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Comprehensive study of the disorders of neural networks in the central nervous system and the biological systems that regulate their restoration

Research Project

Project/Area Number 25221309
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Yamashita Toshihide  大阪大学, 医学系研究科, 教授 (10301269)

Project Period (FY) 2013-05-31 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥202,800,000 (Direct Cost: ¥156,000,000、Indirect Cost: ¥46,800,000)
Fiscal Year 2017: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2016: ¥37,570,000 (Direct Cost: ¥28,900,000、Indirect Cost: ¥8,670,000)
Fiscal Year 2015: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2014: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2013: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Keywords神経科学 / 神経回路 / 神経疾患 / 神経修復 / 神経再生 / 中枢神経疾患 / 中枢神経 / 再生医学
Outline of Final Research Achievements

Disorders of the central nervous system, such as cerebrovascular diseases, cerebrospinal trauma, and encephalomyelitis, often cause spatiotemporal changes in the nervous system and in various biological systems, such as the immune system and vascular system. In this study, we analyzed disorders of the neural networks in the central nervous system and the subsequent restoration process from the perspective of the functional network of biological systems. Further, we analyzed the mechanism by which the spatiotemporal dynamics in those biological systems control a series of processes. Additionally, we elucidated the principles involved in the operation of living organisms with neural network disorders within the central nervous system by observing such disorders and their functional recovery process with respect to the dynamics of the entire biological system and by conducting a comprehensive analysis of the association between each system.

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A+: Progress in the research exceeds the initial goal. More than expected research results are expected.

Report

(9 results)
  • 2018 Research Progress Assessment (Verification Result) ( PDF )
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Abstract ( PDF )   Annual Research Report
  • Research Products

    (54 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Acknowledgement Compliant: 18 results,  Open Access: 11 results) Presentation (30 results) (of which Int'l Joint Research: 7 results,  Invited: 29 results) Remarks (2 results)

  • [Int'l Joint Research] ユトレヒト大学(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling.2017

    • Author(s)
      Fujitani, M., Zhang, S., Fujiki, R., Fujihara, Y. and Yamashita, T.
    • Journal Title

      Mol. Psychiatry

      Volume: 22 Issue: 3 Pages: 364-374

    • DOI

      10.1038/mp.2016.106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cohesin regulates formation of neuronal networks in the brain.2017

    • Author(s)
      Fujita, Y., Masuda, K., Nakato, R., Katou, Y., Tanaka, T., Nakayama, M., Takao, K., Miyakawa, T., Shirahige, K. and Yamashita, T.
    • Journal Title

      J. Exp. Med.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Leptin sustains spontaneous remyelination in the adult central nervous system.2017

    • Author(s)
      Matoba, K., Muramatsu, R. and Yamashita, T.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 40397-40397

    • DOI

      10.1038/srep40397

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain.2017

    • Author(s)
      Kanemitsu, Y., Fujitani, M., Fujita, Y., Zhang, S., Su, Y.Q., Kawahara, Y. and Yamashita, T.
    • Journal Title

      Sci. Rep.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.2016

    • Author(s)
      Hayano, Y., Takasu, K., Koyama, Y., Ogawa, K., Minami, K., Asaki, T., Kitada, K., Kuwabara, S. and Yamashita, T.
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 13 Pages: 2949-2966

    • DOI

      10.1084/jem.20160877

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The P2X4 receptor is required for neuroprotection via ischemic preconditioning.2016

    • Author(s)
      Ozaki, T., Muramatsu, R., Fujinaka, T., Yoshimine, T. and Yamashita, T.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 25893-25893

    • DOI

      10.1038/srep25893

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Repulsive guidance molecule A suppresses angiogenesis.2016

    • Author(s)
      Harada, K., Fujita, Y. and Yamashita, T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 469 Issue: 4 Pages: 993-999

    • DOI

      10.1016/j.bbrc.2015.12.073

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation.2016

    • Author(s)
      Kuroda, M., Muramatsu, R., and Yamashita, T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 482 Issue: 4 Pages: 1160-1164

    • DOI

      10.1016/j.bbrc.2016.12.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior, and memory deficits in mouse.2016

    • Author(s)
      Fujiwara, K., Fujita, Y., Kasai, A., Onaka, Y., Hashimoto, H., Okada, H. and Yamashita, T.
    • Journal Title

