazuhiro Chida, and Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early embryonic Irs-1 signaling governs the neural crest cell survival that is indispensable for catch-up growth in zebrafish embryo induced by the changing environmental oxygen tension2015

    • Author(s)
      Hiroyasu Kamei H, Yosuke Yoneyama, Rie Sawada R, Cunming Duan, Fumihiko Hakuno, Toshiaki Shimizu T, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), regulating alternative pre-mRNA splicing of insulin receptor RNA2015

    • Author(s)
      Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      Gordon Research Conference: IGF & Insulin System in Physiology & Disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Institute Lecture: Insulin receptor substrates (IRSs) form high-molecular-mass complexes with various proteins that control RNA splicing and translation2015

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      Cajal Institute Seminar
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2015-02-25
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Keynote Lecture: Insulin receptor substrates (IRSs) form high-molecular-mass complexes with various proteins that control RNA splicing and translation2015

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      5th Nagasaki University-Pusan University Joint Seminar of Aging Research
    • Place of Presentation
      長崎大学、長崎
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IRS1を恒常的発現したL6筋芽細胞は、細胞競合を引き起こし、筋分化が抑制される2014

    • Author(s)
      伯野史彦、米山鷹介、臼井杏美、尾添淳文、高橋伸一郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] IGFシグナルに応答して変動するユビキチン化タンパク質の網羅的解析2014

    • Author(s)
      吉原英人、土屋光、吉田雪子、田中啓二、高橋伸一郎、佐伯泰
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ユビキチンリガーゼNedd4がIRS-2を介したIGFシグナルを増強する新しい分子機構2014

    • Author(s)
      福嶋俊明、吉原英人、古田遥佳、伯野史彦、佐伯泰、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interaction between insulin receptor substrates (IRSs) and various proteins including diacylglycerol kinase ζ (DGKζ) modulates insulin bioactivities2014

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      invited lectures by Sichuan University
    • Place of Presentation
      Sichuan University, Chengdu, China
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lipopolysaccharide (LPS) treatment increased the protein levels of GKAP42 (42-kDa cGMP-dependent protein kinase anchoring protein) followed by inhibition of glucose transporter (GLUT) 4 translocation to the plasma membrane and glucose uptake in adipocytes2014

    • Author(s)
      Bu Chin Yu, Yasutoshi Ando, Yuko Obata, Asako Takenaka, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Mechanisms by which Nedd4-IRS-2 complexes enhance IGF-I signals, and their roles in IGF-I action in prostate cancer cell proliferation2014

    • Author(s)
      Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impaired mTORC1 activity up-regulates IGFBP-1 synthesis during dietary protein restriction2014

    • Author(s)
      Mika Hino, Kanae Takeuchi, Shin-Ichiro Takahashi, Asako Takenaka
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Constitutive IRS1 expression causes cell competition, leading to defect in myogenic differentiation2014

    • Author(s)
      Fumihiko Hakuno, Yosuke Yoneyama, Atsufumi Ozoe and Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Loss of PI 3-kinase-binding protein PI3KAP/XB130 suppresses thyroid function and induces enlargement of thyroid glands in mice2014

    • Author(s)
      Daisuke Yamanaka, Fumihiko Hakuno, Shiro Minami, Koshi Hashimoto, Kouichi Suzuki, Kazuhiro Chida, and Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells2014

    • Author(s)
      Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, and Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin receptor substrate (IRS)-1 interacts with protein arginine methyltransferase 5 (PRMT5), emerging as a novel regulator of alternative pre-mRNA splicing2014

    • Author(s)
      Atsufumi Ozoe, Yuka Narita, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Tomoichiro Asano, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IRS-1 promotes embryonic growth of zebrafish through IGF-IR signal-dependent and -independent mechanisms in response to developmental stages and environmental oxygen availability2014

    • Author(s)
      Hiroyasu Kamei, Rie Sawada, Yosuke Yoneyama, Fumihiko Hakuno, Toshiaki Shimizu, Shin-Ichiro Takahashi
    • Organizer
      7th International Congress of the GRS and IGF Society
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolution of insulin-like peptides2014

