| Budget Amount *help |
¥213,980,000 (Direct Cost: ¥164,600,000、Indirect Cost: ¥49,380,000)
Fiscal Year 2017: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2016: ¥36,530,000 (Direct Cost: ¥28,100,000、Indirect Cost: ¥8,430,000)
Fiscal Year 2015: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2014: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2013: ¥61,100,000 (Direct Cost: ¥47,000,000、Indirect Cost: ¥14,100,000)
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| Outline of Final Research Achievements |
In this project, we focused on 4 themes, (1) Oxidative stress response regulated with ASK family complexes, (2) Bidirectional osmotic stress response regulated by ASK3, (3) ER stress response and Zn homeostasis regulated by SOD1/Derlin-1 interaction, (4) Mitochondria stress response through cleavage of PGAM5. All of themes are originated from our previous findings, and we have further promoted the knowledge of these stress response in molecular and in vivo level, clarifying novel molecular mechanisms and providing foundation of drug discovery.
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