• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Integrative study for functional analyses of stem cell maintenance factors and visualization of stem cells

Research Project

Project/Area Number 25221303
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionKyushu University

Principal Investigator

Nakayama Keiichi  九州大学, 生体防御医学研究所, 主幹教授 (80291508)

Co-Investigator(Kenkyū-buntansha) 中山 啓子  東北大学, 医学系研究科, 教授 (60294972)
白根 道子  九州大学, 生体防御医学研究所, 准教授 (90398082)
Co-Investigator(Renkei-kenkyūsha) GOTOH Yukiko  東京大学, 大学院薬学系研究科, 教授 (70252525)
Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥216,450,000 (Direct Cost: ¥166,500,000、Indirect Cost: ¥49,950,000)
Fiscal Year 2017: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2016: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2013: ¥51,610,000 (Direct Cost: ¥39,700,000、Indirect Cost: ¥11,910,000)
Keywords幹細胞 / 細胞周期 / p57 / 再生医科学 / 再生医学
Outline of Final Research Achievements

On the basis of our previous studies, we found that 1) low proliferation, 2) low metabolism, 3) low oxidation, which are attributable to p57, Fbw7, and Fbxl5, respectively, are hallmarks of tissue stem cells. The aim of this study is to elucidate the biological significance of p57, Fbw7, and Fbxl5 for stem cell function and maintenance. During the course of this study, we noticed that p57 is the most restricted marker for stem cells. We thus traced the lineage of p57-positive cells in mice, and found that p57 shows a stem cell-specific expression pattern in hematopoietic, neural, and intestinal stem cells. Furthermore, ablation of p57 gene in stem cells impaired the function and maintenance of stem cells with the cell cycle being aberrantly activated. These results thus suggested that cell cycle arrest induced by p57 CDK inhibitor is essential for stem cell function and maintenance. We also demonstrated that p57 is also required for cancer stem cells.

Assessment Rating
Verification Result (Rating)

A-

Assessment Rating
Result (Rating)

A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Report

(10 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (48 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (25 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 25 results,  Open Access: 13 results,  Acknowledgement Compliant: 4 results) Presentation (19 results) (of which Int'l Joint Research: 7 results,  Invited: 15 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.2018

    • Author(s)
      Nakayama S, Yumimoto K, Kawamura A, Nakayama KI.
    • Journal Title

      J. Biol. Chem.

      Volume: 293(15) Issue: 15 Pages: 5705-5714

    • DOI

      10.1074/jbc.ra117.000741

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.2018

    • Author(s)
      Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Minori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.
    • Journal Title

      Cancer Res.

      Volume: 78 Issue: 5 Pages: 1334-1346

    • DOI

      10.1158/0008-5472.can-17-3303

    • NAID

      120006452378

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robotic crowd biology with Maholo LabDroids.2017

    • Author(s)
      Yachie N; Robotic Biology Consortium (inc. Masaki Matsumoto)., Natsume T.
    • Journal Title

      Nature Biotechnology

      Volume: 35 Issue: 4 Pages: 310-312

    • DOI

      10.1038/nbt.3758

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.2017

    • Author(s)
      Muto, Y., *Nishiyama, M., Nita, A., Moroishi, T., *Nakayama, K. I.
    • Journal Title

      Nature Commun.

      Volume: 8 Issue: 1 Pages: 16114-16114

    • DOI

      10.1038/ncomms16114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages2017

    • Author(s)
      Nakatsumi Hirokazu、Matsumoto Masaki、Nakayama Keiichi I.
    • Journal Title

      Cell Reports

      Volume: 21 Issue: 9 Pages: 2471-2486

    • DOI

      10.1016/j.celrep.2017.11.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis for the assembly of the Ragulator-Rag GTPase complex.2017

    • Author(s)
      Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.
    • Journal Title

      Nat Commun.

      Volume: 8 Issue: 1 Pages: 1625-1625

    • DOI

      10.1038/s41467-017-01762-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.2017

    • Author(s)
      Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M
    • Journal Title

      Mol Cell

      Volume: Nov 16;68(4) Issue: 4 Pages: 645-658

    • DOI

      10.1016/j.molcel.2017.10.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp22017

    • Author(s)
      Zhang Shihao、Chen Qinghua、Liu Qingxu、Li Yuxi、Sun Xiufeng、Hong Lixin、Ji Suyuan、Liu Chengyan、Geng Jing、Zhang Weiji、Lu Zhonglei、Yin Zhen-Yu、Zeng Yuanyuan、Lin Kwang-Huei、Wu Qiao、Li Qiyuan、Nakayama Keiko、Nakayama Keiich I.、Deng Xianming、Johnson Randy L.、Zhu Liang、Gao Daming、Chen Lanfen、Zhou Dawang
    • Journal Title

