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Integrative studies on the dynamism of mesenchymal cells during tissue restoration/regeneration

Research Project

Project/Area Number 25221205
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Integrative animal science
Research InstitutionThe University of Tokyo

Principal Investigator

Ozaki Hiroshoi  東京大学, 大学院農学生命科学研究科(農学部), 教授 (30134505)

Co-Investigator(Kenkyū-buntansha) 堀 正敏  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (70211547)
日下部 守昭  東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (60153277)
池田 正浩  宮崎大学, 農学部, 教授 (60281218)
飯野 哲  福井大学, 学術研究院医学系部門, 教授 (40242854)
堀口 和秀  福井大学, 学術研究院医学系部門, 准教授 (20377451)
下島 直樹  慶應義塾大学, 医学部(信濃町), 講師 (30317151)
Project Period (FY) 2013-05-31 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥196,300,000 (Direct Cost: ¥151,000,000、Indirect Cost: ¥45,300,000)
Fiscal Year 2016: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2015: ¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2014: ¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2013: ¥55,120,000 (Direct Cost: ¥42,400,000、Indirect Cost: ¥12,720,000)
Keywords間葉系細胞 / 筋線維芽細胞 / 平滑筋細胞 / 上皮細胞 / 組織修復・再生 / 免疫炎症応答 / 内皮細胞 / 炎症 / 細胞運動 / 組織修復・再生 / 臓器線維化 / 細胞外マトリックス / テネイシンC
Outline of Final Research Achievements

Fibrosis in parenchyma organs is a mortal disease if not properly treated. At present, few drugs are effective in treating fibrosis, and relatively few studies have been conducted on the mechanism of fibrosis comparing with other chronic diseases such as cancer. Major works on fibrosis have focused on the immune and collagen expression mainly noticing the effect of TGFb. The purpose of this study is to know if the control of motility function of mesenchymal origin myofibroblasts, which play critical roles in fibrogenic responses, is benefit for suppressing this disease. In this study, we identified that CPI-17 and tenascin-C as a key marker of these transdifferentiated cells in which many inflammatory mediators such as IL-1beta、IL-17、IL-33、PGD2、ATP、NO and EGF play important roles in these reactions. We also presented new seeds targeting mesenchimal origin myofibroblast like cells.

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(9 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (134 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (54 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 54 results,  Acknowledgement Compliant: 19 results,  Open Access: 21 results) Presentation (75 results) (of which Int'l Joint Research: 7 results,  Invited: 11 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Characterization of urinary exosomal release of aquaporin-1 and -2 after renal ischemia-reperfusion in rats2018

    • Author(s)
      Asvapromtada Siree、Sonoda Hiroko、Kinouchi Minami、Oshikawa Sayaka、Takahashi Saki、Hoshino Yuya、Sinlapadeelerdkul Thitaporn、Yokota-Ikeda Naoko、Matsuzaki Toshiyuki、Ikeda Masahiro
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 314 Issue: 4 Pages: F584-F601

    • DOI

      10.1152/ajprenal.00184.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus2018

    • Author(s)
      Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H, Hori M
    • Journal Title

      Neurogastroenterol Motil

      Volume: 15 Issue: 8

    • DOI

      10.1111/nmo.13334

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of actin polymerization by marine toxin pectenotoxin-22018

    • Author(s)
      Hori M, Yazama F, Matsuura Y, Yoshimoto R, Kaneda T, Yasumoto T, Ozaki H, Karaki H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 225-234

    • DOI

      10.1292/jvms.17-0654

    • NAID

      130006339633

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II, a unique vasoactive agent dissociates myosin light chain phosphorylation from contraction2018

    • Author(s)
      Hirano T, Kaneda T, Ozaki H, Hori M
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 219-224

    • DOI

      10.1292/jvms.17-0415

    • NAID

      130006339672

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of myosin light chain kinase and CPI-17 by TGF-b accelerates contractile activity in intestinal epithelial cells2018

    • Author(s)
      Md. Shafiqul Islam, Kaji N, Mikawa S, Yang Q, Kusabe M, Hori M, Ozaki H
    • Journal Title

      J Vet Med Sci

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration with diosgenin enhances the induction of intestinal T helper 1-like regulatory T cells in a murine model of food allergy.2017

    • Author(s)
      Huang C-H, Wang C-C, Lind Y-J, Hori M, Jan T-R.
    • Journal Title

      International Immunopharmacology

      Volume: 42 Pages: 59-66

    • DOI

      10.1016/j.intimp.2016.11.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micro-coordination of Pacemaker Potentials in the Intestine of the Mouse.2017

    • Author(s)
      Morishita H, Iwata N, Takai C, Mochizuki N, Kaji N, Hori M, Kajioka S, Nakayama S.
    • Journal Title

      Gastroenterology

      Volume: 5085(17) Issue: 8 Pages: 35483-35485

    • DOI

      10.1053/j.gastro.2017.04.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice2017

    • Author(s)
      Yang Q, Fujii W, Kaji N, Kakuta S, Kada K, Kuwahara M, Tsubone H, Ozaki H, Hori M
    • Journal Title

