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Synchrotron radiation micro-CT based analyses of 3D micro-architectures in lung diseases

Research Project

Project/Area Number 25240047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionThe University of Tokushima

Principal Investigator

Niki Noboru  徳島大学, 大学院理工学研究部, 教授 (80116847)

Co-Investigator(Kenkyū-buntansha) 河田 佳樹  徳島大学, ソシオテクノサイエンス研究部, 准教授 (70274264)
梅谷 啓二  公益財団法人高輝度光科学研究センター, 利用研究促進部門, 主幹研究員 (50344396)
中野 恭幸  滋賀医科大学, 医学部, 准教授 (00362377)
花岡 淳  滋賀医科大学, 医学部, 講師 (00452243)
村田 喜代史  滋賀医科大学, 医学部, 教授 (20127038)
伊藤 春海  福井大学, 高エネルギー医学研究センター, 特命教授 (40026943)
阪井 宏彰  京都大学, 医学(系)研究科(研究院), 非常勤講師 (50362489)
高橋 雅士  滋賀医科大学, 医学部, 非常勤講師 (20179526)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Keywords肺3次元ミクロ形態 / 肺胞毛細血管 / 3次元ミクロ病態(肺がん・COPD・間質性肺炎) / 放射光マイクロCT / 薄型蛍光板と拡大光学系 / 大容量3次元画像解析 / 放射光マクロCT / 大視野CT
Outline of Final Research Achievements

Quantitative understanding of spatial arrangement of the mirco-architectures is crucial for diagnosing the onset possibility of tissue disorder in an early-stage of pulmonary disease. Our goals of this research were as follows: establishing a preparation method for inflated lung specimens maintaining its precise 3D context within the intact lung secondary lobule in which micro vascular networks from arteriole and venule to alveolar capillaries are enhanced by perfusion of nanoparticle contrast agents and revealing how an onset of an early-stage of pulmonary disease deforms pulmonary micro-architectures using the synchrotron radiation microcomputed tomography (SRμCT). Our development of SRμCT allowed us to analyze 3D micro-architectures in the secondary pulmonary lobule. Our approach has the potential to efficiently provide the data needed for elucidation of lung 3D micro anatomy and pathology.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (41 results)

All 2017 2016 2015 2014 2013

All Journal Article (7 results) (of which Acknowledgement Compliant: 1 results,  Peer Reviewed: 5 results) Presentation (34 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results)

  • [Journal Article] 胸部CT検診のCADシステムにおける3次元表示2015

    • Author(s)
      河田佳樹,鈴木秀宣,仁木登
    • Journal Title

      医学物理

      Volume: 35 Pages: 211-216

    • NAID

      130005162127

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 計算解剖モデルに基づく診断支援2014

    • Author(s)
      仁木登,河田佳樹,鈴木秀宣,松廣幹雄
    • Journal Title

      INNERVISION

      Volume: 29 Pages: 19-21

    • NAID

      130000886607

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Evaluation of a near-infrared-type contrast medium extravasation detection system using a swine model2014

    • Author(s)
      T.Ishihara, T.Kobayashi, N.Ikeno, T.Hayashi, M.Sakakibara, N.Niki, M.Satake, N.Moriyama
    • Journal Title

      J Comput Assist Tomogr

      Volume: 38 Issue: 2 Pages: 285-292

    • DOI

      10.1097/rct.0000000000000013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood vessel-based liver segmentation using the portal phase of an abdominal CT dataset2013

    • Author(s)
      A.S.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada
    • Journal Title

      Medical Physics

      Volume: 40 Issue: 11 Pages: 113501-113518

    • DOI

      10.1118/1.4823765

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 保健医療分野における情報視覚化2013

    • Author(s)
      豊田修一,片貝智恵,仁木登
    • Journal Title

      情報処理学会デジタルプラクティス

      Volume: 4 Pages: 251-259

    • NAID

      40019768033

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胸部マルチスライスCT 画像を用いた骨粗鬆症診断支援システム2013

    • Author(s)
      高橋英治,鈴木秀宣,河田佳樹,仁木登,中野恭幸,上野淳二,原田雅史,森山紀之
    • Journal Title

      電子情報通信学会論文誌

      Volume: J.96-D Pages: 892-900

    • NAID

      110008726033

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胸部マルチスライスCT画像における葉間裂抽出法2013

    • Author(s)
      松廣幹雄,鈴木秀宣,河田佳樹,仁木登,上野淳二,中野恭幸,小川惠美子,室繁郎,大松広伸,森山紀之
    • Journal Title

      電子情報通信学会論文誌

      Volume: J.96-D Pages: 834-843

    • NAID

      110009596331

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射光CTを用いた細葉の肺3次元ミクロ構造解析2017

    • Author(s)
      前田亘輝,小林裕弥,斉藤くるみ,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,伊藤春海
    • Organizer
      第24回日本CT検診学会学術集会
    • Place of Presentation
      あわぎんホール (徳島県徳島市)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射光造影CTを用いた肺二次小葉のミクロ構造解析2017