      Cancer Cell

      Volume: 31 Issue: 5 Pages: 669-684.e7

    • DOI

      10.1016/j.ccell.2017.04.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells.2017

    • Author(s)
      Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A., Nakayama, K. I.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 37 Issue: 8

    • DOI

      10.1128/mcb.00470-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.2017

    • Author(s)
      Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP.
    • Journal Title

      Nature

      Volume: 541 Issue: 7636 Pages: 228-232

    • DOI

      10.1038/nature21034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.2017

    • Author(s)
      Ohnishi, T., Shirane, M., and Nakayama, K. I.
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 709-719

    • DOI

      10.1038/srep41130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice2016

    • Author(s)
      Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., Nakayama, K. I.
    • Journal Title

      Nature

      Volume: 537 Issue: 7622 Pages: 675-679

    • DOI

      10.1038/nature19357

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome2016

    • Author(s)
      Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A., Besson, A.
    • Journal Title

      J. Pathol.

      Volume: 239 Issue: 3 Pages: 250-261

    • DOI

      10.1002/path.4721

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development.2015

    • Author(s)
      Nishiyama, M., Nita, A., Yumimoto, K., Nakayama, K. I.
    • Journal Title

      Stem Cells

      Volume: 33 Issue: 11 Pages: 3327-3340

    • DOI

      10.1002/stem.2088

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells2015

    • Author(s)
      Shohei Furutachi, Hiroaki Miya, Tomoyuki Watanabe, Hiroki Kawai, Norihiko Yamasaki, Yujin Harada, Itaru Imayoshi, Mark Nelson, Keiichi I. Nakayama, Yusuke Hirabayashi and Yukiko Gotoh
    • Journal Title

      Nature Neuroscience

      Volume: 印刷中 Issue: 5 Pages: 657-65

    • DOI

      10.1038/nn.3989

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.2015

    • Author(s)
      agida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A.
    • Journal Title

      Dev Biol.

      Volume: 407(2) Issue: 2 Pages: 331-43

    • DOI

      10.1016/j.ydbio.2015.07.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner2015

    • Author(s)
      Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K., Nakayama, K. I.
    • Journal Title

      J. Clin. Invest.

      Volume: 125 Issue: 2 Pages: 621-635

    • DOI

      10.1172/jci78782

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling.2014

    • Author(s)
      Matsumoto, A., Takeishi, S., Nakayama, K. I.
    • Journal Title

      Blood

      Volume: 123 Issue: 22 Pages: 3429-39

    • DOI

      10.1182/blood-2013-10-532390

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells2014

    • Author(s)
      Shoichiro Takeishi, Keiichi I. Nakayama
    • Journal Title

      British Journal of Cancer

      Volume: 111 Issue: 6 Pages: 1054-1059

    • DOI

      10.1038/bjc.2014.259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal2014

    • Author(s)
      Kanatsu-Shinohara, M., Onoyama, I., Nakayama, K. I., Shinohara, T.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 111 Issue: 24 Pages: 8826-8831

    • DOI

      10.1073/pnas.1401837111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.2014

    • Author(s)
      Lu Z
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 3463-3463

    • DOI

      10.1038/ncomms4463

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis2013

    • Author(s)
      Furutachi S, Matsumoto A, Nakayama K.I, Gotoh Y
    • Journal Title

      EMBO J.

      Volume: 32 Issue: 7 Pages: 970-981

    • DOI

      10.1038/emboj.2013.50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] F-box and WD repeat domain containing-7 (Fbxw7) targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation2013

    • Author(s)
      Yumimoto K., Matsumoto M., Onoyama I., Imaizumi K., Nakayama KI.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 40 Pages: 28488-502

    • DOI

      10.1074/jbc.m113.465179

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex2013

    • Author(s)
      Yumimoto, K. Muneoka, T. Tsuboi, T. Nakayama, K. I.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 45 Pages: 32766-32776

    • DOI

      10.1074/jbc.m113.511303

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.2013

    • Author(s)
      Zhao H
    • Journal Title

      Cancer Cell

      Volume: 24 Issue: 5 Pages: 645-659

    • DOI

      10.1016/j.ccr.2013.09.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 次世代プロテオミクスによる「第二のワールブルグ効果」の発見2017