      FASEB J

      Volume: 32(4) Issue: 4 Pages: 2095-2109

    • DOI

      10.1096/fj.201700794r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The anti-inflammatory pathway regulated via nicotinic acetylcholine receptors in rat intestinal mesothelial cells2017

    • Author(s)
      Taiki Mihara, Wataru Otsubo, Kazuhide Horiguchi, Shoma MikawaNoriyuki Kaji, Satoshi Iino, Hiroshi Ozaki and Masatoshi Hori
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 11 Pages: 1795-1802

    • DOI

      10.1292/jvms.17-0304

    • NAID

      130006199240

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression2017

    • Author(s)
      Mihara T, Mikawa S, Kaji N, Endo M, Oikawa T, Tong-Rong J, Ozaki H, Hori M. Inflammation
    • Journal Title

      Inflammation

      Volume: 40(4) Issue: 4 Pages: 1331-1341

    • DOI

      10.1007/s10753-017-0576-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zingiberis Siccatum Rhizoma, the active component of the Kampo formula Daikenchuto, induces anti-inflammatory actions through α7 nicotinic acetylcholine receptor activation2017

    • Author(s)
      Endo M, Hori M, Mihara T, Ozaki H, Oikawa T, Odaguchi H, Hanawa T
    • Journal Title

      Neurogastroenterol Motil

      Volume: 29(12) Issue: 12

    • DOI

      10.1111/nmo.13139

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive DNA microarray expression profiles of tumors in tenascin-C-knockout mice.2017

    • Author(s)
      Matsumoto, K., Nakai, Y., Hoshino, M., Yamazaki, K., Takioto, Y., Takadera, S., Nakagawa, T., Nishimura, R., and Kusakabe, M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 81 Issue: 10 Pages: 1926-1936

    • DOI

      10.1080/09168451.2017.1362975

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation2016

    • Author(s)
      Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM, Ozaki H, Hori M
    • Journal Title

      Pharmacological Research

      Volume: 111 Pages: 838-848

    • DOI

      10.1016/j.phrs.2016.07.030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells.2016

    • Author(s)
      Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.
    • Journal Title

      British Journal of Pharmacology

      Volume: 173 Issue: 16 Pages: 2532-2542

    • DOI

      10.1111/bph.13535

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Acetazolamide enhances the release of urinary exosomal2016

    • Author(s)
      Abdeen, A., Sonoda, H., Oshikawa, S., Hoshino, Y., Kondo, H., Ikeda, M.
    • Journal Title

      Nephrol. Dial. Transplant.

      Volume: in press Issue: 10 Pages: 1623-1632

    • DOI

      10.1093/ndt/gfw033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Aquaporins in urinary extracellular vesicles (exosomes).2016

    • Author(s)
      Oshikawa S, Sonoda H, Ikeda M.
    • Journal Title

      Int J Mol Sci.

      Volume: 17 Issue: 6 Pages: 640-6

    • DOI

      10.3390/ijms17060957

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model2016

    • Author(s)
      Fujimura T*, Shibata S*, Shimojima N, Morikawa Y, Okano H, Kuroda T. (*equally contributed first author)
    • Journal Title

      PLoS One

      Volume: 11(3):e0150579. Issue: 3 Pages: 1-14

    • DOI

      10.1371/journal.pone.0150579

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acetazolamide enhances the release of urinary exosomal aquaporin-12016

    • Author(s)
      Abdeen, A., Sonoda, H., Oshikawa, S., Hoshino, Y., Kondo, H., and Ikeda, M.
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo2015

    • Author(s)
      Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, Murata T.
    • Journal Title

      PLoS One

      Volume: 9;10(7) Issue: 7 Pages: e0132367-e0132367

    • DOI

      10.1371/journal.pone.0132367

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat2015

    • Author(s)
      Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 11 Pages: 1443-1449

    • DOI

      10.1292/jvms.15-0198

    • NAID

      130005112081

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice2015

    • Author(s)
      Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, Hori M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 10 Pages: 1195-1199

    • DOI

      10.1292/jvms.15-0182

    • NAID

      130005107606

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus.2015

    • Author(s)
      Maehara T; Matsumoto K; Horiguchi K; Kondo M; Iino S; Horie S; Murata T; Tsubone H; Shimada S; Ozaki H; Hori M.
    • Journal Title

      Br J Pharmacol

      Volume: 172(4) Issue: 4 Pages: 1136-1147

    • DOI

      10.1111/bph.13006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of postmortem imaging system for anatomical education in skull base surgery.2015

    • Author(s)
      Kodera T, Arishima H, Kitai R, Kikuta K, Iino S, Noriki S, Naiki H.
    • Journal Title

      Neurosurg Rev.

