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Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

Research Project

Project/Area Number 25221302
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

ICHIJO Hidenori  東京大学, 大学院薬学系研究科(薬学部), 教授 (00242206)

Co-Investigator(Renkei-kenkyūsha) NAGURO Isao  東京大学, 大学院薬学系研究科, 准教授 (80401222)
FUJISAWA Takao  東京大学, 大学院薬学系研究科, 助教 (50636644)
SEKINE Shiori  東京大学, 大学院薬学系研究科, 助教 (70612654)
Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥213,980,000 (Direct Cost: ¥164,600,000、Indirect Cost: ¥49,380,000)
Fiscal Year 2017: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2016: ¥36,530,000 (Direct Cost: ¥28,100,000、Indirect Cost: ¥8,430,000)
Fiscal Year 2015: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2014: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2013: ¥61,100,000 (Direct Cost: ¥47,000,000、Indirect Cost: ¥14,100,000)
KeywordsASK1 / ASKファミリー / 酸化ストレス / 浸透圧ストレス / 小胞体ストレス / ミトコンドリアストレス / シグナル伝達 / ストレス
Outline of Final Research Achievements

In this project, we focused on 4 themes, (1) Oxidative stress response regulated with ASK family complexes, (2) Bidirectional osmotic stress response regulated by ASK3, (3) ER stress response and Zn homeostasis regulated by SOD1/Derlin-1 interaction, (4) Mitochondria stress response through cleavage of PGAM5. All of themes are originated from our previous findings, and we have further promoted the knowledge of these stress response in molecular and in vivo level, clarifying novel molecular mechanisms and providing foundation of drug discovery.

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A+: Progress in the research exceeds the initial goal. More than expected research results are expected.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (104 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (40 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 40 results,  Open Access: 27 results,  Acknowledgement Compliant: 12 results) Presentation (62 results) (of which Int'l Joint Research: 14 results,  Invited: 16 results) Book (1 results)

  • [Int'l Joint Research] The Children's Hospital of Philadelphia,/Thomas Jefferson University/Robert Wood Johnson Medical School(米国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] ASK family kinases mediate cellular stress and redox signaling to circadian clock2018

    • Author(s)
      Imamura Kiyomichi、Yoshitane Hikari、Hattori Kazuki、Yamaguchi Mitsuo、Yoshida Kento、Okubo Takenori、Naguro Isao、Ichijo Hidenori、Fukada Yoshitaka
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 14 Pages: 3646-3651

    • DOI

      10.1073/pnas.1719298115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress2018

    • Author(s)
      Watanabe Kengo、Umeda Tsuyoshi、Niwa Kuniyoshi、Naguro Isao、Ichijo Hidenori
    • Journal Title

      Cell Reports

      Volume: 22 Issue: 11 Pages: 2809-2817

    • DOI

      10.1016/j.celrep.2018.02.045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.2018

    • Author(s)
      Galluzzi, L. et al.
    • Journal Title

      Cell Death Differ.

      Volume: 25 Issue: 3 Pages: 486-541

    • DOI

      10.1038/s41418-017-0012-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] mASKing cancer cells in a tumor microenvironment2018

    • Author(s)
      Kamiyama Miki、Naguro, Isao、Ichijo Hidenori
    • Journal Title

      Cell Cycle

      Volume: 17 Issue: 2 Pages: 139-140

    • DOI

      10.1080/15384101.2017.1407402

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptosis signal-regulating kinase 1 in regulated necrosis2018

    • Author(s)
      Hattori Kazuki、Ichijo Hidenori
    • Journal Title

      Cell Cycle

      Volume: 17 Issue: 1 Pages: 5-6

    • DOI

      10.1080/15384101.2017.1397330

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging2017

    • Author(s)
      Hasegawa Yu、Toyama Kensuke、Uekawa Ken、Ichijo Hidenori、Kim-Mitsuyama Shokei
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 61 Issue: 1 Pages: 259-263

    • DOI

      10.3233/jad-170645

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1 negative regulator PRMT1.2017

    • Author(s)
      Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H., Matsuzawa, A.
    • Journal Title

      Cell Rep.