    • Author(s)
      中山敬一
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Next-generation proteomics unveils a global landscape of cancer metabolism2017

    • Author(s)
      Nakayama Keiichi I.
    • Organizer
      The 1st International Symposium for Trans-Omics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fbxw7 is essential for quiescence and drug resistance in cancer stem cell2017

    • Author(s)
      Nakayama Keiichi I.
    • Organizer
      Cullin RING ligases and Protein Neddylation: Biology and Therapeutics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Large-scale targeted proteomics unveils a global landscape of cancer metabolism2016

    • Author(s)
      Keiichi Nakayama
    • Organizer
      The 10th AACR-JCA Joint Conference on Breakthrough in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Maui, USA
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 造血幹細胞の機能維持におけるユビキチンリガーゼFBXL5による鉄代謝制御の重要性2016

    • Author(s)
      武藤義治, 西山正章, 仁田暁大, 諸石寿朗, 中山敬一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] 静止期維持因子p57は+4ポジション幹細胞の制御を介して腸管上皮の恒常性を維持する2016

    • Author(s)
      比嘉綱己, 沖田康孝, 松本有樹修, 武石昭一郎, 中津海洋一, 中山敬一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell cycle regulation in cancer stem cell2016

    • Author(s)
      Nakayama, K. I.
    • Organizer
      The 47th International Symposium of The Princess Takamatsu Cancer Research Fund: Current status and perspectiveof cancer stem cell research
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell cycle regulation in cancer stem cell2016

    • Author(s)
      Nakayama, K. I.
    • Organizer
      The Cell Cycle from Mechanism to Therapy
    • Place of Presentation
      トロント
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 次世代プロテオミクスが解き明かす生命システムの全体像2015

    • Author(s)
      中山敬一
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] p57は静止状態の腸管幹細胞を制御することで腸管上皮の恒常性を維持する2015

    • Author(s)
      比嘉綱己, 沖田康孝, 松本有樹修, 武石昭一郎, 中山敬一
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Deep and absolute quantification of human proteome unveils a global landscape of cancer metabolism2014

    • Author(s)
      Nakayama, K. I.
    • Organizer
      The 4th Japan-France Cancer Workshop
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 癌幹細胞の理解と制御:癌を完治させる治療戦略2014

    • Author(s)
      中山敬一
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ユビキチンリガーゼFBXL5による鉄代謝制御とその破綻2014

    • Author(s)
      中山敬一
    • Organizer
      第38回鉄バイオサイエンス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Disruption of quiescence by p57 ablation confers oncogene addiction on leukemia stem cells through altered microenvironmental regulation2014

    • Author(s)
      Takeishi, S., Matsumoto, A., Nakayama, K. I.
    • Organizer
      The 12th Stem Cell Research Symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] What is the Warburg effect? Next-generation proteomics uncovers the secret of cancer2013

    • Author(s)
      Keiichi I. Nakayama
    • Organizer
      3rd GDRI French Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Year and Date
      2013-11-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fbw7 is essential for maintenance of quiescence and function of cancer stem cells2013

    • Author(s)
      Keiichi I. Nakayama
    • Organizer
      The 23rd Hot Spring Harbor Symposium: Recent Advances in Stem Cell Biology 2013
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2013-11-05
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がん治療におけるFbxw7抑制の二面性:光と影2013

    • Author(s)
      中山敬一
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cell cycle and cancer stem cells: Abrogation of quiescence by Fbw7 ablation eliminates leukemia stem cells2013

    • Author(s)
      Keiichi I. Nakayama
    • Organizer
      ISEH 42nd Annual Scientific Meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2013-08-23
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fbw7 is essential for maintenance of quiescence and function of cancer stem cells2013

    • Author(s)
      Keiichi I. Nakayama
    • Organizer
      35th Naito Conference
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2013-07-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 実験医学別冊「見つける、量る、可視化する!質量分析実験ガイド」2013

    • Author(s)
      松本雅記、中山敬一
    • Total Pages
      10
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] がん基盤生物学ー革新的シーズ育成に向けてー2013

    • Author(s)
      武石昭一郎、中山敬一
    • Total Pages
      8
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Remarks] 九州大学生体防御医学研究所分子医科学分野

    • URL

      http://www.bioreg.kyushu-u.ac.jp/saibou/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report 2014 Annual Research Report 2013 Annual Research Report
  • [Remarks] Department of Molecular and Cellular Biology

    • URL

      http://www.bioreg.kyushu-u.ac.jp/saibou/index_en.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-06-20   Modified: 2019-05-15  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi