| Budget Amount *help |
¥195,260,000 (Direct Cost: ¥150,200,000、Indirect Cost: ¥45,060,000)
Fiscal Year 2017: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2016: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2015: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
Fiscal Year 2014: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2013: ¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
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| Outline of Final Research Achievements |
To elucidate the effects of salt loading to the living organism, we started with investigating the WNK signaling system. Since the WNK signal is a recently discovered, novel regulatory system with most of its functions unknown, we first sought to elucidate its roles in each organ, to clarify its regulatory mechanisms, and to identify downstream target molecules. As a result, we have revealed that, in addition to its role in renal sodium handling, the WNK signal plays important roles in various tissues such as regulation of blood pressure via tonus regulation in vascular smooth muscle, adipocyte and myocyte differentiation, and control of immunological response. Next, we have shown how its dysregulation can lead to pathological consequences in response to salt loading or kidney injury. Moreover, we have established a unique chemical compound screening system and obtained promising drug seeds to regulate WNK signaling, paving the way for developing novel therapeutic intervention.
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