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
    • Place of Presentation
      Nakashima Hall, The University of Tokyo, Tokyo
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of insulin receptor substrate-1 in catch-up growth: A lesson from tiny fish embryo2014

    • Author(s)
      Hiroyasu Kamei and Shin-Ichiro Takahashi
    • Organizer
      Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
    • Place of Presentation
      Nakashima Hall, The University of Tokyo, Tokyo
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phospho-tyrosine independent roles of insulin receptor substrates2014

    • Author(s)
      Fumihiko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      Evolution of Insulin-like Peptides and Their Function: Development, Growth, Metabolism and Ageing
    • Place of Presentation
      Nakashima Hall, The University of Tokyo, Tokyo
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IGF-1を知る~アクロメガリー診療への扉~ IGF-1活性とその調節2014

    • Author(s)
      高橋伸一郎
    • Organizer
      第10回アクロメガリーフォーラム
    • Place of Presentation
      京都
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アミノ酸シグナルとインスリン様活性-低タンパク質栄養状態に応答した成長遅滞と脂肪肝誘導の仕組み2014

    • Author(s)
      高橋伸一郎
    • Organizer
      早稲田大学先進理工学研究科生命医科学講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mechanisms for Regulation of Acetylation of Insulin-Receptor Substrate (IRS)-1, Regulating Insulin-Like Growth Factor (IGF) Signaling2014

    • Author(s)
      Kumiko Fujieda, Yosuke Yoneyama, Akihiro Ito, Minoru Yoshida, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      ICE/ENDO 2014
    • Place of Presentation
      McComick Place West, Chicago Illinois, USA
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低タンパク質食給餌ラットから単離した肝細胞ではインスリン依存性acetyl-CoA carboxylase 遺伝子発現が増強する2014

    • Author(s)
      田口雄亮、豊島由香、時田玲子、加藤久典、高橋伸一郎、南史朗
    • Organizer
      第68回日本栄養・食糧学会
    • Place of Presentation
      酪農学園大学・札幌
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪細胞のインスリン依存性糖輸送機構における新規Akt基質の生理的意義2014

    • Author(s)
      曽根芽里、笠原浩平、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 甲状腺細胞の増殖に必須なアダプタータンパク質PI3KAPの遺伝子欠損は甲状腺機能を低下させる2014

    • Author(s)
      山中大介、伯野史彦、南史朗、高橋伸一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構2014

    • Author(s)
      成田佑果、尾添淳文、福嶋俊明、片岡直行、伊藤 昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低酸素環境で成長が遅滞したゼブラフィッシュ胚が常酸素環境で追いつき成長を起こす機構の解明:インスリン受容体基質(IRS)-1の機能2014

    • Author(s)
      亀井宏泰、山口里恵、米山鷹介、伯野史彦、清水俊明、高橋伸一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュの初期発生におけるphosphatidylinositol 3-kinase(PI3K)の新規結合タンパク質の役割2014

    • Author(s)
      川内啓希、山中大介、亀井宏泰、南史朗、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いたSHOX(short stature homeobox containing)遺伝子の胚発生における役割の解析2014

    • Author(s)
      山口里恵、亀井宏泰、伯野史彦、高橋伸一郎、清水俊明
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] インスリン抵抗性発生の新しい機序としてのGLUT4のセリンリン酸化2014

    • Author(s)
      高橋伸一郎、久保真実子、渡部千尋、笠原浩平、曽根芽里、千田和広、伯野史彦
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] アミノ酸欠乏培地で培養した肝細胞ではインスリン受容体基質(IRS)-2量が増加し脂肪蓄積が起こる2014

    • Author(s)
      森友美、亀井宏泰、赤西成美、尾添淳文、伯野史彦、千田和広、加藤久典、豊島由香、竹中麻子、高橋伸一郎
    • Organizer
      日本農芸化学会大会2014年度
    • Place of Presentation
      川崎
    • Year and Date
      2014-03-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] Constitutive IRS1 expression suppressed cell invasion and migration, leading to inhibition of myogenesis in L6 myoblasts2013

    • Author(s)
      Fumihiko Hakuno, Yosuke Yoneyama, Kazuhiro Chida, Shin-Ichiro Takahashi
    • Organizer
      2013 ASCB Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2013-12-14 – 2013-12-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of insulin receptor substrate-1 interacting with clathrin adaptor AP-2 complex at submembranous actin cytoskeleton2013