      Volume: 38 Issue: 1 Pages: 165-170

    • DOI

      10.1007/s10143-014-0574-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.2015

    • Author(s)
      Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
    • Journal Title

      Nat Commun

      Volume: 10;6 Issue: 1 Pages: 7514-7514

    • DOI

      10.1038/ncomms8514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-neuronal cholinergic system in regulation of immune function with a focus on 7 nAChRs.2015

    • Author(s)
      Kawashima K, Fujii T, Moriwaki Y, Misawa H, Horiguchi K
    • Journal Title

      Inter Immunopharmacol

      Volume: 印刷中 Issue: 1 Pages: 127-134

    • DOI

      10.1016/j.intimp.2015.04.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells2015

    • Author(s)
      Park C, Lee MY, Slivano OJ, Park PJ, Ha S, Berent RM, Fuchs R, Collins NC, Yu TJ, Syn H, Park JK, Horiguchi K5, Miano JM, Sanders KM, Ro S
    • Journal Title

      Cell Death Dis

      Volume: 3;6 Issue: 12 Pages: e2011-e2011

    • DOI

      10.1038/cddis.2015.353

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease2015

    • Author(s)
      Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y
    • Journal Title

      Cytotechnology

      Volume: nd

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation.2014

    • Author(s)
      Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T.
    • Journal Title

      J Immunol

      Volume: Dec 15;193(12) Issue: 12 Pages: 5835-40

    • DOI

      10.4049/jimmunol.1303478

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages.2014

    • Author(s)
      Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M.
    • Journal Title

      J Pharmacol Sci

      Volume: 125(4) Pages: 394-405

    • NAID

      130004677798

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation.2014

    • Author(s)
      Kobayashi K, Sato K, Kida T, Omori K, Hori M, Ozaki H, Murata T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: Aug;34(8) Issue: 8 Pages: 1716-22

    • DOI

      10.1161/atvbaha.114.303890

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multiple roles of prostaglandin E2 -EP signal in vascular permeability2014

    • Author(s)
      Omori K, Kida T, Hori M, Ozaki H, Murata T.
    • Journal Title

      Br J Pharmacol

      Volume: Nov;171(21) Issue: 21 Pages: 4879-89

    • DOI

      10.1111/bph.12815

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mast cell-derived prostaglandin d2 inhibits colitis and colitis-associated colon cancer in mice2014

    • Author(s)
      Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
    • Journal Title

      Cancer Res

      Volume: Jun 1;74(11) Pages: 3011-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Alpha Lipoic Acid supressed migration and invasion via downregulation of cell surface β1-integrin expression in badder cancer cells2014

    • Author(s)
      Yamasaki, M., Iwase, M., Kawano, K., Sakakibara, Y., Suiko, M., Ikeda, M., Nishiyama, K.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 54 Pages: 18-25

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rikkunshito, a Kampo medicine, ameliorates post-operative ileus by anti-inflammatory action2014

    • Author(s)
      Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T.
    • Journal Title

      J Pharmacol Sci

      Volume: 124(3) Pages: 374-85

    • NAID

      130003391491

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The role of cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-112014

    • Author(s)
      Takahashi, S., Muta, K., Sonoda, H., Kato, A., Abdeen, A., Ikeda, M.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 315-320

    • DOI

      10.1016/j.fob.2014.03.005

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in the myenteric layer in mouse ileal longitudinal smooth muscles.2014

    • Author(s)
      Tanahashi Y, Ichimura Y, Kimura K, Matsuyama H, Iino S, Komori S, Unno T.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol.

      Volume: 387 Issue: 4 Pages: 377-388

    • DOI

      10.1007/s00210-013-0944-2

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SLURP-1, an endogenous 7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity.2014

    • Author(s)
      藤井 健志
    • Journal Title

      Journal of Neuroimmunology

      Volume: 267 Issue: 1-2 Pages: 4349-4349

    • DOI

      10.1016/j.jneuroim.2013.12.003

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during theprogression of skin inflammation.2014

    • Author(s)
      Hana Sarashina, Yoshiki Tsubosaka, Keisuke Omori, Kosuke Aritake, Takayuki Nakagawa, Masatoshi Hori, Hiroyuki Hirai, Masataka Nakamura, Shuh Narumiya, Yoshihiro Urade, Hiroshi Ozaki and Takahisa Murata
    • Journal Title

      The Journal of Immunology

      Volume: 192(1) Issue: 1 Pages: 459-65

    • DOI

      10.4049/jimmunol.1302080

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac12014

    • Author(s)
      Kida T, Omori K, Hori M, Ozaki H, Murata T
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 348(1) Issue: 1 Pages: 125-130

    • DOI

      10.1124/jpet.113.209288

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice.2014

    • Author(s)
      Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H.
    • Journal Title

      British Journal of Pharmacology

      Volume: 171 Issue: 2 Pages: 375-388

    • DOI

      10.1111/bph.12452

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors.2014

    • Author(s)
      Endo M, Hori M, Ozaki H, Oikawa T, Hanawa T.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 6 Pages: 1026-1039

    • DOI

      10.1007/s00535-013-0854-6

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diverse effects of prostaglandin E2 on vascular contractility2014

    • Author(s)
      Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, Murata T
    • Journal Title

      Heart Vessels

      Volume: 29(3) Issue: 3 Pages: 390-395

    • DOI

      10.1007/s00380-013-0374-6

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary excretion pattern of exosomal aquaporin-2 in rats that received gentamicin.2014