    • Author(s)
      前田亘輝,小林裕弥,斉藤くるみ,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,伊藤春海
    • Organizer
      第9回呼吸機能イメージング研究会学術集会【優秀演題cum laude award】
    • Place of Presentation
      京都大学 百周年時計台記念館 (京都府京都市)
    • Year and Date
      2017-01-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Three-dimensional microstructure analysis of human lung specimens using a synchrotron radiation micro-CT2017

    • Author(s)
      K.Saito, K.Maeda, Y.Kobayashi, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Itoh
    • Organizer
      International Forum on Medical Imaging in Asia (IFMIA) 2017
    • Place of Presentation
      Tenbusu Naha  (Naha-city, Okinawa)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射光CTによる肺3次元ミクロ構造解析2017

    • Author(s)
      斉藤くるみ,前田亘輝,小林裕弥,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,伊藤春海
    • Organizer
      第12回京滋呼吸器リサーチフォーラム 【優秀賞】
    • Place of Presentation
      京都リサーチパーク(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Multiscale function and pathology modeling of respiratory system2016

    • Author(s)
      N.Niki
    • Organizer
      The 55th Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Toyama International Conference Center (Toyama-city, Toyama)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microstructure analysis of the pulmonary acinus by a synchrotron radiation CT2016

    • Author(s)
      K.Minami, K.Maeda, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Ohmatsu, H.Itoh
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Town & Country Resort and Convention Center (San Diego, California, USA)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lung 3D micro analysis using synchrotron radiation CT2016

    • Author(s)
      N.Niki
    • Organizer
      1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging
    • Place of Presentation
      Awaji Yumebutai International Conference Center (Awaji City, Hyogo, Japan)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of the microstructure of the secondary pulmonary lobules by a synchrotron radiation CT2016

    • Author(s)
      K.Minami, K.Maeda, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Ohmatsu, H.Itoh
    • Organizer
      1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging
    • Place of Presentation
      Awaji Yumebutai International Conference Center (Awaji City, Hyogo, Japan)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射光造影CTを用いた肺細葉のミクロ構造解析2016

    • Author(s)
      前田亘輝,三並浩一,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,大松広伸,伊藤春海
    • Organizer
      電子情報通信学会技術研究報告医用画像
    • Place of Presentation
      那覇市ぶんかテンブス館(沖縄県那覇市)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放射光CTによる肺3次元ミクロ構造解析2016

    • Author(s)
      斉藤くるみ,前田亘輝,小林裕弥,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,伊藤春海
    • Organizer
      第39回日本生体医工学会中国四国支部大会
    • Place of Presentation
      第39回日本生体医工学会中国四国支部大会(徳島県徳島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射光CTを用いた肺細葉のミクロ構造解析2016

    • Author(s)
      前田亘輝,小林裕弥,斉藤くるみ,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,伊藤春海
    • Organizer
      電子情報通信学会技術研究報告医用画像
    • Place of Presentation
      東京農工大学小金井キャンパス科学博物館3F講堂 (東京都小金井市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射光CTを用いた造影肺標本のミクロ構造解析2015

    • Author(s)
      三並浩一,前田亘輝,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,大松広伸,伊藤春海
    • Organizer
      第38回日本生体医工学会中国四国支部大会,(若手奨励賞)
    • Place of Presentation
      広島市立大学(広島県広島市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of 36M-pixel micro-CT using digital single-lens reflex camera2015

    • Author(s)
      K.Umetani, Y.Kawata, N.Niki, H.Itoh
    • Organizer
      IEEE International Conference on Imaging Systems and Techniques
    • Place of Presentation
      IEEE International School of Imaging (Macau, China)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射光CTを用いた造影肺標本のミクロ構造解析2015

    • Author(s)
      三並浩一,前田亘輝,河田佳樹,仁木登,梅谷啓二,中野恭幸, 阪井宏彰,大松広伸, 伊藤春海
    • Organizer
      電子情報通信学会技術研究報告医用画像
    • Place of Presentation
      電気通信大学(東京都調布市)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放射光CTによる肺二次小葉のミクロ構造解析2015

    • Author(s)
      三並浩一,前田亘輝,河田佳樹,仁木登,梅谷啓二,中野恭幸, 阪井宏彰,大松広伸, 伊藤春海
    • Organizer
      日本医用画像工学会大会
    • Place of Presentation
      金沢歌劇座(石川県金沢市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナノ粒子造影CTの性能評価2015

    • Author(s)
      前田亘輝,三並浩一,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,大松広伸,伊藤春海
    • Organizer
      日本医用画像工学会大会
    • Place of Presentation
      金沢歌劇座(石川県金沢市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放射光CTを用いた造影肺標本のミクロ構造解析2015

    • Author(s)
      三並浩一,前田亘輝,河田佳樹,仁木登,梅谷啓二,中野恭幸,阪井宏彰,大松広伸,伊藤春海
    • Organizer
      第10回京滋呼吸器リサーチフォーラム(優秀賞)
    • Place of Presentation
      京都リサーチパーク(京都府京都市)
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nonlinear dimensionality reduction of CT histogram based feature space for predicting recurrence-free survival in non-small-cell lung cancer2015