      Volume: 21 Issue: 9 Pages: 2447-2457

    • DOI

      10.1016/j.celrep.2017.11.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of apoptosis signal-regulating kinase-1 in house dust miteinduced allergic asthma in mice2017

    • Author(s)
      Maruoka, S., Gon, Y., Mizumura, K., Okamoto, S., Tsuya, K., Shikano, S., Soda, K., Naguro, I., Ichijo, H. and Hashimoto, S.
    • Journal Title

      Allergology International

      Volume: 66 Issue: Supplement.1 Pages: S50-S52

    • DOI

      10.1016/j.alit.2017.05.007

    • NAID

      130006182289

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway2017

    • Author(s)
      Hattori Kazuki、Ishikawa Hiroyuki、Sakauchi Chihiro、Takayanagi Saki、Naguro Isao、Ichijo Hidenori
    • Journal Title

      EMBO reports

      Volume: 18 Issue: 11 Pages: 2067-2078

    • DOI

      10.15252/embr.201744228

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.2017

    • Author(s)
      Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., Ichijo, H.
    • Journal Title

      Cell Death and Differentiation

      Volume: 24 Issue: 12 Pages: 2066-2076

    • DOI

      10.1038/cdd.2017.114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures of PGAM5 provide insight into active site plasticity and multimeric assembly.2017

    • Author(s)
      Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schroder, M., Sekine, S., Ichij, H., Engen, J. R., Takeda, K., Knapp, S.
    • Journal Title

      Structure 25, 1089-1099 (2017)

      Volume: 25 Issue: 7 Pages: 1089-1099

    • DOI

      10.1016/j.str.2017.05.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Apoptosis signal-regulating kinase 1 regulates platelet granule secretion, thromboxane A2 generation, and thrombus formation in mice.2017

    • Author(s)
      Naik, M.-U. Patel, P., Derstine, R., Turaga, R., Chen, X., Golla, K., Neeves, K.-B., Ichijo, H. and Naik, U.-K.
    • Journal Title

      Blood

      Volume: 29 Issue: 9 Pages: 1197-1209

    • DOI

      10.1182/blood-2016-07-729780

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] iPSC-based drug repositioning identifies the Src/c-Abl pathway as a therapeutic target for ALS motor neurons.2017

    • Author(s)
      Imamura, K. et al.
    • Journal Title

      Sci. Transl. Med.

      Volume: in pres

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pleiotropic properties of ASK1.2017

    • Author(s)
      Sakauchi C, Wakatsuki H, Ichijo H, Hattori K.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1861 Issue: 1 Pages: 3030-3038

    • DOI

      10.1016/j.bbagen.2016.09.028

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KLHDC10 deficiency protects mice against TNFα-induced systemic inflammation.2016

    • Author(s)
      Yamaguchi, N., Sekine, S., Naguro, I., Sekine, Y. and Ichijo, H.
    • Journal Title

      PLOS one

      Volume: 11 Issue: 9 Pages: e0163118-e0163118

    • DOI

      10.1371/journal.pone.0163118

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.2016

    • Author(s)
      Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S.
    • Journal Title

      Elife

      Volume: 18357 Pages: 18357-18357

    • DOI

      10.7554/elife.18357

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitogen-activated protein kinases as key players in osmotic stress signaling.2016

    • Author(s)
      Zhou, X., Naguro, I., Ichijo, H. and Watanabe, K.
    • Journal Title

      Biochem. Biophys. Acta

      Volume: 1860 Issue: 9 Pages: 2037-2052

    • DOI

      10.1016/j.bbagen.2016.05.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mislocalization, aggregation formation and defect in proteolysis in ALS2016

    • Author(s)
      Tsubota, A., Ichijo, H. and Homma, K.
    • Journal Title

      AIMS Molecular Science

      Volume: 3 Issue: 2 Pages: 246-268

    • DOI

      10.3934/molsci.2016.2.246

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASK1 signaling regulates brown and beige adipocyte maturation2016

    • Author(s)
      Kazuki H, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, and Ichijo H
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11158-11158

    • DOI

      10.1038/ncomms11158

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress2016

    • Author(s)
      Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
    • Journal Title

      EBioMedicine

      Volume: 6 Pages: 82-92

    • DOI

      10.1016/j.ebiom.2016.01.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.2016

    • Author(s)
      Maruyama J, Kobayashi Y, Umeda T, Vandewalle A, Takeda K, Ichijo H, Naguro I.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 18710-18710

    • DOI

      10.1038/srep18710

    • NAID

      120006987229

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.2016

    • Author(s)
      Hayashi, Y., Homma, K. and Ichijo, H.
    • Journal Title

      Adv. Biol. Regul.