    • Author(s)
      Yosuke Yoneyama, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      2013 ASCB Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2013-12-14 – 2013-12-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミトコンドリア局在型フォスファターゼPGAM5は、インスリン受容体基質のセリン/スレオニンリン酸化と安定性の調節に機能している2013

    • Author(s)
      米山鷹介、鋳延淳一、木田友佳子、福嶋俊明、関根史織、浅野知一郎、千田和広、武田弘資、伯野史彦、高橋伸一郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん細胞では、脱ユビキチン化酵素USP9XによりIGF-I受容体およびIRS-2の分解が抑制され、IGF依存性増殖が亢進している2013

    • Author(s)
      古田遥佳、吉原英人、福嶋俊明、佐伯泰、田中啓二、伊藤昭博、吉田稔、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nedd4-IRS2複合体の形成機構と複合体ががん細胞の過増殖誘導に果たす役割2013

    • Author(s)
      福嶋俊明、吉原英人、古田遥佳、伯野史彦、千田和広、佐伯泰、田中啓二、伊藤昭博、吉田稔、中津佑介、鎌田英明、高橋伸一郎、浅野知一郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRS結合タンパク質、DGKζを介した新しい糖取り込みの調節機構2013

    • Author(s)
      劉亭妤、柿野衛、冨士本仁、伊藤昭博、吉田稔、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intracellular localization of insulin receptor substrates determines exerted insulin-like activities2013

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      Obesity, Diabetes and Cancer: the roles of insulin and insulin-like growth factors
    • Place of Presentation
      Taormina, Italy
    • Year and Date
      2013-10-04
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A deubiquitinating enzyme, USP7, is associated with insulin receptor substrate (IRS)-2 forming a negative feedback llop in insulin/IGF signaling2013

    • Author(s)
      Hidehito Yoshihara, Toshikai Fukushima, Furuta Haruka, Fumihiko Hakuno, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Shunichiro Iemura, Tohru Natsume, Takahashi Shin-Ichiro
    • Organizer
      EMBO Conference
    • Place of Presentation
      Riva del Garda, Italy
    • Year and Date
      2013-10-01 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] インスリン受容体基質結合タンパク質、PINCH2を発現するトランスジェニックマウスにおけるインスリンシグナル・生理活性の解析2013

    • Author(s)
      勝部祐介、岡野真由子、植村健治、高瀬和典、伯野史彦、髙橋伸一郎、太田昭彦、戸村秀明
    • Organizer
      第106回日本繁殖生物学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-09-12 – 2013-09-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] ユビキチン結合ドメインタンパク質によるユビキチンシグナルの発動メカニズム2013

    • Author(s)
      吉原英人、海保愛、新井直子、土屋光、高橋伸一郎、田中啓二、佐伯泰
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] A deubiquitinating enzyme, USP7, is associated with IRS-2 forming a negative feedback loop in IGF signaling2013

    • Author(s)
      Hidehito Yoshihara, Fumihko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional analysis of ubiquitin specific protease USP9X which interacts with IRSs.2013

    • Author(s)
      Haruka Furuta, Fumihko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] IRS-1 expression suppressed cell invasion, leading to inhibition of myogenesis.2013

    • Author(s)
      Fumihiko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of expression of insulin receptor isoforms2013

    • Author(s)
      Yuka Narita, Fumihko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] Kynote lecture: IRSome: novel complexes to mediate/modulate insulin-like activities2013

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-16
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Novel mechanisms for the expression of insulin/IGF bioactivities by IRS-1-RNA complex2013

    • Author(s)
      Atsufumi Ozoe, Fumihko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ubiquitin-conjugation to IRS by ubiquitin ligase Nedd4 drives Insulin/IGF signaling2013

    • Author(s)
      Toshiaki Fukushima, Fumihko Hakuno and Shin-Ichiro Takahashi
    • Organizer
      INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2013-08-12 – 2013-08-16
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低タンパク質食摂取がインスリン受容体基質(IRS)-2 に及ぼす影響の解析2013