    • Author(s)
      Ahmed Abdeen, Hiroko Sonoda, Ragab El-Shawarby, Saki Takahashi, Masahiro Ikeda
    • Journal Title

      American Journal of Physiology. Renal Physiology

      Volume: 307 Issue: 11 Pages: F1227-F1237

    • DOI

      10.1152/ajprenal.00140.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells2014

    • Author(s)
      Masao Yamasaki, Masahiro Iwase, Kazuo Kawano, Yoichi Sakakibara, Masahito Suiko, Masahiro Ikeda, Kazuo Nishiyama
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 1 Pages: 18-25

    • DOI

      10.3164/jcbn.13-57

    • NAID

      130004466739

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Anoikis-Resistant Cells in Mouse Colonic Epithelium.2013

    • Author(s)
      Kawasaki H, Yoshida T, Horiguchi K, Ohama T, Sato K
    • Journal Title

      J Vet Med Sci

      Volume: 75(9) Pages: 1173-1180

    • NAID

      130003362200

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of M2 and M3 muscarinic receptors in the generation of  rhythmic motor activity in mouse small intestine.2013

    • Author(s)
      Tanahashi Y, Waki N, Unno T, Matsuyama H, Iino S,  Kitazawa T, Yamada M,   Komori S.
    • Journal Title

      Neurogastroenterology and Motility

      Volume: 25 Issue: 10 Pages: 687-697

    • DOI

      10.1111/nmo.12194

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration of Ileal Pacemaker Activity in Mice Lacking Interleukin-102013

    • Author(s)
      Habibul B. Shozib, Haruhiko Suzuki, Satoshi Iino,Shinsuke Nakayama
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 19(8) Issue: 8 Pages: 1577-85

    • DOI

      10.1097/mib.0b013e31828eedf5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway2013

    • Author(s)
      Kobayashi K、Tsubosaka Y, Hori M
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 33 Issue: 3 Pages: 565-571

    • DOI

      10.1161/atvbaha.112.300993

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts2013

    • Author(s)
      Iwanaga K, Murata T, Hori M, Ozaki H
    • Journal Title

      Eur J Pharmacol

      Volume: 702(1-3) Issue: 1-3 Pages: 158-164

    • DOI

      10.1016/j.ejphar.2013.01.025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes2013

    • Author(s)
      Shingo Maeda
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: (印刷中) Issue: 1-2 Pages: 17-25

    • DOI

      10.1016/j.vetimm.2013.01.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement2013

    • Author(s)
      Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110(13) Issue: 13 Pages: 5205-5210

    • DOI

      10.1073/pnas.1218091110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin D<sub>2</sub> Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor2013

    • Author(s)
      Ayabe S, Kida T, Hori M, Ozaki H, Murata T.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 121 Issue: 4 Pages: 312-317

    • DOI

      10.1254/jphs.12275FP

    • NAID

      10031171141

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells2013

    • Author(s)
      Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33(7) Issue: 7 Pages: 1663-1669

    • DOI

      10.1161/atvbaha.113.301565

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UDP induces intestinal epithelial migration via the P2Y6 receptor2013

    • Author(s)
      Nakamura T, Murata T, Hori M, Ozaki H
    • Journal Title

      Br J Pharmacol

      Volume: 170(4) Issue: 4 Pages: 883-892

    • DOI

      10.1111/bph.12334

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Proof of importance of phospho-CPI-17 at Thr38 in maintenance of normotensive pressure using genetically modified mice2018

    • Author(s)
      Hori M
    • Organizer
      第95回 日本生理学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neural anti-inflammatory action mediated through two types of ACh receptors of small intestine in POI model mice. For Mosapride citrate2017

    • Author(s)
      Hori M
    • Organizer
      ANMA & JSNM Joint Meeting 2017 (5th Biennial Congress of the Asian Neurogastroenterology & Motility Association (ANMA) and 19th Japanese Society of Neurogastroenterology and Motility (JSNM))
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CPI-17ノックアウトマウスを用いた気管支平滑筋の収縮におけるCPI-17の機能解析2017

    • Author(s)
      加田 浩大、 Qunhui Yang、 梶 典幸、 尾崎 博、 堀 正敏
    • Organizer
      第59回日本平滑筋学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 5-フルオロウラシルによる腸管上皮細胞のアポトーシスはセロトニン3A受容体シグナルを介して増強される2017

    • Author(s)
      三河 翔馬、梶 典幸、三原 大輝、尾崎 博、堀 正敏
    • Organizer
      第137回日本薬理学会関東部会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pathogenic role of P2X7 in postoperative ileus2017

    • Author(s)
      Yamazaki T, Mikawa S, Kaji N, Ozaki H, Hori M
    • Organizer
      The 90th Annual Meeting of the Japanese Pharmacological Society
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The importance of intestinal macrophages for the anti-inflammatory action mediated by α7nAChR on postoperative ileus2017

    • Author(s)
      Nakashima J, Mihara T, Kaji N, Ozaki H, Hori M
    • Organizer
      The 90th Annual Meeting of the Japanese Pharmacological Society
    • Related Report
      2016 Annual Research Report
  • [Presentation] 消化器疾患の薬物治療2017