      Volume: 60 Pages: 95-104

    • DOI

      10.1016/j.jbior.2015.10.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.2015

    • Author(s)
      Fujisawa, T., Yamaguchi, N., Kadowaki, H., Tsukamoto, Y., Tsuburaya, N., Tsubota, A., Takahashi, H., Naguro, I., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Homma, K. and Ichijo, H.
    • Journal Title

      Neurobiol. Dis.

      Volume: 82 Issue: 2 Pages: 478-486

    • DOI

      10.1093/hmg/ddv467

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of Cellular Signalling by Thioredoxin2015

    • Author(s)
      Machida, T., Ichijo, H. and Naguro, I.
    • Journal Title

      Redox Proteins in Supercomplexes and Signalosomes

      Volume: CRC Press Pages: 255-274

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.2015

    • Author(s)
      Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H
    • Journal Title

      Cell reports

      Volume: 13 Issue: 5 Pages: 944-956

    • DOI

      10.1016/j.celrep.2015.09.047

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.2015

    • Author(s)
      Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto T, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H
    • Journal Title

      Neurobiology of Disease

      Volume: 82 Pages: 478-486

    • DOI

      10.1016/j.nbd.2015.08.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.2015

    • Author(s)
      Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
    • Journal Title

      Science Signaling

      Volume: 8 Issue: 388 Pages: 1-12

    • DOI

      10.1126/scisignal.aab1883

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice.2015

    • Author(s)
      Toyama, K., Koibuchi, N., Hasegawa, Y., Uekawa, K., Yasuda, O., Sueta, D., Nakagawa, T., Ma, M., Kusaka, H., Lin, B., Ogawa, H., Ichijo, H. and Kim-Mitsuyamam S.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 10844-10844

    • DOI

      10.1038/srep14028

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of cytohesins protects against genetic models of motor neuron disease.2015

    • Author(s)
      Zhai, J., Zhang, L., Mojsilovic-Petrovic, J., Jian, X., Thomas, J., Homma, K., Schmitz, A., Famulok, M., Ichijo, H., Argon, Y., Randazzo, P. and Kalb, R.
    • Journal Title

      J. Neurosci.

      Volume: 35 Issue: 24 Pages: 9086-9105

    • DOI

      10.1523/jneurosci.5032-13.2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression2015

    • Author(s)
      Kamiyama, M., Naguro, I. and Ichijo, H.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 785-796

    • DOI

      10.1111/cas.12676

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis2015

    • Author(s)
      Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.
    • Journal Title

      J Biol Chem

      Volume: in press Issue: 17 Pages: 10791-10803

    • DOI

      10.1074/jbc.m114.623280

    • NAID

      120007150218

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an activator of the GAPDH-Siah1 Stress-Signaling Cascade.2015

    • Author(s)
      Tristan C.A., Ramos A., Shahani N., Emiliani F.E., Nakajima H., Noeh C.C., Kato Y., Takeuchi T., Noguchi T., Kadowaki H., Sedlak T.W., Ishizuka K., Ichijo H., Sawa, A.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 1 Pages: 56-64

    • DOI

      10.1074/jbc.m114.596205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial proteolysis: Its emerging roles in stress responses.2015

    • Author(s)
      Sekine, S. and Ichijo, H.
    • Journal Title

      B.B.A.

