| Budget Amount *help |
¥191,880,000 (Direct Cost: ¥147,600,000、Indirect Cost: ¥44,280,000)
Fiscal Year 2017: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2016: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2015: ¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2014: ¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2013: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Outline of Final Research Achievements |
The immune system maintains homeostasis by positive and negative signaling, and dysregulation of thissytem leads to immune diseases such as allergies. This study aims to elucidate the basic principle of cytokines and their regulation which maintain the immune homeostasis, and to apply our findings to treatment of diseases. In this study, we found three important immunological factors that regulates the inflammatory responses. The first is NR4a transcription factors, which are necessary for the development and maintenance of regulatory T cells. The second is Smad transcription factors, which control the production of TGFβ, an immunosuppressive factor. The third is preparing macrophages which are involved in resolution of inflammation by clearing the factors released from dead cells.
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