    • Author(s)
      堀 正敏
    • Organizer
      平成28年度日本獣医師会 獣医学術学会年次大会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] c-Kitシグナル異常を持つマウスにおける小腸カハール介在細胞の発生2017

    • Author(s)
      飯野哲、堀口里美、堀口和秀、橋本隆
    • Organizer
      日本顕微鏡学会 第73回学術講演会
    • Related Report
      2016 Annual Research Report
  • [Presentation] TNBS腸炎モデルマウスを用いた結腸筋層の傷害と回復過程研究2017

    • Author(s)
      飯野哲、堀口和秀、堀口里美、橋本隆、川原真代、杉本京平
    • Organizer
      第49回日本臨床分子形態学会総会・学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] The anti-inflammatory effect of honokiol on postoperative ileus.2016

    • Author(s)
      Mihara T, Mikawa S, Kaji N, Jan T-R, Ozaki H and Hori M
    • Organizer
      The 89th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Th1 inflammatory signaling impairs pacemaker function of interstitial cells of Cajal through nitric oxide-induced oxidative stress.2016

    • Author(s)
      Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H and Hori M
    • Organizer
      The 89th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] The anti-inflammatory action of honokiol, a herbal medicinal product, on postoperative ileus2016

    • Author(s)
      Mihara T,Mikawa S, Kaji N, Jan T-R, Ozaki H and Hori M
    • Organizer
      The Joint Symposium of the 7th Veterinary Research among Universities of Veterinary Medicine in East Asia
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural anti-inflammatory signaling via activating 5-HT4 receptor in gastrointestine2016

    • Author(s)
      Hori M
    • Organizer
      The Joint Symposium of the 7th Veterinary Research among Universities of Veterinary Medicine in East Asia
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Th1 inflammatory signaling impairs pacemaker function of interstitial cells of Cajal through nitric oxide-induced oxidative stress2016

    • Author(s)
      Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H and Hori M
    • Organizer
      The 89th Annual Meeting of the Japanese Pharmacological Society
    • Related Report
      2016 Annual Research Report
  • [Presentation] The function of intestinal pacemaker cells is impaired by nitric oxide derived from resident macrophages and smooth muscle cells during Th1 inflammation2016

    • Author(s)
      Kaji N, Horiguchi K, Iino S, Nakayama S, Ozaki H and Hori M
    • Organizer
      The 24th International Symposium on Molecular Cell Biology of Macrophages (MMCB2016)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大建中湯の構成生薬・乾姜の抗炎症作用を介した術後腸管麻痺改善効果2015

    • Author(s)
      遠藤真理、堀正敏、尾崎博、及川哲郎、小田口浩、花輪嘉彦
    • Organizer
      第17回神経消化器病学会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県 国頭郡)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後イレウスにおけるホオノキの樹皮成分、ホノキオールによる抗炎症作用2015

    • Author(s)
      三原大輝、三河翔馬、梶典幸、トン・ロン ジャン、尾崎博、堀正敏
    • Organizer
      第17回神経消化器病学会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県 国頭郡)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] PTSDモデルラットの脳内におけるCRHの発現変化2015

    • Author(s)
      橋本隆、松田賢一、吉井崇喜、河田光博、飯野 哲
    • Organizer
      日本解剖学会第75回中部支部学術集会
    • Place of Presentation
      福井
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス消化管筋層のカハール介在細胞と線維芽細胞におけるムスカリン性アセチルコリン受容体の発現解析2015

    • Author(s)
      堀口里美,堀口和秀,飯野哲
    • Organizer
      日本解剖学会第75回中部支部学術集会
    • Place of Presentation
      福井
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 消化管におけるカハール介在細胞とその類縁細胞2015

    • Author(s)
      飯野 哲、堀口和秀
    • Organizer
      第47回日本臨床分子形態学会
    • Place of Presentation
      長崎
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 消化管間質を構成する細胞群の形態学的特性2015

    • Author(s)
      飯野 哲、堀口和秀
    • Organizer
      第57回日本平滑筋学会 シンポジウム
    • Place of Presentation
      山口
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 術後イレウスにおけるInterstitial cells of Cajalの病態変化特性2015

    • Author(s)
      梶 典幸、中山 晋介、飯野 哲、堀口 和秀、尾崎 博、堀 正敏
    • Organizer
      第57回日本平滑筋学会
    • Place of Presentation
      山口大学医学部(宇部市)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大建中湯の抗炎症作用~術後腸管麻痺モデルマウスで抗炎作用を発揮する生薬の同定~2015

    • Author(s)
      遠藤真理、堀 正敏、尾崎博、及川哲郎、花輪壽彦
    • Organizer
      第32回和漢医薬学会
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] The expression of small conductance calcium-activated potassium (SK3) channel is specifically concentrated at interstitial cells of the spaces between detrusor smooth muscle cells in the fuinea pig urinary bladder2015

    • Author(s)
      T Hayashi, M Takeya, K Uemura, T Kanazawa, S Iino, T Igawa, K Nakamura
    • Organizer
      Symposium on Multicellular Inputs Regulating Muscle Excitability
    • Place of Presentation
      Granlibakken Tahoe in Tahoe City, California
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Anti-inflammatory pathway via activation of cholinergic receptors in small intestine2015

    • Author(s)
      Kimura H, Imura Y, Kaji N, Mikawa S, Ozaki H, Hori M
    • Organizer
      Multicellular Inputs regulating muscle excitability
    • Place of Presentation
      Granlibakken Tahoe (Tahoe city, CA USA)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anti-inflammatory pathway via activation of cholinergic receptors in small intestine2015

    • Author(s)
      Kimura M, Imura Y, Kaji N, Mikawa S, Ozaki H, Hori M
    • Organizer
      Symposium on Multicellular inputs Regulating Muscle Excitability
    • Place of Presentation
      Granlibakken Tahoe (Tahoe city, CA USA)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anti-inflammatory pathway via activation of cholinergic receptors in small intestine2015

    • Author(s)
      Hori M, Kimura H, Imura Y, Kaji N, Mikawa S, Ozaki H.
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015 (23th MMCB)
    • Place of Presentation
      Ito International Research Center (Tokyo)
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tenascin-C mediates the suppressive effects on inflammation by the mesenchymal stem cell in dextran sulfate sodium induced colitis2015

    • Author(s)
      2)Atsushi Hoshino, Hisashi Hashimoto, Seiji Arihiro, Hiroshi Ozaki, Masatoshi Hori, Moriaki Kusakabe
    • Organizer
      DDW 2015
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス消化管におけるカハール介在細胞と線維芽細胞におけるムスカリン性アセチルコリン受容体の発現2015

    • Author(s)
      堀口 里美, 堀口 和秀, 飯野 哲
    • Organizer
      第120回日本解剖学会全国学術集会・第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成体マウス消化管におけるテネイシンC 産生細胞2015

    • Author(s)
      堀口 和秀, 堀口 里美, 日下部 守昭, 尾崎 博, 飯野 哲
    • Organizer
      第120回日本解剖学会全国学術集会・第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] DSS腸炎モデルに対する間葉系幹細胞(MSCs)による炎症抑制効果はテネイシンCを介する2015

    • Author(s)
      星野優、橋本尚詞、有廣誠二、田尻久雄、日下部守昭
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 術後イレウスモデルマウスにおけるカハール介在細胞の可塑性 Animal model of postoperative ileus is unique model to determine plastic property of ICC during infl ammation2015

    • Author(s)
      梶 典幸、中山 晋介、堀口 和秀、飯野 哲、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 (愛知県)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管におけるα7nACh受容体活性化を介した抗炎症作用 Antiinfl ammatory signaling via activation of α7nACh receptors in small intestine2015

    • Author(s)
      堀 正敏、猪村優貴、木村仁美、村田幸久、尾崎 博
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 (愛知県)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mast cell-derived PGD2 attenuates anaphylaxis 肥満細胞由来のPGD2 はアナフィラキシーショックを抑制する2015

    • Author(s)
      山田 涼太、中村 達朗、前田 真吾、有竹 浩介、堀 正敏、裏出 良博、尾崎 博、村田 幸久
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場 (愛知県)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] オンダンセトロンは腹腔マクロファージの5-HT3a受容体を阻害し術後イレウスを改善する2015

    • Author(s)
      堀 正敏、前原 都有子、松本 健次郎、村田 幸久、尾崎 博
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      京王プラザホテル (東京都)
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combined treatment with IFN-γ and LPS impairs pacemaker activity of interstitial cells of Cajal in small intestine2015

    • Author(s)
      N Kaji, T Murata, H Ozaki, M Hori
    • Organizer
      The Joint Symposium of the 6th Veterinary Research and the 3rd Veterinary Education among Universities of Veterinary Medicine in East Asia
    • Place of Presentation
      National Taiwan University (Taiwan)
    • Year and Date
      2015-02-02 – 2015-02-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 虚血再灌流による腎線維化モデルに おける尿中exosomeアクアポリン2タンパク質排泄量の変化についての検討2014

    • Author(s)
      園田紘子、木内みな美、髙橋早樹、池田正浩
    • Organizer
      第67回日 本薬理学会西南部会
    • Place of Presentation
      北九州
    • Year and Date
      2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Negative transcriptional regulation of aquaporin-1 by unfolded protein response2014

    • Author(s)
      Ayaka Kato, Hiroko Sonoda, Kanako Shigemura, Saki Takahashi and Masahiro Ikeda
    • Organizer
      American Society of Nephrology 47th Annual Meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] The decreased excretion of urinary exosomal aquaporin-2 during gentamicin-induced urine concentrating defect in rats2014

    • Author(s)
      Hiroko Sonoda, Ahmed Abdeen, Masahiro Ikeda
    • Organizer
      American Society of Nephrology 47th Annual Meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Urinary excretion patterns of exosomal AQP1 and AQP2 in a rat model of renal tubulointerstitial fibrosis2014

    • Author(s)
      Minami Kinouchi, Hiroko Sonoda, Saki Takahashi, Naoko Yokota-Ikeda, Masahiro Ikeda
    • Organizer
      American Society of Nephrology 47th Annual Meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 術後イレウスにおけるセロトニン受容体を介した抗炎症作用(シンポジウム;脳・神経・消化管の機能障害の基礎と臨床)2014

    • Author(s)
      堀 正敏、木村 仁美、土田 泰昭、猪村 優貴、尾崎 博
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大建中湯のα7 ニコチン性アセチルコリン受容体活性化による抗炎症作用を介した術後腸管麻痺改善効果~抗炎症作用を有する生薬の同定~2014

    • Author(s)
      遠藤 真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-HT4 受容体刺激による抗炎症作用はα7nACh 受容体依存性とmACh 受容体依存性の経路を介する2014

    • Author(s)
      木村 仁美、猪村 優貴、梶 典幸、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管機能におけるニューロキニン受容体阻害薬マロピタントの薬理学的解析2014

    • Author(s)
      山本 将平、梶 典幸、村田 幸久、尾崎 博、堀 正敏
    • Organizer
      第16回神経消化器病学会合同学術集会2014
    • Place of Presentation
      学術総合センター (東京都)
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管間質細胞におけるサイトグロビン発現2014

    • Author(s)
      飯野 哲, 堀口 和秀, 堀口 里美
    • Organizer
      第55回日本組織細胞化学会総会
    • Place of Presentation
      松本市
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The analysis of gene expression profiling in the tumor of tenascin-C knockout mice by cDNA microarray2014

    • Author(s)
      松本香織、中川貴之、西村亮平、日下部守昭
    • Organizer
      .第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食物アレルギーにおける新規バイオマーカーの発見2014

    • Author(s)
      前田 真吾、中村 達朗、有竹 浩介、裏出 良博 2、村田 幸久
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unfolded protein response誘導によるアクアポリン1発現調節2014

    • Author(s)
      加藤綾華、園田紘子、重村可南子、高橋早樹、池田正浩
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎線維化モデルにおける腎機能に重 要な尿中exosomeタンパク質のバイオマーカーとしての有用性に関する検討2014

    • Author(s)
      内みな美、園田紘子、髙橋早樹、池田正浩
    • Organizer
      第157回 日本獣医学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高食塩食負荷はマウス集合リンパ管の収縮頻度を増強する2014

    • Author(s)
      水野 理介、一色 政志、西本 光宏、藤田 敏郎、堀 正敏、尾崎 博
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combined treatment with IFN-c and LPS impaired pacemaker activity of interstitial cells of Cajal in small intestine2014

    • Author(s)
      N. Kaji, T. Murata, H. Ozaki, M. Hori
    • Organizer
      The 1st Federation of Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Guangzhou Baiyun International Convention Center (China)
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ameliorative actions of muscularis inflammation by antiemetic drugs, 5-HT3a receptor antagonists, in post-operative ileus2014

    • Author(s)
      H. Masatoshi, T. Maehara, Y. Imura, K. Matsumoto, S Horie, K. Horiguchi, S Iino, M. Kondo, S. Shimada, H. Tsubone, T. Murata, H. Ozaki
    • Organizer
      The 1st Federation of Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Guangzhou Baiyun International Convention Center (China)
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 六君子湯の術後腸管麻痺改善効果の作用機序2014

    • Author(s)
      遠藤真理、堀 正敏 、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      和漢医薬学会学術集会
    • Place of Presentation
      幕張メッセ (千葉県)
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス盲腸においてc-Kitを発現する平滑筋細胞2014

    • Author(s)
      飯野 哲, 堀口 和秀
    • Organizer
      第56回日本平滑筋学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] IFN-ɤ/LPSシグナルはInterstitial cell of Cajalのペースメーカー機能を障害する2014

    • Author(s)
      梶 典幸、村田幸久、尾崎 博、堀 正敏
    • Organizer
      第56回日本平滑筋学会総会
    • Place of Presentation
      新横浜プリンスホテル (神奈川県)
    • Year and Date
      2014-08-06 – 2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] cDNAマイクロアレイによるテネイシン-Cノックアウトマウスの腫瘍の遺伝子発現プロファイリング解析2014

    • Author(s)
      松本香織、中川貴之、西村亮平、日下部守昭
    • Organizer
      第23回乳癌基礎研究会
    • Place of Presentation
      筑波
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibition of macrophages but not neutrophils infiltration by 5-HT₄R stimulation Is mediated through α7nAChR activation post-operative ileus2014

    • Author(s)
      Hitomi Kimura, Yuki Imura, Noriyuki Kaji, Takahisa Murata, Hirokazu Tsubone, Hiroshi Ozaki, Masatoshi Hori
    • Organizer
      The 22nd International Symposium on Molecular of Macrophages
    • Place of Presentation
      The Kobe Chamber of Commerce and Industry (兵庫県)
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] c-Kitを発現する盲腸平滑筋細胞2014

    • Author(s)
      飯野 哲, 堀口 里美, 堀口 和秀
    • Organizer
      第70回日本顕微鏡学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 消化管における各種間質細胞でのサイトグロビン発現2014