      Volume: 1850 Issue: 2 Pages: 274-280

    • DOI

      10.1016/j.bbagen.2014.10.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Apoptosis Signal Regulating Kinase 1 Modulates the Phenotype of α-Synuclein Transgenic Mice.2015

    • Author(s)
      Lee, K.-W., Woo, J.-M., Im, J.-Y., Park, E.-S., He, L., Ichijo, H., Junn, E. and Mouradian M. M.
    • Journal Title

      Neurobiol. Aging

      Volume: 36 Issue: 1 Pages: 519-526

    • DOI

      10.1016/j.neurobiolaging.2014.07.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential versus accessory aspects of cell death: recommendations of the NCCD 20152014

    • Author(s)
      Galluzzi, L. et al.
    • Journal Title

      Cell Death Differentiation

      Volume: 22 Issue: 1 Pages: 58-73

    • DOI

      10.1038/cdd.2014.137

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival.2014

    • Author(s)
      Eaton, G. J., Zhang, Q. S., Diallo, C., Matsuzawa, A., Ichijo, H., Steinbeck, M. J., Freeman, T. A.
    • Journal Title

      Cell Death Dis.

      Volume: 5 Issue: 11 Pages: e1522-e1522

    • DOI

      10.1038/cddis.2014.480

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses2014

    • Author(s)
      Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
    • Journal Title

      Sci. Signal.

      Volume: 7 Issue: 323

    • DOI

      10.1126/scisignal.2004841

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses2014

    • Author(s)
      Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A. and Ichijo, H.
    • Journal Title

      Sci. Signal.

      Volume: 7 Issue: 309

    • DOI

      10.1126/scisignal.2004822

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.2014

    • Author(s)
      Okada, M., Matsuzawa, A., Yoshimura, A. and Ichijo, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 47 Pages: 32926-32936

    • DOI

      10.1074/jbc.m114.579961

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SOD1 as a molecular switch for initiating the homeostatic ER stress respouse under zinc deficiency.2013

    • Author(s)
      Homma, K., Fujisawa. T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
    • Journal Title

      Molecular Cell

      Volume: 52 Issue: 1 Pages: 75-86

    • DOI

      10.1016/j.molcel.2013.08.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ストレスシグナルのメカニズム解明から創薬へ2017

    • Author(s)
      一條秀憲
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] レドックスをはじめとする多様なストレスシグナルにおけるASKファミリーの機能2017

    • Author(s)
      一條秀憲
    • Organizer
      第13回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      奈良女子大学(奈良県奈良市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASK1-JNK/p38 axis regulates tumor lung metastasis and platelet functions through phosphorylation of ADP receptor P2Y122017

    • Author(s)
      Miki Kamiyama1, Kosuke Fuse1, Isao Naguro1, Hidenori Ichijo1
    • Organizer
      Keystone Symposia Kinases: Next-Generation Insights and Approaches
    • Place of Presentation
      Colorado, United States of America
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ASK1 signaling regulates brown adipocyte maturation2017

    • Author(s)
      Hattori, K., Wakatsuki, H., Naguro, I. and Ichijo, H.
    • Organizer
      Keystone Symposia Kinases: Next-Generation Insights and Approaches
    • Place of Presentation
      Colorado, United States of America
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The mechanism of PKA-dependent ASK1 activation leading to adipocyte maturation2017

    • Author(s)
      Sakauchi, C., Takayanagi, S., Hattori, K. and Ichijo, H.
    • Organizer
      Keystone Symposia Kinases: Next-Generation Insights and Approaches
    • Place of Presentation
      Colorado, United States of America
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological and pathophysiological roles of SOD1 under Zinc deficiency2017

    • Author(s)
      Hidenori Ichijo
    • Organizer
      ISZB 5th meeting, in collaboration with Zinc-Net
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ASK family kinases in Stress Signaling and Disease2017

    • Author(s)
      Hidenori Ichijo
    • Organizer
      58th International Symposium on "Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ストレスシグナルの分子細胞生物学-その破綻と疾患と創薬-2017

    • Author(s)
      一條秀憲
    • Organizer
      第6回山梨医学フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ASK family kinases in Stress Signaling and Disease2017

    • Author(s)
      Hidenori Ichijo
    • Organizer
      第48回高松宮妃癌研究基金国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新たなストレスシグナル機構の発見から創薬基盤形成へ2017

    • Author(s)
      一條秀憲
    • Organizer
      上原賞受賞記念公園
    • Place of Presentation
      大正製薬上原記念ホール(東京都豊島区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞がストレスを感じる仕組みの解明から創薬へ~多様で複雑なストレス応答機構のハブとなるASKファミリー分子の解明を目指して=2017

    • Author(s)
      一條秀憲
    • Organizer
      第225回生命科学フォーラム
    • Place of Presentation
      日本記者クラブ(東京都千代田区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゲノムワイドsiRNAスクリーニングによるSOD1の構造制御機構の解明 A genome-wide siRNA screening of the genes responsible for regulating SOD1 conformation2016

    • Author(s)
      本間 謙吾、一條 秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASK1シグナルは褐色脂肪細胞の成熟化を制御し、個体の代謝に寄与する ASK1 signaling regulates brown adipocyte maturation and contributes to the metabolic activity2016

    • Author(s)
      服部一輝、名黒功、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] NADによる高浸透圧ストレス依存的ASK3不活性化制御 NAD regulation in ASK3 inactivation under hyperosmotic stress2016

    • Author(s)
      渡邊謙吾,名黒功,一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 血小板と血管内皮細胞におけるASK1が協調的に肺へのがん転移を制御する ASK1 in platelets and vascular endothelial cells coordinately regulates tumor lung metastasis2016

    • Author(s)
      神山美樹、名黒功、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高浸透圧ストレス下形成されるASK3顆粒構成因子の解析2016

    • Author(s)
      椎崎繁、名黒功、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞膨張感知分子を同定するためのゲノムワイドsiRNAスクリーニング Genome-wide siRNA Screens for Volume Sensors in Cell Swelling2016

    • Author(s)
      丹羽國祥,渡邊謙吾,名黒功,一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリア内膜局在型プロテインホスファターゼPGAM5の細胞レベル・個体レベルでの生理機能解析 The analysis of physiological roles of a mitochondrial inner membrane-resident protein phosphatase PGAM5 in vitro and in vivo2016

    • Author(s)
      菅原祥、服部一輝、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸化ストレス依存的な細胞死におけるMAPKの活性化パターンのシグナルセル解析2016

    • Author(s)
      石川万葉、名黒功、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脂肪細胞の分化を導くPKA依存的なASK1活性化のメカニズム The mechanism of PKA-dependent ASK1 activation leading to adipocyte maturation2016

    • Author(s)
      坂内千尋、服部一輝、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 浸透圧ストレス応答性キナーゼASK3のプロテアソームによる活性制御 Activity regulation of osmo-responsive kinase ASK3 by proteasome2016

    • Author(s)
      周翔宇,渡邊謙吾,名黒功, 一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゲノムワイドsiRNAスクリーニングによる亜鉛欠乏依存的なSOD1の構造変化を制御する因子の同定 Genome-wide siRNA screening identified mediators of SOD1 structural change under zinc deficiency2016

    • Author(s)
      坪田 充司, 本間 謙吾, 一條 秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸化ストレス強度依存的な細胞死形態の解析2016

    • Author(s)
      西田卓人、名黒功、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ALS発症機構としてのSOD1-Derlin-1結合を介したERAD阻害メカニズムの解析2016

    • Author(s)
      林 裕輝、本間 謙吾、一條 秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASK1の甲状腺における新規機能解析2016

    • Author(s)
      福和大翔、服部一輝、一條秀憲
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASKファミリーによるストレスシグナルとがん2016

    • Author(s)
      一條秀憲
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASK1シグナルは褐色脂肪細胞の成熟化を導く2016

    • Author(s)
      服部一輝、一條秀憲
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウン(東京都江東区)
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Stress-induced apoptosis2016

    • Author(s)
      Hidenori Ichijo
    • Organizer
      The 15th KICancer Retreat
    • Place of Presentation
      カロリンスカ研究所(ストックホルム、スウェーデン)
    • Year and Date
      2016-09-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] SOD-1-Derlin-1結合を標的としたALS治療薬の基盤開発2016

    • Author(s)
      圓谷奈保美、本間謙吾、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ubiquitin-dependent ASK1 signaling through novel interacting partner, beta-Trcp2016

    • Author(s)
      Ran Cheng、服部一輝、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化ストレス依存的な細胞死におけるMAPKの活性化パターンのシングルセル解析2016