      Transl. Psychiatry

      Volume: 6 Issue: 3 Pages: e766-e766

    • DOI

      10.1038/tp.2016.31

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans2016

    • Author(s)
      Hajime Hamasaki, Masashi Fujitani, Toshihide Yamashita
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 471 Issue: 4 Pages: 522-527

    • DOI

      10.1016/j.bbrc.2016.02.042

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Microglia in central nervous system repair after injury.2016

    • Author(s)
      Jin, X. and Yamashita, T.
    • Journal Title

      J. Biochem

      Volume: 印刷中

    • NAID

      40020833554

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases.2015

    • Author(s)
      van Erp, S., van den Heuvel, D.M.A., Fujita, Y., Robinson, R.A., Hellemons, A.J., Adolfs, Y., Van Battum, E.Y., Blokhuis, A.M., Kuijpers, M., Demmers, J., Hedman, H., Hoogenraad, C.C., Siebold, C., Yamashita, T. and Pasterkamp, R.J.
    • Journal Title

      Dev. Cell

      Volume: 35 Issue: 5 Pages: 537-552

    • DOI

      10.1016/j.devcel.2015.11.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.2015

    • Author(s)
      Muramatsu, R., Kuroda, M., Matoba, K., Hsiaoyun, L., Takahashi, C., Koyama, Y. and Yamashita, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 18 Pages: 11515-11525

    • DOI

      10.1074/jbc.m114.587253

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acetylation of NDPK-D regulates its subcellular localization and cell survival.2015

    • Author(s)
      Fujita, Y., Fujiwara, K., Zenitani, S. and Yamashita, T.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 10 Pages: e0139616-e0139616

    • DOI

      10.1371/journal.pone.0139616

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury.2015

    • Author(s)
      Miyake, S., Muramatsu, R., Hamaguchi, M. and Yamashita, T.
    • Journal Title

      Cell Death Dis.

      Volume: 6 Issue: 2 Pages: e1638-e1638

    • DOI

      10.1038/cddis.2015.5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling.2015

    • Author(s)
      Sumimoto, S., Muramatsu, R. , Yamashita, T.
    • Journal Title

      Brain Res.

      Volume: 1594 Pages: 46-51

    • DOI

      10.1016/j.brainres.2014.07.048

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Repulsive guidance molecule-a is involved in Th17 cell-induced neurodegeneration in autoimmune encephalomyelitis.2014

    • Author(s)
      Shogo Tanabe, Toshihide Yamashita
    • Journal Title

      Cell Reports

      Volume: 9 Issue: 4 Pages: 1459-1470

    • DOI

      10.1016/j.celrep.2014.10.038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex.2014

    • Author(s)
      Zhang, S., Kanemitsu, Y., Fujitani, M. and Yamashita, T.
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 5984-5984

    • DOI

      10.1038/srep05984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vascular endothelial cells promote cortical neurite outgrowth via an integrin beta3-dependent mechanism2014

    • Author(s)
      Sumimoto, S., Muramatsu, R. , Fujii, S., Yamashita, T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 450 Issue: 1 Pages: 593-597

    • DOI

      10.1016/j.bbrc.2014.06.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Wnt/β-catenin signaling in the development of neuropathic pain.2014

    • Author(s)
      Itokazu T, Hayano Y, Takahashi R, Yamashita T.
    • Journal Title

      Neurosci Res.

      Volume: 79 Pages: 34-40

    • DOI

      10.1016/j.neures.2013.12.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth.2013

    • Author(s)
      Hasebe, N., Fujita, Y., Ueno, M., Yoshimura, K., Fujino, Y. and Yamashita, T.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 12 Pages: e82321-e82321

    • DOI

      10.1371/journal.pone.0082321

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中枢神経回路の修復を促進する治療戦略2016

    • Author(s)
      山下俊英
    • Organizer
      第59回日本脳循環代謝学会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 視神経保護と再生の分子治療戦略2016

    • Author(s)
      山下俊英
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neural network reorganization and functional recovery after central nervous system injury.2016

    • Author(s)
      Yamashita, T.
    • Organizer
      Molecular Neuroscience Forum at Weizmann Institute of Science
    • Place of Presentation
      Lehovat
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of neural network reorganization after the central nervous system injury2016

    • Author(s)
      山下俊英
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 中枢神経炎症の制御及び障害修復機構2016

    • Author(s)
      山下俊英
    • Organizer
      第1回Japanese School of Neuroimmunologyシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Challenges for finding a cure for patients with the CNS injuries.2016