    • Author(s)
      飯野 哲, 堀口 和秀:
    • Organizer
      第70回日本顕微鏡学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 5-HT4受容体刺激による術後イレウス改善効果はα7nACh受容体依存性と非依存性の経路を介する

    • Author(s)
      木村 仁美、猪村 優貴、梶 典幸、村田 幸久、局 博一、尾崎 博、堀 正敏
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2014 Annual Research Report
  • [Presentation] トロンボキサンA2は血管透過性の亢進を介して肺炎を悪化させる

    • Author(s)
      堀上 大貴、小林 幸司、堀 正敏、尾崎 博、村田 幸久
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満細胞由来のPGD2は食物アレルギーを抑制する

    • Author(s)
      中村 達朗、前田 真吾、前原 都有子、有竹 浩介、裏出 良博、村田 幸久
    • Organizer
      第157日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changes in the excretion of urinary exosomal AQP1 and AQP2 in rats with PAN-induced nephrotic syndrome

    • Author(s)
      A. Kaito, H. Sonoda, S. Takahashi, M. Ikeda
    • Organizer
      46th American Society of Nephrology Annual Meeting
    • Place of Presentation
      Atlanta, GA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多臓器不全のラボにおける解析

    • Author(s)
      池田正浩
    • Organizer
      平成25年度日本獣医師会獣医学術学会年次大会
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] 消化管筋層のカハール介在細胞と線維芽細胞におけるムスカリン性アセチルコリン受容体の発現

    • Author(s)
      飯野 哲、堀口里美、堀口和秀
    • Organizer
      第55回日本平滑筋学会総会
    • Place of Presentation
      旭川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成体マウス消化管におけるテネイシンC発現

    • Author(s)
      堀口和秀、堀口里美、日下部守昭、尾崎博、飯野哲
    • Organizer
      第119回 日本解剖学会総会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス盲腸筋層に観察されたc-Kit発現平滑筋細胞

    • Author(s)
      飯野 哲、堀口 和秀
    • Organizer
      第119回 日本解剖学会総会
    • Place of Presentation
      栃木
    • Related Report
      2013 Annual Research Report
  • [Presentation] TIF (tenascin inducing factor) はテネイシンCの翻訳調節因子である

    • Author(s)
      ・ 福田香織、斉藤友睦、中川貴之、西村亮平、日下部守昭
    • Organizer
      第22回乳癌基礎研究会
    • Place of Presentation
      津
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tenascin-C produced by cancerous cells is translationally regulated by humoral factor from cancer-associated fibroblast.

    • Author(s)
      ・ Fukuda-Matsumoto K., Saito T., Nakagawa T., Nishimura R., Kusakabe M
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] α7nACh受容体刺激は術後イレウスにおけるマクロファージ浸潤を特異的に抑制する

    • Author(s)
      堀 正敏、猪村優貴、村田幸久、尾崎博
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島ビューホテル、コラッセふくしま、ホテル福島グリーンパレス(福島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上皮下筋線維芽細胞におけるテネンシンC発現増加はマウス小腸粘膜保護に重要である

    • Author(s)
      Md Shafiqul Islam、日下部守昭、堀口和秀、飯野哲、中村達郎、岩永剛一、橋本尚詞、松本敏、村田幸久、堀正敏、尾崎博
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] TXA2は内皮バリアを崩壊させて急性肺炎を悪化させる

    • Author(s)
      堀上大貴、小林幸司、堀正敏、尾崎博、村田幸久
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-17AはiNOS発現を介して消化管平滑筋収縮を抑制する

    • Author(s)
      森大祐、渡辺伸昌、神沼修、村田幸久、尾崎博、堀正敏
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 六君子湯の抗炎症作用による術後腸管麻痺改善効果

    • Author(s)
      遠藤真理、堀 正敏、及川哲郎、尾崎博、花輪壽彦
    • Organizer
      第15回 神経消化器病学会
    • Place of Presentation
      ビックハート出雲(島根県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 病態と平滑筋収縮蛋白系の制御異常

    • Author(s)
      堀正敏
    • Organizer
      第55回日本平滑筋学会総会
    • Place of Presentation
      旭川市第節クリスタルホール(北海道)
    • Related Report
      2013 Annual Research Report
  • [Book] Regulation of aquaporins by vasopressin in the kidney2015

    • Author(s)
      Ikeda M, Matsuzaki T
    • Total Pages
      30
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report
  • [Remarks] 組織再生・修復における間葉系細胞のダイナミズム

    • URL

      http://www.vm.a.u-tokyo.ac.jp/yakuri/kiban-s-new/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 組織修復・再生における間葉系細胞のダイナミズム:統合型研究

    • URL

      http://www.vm.a.u-tokyo.ac.jp/yakuri/kiban-s-new/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 基盤研究S: 組織修復・再生における間葉系細胞のダイナミズム:統合型研究

    • URL

      http://webpark1713.sakura.ne.jp/kiban-s-new/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 組織修復・再生における間葉系細胞のダイナミズム 基盤研究S

    • URL

      http://www.vm.a.u-tokyo.ac.jp/yakuri/kiban-s-new/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-06-20   Modified: 2019-07-29  

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