    • Author(s)
      石川万葉、名黒功、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化ストレスにより引き起こされるネクローシス様細胞死の解析2016

    • Author(s)
      西田卓人、名黒功、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ASKファミリーの甲状腺における新規機能解析2016

    • Author(s)
      福和大翔、服部一輝、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 浸透圧ストレス依存的なASK3活性制御機構におけるTRAF2の機能解析 Analysis of the role of TRAF2 in the regulation of ASK3 activity under osmotic stress2016

    • Author(s)
      塩田光司、渡邊謙吾、一條秀憲
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ASK1-p38 axis regulates cold stress-induced cell death2016

    • Author(s)
      Kazuki Hattori, Chihiro Sakauchi, Isao Naguro and Hidenori Ichijo
    • Organizer
      Gordon Research Conferences -Cell Death-
    • Place of Presentation
      PGA Catalunya BUsiness and Convention Centre (Girona, Spain)
    • Year and Date
      2016-07-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of an image-based detection system of cell death in cell competition to perform a genomewide siRNA screen2016

    • Author(s)
      Yosuke Kawarazaki, Isao Naguro and Hidenori Ichijo
    • Organizer
      Gordon Research Conferences -Cell Death-
    • Place of Presentation
      PGA Catalunya BUsiness and Convention Centre (Girona, Spain)
    • Year and Date
      2016-07-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ASK1 in platelets and vascular endothelial cells coordinately regulates tumor lung metastasis2016

    • Author(s)
      Miki Kamiyama、Isao Naguro、Hidenori Ichijo
    • Organizer
      第41回内藤コンファレンス
    • Place of Presentation
      ガトーキングダム(北海道札幌市)
    • Year and Date
      2016-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] SOD1-Derlin-1結合を標的としたALS治療薬の基盤開発2016

    • Author(s)
      本間謙吾、圓谷奈保美、一條秀憲
    • Organizer
      日本細胞生物学会大会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血小板と血管内皮細胞におけるASK1が協調的に肺へのがん転移を制御する2016

    • Author(s)
      神山美樹、名黒功、一條秀憲
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] ASK1 regulates tumor lung metastasis and platelet functions2016

    • Author(s)
      Miki Kamiyama, Isao Naguro, Hidenori Ichijo
    • Organizer
      International Conference on Thrombosis and Hemostasis In Cancer
    • Place of Presentation
      Bergamo, Italy
    • Year and Date
      2016-04-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸化ストレス、小胞体ストレス、浸透圧ストレス、熱産生2016

    • Author(s)
      一條秀憲
    • Organizer
      第5回徳島文理大学薬学部学術講演会
    • Place of Presentation
      徳島文理大学(徳島県徳島市)
    • Year and Date
      2016-01-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ストレスシグナルと疾患~酸化ストレス、小胞体ストレス、浸透圧ストレス、熱産生~2016

    • Author(s)
      一條秀憲
    • Organizer
      第4回AAA(Academy of Aging and Cardiovascular-Diabetes Research)
    • Place of Presentation
      ロイヤルパークホテル(東京都中央区)
    • Year and Date
      2016-01-09
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞がストレスを感じる仕組みの解明から創薬へ2016

    • Author(s)
      一條秀憲
    • Organizer
      山形大学講義・セミナー
    • Place of Presentation
      山形大学(山形県山形市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞がストレスを感じる仕組みの解明から創薬へ2016

    • Author(s)
      一條秀憲
    • Organizer
      愛媛大学セミナー
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞がストレスを感じる仕組みの解明から創薬へ2016

    • Author(s)
      一條秀憲
    • Organizer
      第45回脳神経化学コアセンターセミナー
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] ストレスシグナルのメカニズム解明から創薬へ2016

    • Author(s)
      一條秀憲
    • Organizer
      第8回機能生化セミナー
    • Place of Presentation
      宮崎大学(宮崎県宮崎市)
    • Related Report
      2015 Annual Research Report
  • [Presentation] ストレスシグナルのメカニズム解明から創薬へ2016

    • Author(s)
      一條秀憲
    • Organizer
      第8回機能生化セミナー
    • Place of Presentation
      東京大学(東京都文京区)
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小胞体ストレスと神経細胞死2015

    • Author(s)
      一條秀憲
    • Organizer
      第9回臨床ストレス応答学会大会
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山県岡山市)
    • Year and Date
      2015-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of stress signaling in cell death and disease2015

    • Author(s)
      Hidenori Ichijo
    • Organizer
      Fifty-sixth International Symposium on "Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues"
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2015-10-05
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ER stress-dependent motoneuron toxicity and PPI-targeted drug screening in ALS.2015

    • Author(s)
      Hidenori Ichijo
    • Organizer
      6th Cisbio htrf symposium
    • Place of Presentation
      Cape Cod, Brewster, MA, USA
    • Year and Date
      2015-09-14
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小胞体ストレスと神経細胞死2015

    • Author(s)
      一條秀憲
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀 (東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ストレスシグナルのリン酸化シグナル伝達系の解明2015

    • Author(s)
      一條秀憲
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ubiquitin-dependent deguradation of ASK1 signaling pathway2015

    • Author(s)
      Hidenori Ichijo
    • Organizer
      International Symposium on Ubiquitin and Diseases
    • Place of Presentation
      Hunan, China
    • Year and Date
      2015-06-14
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ASK1はADPシグナルへの作用を介して血小板の機能を制御する2015

    • Author(s)
      一條秀憲
    • Organizer
      日本薬学会九州支部特別講演会
    • Place of Presentation
      長崎大学薬学部(長崎県長崎市)
    • Year and Date
      2015-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアストレスシグナルの機能解析2014

    • Author(s)
      一條秀憲
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2013 Annual Research Report
  • [Presentation] SOD1 as a molecular switch for initiating the homeostatic ER stress response under conditions of zinc deficiency2014

    • Author(s)
      Homma, K., Ichijo, H.
    • Organizer
      The 4th International ISZB Meeting
    • Place of Presentation
      CA, USA
    • Year and Date
      2014-09-14 – 2014-09-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] Oxidative stress-activated kinase ASK1 is involved in the tumorigenesis and tumor metastasis2014

    • Author(s)
      Naguro, I., Kamiyama, M., Ichijo, H.
    • Organizer
      Thiol-Based Redox Regulation & Signaling(Gordon Research Conference)
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ubiquitin-dependent regulation of ASK1 stress signaling in cell death2014

    • Author(s)
      Hidenori Ichijo
    • Organizer
      2014 KSBMB Annual Meeting
    • Place of Presentation
      COEX, Seaul, Korea
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Stress Signaling in Cell Death and Disease2013

    • Author(s)
      Ichijo, H.
    • Organizer
      The 8th Japan-Korea conference on cellular signalling for young scientists
    • Place of Presentation
      長崎
    • Year and Date
      2013-11-06 – 2013-11-07
    • Related Report
      2013 Annual Research Report
  • [Presentation] レドックス場としてのASK1シグナル複合体と細胞死2013

    • Author(s)
      一條秀憲
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11 – 2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Time resolved fluorescence-based screening assay for iidentification of chemical compounds that inhibit the interaction between ALS-related SOD1 Mutants2013

    • Author(s)
      Tsuburaya, N., Homma, K., Fujisawa, T., Ichijo, H.
    • Organizer
      RICT2013
    • Place of Presentation
      ニース, France
    • Year and Date
      2013-07-03 – 2013-07-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ask1 is involved in tumor metastasis in lung metastasis model through regulation of platelet functions2013

    • Author(s)
      Naguro, I., Ichijo, H., Kamiyama, M.
    • Organizer
      Next-Gen Kinase Inhibitors
    • Place of Presentation
      ボストン,USA
    • Year and Date
      2013-06-17 – 2013-06-19
    • Related Report
      2013 Annual Research Report
  • [Book] Advances in BIOLOGICAL REGULATION2017

    • Author(s)
      Guest Editors: Hidenori Ichijo and Isao Naguro
    • Total Pages
      90
    • Publisher
      ELSEVIER
    • Related Report
      2017 Annual Research Report

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Published: 2013-06-20   Modified: 2022-01-28  

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