    • Author(s)
      Yamashita, T.
    • Organizer
      2016 Biennial Meeting
    • Place of Presentation
      Liverpool
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経再生の最前線2016

    • Author(s)
      山下俊英
    • Organizer
      第39回日本顔面神経学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 中枢神経回路の障害と修復を制御する生体システム2016

    • Author(s)
      山下俊英
    • Organizer
      第63回日本生化学会近畿支部例会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis.2016

    • Author(s)
      Yamashita, T.
    • Organizer
      The 1st RGM international symposium
    • Place of Presentation
      淡路島
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経回路の障害と修復を制御する分子機構2016

    • Author(s)
      山下俊英
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Mechanisms of neural network reorganization under neurodegenrative disorders.2016

    • Author(s)
      Yamashita, T.
    • Organizer
      2016 Golden Helix Symposium
    • Place of Presentation
      Mansoura, Egypt
    • Year and Date
      2016-01-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経回路の障害と修復を制御する生体システム2015

    • Author(s)
      山下俊英
    • Organizer
      Advans研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中枢神経障害後の神経回路再編成と機能回復のメカニズム2015

    • Author(s)
      山下俊英
    • Organizer
      第2回再生医療とリハビリテーション研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biological mechanisms of neural rewiring regulation in the central nervous system.2015

    • Author(s)
      Yamashita, T.
    • Organizer
      Special Seminar at Shriners Hospitals Pediatric Research Center, Temple University School of Medicine
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経回路の障害と修復を制御するメカニズム2015

    • Author(s)
      山下俊英
    • Organizer
      新潟大学大学院医歯学総合研究科大学院セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 軸索変性を正と負に制御する分子機構2015

    • Author(s)
      山下俊英
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中枢神経障害後の神経回路再編成と機能回復のメカニズム2015

    • Author(s)
      山下俊英
    • Organizer
      第8回 上肢の神経機能回復セミナー
    • Place of Presentation
      角館
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biological mechanisms of neural rewiring regulation in the central nervous system.2015

    • Author(s)
      Yamashita, T.
    • Organizer
      1st Asia-Oceanian Congress for NeuroRehabilitation
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経炎症と神経変性:両者を制御する因子群の機能2015

    • Author(s)
      山下俊英
    • Organizer
      第13回新潟多発性硬化症研究会
    • Place of Presentation
      新潟
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biological mechanisms of neural rewiring regulation in the central nervous system2015

    • Author(s)
      山下俊英
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脳脊髄炎と血管新生を制御する因子2015

    • Author(s)
      山下俊英
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] RGMa regulates T cell responses and neurodegeneration in autoimmune encephalomyelitis.2015

    • Author(s)
      Yamashita, T.
    • Organizer
      Sendai Conference 2015
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RGMa modulates T cell responses and is involved in Th17 cell-induced neurodegeneration in autoimmune encephalomyelitis.2015

    • Author(s)
      Yamashita, T.
    • Organizer
      NCNP神経免疫国際シンポジウム
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiple sclerosis; neuroscience “Molecular mechanism of neurodegeneration induced by encephalomyelitis”2015

    • Author(s)
      山下俊英
    • Organizer
      第56回日本神経学会学術大会 Neuroscience Frontier Symposium
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] RGMa modulates T cell responses and is involved in Th17 cell-induced neurodegeneration in autoimmune encephalomyelitis2015

    • Author(s)
      山下俊英
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会 シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 軸索再生阻害因子を標的とした視神経再生および網膜保護2014

    • Author(s)
      山下俊英
    • Organizer
      第52回日本神経眼科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Bidirectional tuning of microglia during the developing cortex: From neurogenesis to neural circuit formation.2014

    • Author(s)
      Yamashita, T.
    • Organizer
      Korean Brain Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 皮質脊髄路の形成と修復を司る分子機構2014

    • Author(s)
      山下俊英
    • Organizer
      Neuroscience2014
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「中枢神経再生」の神経科学的基盤2014

    • Author(s)
      山下俊英
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      博多
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] RGMa inhibits angiogenesis in neovascular age-related macular regeneration.2014

    • Author(s)
      Harada, K., Fujita, Y., Yamashita, T.
    • Organizer
      World Ophthalmology Congress of the International Council of Ophthalmology 2014
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Annual Research Report
  • [Remarks] 中枢神経回路の障害と修復を制御する生体システムの統合的研究

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/researchk7.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科分子神経科学

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report

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Published: 2013-06-20   Modified: 2019-07-29  

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