Elucidation of Wnt signaling network controlling bone metabolism
| Project/Area Number |
25221310
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Udagawa Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
Kobayashi Yasuhiro 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
Nakamura Hiroaki 松本歯科大学, 歯学部, 教授 (50227930)
Taguchi Akira 松本歯科大学, 歯学部, 教授 (70243582)
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| Project Period (FY) |
2013-05-31 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥131,820,000 (Direct Cost: ¥101,400,000、Indirect Cost: ¥30,420,000)
Fiscal Year 2015: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2014: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2013: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
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| Keywords | 破骨細胞 / 骨芽細胞 / Ｗｎｔ / ＲＡＮＫＬ / ＯＰＧ / 骨代謝共役 / Wnt / OPG / RANKL |
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| Outline of Final Research Achievements |
Osteoclasts resorb old bone, and osteoblasts make new bone at the resorption site. Therefore, bone tissue is re-formed throughout the life. Although bone formation by osteoblasts is tightly coupled with bone resorption by osteoclasts, the molecular mechanism of the coupling phenomena is unknown. Wnt signaling is an important signal that regulates bone metabolism. In the present study, we showed that (1) Wnt molecules, which osteoclasts and osteoblasts secrete, strictly regulate bone metabolism, (2) osteoclasts regulates osteoblast function through the control of the Wnt signaling, and (3) Wnt signal regulatory agents will become good drugs for osteoporosis treatment.
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| Assessment Rating |
Verification Result (Rating)
B
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Assessment Rating |
Result (Rating)
A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.
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Report
(8 results)
Research Products
(22 results)
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[Journal Article] Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015
Author(s)
Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
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Journal Title
J Cell Sci
Volume: 128
Pages: 4353-4365
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
Related Report
Peer Reviewed / Open Access
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