    • Author(s)
      Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Renaissance Orlando (Orlando, Florida, United States)
    • Year and Date
      2015-02-21 – 2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer2015

    • Author(s)
      H.Suzuki, R.Mizuguchi, M.Matsuhiro, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Renaissance Orlando (Orlando, Florida, United States)
    • Year and Date
      2015-02-21 – 2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] eripleural lung disease detection based on multi-slice CT images2015

    • Author(s)
      M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Renaissance Orlando (Orlando, Florida, United States)
    • Year and Date
      2015-02-21 – 2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microstructure analysis of the pulmonary acinus using a synchrotron radiation CT2015

    • Author(s)
      Y.Tokumoto, K.Minami, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Sakai, H.Ohmatsu, H.Itoh
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Renaissance Orlando (Orlando, Florida, United States)
    • Year and Date
      2015-02-21 – 2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] CAD工学的課題解決から臨床応用に向けて2014

    • Author(s)
      仁木登
    • Organizer
      日本医用画像工学会大会
    • Place of Presentation
      東京慈恵会医科大学(東京都港区)
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 放射光CT 画像による肺二次小葉の肺ミクロ構造解析2014

    • Author(s)
      三並浩一,徳元祥貴,河田佳樹,仁木登,梅谷啓二,中野恭幸,大松広伸,伊藤春海
    • Organizer
      日本医用画像工学会大会
    • Place of Presentation
      東京慈恵会医科大学(東京都港区)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高解像度マイクロCT用36M画素X線検出器の開発2014

    • Author(s)
      梅谷啓二,河田佳樹,福岡泰規,徳元祥貴,仁木登
    • Organizer
      日本医用画像工学会大会
    • Place of Presentation
      東京慈恵会医科大学(東京都港区)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Recurrence-free survival prediction of non-small cell lung cancer based on a nonparametric Bayesian analysis of CT histograms2014

    • Author(s)
      Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Kusumoto, T.Tsuchida, M.Satake, K.Eguchi, M.Kaneko, N.Moriyama
    • Organizer
      CARS International Journal of Computer Assisted Radiology and Surgery
    • Place of Presentation
      Fukuoka International Convention Center (福岡県福岡市)
    • Year and Date
      2014-06-25 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Automatic extraction of abdominal blood vessel through the portal phase of a CT dataset2014

    • Author(s)
      A.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada
    • Organizer
      CARS International Journal of Computer Assisted Radiology and Surgery
    • Place of Presentation
      Fukuoka International Convention Center (福岡県福岡市)
    • Year and Date
      2014-06-25 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] CADe and CADx for lung cancer CT images2014

    • Author(s)
      Noboru Niki
    • Organizer
      CARS International Journal of Computer Assisted Radiology and Surgery
    • Place of Presentation
      Fukuoka International Convention Center (福岡県福岡市)
    • Year and Date
      2014-06-25 – 2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肺がんのマルチスケールCT画像解析と臨床応用2014

    • Author(s)
      仁木登
    • Organizer
      第67回岐阜呼吸器疾患研究会
    • Place of Presentation
      岐阜県医師会館(岐阜県岐阜市)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Potential usefulness of a topic model-based categorization of lung cancers as quantitative CT biomarkers for predicting the recurrence risk after curative resection2014

    • Author(s)
      Y.Kawata, N.Niki, H.Ohmatsu, K.Aokage, M.Satake, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Town & Country Resort and Convention Center(San Diego, California, United States )
    • Related Report
      2013 Annual Research Report
  • [Presentation] Longitudinal follow-up study of smoking-induced emphysema progression in low-dose CT screening of lung cancer2014

    • Author(s)
      H.Suzuki, Y.Kawata, N.Niki, Y.Nakano, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Town & Country Resort and Convention Center(San Diego, California, United States )
    • Related Report
      2013 Annual Research Report
  • [Presentation] Microstructure analysis of the pulmonary lung of the secondary lobules by a synchrotron radiation CT2014

    • Author(s)
      Y.Fukuoka, Y.Kawata, N.Niki, K.Umetani, Y.Nakano, H.Ohmatsu, N.Moriyama, H.Itoh
    • Organizer
      Proc. SPIE Medical Imaging
    • Place of Presentation
      Town & Country Resort and Convention Center(San Diego, California, United States )
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multiscale image analysis of lung CT images2013

    • Author(s)
      Noboru Niki
    • Organizer
      MICCAI Workshop
    • Place of Presentation
      Nagoya University(Aichi)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Multi-scale organ modeling: from macro to micro2013

    • Author(s)
      Noboru Niki
    • Organizer
      IEEE-EBMC
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human pulmonary acinar analysis through 3D SRμCT images2013

    • Author(s)
      Noboru Niki
    • Organizer
      CARS International Journal of Computer Assisted Radiology and Surgery
    • Place of Presentation
      ハイデルベルグ国際会議場(ドイツ)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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