    • Author(s)
      丸井未槻、日野美佳、金子梨紗、尾崎依、吉原英人、亀井宏泰、伯野史彦、高橋伸一郎、竹中麻子
    • Organizer
      第5回日本アミノ酸学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-07-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] インスリン受容体基質(IRS)-1のアセチル化酵素と脱アセチル化酵素の特定2013

    • Author(s)
      藤枝久美子、米山鷹介、伊藤明博、吉田稔、千田和広、伯野史彦、高橋伸一郎
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular mechanisms of porentiation of insulin-like growth factors (IGFs) bioactivity by other extracellular factors2013

    • Author(s)
      Shin-Ichiro Takahashi
    • Organizer
      Department Lecture at Arizona State University
    • Place of Presentation
      Tempe Phoenix, AZ, USA
    • Year and Date
      2013-06-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles of Insulin Receptor Substrate Complexes Containing Rabankyrin-5 in Insulin-Like Growth Factor-I-Induced Macropinocytosis2013

    • Author(s)
      Takayuki Yano, Yosuke Yoneyama, Toshiaki Matsui, Hiroshi Okajima, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
    • Organizer
      ENDO2013
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2013-06-15
    • Related Report
      2013 Annual Research Report
  • [Book] Progress in Molecular Biology and Translational Science2016

    • Author(s)
      Girnita L, Takahashi S-I, Crudden C, Fukushima T, Worrall C, Furuta H, Yoshihara H, Hakuno F, Girnita A.
    • Total Pages
      34
    • Publisher
      Elsevier Inc
    • Related Report
      2015 Annual Research Report
  • [Book] 「農学入門」第三部10章「農学と動物科学:巨大な細胞社会を統御する仕組みを知り利用する」2013

    • Author(s)
      高橋伸一郎
    • Total Pages
      30
    • Publisher
      養賢堂
    • Related Report
      2013 Annual Research Report
  • [Remarks] 生体の生命維持に必須な 細胞内シグナルのクロストークを科学する

    • URL

      http://endo.ar.a.u-tokyo.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] NHK 高校講座:生物基礎 第3回「生命活動を支える代謝」

    • URL

      http://www.nhk.or.jp/kokokoza/tv/seibutsukiso/

    • Related Report
      2017 Annual Research Report
  • [Remarks] NHK 高校講座:生物基礎 第22回「ホルモンによる調節(1)血液によって送られる司令」

    • URL

      http://www.nhk.or.jp/kokokoza/tv/seibutsukiso/

    • Related Report
      2017 Annual Research Report
  • [Remarks] NHK 高校講座:生物基礎 第23回「ホルモンによる調節(2)ホルモン分泌量の調節」

    • URL

      http://www.nhk.or.jp/kokokoza/tv/seibutsukiso/

    • Related Report
      2017 Annual Research Report
  • [Remarks] NHK 高校講座:生物基礎 第24回「血糖値の調節」

    • URL

      http://www.nhk.or.jp/kokokoza/tv/seibutsukiso/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 生体の生命維持に必須な細胞内シグナルのクロストークを科学する

    • URL

      http://endo.ar.a.u-tokyo.ac.jp/shingroup/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 生体の生命維持に必須な細胞内シグナルの クロストークを科学する

    • URL

      http://endo.ar.a.u-tokyo.ac.jp/shingroup/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report 2013 Annual Research Report
  • [Remarks] 2型糖尿病の原因の一つであるインスリン抵抗性発生機構の一部を解明

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2015/20150409-1.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 動物の成長や細胞の増殖の新しい機能を発見

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 2型糖尿病の原因の一つであるインスリン抵抗性発症機構の一部を解明

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2015/20150409-1.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 動物の成長や細胞の増殖の新しい調節機構を発見:インスリン受容体基質のユビキチン化の知られざる意義

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2015/20150420-1.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 動物の成長や細胞の増殖の新しい調節機構を発見

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html

    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] International Seminar of Core-to-Core Project “Insulin-like Signaling and Nutrient Signaling”2017

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] Gordon Research Conference on IGF & insulin physiology & Diseases2017

    • Related Report
      2016 Annual Research Report

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Published: 2013-06-20   Modified: 2022-04-28  

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